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The RNAWorldTony Z. JiaEarth-Life Science InstituteTokyo Institute of Technology
The Modern Cell
The Modern Cell
DNA
The Modern Cell
DNA
The Modern Cell
DNAP
The Modern Cell
DNA RNAP
The Modern Cell
DNA RNAPP
The Modern Cell
DNA RNA ProteinsPP
The Modern Cell
DNA RNA ProteinsPPPP
Ribosome
The Central Dogma
DNA RNA ProteinsPPP
RNA World Theory• RNA can store and pass down genetic information
• Similar in structure to DNA
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GC
DNA
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A
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RNA
RNA World Theory• RNA can store and pass down genetic information• RNA can catalyze chemical processes (ribozymes)
Martick, Scott, Cell. 2014
RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
Outstanding Issues
Mariani et al., Biochemistry. 2019He et al., Nature Chem. 2016
Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
Outstanding Issues
Li, et al., JACS. 2017
Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
Degradation
Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
Suggested Reading● Robertson MP, Joyce GF. The origins of the RNA world.
Cold Spring Harb Perspect Biol. 2012, 4.
● Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018, 10.
● Hud NV. Searching for lost nucleotides of the pre-RNA World with a self-refining model of early Earth. Nat Commun. 2018, 9.
● Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019, 363.
