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The Paleo Diet Presented by Erin McLean

The Paleo Diet

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The Paleo Diet. Presented by Erin McLean. Overview. Paleo diet in a nutshell Review of literature Journal Club article Methodology Results Discussion Summary Discussion questions References. Paleo Diet …in a nutshell. Eat:. Paleo Diet …in a nutshell. Don’t Eat:. - PowerPoint PPT Presentation

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Page 1: The Paleo Diet

The Paleo Diet

Presented by Erin McLean

Page 2: The Paleo Diet

Overview• Paleo diet in a nutshell• Review of literature• Journal Club article

– Methodology – Results– Discussion

• Summary • Discussion questions• References

Page 3: The Paleo Diet

Paleo Diet…in a nutshell

• Eat:

Page 4: The Paleo Diet

Paleo Diet…in a nutshell

• Don’t Eat:

Page 5: The Paleo Diet

Review of LiteratureA Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart

disease

• Purpose:– To compare the effects of the Paleo diet to a

Mediterranean-like diet on glucose tolerance and insulin response in IHD patients with glucose-intolerance

(Lindeberg et al., 2007, p. 1796)

Page 6: The Paleo Diet

Review of LiteratureA Palaeolithic diet improves glucose tolerance more than a

Mediterranean-like diet in individuals with ischaemic heart disease

• Methods:– 12-week controlled dietary intervention trial– 29 male IHD patients with glucose intolerance and

waist circumference >94 cm recruited– Subjects randomized to the Paleo diet (n=14) or

the Consensus diet (n=15)– All subjects given written dietary advice and

recipes according to assigned diet– Outcome measures included glucose AUC and

insulin AUC in OGTTs, weight change, and waist circumference(Lindeberg et al., 2007, p. 1795-1797)

Page 7: The Paleo Diet

Review of LiteratureA Palaeolithic diet improves glucose tolerance more than a

Mediterranean-like diet in individuals with ischaemic heart disease

• Results:

– Glucose AUC ↓ 26% in Paleo group (P=0.0001) and 7% in Consensus group (P=0.08)

• Glucose AUC improvement in Paleo group independent of change in waist circumference

– Change in waist circumference ↓ 5.6 cm in Paleo group (P=0.0008) and 2.9 cm in Consensus group (P=0.03)

– Trend toward larger ↓ in insulin AUC in Paleo group but considered NS due to association between insulin AUC and change in weight (Lindeberg et al., 2007, p. 1795)

Page 8: The Paleo Diet

Review of LiteratureA Palaeolithic diet improves glucose tolerance more than a

Mediterranean-like diet in individuals with ischaemic heart disease

• Conclusion:– Glucose tolerance may be enhanced on the Paleo

diet independently of ↓ in waist circumference

(Lindeberg et al., 2007, p. 1796)

Page 9: The Paleo Diet

Review of LiteratureA Palaeolithic diet improves glucose tolerance more than a

Mediterranean-like diet in individuals with ischaemic heart disease

• Evaluation of Article:– Accurate summary of current body of knowledge– Possible bias– Conclusions appropriate

Page 10: The Paleo Diet

Review of LiteraturePaleo diet versus modified Paleo diet: A randomized control

trial of weight loss and biochemical benefit

• Purpose:– To compare physiological and metabolic

improvements in subjects consuming either a Paleo or modified Paleo diet

(Martin et al., 2013, p. A-35)

Page 11: The Paleo Diet

Review of LiteraturePaleo diet versus modified Paleo diet: A randomized control

trial of weight loss and biochemical benefit

• Methods:

– 5-week clinical dietary intervention study

– 20 subjects recruited and placed in Paleo diet or modified Paleo diet group

– Each group given specific dietary instructions and required to submit weekly diet compliance records

– Outcome measures included body composition and weight, lipid profiles, insulin sensitivity, and BP

(Martin et al., 2013, p. A-35)

Page 12: The Paleo Diet

Review of LiteraturePaleo diet versus modified Paleo diet: A randomized control

trial of weight loss and biochemical benefit

• Results:– Both diet groups exhibited significant ↓(P<0.05)

in:• Weight (-3.3 ± 0.4 kg)• BMI (-1.2 ± 0.2 kg/m²)• FFM (-0.9 ± 0.3 kg)• Fat mass (-2.2 ± 0.3 kg)• % body fat (-1.6 ± 0.4%)

– Lipid profiles, insulin sensitivity, and BP measures improved but no significant difference measured between diet groups(Martin et al., 2013, p. A-35)

Page 13: The Paleo Diet

Review of LiteraturePaleo diet versus modified Paleo diet: A randomized control

trial of weight loss and biochemical benefit

• Conclusion:– Following a modified Paleo diet may result in

physiological improvements similar to those observed in the more restrictive Paleo diet

(Martin et al., 2013, p. A-35)

Page 14: The Paleo Diet

Journal Club Presents…

Metabolic and physiologic improvements from consuming a paleolithic,

hunter-gatherer type diet

LA Frassetto, M Schloetter, M Mietus-Synder, RC Morris Jr and A Sebastian

Page 15: The Paleo Diet

Purpose• To compare the effects of a paleolithic-type

diet with that of a usual diet on metabolic and physiological variables

(Frassetto et al., 2009, p. 948)

Page 16: The Paleo Diet

Methodology: Subjects

• Subject Recruitment Criteria:– Nonobese men and women– 18 years of age or older– No medical problems– No medications– Minimal regular physical activity– Pass telephone screening– Pass graded maximal exercise treadmill test

(Frassetto et al., 2009, p. 948)

Page 17: The Paleo Diet

Methodology: Subjects

• Recruited Subjects:– 11 participants enrolled/9 participants completed

study– 6 males/3 females– Age: 38 ± 12 years– BMI: 27.8 ± 2.4 kg/m²

(Frassetto et al., 2009, p. 949)

Page 18: The Paleo Diet

Methodology: Design

• Design:– Research type:

• Outpatient, metabolically controlled study

– Diets:• Usual diet (days -2 to 0)• Three ramp-up diets (7 days)• Paleo diet (10 days)

(Frassetto et al., 2009, p. 947-948)

Page 19: The Paleo Diet

Methodology: Design• Usual Diet (3 days):

– Participants ate usual diet– Testing:

• Baseline 24-h urine collections for electrolyte profile• Fasting blood samples for lipid, glucose, and insulin

profiles• BP measurements

– Dietitian interview:• Five-pass, 24-h diet recall of usual diet

(Frassetto et al., 2009, p. 948)

Page 20: The Paleo Diet

Methodology: Design

• Ramp-up Diets (7 days):– Intervention phase– Diets developed by research dietitians– Diets utilized for adaptation purposes

• Fiber • Potassium

(Frassetto et al., 2009, p. 948)

Page 21: The Paleo Diet

Methodology: Design

• Ramp-up Diets Con’t:– Ramp 1 diet: 1 day, 125 mmol K

–Ramp 2 diet: 3 days, 180 mmol K˗ Ramp 3 diet: 3 days, 259 mmol K

(Frassetto et al., 2009, p. 951)

Page 22: The Paleo Diet

Methodology: Design

• Paleo Diet (10 days):Included Foods Excluded FoodsMeat Dairy products

Fish Legumes

Poultry Cereals

Eggs Grains

Fruits Potatoes

Vegetables Products containing KCl

Tree nuts

Canola oil

Mayonnaise

Honey

˗ Domestic meat, carrot juice, and mayonnaise included due to similarity of nutritional content to preagricultural foods.

(Frassetto et al., 2009, p. 949)

Page 23: The Paleo Diet

Methodology: Design

• Paleo Diet Con’t:– 3 meals/3 snacks– Same diet consumed daily– 1 meal/day consumed at research center– All other meals packed for take-out– 24-h urinary sodium and potassium excretion

utilized as dietary compliance marker

(Frassetto et al., 2009, p. 949)

Page 24: The Paleo Diet

Methodology: Design

• Paleo Diet Con’t:– Maintenance energy needs calculated based on

participant weight and daily activity level– Body weight measured daily to eliminate weight

loss

(Frassetto et al., 2009, p. 949)

Page 25: The Paleo Diet

Methodology: Outcome Measures

• Outcome Measures:Main Outcome Measures Outcome Measures

Electrolyte excretion Usual vs. Paleo diet intakes

Lipid profile Weight change

Glucose & insulin profiles Total body/intracellular water content

Blood pressure & vascular reactivity

Creatinine clearance

Urinary calcium/creatinine clearance Urine pH

(Frassetto et al., 2009, p. 949-952)

Page 26: The Paleo Diet

Methodology: Procedures

• First 3 Days (Usual diet, days -2 to 0):– Baseline 24-h urine collections for electrolyte profile– Fasting blood samples for lipid, glucose, insulin

profiles– BP and vascular reactivity

• Last 3 Days (Paleo diet, 15 to 17):– All initial tests repeated – Results from first 3 days averaged/results from last 3

days averaged

(Frassetto et al., 2009, p. 948-949)

Page 27: The Paleo Diet

Methodology: Procedures

• Electrolyte Profile:

– Data obtained from 24-h urine collection

– Averaged days -2 to 0 and 15 to 17 for each participant

– Mean values compared before and after Paleo diet

(Frassetto et al., 2009, p. 948-949)

Page 28: The Paleo Diet

Methodology: Procedures

• Lipid Profile:

– Data obtained from fasting blood samples

– Averaged days -2 to 0 and 15 to 17 for each participant

– Mean values compared before and after Paleo diet

(Frassetto et al., 2009, p. 948-949)

Page 29: The Paleo Diet

Methodology: Procedures

• Glucose & Insulin Profiles:

– Data obtained from fasting blood samples

– Blood samples obtained at 0 (fasting), 30, 60, and 120 min during 2-h OGTT

– Insulin AUC from 2-h OGTT calculated using trapezoidal method

– Insulin sensitivity calculated using homeostatic assessment model

– Mean values compared before and after Paleo diet(Frassetto et al., 2009, p. 948-949)

Page 30: The Paleo Diet

Methodology: Procedures

• BP and Vascular Reactivity:

– BP measured after 10 min of sitting at 1 min intervals for 3 min

– Mean values compared before and after Paleo diet

– BAD and blood flow measured at baseline and after cuff occlusion for 5 min

(Frassetto et al., 2009, p. 949)

Page 31: The Paleo Diet

Methodology: Data Analysis

• Data Analysis:– Repeated measures analysis with post hoc paired

t-tests – Regression analysis– Range and medium data – Measured consistency of directional changes in

outcome variables – Statistics reported as mean ± s.d.

(Frassetto et al., 2009, p. 949)

Page 32: The Paleo Diet

Results • Electrolyte Profile:

– Urinary Na content ↓ by 89 ± 73 mmol/d (P=0.007)

– Urinary Cl content ↓ by 76 ± 64 mmol/d (P=0.007)

– Urinary K content ↑ by 71 ± 54 mmol/d (P=0.004)

– Ratio of urinary K/Na excretion ↑ from 0.5 ± 0.1 to 2.2 ± 0.6 (P<0.001)

– Urinary Ca/creatinine excretion ↓ by 10 ± 5 mmol Ca/88400 mmol Cr/d (P=0.001)

(Frassetto et al., 2009, p. 949-950)

Page 33: The Paleo Diet

Results

• Lipid Profile:

– Total cholesterol ↓ by 0.8 ± 0.6 mmol/l (16%; P=0.007)

– LDL cholesterol ↓ by 0.7 ± 0.5 mmol/l (22%; P=0.003)

– VLDL cholesterol ↓ by 0.2 ± 0.1 mmol/l (35%; P=0.01)

– Triglycerides ↓ by 0.3 ± 0.3 mmol/l (35%; P=0.01)

(Frassetto et al., 2009, p. 950)

Page 34: The Paleo Diet

Results • Glucose & Insulin Profiles:

– Mean fasting glucose ↓ by 5% but NS

– Fasting insulin ↓ by 68% from baseline (P=0.07)

– Insulin AUC ↓ by 181 ± 132 pmol (P=0.006)

– Insulin/glucose AUC of usual vs. Paleo diet ↓ from 20 ± 10 to 12 ± 9 mg/M (P=0.005)

(Frassetto et al., 2009, p. 950)

Page 35: The Paleo Diet

Results• BP and Vascular Reactivity:

– Mean diastolic BP ↓ by -3.4 ± 2.7 mmHg (P=0.006)

– Mean arterial pressure ↓ by -3 ± 3 mmHg (P=0.01)

– Trend toward ↓ in systolic BP but NS

– Baseline BAD NS before or on Paleo diet

– Peak BAD during hyperemia ↑ by 0.19 ± 0.23 mm (P=0.05)

(Frassetto et al., 2009, p. 950, 952)

Page 36: The Paleo Diet

Results • No significant change in:

– Weight– Total body/intracellular water content– Mean creatinine clearance– Urine pH

(Frassetto et al., 2009, p. 949-950)

Page 37: The Paleo Diet

Results• Strength of Evidence (EAL):

– Evidence found in this research is given a Grade II (fair) status.

Strength of Evidence

Quality Fair (II)

Consistency Good (I)

Quantity Limited (III)

Clinical Impact Good (I)

Generalizability Fair (II)

Page 38: The Paleo Diet

Discussion • Subjects exhibited improved lipid profiles, insulin

secretion, and BP and vascular reactivity. This occurred in a short period of time without:

• Losing weight• Increasing physical activity levels• Taking medications

• Further research needed to compare effects of common intervention diets to Paleo diet in determining relative health efficacy

(Frassetto et al., 2009, p. 952-954)

Page 39: The Paleo Diet

Summary• Paleo diet theorized to be more conducive to

human digestive and metabolic systems

• Limited research on Paleo diet

• In featured article, improved circulatory, carbohydrate and lipid metabolism/physiology observed from consuming Paleo diet

Page 40: The Paleo Diet

Discussion Question #1

Paleo diet in standard clinical practice?

Page 41: The Paleo Diet

Discussion Question #2

Population that Paleo diet would appeal to?

Page 42: The Paleo Diet

Discussion Question #3

Credence to idea of following diet in line with human evolutionary biochemistry?

Page 43: The Paleo Diet

References[Caveman and woman]. (n.d.). Retrieved September 30, 2013, from

http://yaniblog.blogspot.com/2012/11/lego-minifig-troubles.html[Caveman running]. (n.d.). Retrieved September 30, 2013, from

http://lego.wikia.com/wiki/Caveman[Cavemen spearing elephant]. (n.d.). Retrieved September 30, 2013, from

http://www.nerdfitness.com/blog/2010/10/04/the-beginners-guide-to-the-paleo-diet/Comet, R. (2001, January 1). Potatoes [Digital image]. Retrieved September 30, 2013, from

http://visualsonline.cancer.gov/details.cfm?imageid=2653[Dairy products]. (n.d.). Retrieved September 30, 2013, from http://www.wdpa.net/Frassetto, L. A., Schloetter, M., Mietus-Synder, M., Morris Jr, R. C., & Sebastian, A. (2009).

Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. European Journal of Clinical Nutrition, 63, 947-955. doi: 10.1038/ejcn.2009.4

Kosoris, S. (2010, September 5). Caveman [Digital image]. Retrieved September 30, 2013, from http://www.chethstudios.net/2010/09/50-incredibly-creative-lego-creations.html

Lego caveman 1 [Digital image]. (n.d.). Retrieved September 30, 2013, from http://hongkongcavalierdave.deviantart.com/art/Lego-Caveman-1-206782315

Page 44: The Paleo Diet

ReferencesLindeberg, S., Jönsson, T., Granfeldt, Y., Borgstrand, E., Soffman, J., Sjöström, K., & Ahrén, B. (2007).

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia, 50(9), 1795-1807. doi: 10.1007/s00125-007-0716-y

Manieri, L. (2008, March 7). Legumes and cereals [Digital image]. Retrieved September 30, 2013, from http://www.dreamstime.com/royalty-free-stock-images-legumes-cereals-image4527449

Martin, C. A., & Akers, J. (2013). Paleo diet versus modified paleo diet: A randomized control trial of weight loss and biochemical benefit [Abstract]. Journal of the Academy of Nutrition and Dietetics, 113(9), suppl 3, A-35. Retrieved September 30, 2013, from http://download.journals.elsevierhealth.com/pdfs/journals/2212-2672/PIIS2212267213007934.pdf

McCarthy, J. (n.d.). [Foods on Paleo diet]. Retrieved September 30, 2013, from http://theotherpress.ca/paleo-diet-hot-trend-or-a-survival-guide/

[Oatmeal]. (n.d.). Retrieved September 30, 2013, from http://coisasdemeninasvaidosas.blogspot.com/2013_06_01_archive.html

Sears, K. (2013). [Table salt]. Retrieved September 30, 2013, from http://www.realsimple.com/home-organizing/cleaning/all-natural-cleaning-solutions-00000000011547/page10.html

[Standing caveman]. (n.d.). Retrieved September 30, 2013, from http://lethereatclean.com/2013/06/10/why-i-love-to-hate-the-paleo-diet/