The new SMA PRO core range - Mother and Baby Health€¦ · The new SMA® PRO core range . FOR HEALTHCARE PROFESSIONAL USE ONLY The first 1000 days – a crucial time for a baby’s

FOR HEALTHCARE PROFESSIONAL USE ONLY

®Registered Trademark

Building a nutritional foundation for life in the first 1000 days

The new SMA® PRO core range


The first 1000 days – a crucial time for a baby’s development

From conception to the age of two, the first 1000 days of a baby’s life are crucial.

What happens during this time can have a major impact on a baby’s future health.1–3

Making the right decisions now can help deliver lifelong benefits.

FOR HEALTHCARE PROFESSIONAL USE ONLYFOR HEALTHCARE PROFESSIONAL USE ONLY

Making the right infant nutrition choices in the first 1000 days

1970s

2000s

1960s

1980s

2016

A major advance in infant formula was the development of the first high-quality, whey-dominant formula with a composition of whey protein and casein similar to that of breast milk

SMA® Wysoy®, a soya formula, was

developed for infants who are allergic to cows’ milk protein

or lactose-intolerant

Partially hydrolysed whey-based formula developed to reduce the risk of eczema in infants8

First alpha-lactalbumin- enriched first milk

developed and shown to have prebiotic effect9–11

SMA® PRO First Infant Milk – clinically proven to deliver growth comparable to breastfed infants12

Breastfeeding is the best way to feed a baby.4

For a new baby’s health, protein is extremely important as it is one of the main drivers for growth.

Because the protein in breast milk is adapted to a baby’s needs,5 a breastfed baby tends to grow more slowly than a formula fed baby6 and this slower growth rate has shown significant long-term health benefits including a lower risk of obesity, cardiovascular disease and diabetes.7

Over the past 90 years, SMA® Nutrition has invested in early life nutrition research. As a result, SMA® PRO is born. Inspired by specific nutritional needs of babies, SMA PRO represents some of our most advanced formulas yet.


SMA® PRO First Infant Milk





New SMA® PRO First Infant Milk is an easy to digest,13 nutritionally complete infant milk with a unique protein profile that is closer to breast milk14 and is the only First Infant Milk clinically proven to achieve a growth rate comparable with a breastfed baby12


New SMA® PRO First Infant Milk – in line with expert opinion


International regulatory bodies and key opinion leaders have published recommendations concerning improvement in formula composition and SMA® Nutrition has responded in ways that closely reflect this expert opinion:

Our most advanced formula yet

Of the essential amino acids, four have been shown, when supplied in excess, to be associated with increased release of insulin. This may trigger a cascade of reactions in the body which may result in faster growth16

SMA PRO First Infant Milk has lower levels of insulinogenic amino acids compared with other first infant milks14

››

“ The breast milk content of amino acids is the best estimate of infant amino acid requirements”

WHO/FAO/UNU 201415

SMA PRO First Infant Milk has an essential amino acid profile similar to that of breast milk14

››


Protein quality and quantity


Protein composition of First Infant Milk

*Powder only, liquids will vary.

“ Protein intakes of infants are generally well above the requirements, so protein content of Infant Formula and Follow-on Formula could be reduced”

European Food Safety Authority 201417

SMA® PRO First Infant Milk is the lowest protein formula available at 1.25 g*/100 ml (1.87 g*/100 kcal)18

››

The protein content of SMA PRO First Infant Milk is close to the whey to casein ratio in early lactation ~ 80:205

New SMA PRO

First Infant Milk18

Aptamil Pronutra+ First Infant

Milk19

Aptamil Profutura

First Infant Milk20

C&G First Infant

Milk21

HIPP First Infant

Milk22

Protein g/100 ml

1.25 1.3 1.3 1.3 1.25

[Whey:casein] [70:30] 60:40 60:40 60:40 60:40

Protein g/100 ml and Whey: Casein in First Infant Milk


High quality, low quantity protein levels resulting in growth comparable with a breastfed baby

Taken from Grathwohl meta analysis12

Weight-for-age

Length-for-age

Head circumference

BMI

-3 -1.5 -1 -0.5 0 0.5 1 1.5 2 2.5 3-2.5 -2

Z-scores

SMA PRO First Infant Milk versus WHO growth standard z-scores at 4 months

Acceleratedgrowth

Retardedgrowth

WHO growth standard

SMA® PRO First Infant Milk is the only clinically proven First Infant Milk to achieve a growth rate comparable with a breastfed baby as defined by WHO growth standards12

The UK WHO Growth Charts describe the optimal growth for healthy, breastfed children6

Growth within -/+ 0.5 standard deviation of WHO growth standards is desirable.

››


Supporting appropriate growth in the first 1000 days

The only first infant milk clinically proven to achieve a growth rate comparable with a breastfed baby12

Made using an exclusive protein process

Protein 1.25 g*/100 ml (1.87 g*/100 kcal)

Unique amino acid profile similar to that of breast milk14

Contains GOS/FOS† for increased gastrointestinal comfort and softer stools similar to that of breastfed infant23,24

*Powder only, liquid will vary.†In powder formulation only; GOS/FOS = Galacto-oligosaccharides/Fructo-oligosaccharides.

Available in: – 70 ml plastic bottles (hospital use only) – SMA® PRO First Infant Milk starter pack

(6 x 70 ml bottles with hygienic teats)– 400 g and 800 g cans of powder– 200 ml and 1 L Tetra-Pak®

In line with science12


SMA® PRO Follow-on Milk

FOR HEALTHCARE PROFESSIONAL USE ONLY FOR HEALTHCARE PROFESSIONAL USE ONLY


New SMA® PRO Follow-on Milk, our most advanced formula yet, now with our exclusive protein process* and NUTRI-STEPS™ to help support a nutritional foundation for life


*Made with SMA® Nutrition’s unique protein technology.


Breast milk composition evolves to match a growing infant’s needs

The protein content of breast milk in the first year of lactation


“ Breastfeeding is an unequalled way of providing ideal food for the healthy growth and development of infants”

WHO 25

Adapted from Lönnerdal et al.5

and Kunz et al.26

0.0

0.5

1.0

1.5

2.0

2.5

126543210

Pro

tein

co

nten

t (g

/10

0 m

l)

Months

Breast milk

The protein content of breast milk decreases over the duration of breastfeeding

If breastfeeding is not possible, SMA® PRO Follow-on Milk has been adapted to support appropriate growth.27–29 It contains 1.3 g protein/100 ml which is the lowest protein follow-on formula available30–34

FOR HEALTHCARE PROFESSIONAL USE ONLYFOR HEALTHCARE PROFESSIONAL USE ONLY FOR HEALTHCARE PROFESSIONAL USE ONLY

SMA® PRO Follow-on Milk: Supporting appropriate growth in infants 6–12 months


The protein composition of SMA PRO Follow-on Milk mimics the 50:50 whey:casein ratio of mature breast milk5

SMA PRO Follow-on Milk is the lowest protein follow-on formula available at 1.3 g/100 ml (2.0 g/100 kcal)

New SMA PRO Follow-on

Milk30

Aptamil Pronutra+ Follow-on

Milk31

Aptamil Profutura Follow-on

Milk34

C&G Follow-on

Milk32

HIPP Follow-on

Milk33

Protein g/100 ml

1.3 1.4 1.4 1.4 1.5

[Whey:casein] [50:50] 50:50 50:50 20:80 40:60

“ Protein intakes of infants are generally well above the requirements, so protein content of Infant Formula and Follow-on Formula could be reduced”

European Food Safety Authority 201417

››


Addressing the challenge of achieving optimal nutrition in infants

“ From the age of 6 months, all infants and toddlers should receive iron-rich foods, including meat products and/or iron-fortified foods”

ESPGHAN 201435

SMA® PRO Follow-on Milk is designed to complement the weaning diet

*Powders only, liquids will vary.

63% 68% 86%

of their daily iron of their daily calcium of their daily vitamin D

help support normal cognitive development

help support normal growth and development of bone

As a percentage of infant’s daily requirements, 500 ml of SMA® PRO Follow-on Milk provides:36*

SMA PRO Follow-On Milk is fortified with iron which dietary surveys show can be lacking in infant diets37,38

››

FOR HEALTHCARE PROFESSIONAL USE ONLYFOR HEALTHCARE PROFESSIONAL USE ONLY FOR HEALTHCARE PROFESSIONAL USE ONLY

New SMA® PRO Follow-on Milk for infants 6–12 months

Exclusive protein process – Made with SMA® Nutrition’s unique protein technology.

Omega 3 & 6 +

GOS/FOSVitamin

D

ExclusiveProteinProcess‡

NUTRI-STEPS TM

Iron

Iron which helps to support normal cognitive development

Vitamin D and calcium to help support the normal growth and development of bone

Omega 3 & 6 to help support normal growth and development*

Contains GOS/FOS†

* Beneficial effect of essential fatty acids is obtained with a daily intake of 10 g linoleic acid and 2 g of α-linolenic acid. † In powder formulation only; GOS/FOS = Galacto-oligosaccharides/Fructo-oligosaccharides.®Registered Trademark

Helping infants achieve the recommended intakes of micronutrients

Fortified with:


SMA® PRO Toddler Milk



New SMA® PRO Toddler Milk protein has been reduced from 1.8 g to 1.5 g/100 ml. The vitamin D has been increased from 1.5 to 1.9 µg/100 ml. Our most advanced formula yet with lower protein content and increased vitamin D*


*Compared to our previous SMA Toddler Milk®.


New SMA® PRO Toddler Milk: Continuing to support a child’s nutritional needs


Vitamin D and calcium to help support the normal growth and development of bone

Iron which helps to support normal cognitive development

Iodine to help support normal growth

Omega 3 & 6 to help support normal growth and development*

Vitamin D& Calcium

N

UTRI-STEPS TM

Iron

Iodine

Omega3 & 6


Specially tailored combination of nutrients for toddlers.

The protein in new SMA PRO Toddler Milk has been reduced from 1.8 g to 1.5 g/100 ml

Research shows the importance of providing the right amount of protein in the diet to help support appropriate growth27–29

››

Fortified with:

* Beneficial effect of essential fatty acids is obtained with a daily intake of 10 g of linoleic acid and 2 g of α-linolenic acid.®Registered Trademark


New SMA® PRO Toddler Milk for toddlers aged 1–3 years

Designed to complement the toddler diet, providing important nutrients shown to be at risk in toddler diets38,39

As a percentage of toddlers’ daily requirements, 2 x 200 ml servings of SMA PRO Toddler Milk provides:36

*The type of iron in new SMA PRO Toddler Milk is non-haem iron. ®Registered Trademark

Evidence shows that toddlers who consumed fortified milks (compared to those whose main milk was cows’ milk) had higher mean intakes of vitamin D and iron, and a lower intake of protein38,41

108% 60% 60% 108% 60%of their daily

vitamin Dof their daily

calciumof their daily

ironof their daily

vitamin Cof their daily

iodine

help support normal growth

and development of bone

help support normal

cognitive development

contributes to increasing

non-haem iron absorption40

help support normal growth

of children


SummaryFOR HEALTHCARE PROFESSIONAL USE ONLY

The programming that takes place during the first 1000 days of life has a significant impact on later health outcomes1–3

Breastfeeding is the best way to feed a baby4

The diets of many infants and toddlers may be sub-optimal:37,42

– Intakes of essential nutrients including iron and vitamin D may be insufficient

SMA® Nutrition has a long heritage in research and innovation in formula milks with nutritional content specifically tailored to the different stages of development


SMA® PRO Follow-on Milk, is the lowest protein follow-on milk available in the UK and Ireland at 1.3 g/100 ml.30–34

SMA® PRO First Infant Milk has a unique protein profile that is closer to breast milk and is the only first infant milk clinically proven to achieve a growth rate comparable with a breastfed baby.


SMA® PRO Toddler Milk, is our lowest protein toddler milk, reduced from 1.8 g/100 ml to 1.5 g/100 ml.


Important NoticeFOR HEALTHCARE PROFESSIONAL USE ONLY

IMPORTANT NOTICE: Breast milk is best for babies and breastfeeding should continue for as long as possible. Good maternal nutrition is important for the preparation and maintenance of breastfeeding. Introducing partial bottle-feeding may have a negative effect on breastfeeding and reversing a decision not to breastfeed is difficult. A caregiver should always seek the advice of a doctor, midwife, health visitor, public health nurse, dietitian or pharmacist on the need for and proper method of use of infant formulae and on all matters of infant feeding. Social and financial implications should be considered when selecting a method of infant feeding. Infant formulae should always be prepared and used as directed. Inappropriate foods or feeding methods, or improper use of infant formula, may present a health hazard. • SMA® PRO Follow-on Milk is only suitable for babies over 6 months as part of a mixed diet. It should not be used as a substitute for breast milk during the first 6 months of life. The decision to start weaning or to use this product before 6 months, should be made only on the advice of a doctor, midwife, health visitor, public health nurse, dietitian or pharmacist, based on baby’s individual needs. • SMA® PRO Toddler Milk is for young children from 1–3 years, as part of a healthy balanced diet and it is not a breast milk substitute. Breastfeeding should continue for as long as possible.


References

1. United Nations System 2006. Standing Committee on Nutrition. Third World Urban Forum, Vancouver. Available at: http://www.unscn.org/files/Statements/The_Double_Burden_of_Malnutrition_A_Challenge_for_cities_Worldwide.pdf. Accessed 24 September 2015.

2. Vickers MH. Early Life Nutrition, Epigenetics and Programming of Later Life Disease. Nutrients 2014; 6: 2165–2178.

3. Koletzko et al. Early nutrition programming of long-term health. Proceedings of the Nutrition Society 2012; 71: 371–378.

4. World Health Organization. Evidence on the long-term effects of breastfeeding. Systematic reviews and meta-analyses. WHO Press, World Health Organization, Geneva, Switzerland, 2007. Available at: http://apps.who.int/iris/bitstream/10665/43623/1/ 9789241595230_eng.pdf. Accessed 29 September 2015.

5. Lönnerdal B. Nutritional and physiologic significance of human milk proteins. American Journal of Clinical Nutrition 2003; 77: 1537–43.

6. WHO UK Growth Charts. http://www.rcpch.ac.uk/improving-child-health/public-health/uk-who-growth-charts/faqs/uk-who-growth-chart-faqs. Accessed 28 September 2015.

7. Singhal & Lucas, 2004. Early origins of cardiovascular disease: is there a unifying hypothesis? The Lancet Volume 363, No. 9421, p1642–1645, 15 May 2004.

8. Von Berg A et al. The effect of hydrolyzed cow’s milk formula for allergy prevention in the first year of life: The German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol 2003; 111: 533–40.

9. Lien E et al. Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin. Journal of Pediatric Gastroenterology and Nutrition 2004; 38: 170–176.

10. Bettler J, Kullen MJ. Infant formula enriched with α-lactalbumin has a prebiotic effect in healthy term infants J Pediatr Gastroenterol Nutr. 2007; 44(1): e197.

11. Kullen M et al. Characterization of peptides derived from alpha-lactalbumin digestion and demonstration of their prebiotic effect through stimulation of bifidobacteria in a model of the gastrointestinal tract. J Pediatr Gastroenterol Nutr 2009; 48(3): E88, 0P3-06.

12. Grathwohl DJ et al. Abstract at EAPS Congress, 2010.13. NHS Choices. Types of infant formula. October 2014. http://

www.nhs.uk/Conditions/pregnancy-and-baby/Pages/types-of-infant-formula.aspx#close. Accessed 28 September 2015.

14. Nestlé data on file, 2014.15. Protein and Amino Acid Requirements in Human Nutrition.

Report of a Joint WHO/FAO/UNU Expert Consensus 2007.16. Kirchberg FF, Harder U, Weber et al. Dietary Protein Intake

Affects Amino Acid and Acylcarnitine Metabolism in Infants Aged 6 Months. J Clin Endocrinol Metab 2015; 100(1): 149–58.

17. EFSA. Scientific Opinion on the essential composition of infant and follow-on formulae. EFSA Journal 2014; 12(7): 3760.

18. SMA® PRO First Infant Milk Datacard. Available September 2015. 19. Aptamil Pronutra+ First Infant Milk data card. Available at

http:// www.aptamilhcp.ie/products/products-aptamil-pronutra-plus?start=2. Accessed 23rd October 2015.

20. Aptamil Profutura First Infant Milk data card. Available at http:// www.aptamilhcp.ie/products/products-profutura? start=3. Accessed 23rd October 2015.

21. Cow & Gate First Infant Milk data card. Available at http:// www.in-practice.co.uk/product-info/standard-milks-0-1-years/first-infant-milk-from-newborn/#undefined2. Accessed 23rd October 2015.

22. HIPP First Infant Milk data card. Available at http://www.hipp4hcps.co.uk/dynamic-content/media/First_infant_milk_PENG_insert.pdf.

23. Vivatvakin B et al. Effect of a whey-predominant starter formula containing LCPUFAs and oligosaccharides (FOS/GOS) on gastrointestinal comfort in infants. Asia Pac J Clin Nutr 2010; 19(4): 473–480.


24. Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Boehm G. Dosage-related bifidogenic effects of galacto- and fructo-oligosaccharides in formula-fed term infants. Journal of Pediatric Gastroenterology and Nutrition 2002; 34: 291–295.

25. World Health Organization. Exclusive breastfeeding. Available at http://www.who.int/nutrition/topics/exclusive_breastfeeding/en/. Accessed 29 September 2015.

26. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr 1992; 81: 107–12.

27. Weber M et al. Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr 2014; 99: 1041–1051.

28. Thorisdottir B et al. Nutrient intake in infancy and body mass index at six years in two population-based cohorts recruited before and after revision of infant dietary recommendations. Ann Nutr Metab 2013; 63: 145–151.

29. Gunther AL et al. Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age. Am J Clin Nutr 2007; 85: 1626–1633.

30. SMA® PRO Follow-on Milk datacard. Available September 2015. 31. Aptamil Follow-on Milk datacard. Available at https://

www.aptamilprofessional.co.uk/pdf/Datacard-Aptamil-Follow-On201306131134.pdf. Accessed 30 September 2015.

32. Cow and Gate Follow-on Milk datacard. Available at http://www.in-practice.co.uk/media/244175/COW-14-207-Datacard-Follow-on-6-plus-months-A4.pdf. Accessed 30 September 2015.

33. HIPP Follow-on Milk datacard. Available at http:// www.hipp4hcps.co.uk/dynamic-content/media/Milks_nutritional_data.pdf. Accessed 30 September 2015.

34. Aptamil Profutura Follow-on Milk datacard. Available at http://www.aptamilhcp.ie/products/products-profutura/57-products/aptamil-profutura/from-6-months/167-aptamil-profutura-first-follow-on?start=3. Accessed 14 October 2015.

35. Domellöf M et al. Iron requirements of infants and toddlers. J Pediatr Gastroenterol Nutr 2014; 58: 119–129.

36. EC (European Commission) (2006). Directive 2006/141/EC on infant formulae and follow-on formulae and amending Directive 1999/21/EC. European Commission.

37. Lennox A et al. (2013) Diet and Nutrition Survey of Infants and Young Children. Available at: https://www.gov.uk/government/publications/diet-and-nutrition-survey-of-infants-and-young-children-2011. Accessed 28 September 2015.

38. Walton J et al. (2013) Nutritional adequacy of diets containing growing up milks or unfortified cow’s milk in Irish children (aged 12–24 months.) Available at http://www.foodandnutritionresearch.net/index.php/fnr/article/view/21836. Accessed 4 October 2015.

39. Gibson S and Sidnell A. Nutrient adequacy and imbalance among young children aged 1–3 years in the UK. Nutrition Bulletin, 2014; 39: 172–180.

40. EFSA Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non-haem iron absorption. EFSA Journal 2014; 12(1): 3514.

41. Sidnell A et al. Nutrient and energy intakes vary depending on the predominant type of milk fed to children aged 12–18 months in the United Kingdom: secondary analysis of data from the Diet and Nutrition Survey of Infants and Young Children (DNSIYC).Poster presented at ESPGHAN Annual Meeting, 6–9 May 2015, Amsterdam. PO-N-0388.

42. Bates B et al. (2012) NDNS Headline Results from Years 1, 2 and 3 (Combined). Department of Health and Food Standards Agency. Available at http://www.natcen.ac.uk/media/175123/national-diet-and-nutrition-survey-years-1-2-and-3.pdf. Accessed 28 September 2015.

SMA Nutrition, 1 City Place, Gatwick, RH6 0PA

In the Republic of Ireland: SMA Nutrition, 3030 Lake Drive, Citywest Business Campus, Dublin 24, Ireland


The new SMA® PRO core range


ZRI 285/11/2015

Documents

The new SMA PRO core range - Mother and Baby Health€¦ · The new SMA® PRO core range . FOR HEALTHCARE PROFESSIONAL USE ONLY The first 1000 days – a crucial time for a baby’s