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The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University of Pennsylvania Medical Center APIII 2006 © Steven C. Horii

The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

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Page 1: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

The radiology experience with adoption of standards: enhancing productivity and workflow

The radiology experience with adoption of standards: enhancing productivity and workflow

Steven C. Horii, MD, FACR, FSCARDepartment of Radiology

University of Pennsylvania Medical Center

APIII 2006 © Steven C. Horii

Page 2: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

DisclosureDisclosure

• Receive royalties from SPIE for a book I co-edited

• Member of an Advisory Board for Philips/Stentor, Inc.

• Compensated speaker for Philips Medical Systems, Inc.

• Receive royalties from SPIE for a book I co-edited

• Member of an Advisory Board for Philips/Stentor, Inc.

• Compensated speaker for Philips Medical Systems, Inc.

Page 3: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

IntroductionIntroduction

• Workflow in radiology and pathology

• Real radiology workflow

• The problem of multiple systems

• The pressure to change

• DICOM

• Workflow in radiology and pathology

• Real radiology workflow

• The problem of multiple systems

• The pressure to change

• DICOM

Page 4: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

IntroductionIntroduction

• Is DICOM enough?

• Integrating the Healthcare Enterprise (IHE)

• Examples of the impact of IHE

• IHE and pathology

• Is DICOM enough?

• Integrating the Healthcare Enterprise (IHE)

• Examples of the impact of IHE

• IHE and pathology

Page 5: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

The perception of pathology and radiologyThe perception of pathology and radiology• The Departments of a hospital

that make money:– Pathology

– Radiology

– The cafeteria

– The gift shop

• The Departments of a hospital that make money:– Pathology

– Radiology

– The cafeteria

– The gift shop

Page 6: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Radiology workflow: the “black box” viewRadiology workflow: the “black box” view• Requests go into the department

• Images and reports come out

• In this respect, workflow in radiology and pathology is perceived to be very similar by referring physicians

• Requests go into the department

• Images and reports come out

• In this respect, workflow in radiology and pathology is perceived to be very similar by referring physicians

Page 7: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Radiology workflow: the insiders viewRadiology workflow: the insiders view• Workflow is very complex

– Multiple systems are involved– Multiple personnel roles are

involved– Tasks and events have a specific

sequence– It is difficult for every person to

know the entire workflow

• Workflow is very complex– Multiple systems are involved– Multiple personnel roles are

involved– Tasks and events have a specific

sequence– It is difficult for every person to

know the entire workflow

Page 8: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Multiple systemsMultiple systems

• Image acquisition– Radiography, CT, MR, NM, US, etc.

– Also our “interface” with patients

• Image acquisition is where DICOM has has its greatest success

• Image acquisition– Radiography, CT, MR, NM, US, etc.

– Also our “interface” with patients

• Image acquisition is where DICOM has has its greatest success

Page 9: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Multiple systemsMultiple systems

• Radiology information system (RIS)– Scheduling– Order entry– Report database (transcription is often

separate)– Patient demographics– Examination management (more

important in film-based operations)

• Radiology information system (RIS)– Scheduling– Order entry– Report database (transcription is often

separate)– Patient demographics– Examination management (more

important in film-based operations)

Page 10: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Multiple systemsMultiple systems

• Digital image management system (DIMS, PACS)– Image capture

– Image storage

– Image display and distribution

– Examination management (the filmless version)

• Digital image management system (DIMS, PACS)– Image capture

– Image storage

– Image display and distribution

– Examination management (the filmless version)

Page 11: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Multiple systemsMultiple systems

• Dictation/transcription system– Conventional dictation (tape-

based)

– Digital dictation (digital voice files)

• Both involve a person transcribing the report into the RIS

• Dictation/transcription system– Conventional dictation (tape-

based)

– Digital dictation (digital voice files)

• Both involve a person transcribing the report into the RIS

Page 12: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Multiple systemsMultiple systems

• Newer methods– Speech recognition– Structured reporting

• Though there are some “manual” variants, these both involve radiologist input to a system that outputs a text report to the RIS

• Newer methods– Speech recognition– Structured reporting

• Though there are some “manual” variants, these both involve radiologist input to a system that outputs a text report to the RIS

Page 13: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Multiple systemsMultiple systems

• Hospital information system (HIS)– Patient information database– Physician order entry– Report distribution– Interface for laboratory

information, electronic chart applications, etc.

• Hospital information system (HIS)– Patient information database– Physician order entry– Report distribution– Interface for laboratory

information, electronic chart applications, etc.

Page 14: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

The pressure of timeThe pressure of time

• Paul Chang: “Radiologists used to hide behind the inefficiencies of film.”– The time-consuming nature of various

steps meant that radiologists could do things like “batch read”

– Any delays resulting from such workflow were buried in the other workflow steps

• Paul Chang: “Radiologists used to hide behind the inefficiencies of film.”– The time-consuming nature of various

steps meant that radiologists could do things like “batch read”

– Any delays resulting from such workflow were buried in the other workflow steps

Page 15: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Workflow delaysWorkflow delays

• Transcription typically picked up tapes at the end of the day and worked overnight

• The radiologist would sign reports the next morning

• Given this, delaying interpretation until mid-day and late afternoon did not change the time the reports were available

• Transcription typically picked up tapes at the end of the day and worked overnight

• The radiologist would sign reports the next morning

• Given this, delaying interpretation until mid-day and late afternoon did not change the time the reports were available

Page 16: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

What began to changeWhat began to change

• Digital dictation

• Reimbursement changes

• Speech recognition and structured reporting

• Digital dictation

• Reimbursement changes

• Speech recognition and structured reporting

Page 17: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Digital dictationDigital dictation

• Transcription services could work as reports came in

• Turn-around time (TAT) began to decrease from 12 or more hours to several hours

• Transcription services could work as reports came in

• Turn-around time (TAT) began to decrease from 12 or more hours to several hours

Page 18: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Reimbursement changesReimbursement changes

• CMS reduced reimbursement rates for imaging procedures, physician appointment durations, and hospital stays– Pressure for reduced hospital stays– Pressure for short “workup” cycles– Need to see more patients or perform

more studies in the same amount of time

• CMS reduced reimbursement rates for imaging procedures, physician appointment durations, and hospital stays– Pressure for reduced hospital stays– Pressure for short “workup” cycles– Need to see more patients or perform

more studies in the same amount of time

Page 19: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Speech recognition and structured reportingSpeech recognition and structured reporting• Reports are essentially complete

when the “dictation” is done

• Report TAT now could be down to minutes

• A great boon to referring physicians

• More work for the radiologist (acting as an editor)

• Reports are essentially complete when the “dictation” is done

• Report TAT now could be down to minutes

• A great boon to referring physicians

• More work for the radiologist (acting as an editor)

Page 20: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Actual problems with speech recognitionActual problems with speech recognition• Wreck a nice beach

• Recognize speech

• Left incite you

• Left in situ

• Violently benign

• 8.9

• Wreck a nice beach

• Recognize speech

• Left incite you

• Left in situ

• Violently benign

• 8.9

Page 21: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

What does radiology workflow look like?What does radiology workflow look like?• Based on Integrating the Healthcare

Enterprise

• A joint effort of:– The Radiological Society of North

America (RSNA)– The Health Informatics management

Systems Society (HIMSS)– American College of Cardiology (ACC)

• Based on Integrating the Healthcare Enterprise

• A joint effort of:– The Radiological Society of North

America (RSNA)– The Health Informatics management

Systems Society (HIMSS)– American College of Cardiology (ACC)

Page 22: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

imagesstored

patientinformation

RIS

examination orders

imagesretrieved

HIS

PACS

procedurescheduled

Prefetch any relevantprior studies

modalityworklist

report

report

Model of radiology workflow

Registration

Orders Placed

Orders Filled

Film

FilmFolder

Image Manager& Archive

FilmLightbox

report ReportRepository

DiagnosticWorkstation

Modality

acquisitionacquisitionin-progressin-progressacquisitioncompleted

acquisitioncompleted

imagesprinted

AcquisitionModality

Page 23: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Workflow is actually worse than thisWorkflow is actually worse than this• Eliot Siegel: in a film-based

environment with no PACS or RIS: request to report ; 59 steps

• Our study (ultrasound): in a PACS-based environment with an RIS, but no interface between the systems: request to report ; 32 steps

• Eliot Siegel: in a film-based environment with no PACS or RIS: request to report ; 59 steps

• Our study (ultrasound): in a PACS-based environment with an RIS, but no interface between the systems: request to report ; 32 steps

Page 24: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

What standards have helped radiology?What standards have helped radiology?

Imaging equipment

Other devices (storage, etc.)

Interface

Page 25: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

The standard for this is DICOMThe standard for this is DICOM

• Move images from image generating equipment to other devices or systems– Typically to a PACS– Occasionally to printers or CD

recorders– What constitutes “imaging equipment”

has been steadily expanding

• Move images from image generating equipment to other devices or systems– Typically to a PACS– Occasionally to printers or CD

recorders– What constitutes “imaging equipment”

has been steadily expanding

Page 26: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Benefits of DICOMBenefits of DICOM

• Enabled PACS

• Elimination of custom interfaces and the problems associated with them:– High cost of the interface and its

maintenance– Problems every time there is a change

in the imaging equipment or PACS

• Enabled PACS

• Elimination of custom interfaces and the problems associated with them:– High cost of the interface and its

maintenance– Problems every time there is a change

in the imaging equipment or PACS

Page 27: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Is DICOM alone sufficient to improve workflow?Is DICOM alone sufficient to improve workflow?• DICOM information object

definitions include many elements that should contain information already in other systems

• How does it get from these into the DICOM metadata?

• DICOM information object definitions include many elements that should contain information already in other systems

• How does it get from these into the DICOM metadata?

Page 28: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

DICOM and other information systemsDICOM and other information systems• DICOM included “hooks” that

were intended for interfacing to other information systems (e.g., the patient name structure and date-time elements)

• Most other information systems “speak” HL7, not DICOM

• DICOM included “hooks” that were intended for interfacing to other information systems (e.g., the patient name structure and date-time elements)

• Most other information systems “speak” HL7, not DICOM

Page 29: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Why not a DICOM – HL7 translator?Why not a DICOM – HL7 translator?• Both DICOM and HL7 suffer from a

similar problem:• DICOM and HL7 have many options,

though DICOM structure is more tightly defined

• How do two systems using different options in these standards communicate?

• Not well

• Both DICOM and HL7 suffer from a similar problem:

• DICOM and HL7 have many options, though DICOM structure is more tightly defined

• How do two systems using different options in these standards communicate?

• Not well

Page 30: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Enter IHEEnter IHE

• In 1997, recognizing the need for PACS to interface with other information systems the RSNA and HIMSS began the IHE effort

• IHE:– Does not develop new standards– Does develop “profiles” that specify

options within standards for particular tasks

• In 1997, recognizing the need for PACS to interface with other information systems the RSNA and HIMSS began the IHE effort

• IHE:– Does not develop new standards– Does develop “profiles” that specify

options within standards for particular tasks

Page 31: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Some IHE terminologySome IHE terminology

• Actor: the application or system that is responsible for certain information or tasks; products may include one or more actors

• Integration profile: the precise description of how standards are to be implemented to address a particular clinical integration need

• Actor: the application or system that is responsible for certain information or tasks; products may include one or more actors

• Integration profile: the precise description of how standards are to be implemented to address a particular clinical integration need

Page 32: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

One example: Scheduled Workflow (SWF) profileOne example: Scheduled Workflow (SWF) profile• In DICOM:

– Modality Worklist: Allows imaging equipment to request patient demographic information from an information system

– Performed Procedure Step: Allows imaging equipment to send a notification that a procedure step has been completed

• In DICOM:– Modality Worklist: Allows imaging

equipment to request patient demographic information from an information system

– Performed Procedure Step: Allows imaging equipment to send a notification that a procedure step has been completed

Page 33: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

One example: Scheduled Workflow (SWF) profileOne example: Scheduled Workflow (SWF) profile• In HL7 specifies Actors for:

– ADT/Patient registration– Order Placer– Order Filler– Image Manager

• Plus the transactions to support these

• In HL7 specifies Actors for:– ADT/Patient registration– Order Placer– Order Filler– Image Manager

• Plus the transactions to support these

Page 34: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

imagesstored

patientinformation

RIS

examination orders

imagesretrieved

HIS

PACS

procedurescheduled

Prefetch any relevantprior studies

modalityworklist

report

report

Scheduled Workflow Profile

Registration

Orders Placed

Orders Filled

Film

FilmFolder

Image Manager& Archive

FilmLightbox

report ReportRepository

DiagnosticWorkstation

Modality

acquisitionacquisitionin-progressin-progressacquisitioncompleted

acquisitioncompleted

imagesprinted

AcquisitionModality

Page 35: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

What does this mean?What does this mean?

• In both our study and that by Dr. Siegel, implementing SWF:– Reduces 32 steps, or

– Reduces 59 steps

– To 9 steps

• In both our study and that by Dr. Siegel, implementing SWF:– Reduces 32 steps, or

– Reduces 59 steps

– To 9 steps

Page 36: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

What is the productivity impact of such reductions?What is the productivity impact of such reductions?• We did a study of technologist task

time in ultrasound

• This involved the manual equivalents of DICOM Modality Worklist and Performed Procedure Step

• The median time was 5 minutes per patient

• We did a study of technologist task time in ultrasound

• This involved the manual equivalents of DICOM Modality Worklist and Performed Procedure Step

• The median time was 5 minutes per patient

Page 37: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

The impact of small times with large volumesThe impact of small times with large volumes• We do approximately 20,000

ultrasound examinations per year

• That 5 minutes per patient works out to 69 person days per year!

• We do approximately 20,000 ultrasound examinations per year

• That 5 minutes per patient works out to 69 person days per year!

Page 38: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

The impact of small times on productivityThe impact of small times on productivity• The same 5 minutes per patient,

given typical sonographer workload in our Section, means enough time to scan at least one additional patient per sonographer per day

• For our section, that means 10 additional patients per day, or 2500 per typical work year

• The same 5 minutes per patient, given typical sonographer workload in our Section, means enough time to scan at least one additional patient per sonographer per day

• For our section, that means 10 additional patients per day, or 2500 per typical work year

Page 39: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

This is just one IHE profile – there are moreThis is just one IHE profile – there are more• At present, approximately twenty

profiles are developed or in “trial implementation” stage

• That does not include profiles developed for cardiology

• At present, approximately twenty profiles are developed or in “trial implementation” stage

• That does not include profiles developed for cardiology

Page 40: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Other profiles that are likely to be of interest in pathologyOther profiles that are likely to be of interest in pathology• Patient Information

Reconciliation – how you reconcile the patient information in studies done before a patient is identified (e.g., the unconscious patient in the Emergency Department)

• Patient Information Reconciliation – how you reconcile the patient information in studies done before a patient is identified (e.g., the unconscious patient in the Emergency Department)

Page 41: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Other profiles that are likely to be of interest in pathologyOther profiles that are likely to be of interest in pathology• Consistent Presentation of Images –

how do you assure that images will look the same across many different displays

• Key Image Note – support for identifying the “key” images in an examination (e.g., slide fields showing pathology of interest)

• Consistent Presentation of Images – how do you assure that images will look the same across many different displays

• Key Image Note – support for identifying the “key” images in an examination (e.g., slide fields showing pathology of interest)

Page 42: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Other profiles that are likely to be of interest in pathologyOther profiles that are likely to be of interest in pathology• Charge Posting – how information

that resides in image management systems can be made available to billing systems

• Portable Data for Imaging – consistent way to record images on removable media (e.g., CD ROM)

• Charge Posting – how information that resides in image management systems can be made available to billing systems

• Portable Data for Imaging – consistent way to record images on removable media (e.g., CD ROM)

Page 43: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Other profiles that are likely to be of interest in pathologyOther profiles that are likely to be of interest in pathology• Post Processing Workflow –

supports additional image processing by specialized systems– For radiology, 3D graphics systems– For pathology, potentially special

staining or processing/imaging (immunofluorescence, electron microscopy)

• Post Processing Workflow – supports additional image processing by specialized systems– For radiology, 3D graphics systems– For pathology, potentially special

staining or processing/imaging (immunofluorescence, electron microscopy)

Page 44: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

IHE and pathologyIHE and pathology

• Since I am not an expert in pathology workflow, it is likely that there are other profiles of interest,

• But also likely that many would need extension or additional specification

• Since I am not an expert in pathology workflow, it is likely that there are other profiles of interest,

• But also likely that many would need extension or additional specification

Page 45: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Where to find out moreWhere to find out more

• The IHE Radiology User’s Handbook (a must!):– http://www.ihe.net/Resources/

index.cfm#handbook

• The IHE Web site:– http://www.ihe.net/

• The IHE Radiology User’s Handbook (a must!):– http://www.ihe.net/Resources/

index.cfm#handbook

• The IHE Web site:– http://www.ihe.net/

Page 46: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

Where to find out moreWhere to find out more

• Integration Statements (surprise! Your vendors may be here!)– http://www.ihe.net/Resources/

ihe_integration_statements.cfm

• Success stories (read how others have used IHE successfully)– http://www.ihe.net/Resources/

user_success_stories.cfm

• Integration Statements (surprise! Your vendors may be here!)– http://www.ihe.net/Resources/

ihe_integration_statements.cfm

• Success stories (read how others have used IHE successfully)– http://www.ihe.net/Resources/

user_success_stories.cfm

Page 47: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

ConclusionConclusion

• Needs in radiology were a tremendous impetus to develop and use standards

• Pressure for improved productivity resulted in an examination of workflow and the growth of the IHE efforts

• Needs in radiology were a tremendous impetus to develop and use standards

• Pressure for improved productivity resulted in an examination of workflow and the growth of the IHE efforts

Page 48: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

ConclusionConclusion

• DICOM and IHE have followed the principle of specialty independence

• Domain knowledge comes from specialties

• Technical knowledge comes from the IT experts on the DICOM and IHE Committees and Working Groups

• This has been a very productive partnership

• DICOM and IHE have followed the principle of specialty independence

• Domain knowledge comes from specialties

• Technical knowledge comes from the IT experts on the DICOM and IHE Committees and Working Groups

• This has been a very productive partnership

Page 49: The radiology experience with adoption of standards: enhancing productivity and workflow Steven C. Horii, MD, FACR, FSCAR Department of Radiology University

AcknowledgementAcknowledgement

• Some of the work reported (technologist task time) was supported in part by NIH NCI Program Project Grant P01-CA53141

• Some of the work reported (technologist task time) was supported in part by NIH NCI Program Project Grant P01-CA53141