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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I. Webb, Samuel N. Young, Leila N. Varghese, Gillian M. Tannahill, Esme C. Hatchell, Ian J. Majewski, Toru Okamoto, Renwick C.J. Dobson, Douglas J. Hilton, Jeffrey J. Babon, Nicos A. Nicola, Andreas Strasser, John Silke, Warren S. Alexander Immunity Volume 39, Issue 3, Pages 443-453 (September 2013) DOI: 10.1016/j.immuni.2013.06.018 Copyright © 2013 Elsevier Inc. Terms and Conditions

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

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Page 1: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism 

James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I. Webb, Samuel N. Young, Leila N. Varghese, Gillian M. Tannahill, Esme C. Hatchell, Ian J. Majewski, Toru Okamoto, Renwick C.J. Dobson, Douglas J. Hilton, Jeffrey J. Babon, Nicos A. Nicola, Andreas Strasser, John Silke,

Warren S. Alexander 

Immunity Volume 39, Issue 3, Pages 443-453 (September 2013)

DOI: 10.1016/j.immuni.2013.06.018

Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Figure 1

Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Figure 2

Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Figure 3

Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Figure 4

Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Figure 5

Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Figure 6

Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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