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The Next Generation of Health Care, Personalized Wellness and Prevention1

The Power of KnowingHistory

NowScientific BreakthroughShamanPalm ReaderTarot Card ReaderHoroscopeHRAPersonalizedGenomics

Have you ever wondered if you are at risk for any of these conditions?

Finding out can bring peace of mind...I was floored when I read my Navigenics results which found that my highest elevated risk condition (96-98%) was colon cancer - I have just been diagnosed with colon cancer. Had I known my genetic risk years ago, I may have been more proactive and caught it even earlier. The cost is a small price to pay to prolong your life, especially if you have young kids or a family to provide for.

-Sempra finance employee, Female, 51Finding out can bring peace of mind...Theres a condition that I have 16 times the risk of developing as compared to the general population: macular degeneration. When added to the fact this is the reason that my grandmother is currently going blind, Im suddenly a very motivated participant in my own health. While its a scary risk number, Im now positioned to have an impact on it, and Im incredibly happy that I know about it.

-Microsoft program manager, Male, 30Finding out can bring peace of mind...For years, I experienced stomach problems that never went away. My sister encouraged me to get a Navigenics genetic test and my results showed I was at high risk of celiac disease. My doctor recommended I cut out gluten from my diet, and in the three weeks since I changed my eating habits, Ive lost eight pounds and my stomach problems have disappeared.

-Urgent care employee, Female, 23Finding out can bring peace of mind...My analysis was mostly reassuring, but showed two areas of increased risk. One was celiac disease, which was a surprise. I followed up the Navigenics report with a serologic test and an upper endoscopy, which were positive for moderately severe celiac disease. It is amazing to me, at the age of 52 years, and being a physician, that my diagnosis and treatment was possible only because of your DNA test.

-Head of oncology company, Male, 52The Navi ExperienceYour Storage at Fort Navi

Your keyYouFort NavigenicsNavi key

0467504676046770467804679Your DNA

We Plug Your InformationInto a Database

Your DNADatabase

+Insight EngineHelp From Your Doctorand a Genetic Health CoachYour MD

Your GeneticCounselor

Your conditionswith a high risk:Diabetes43%Breast Cancer26%Alzheimers12%Actions youcan take:Early screening

Early treatment

Lifestyle change

Right medicationsfor you

Navi Subscription ServiceYour DNAInsight EngineAlerts & updatesabout you

Clinical trialspertinent to you

Additional thingsof interest

Your RisksMedicalInformationConsumerKnowledge

ThinkingAbout You24/ 7The Value of What We Deliver

YouThe bestyou can be+=

Complexity of Business

Sales Channel Access

Regulation

Consumer Engagement

Physician PartneringScienceGeneticsPredictive Science

Is a Barrier to Entry

Employer Clients

Unprecedented response rates averaging 27%14Widespread consumer interestSaid they would have a genetic test for at least one disease conditionStated they would make health care decisions based upon genetic resultsSupport nationwide genetic studyCogent Genomics Attitudes & Trends Aug 2008 Genetics and Public Policy Center at Johns Hopkins University Nov 2008

15Physician & Academic Partners

16

Clinical IntegrationDemonstrated Methods to Engage MDs and Integrate Into Clinical Practice

Only company toReduce the complexity of preventive genomics into focused educational programsIntegrate genetic counseling inservice deliveryProvide personalized tools to drive lifestyle changes based on genomicsAll in a scalable model17Navigenics services28 health conditions24/7 access to our Genetic Counselors Updates for one yearDNA storage

Pharmacogenomics will be introduced in

early 2010

Health Compass Online summary genetic risk report

Available within 2-4 weeksQuestions?Summary slide beforeAdd financial backup slide after questions20