The Master’s Choice . .

Geistlich Bio-Oss® now in an easy-to-use delivery system

delivers.

In just a few steps, you’re readyGeistlich Bio-Oss Pen® now brings you Geistlich Bio-Oss® granules in a convenient, easy-to-use applicator. This new delivery system allows faster and more precise application to the surgical site. Geistlich Bio-Oss Pen® is available in both small granules (green filter cap) and large granules (red filter cap).

1 iData Research Inc., US Dental Bone Graft Substitutes and other Biomaterials Market, 2011. 2 iData Research Inc., European Dental Bone Graft Substitutes and other Biomaterials Market, 2010.3 Ferreira CE et al. J Periodontol 2009;80:1920-1927.4 Wallace SS et al. Ann Periodontol 2003;8:328-343.5 Valentini P et al. Int J Periodontics Restorative Dent 2000;20:245-253.

1. Holding Geistlich Bio-Oss Pen® firmly, tear off the protective seal (A) and unscrew the protection cap (B).

2. Do not remove the red/green filter cap from the Geistlich Bio-Oss Pen® at this point.

3. Place the filter cap into sterile saline solution or patient blood. Pull back and press down the plunger several times until the Geistlich Bio-Oss® granules are completely hydrated. Avoid compressing the granules. Alternatively, a syringe (not included) may be used to inject saline or blood directly through the filter cap.

4. Gently press the plunger to remove any excess fluid.

5. Replace the filter cap (A) with the curved applicator tip (B) and apply Geistlich Bio-Oss® directly to the surgical site.

or

4

A

B

2 4 53

~1–5 x

1

B

A X

For your convenience . . . Geistlich Bio-Oss® delivers

> The leading bone substitute in oral bone regeneration1,2

> Placed every 30 seconds

> Used approximately 2,500 times per day

> More than 4 million patients treated

> In clinical use for more than 25 years

Ideally suited for multiple indications

Small bony defects

Geistlich Bio-Oss Pen® with small granules is recommended for smaller bony defects. Small granules ensure optimal adhesion to the bony walls of the defect.

Lateral sinus floor elevation and large bony defects

Geistlich Bio-Oss Pen® with large granules is recommended for large ridge augmentation and sinus floor elevation procedures. Using Geistlich Bio-Oss® granules alone has been shown to be a highly effective and predictable treatment option for sinus floor elevation procedures.3,4,5

The original Geistlich Bio-Oss® granules contained in Geistlich Bio-Oss Pen® deliver the success you’ve come to count on in a range of therapeutic areas. Geistlich Bio-Oss Pen® is available with small or large granulesto accommodate use in periodontal defects (with or without guided tissue regeneration), extraction sockets, ridge augmentation and peri-implant defects.

* Additional information regarding indications for Geistlich Bio-Oss® and Geistlich Bio-Oss Pen® can be found on the back panel of this brochure.

Leading bone substitute 1,2

Geistlich Bio-Oss®

Designed to meet your clinical needs: an innovative delivery system for Geistlich Bio-Oss® granules.

Saves timePre-filled with Geistlich Bio-Oss® granules, Geistlich Bio-Oss Pen® is ready to use following hydration, reducing the procedure time.

Easy to hydrateGeistlich Bio-Oss Pen® facilitates hydration of the Geistlich Bio-Oss® granules with either sterile physiological saline solution or patient blood.

Optimal access to the defectGeistlich Bio-Oss Pen® is delivered witha curved applicator tip, allowing GeistlichBio-Oss® granules to be easily placed in posterior regions.

Superior consistencyGeistlich Bio-Oss Pen® ensures optimal bonding of the Geistlich Bio-Oss® granules.

Simple to use

Maximizes product useLess waste of Geistlich Bio-Oss® granules due to reduced spillage and minimal residual product remaining in Geistlich Bio-Oss Pen® following use.

The bone substitute you trust now in an easy-to-use applicator.

DOCUMENTED: More than 900 publications RELIaBLE: More than 25 years of clinical experienceExPERIENCED: 160 years of Geistlich collagen competence

Geistlich Bio-Oss Pen®

CaUTION: Federal law restricts these devices to sale by or on the order of a dentist or physician.

Indications:Geistlich Bio-Oss®, Geistlich Bio-Oss Pen® and Geistlich Bio-Oss Collagen® are indicated for the following uses: Augmentation or reconstructive treatment of the alveolar ridge; Filling of periodontal defects; Filling of defects after root resection, apicoectomy, and cystectomy; Filling of extraction sockets to enhance preservation of the alveolar ridge; Elevation of the maxillary sinus floor; Filling of periodontal defects in conjunction with products intended for Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR); and Filling of peri-implant defects in conjunction with products intended for GBR. Warnings:Possible complications which may occur with any surgery include swelling at the surgical site, flap sloughing, bleeding, local inflammation, bone loss, infection or pain. As Geistlich Bio-Oss Collagen® contains collagen, in very rare circumstances cases of allergic reactions may occur.

Indications:Geistlich Bio-Gide® and Geistlich Bio-Gide® Perio are indicated for the following uses: Augmentation around implants placed in immediate and delayed extraction sockets; Localized ridge augmentation for later implantation; Alveolar ridge reconstruction for prosthetic treatment; Filling of bone defects after root resection, cystectomy, removal of retained teeth; GBR in dehiscence defects; and GTR procedures in periodontal defects. Warnings:As they are collagen products, allergic reactions may not be totally excluded. Possible complications which may occur with any surgery include swelling at the surgical site, flap sloughing, bleeding, dehiscence, hematoma, increased sensitivity and pain, bone loss, redness, and local inflammation.

For more information on contraindications, precautions, and directions for use, please refer to the Geistlich Bio-Oss® Pen Instructions for Use at: www.geistlich-na.com/ifu

Small Granules (0.25–1mm)

QUANTITY / VOLUME

0.25g (≈ 0.5cc)0.5g (≈ 1cc)

Large Granules (1–2mm)

QUANTITY / VOLUME

0.5g (≈ 1.5cc)

Customer CareToll-free 855-799-5500

www.geistlich-na.com

Geistlich Pharma North america, Inc.

202 Carnegie Center Princeton, NJ 08540

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