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1. The Opioid Class of Analgesics

2. Legal Terms and Conditions

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3. Opioid Class of Analgesics: Slide 3

4. Legal Terms and Conditions (contd.)

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5. Program Objectives

6. Definitions

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7. Opioids

8. Opioids & Receptor Activity

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9. Mu () Receptor Activation

10. Dose-response Curves

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11. How does this correlate to clinical pain management?

12. Opioid Agonists: Structural Pharmacology

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13. Opioid Rotation (OR)

14. Codeine

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15. Codeine

16. Morphine

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17. Morphine

18. M-3-G (morphine-3-glucuronide)

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19. M-6-G (morphine-6-glucuronide)

20. M-6-G and M-3-G (continued)

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21. Renal Dysfunction and Morphine

22. Hepatic Dysfunction and Morphine

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23. Pruritus and Morphine

24. Oxycodone

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25. Oxycodone

26. Oxycodone

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27. Hydrocodone

28. Hydromorphone (HM)

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29. Biotransformation of HM

30. Metabolite Profile of Hydromorphone

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31. Potential Role of HM Metabolites

32. Methadone

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33. Methadone

34. Methadone

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35. Propoxyphene

36. Meperidine

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37. Normeperidine

38. Fentanyl

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39. Levorphanol and Congeners

40. Buprenorphine

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41. Agonist-antagonists

42. Opioid Antagonists

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43. Summary

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