Vol. 267, No. 3 The Journal of January 25,1992

Biological Chemistry Copyright 0 1992 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U.S.A.

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CONTENTS*

MINIREVIEW 1464

Voltage-sensitive Ca2+ channels. Richard J. Miller

COMMUNICATIONS Mammalian DNA polymerase /3 can substitute for DNA polymerase I during DNA replication in Esch- erichia coli.

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Joann B. Sweasy and Lawrence A. Loeb

Purification and characterization of the carboxyl- terminal transactivation domain of Vmw65 from herpes simplex virus type 1. 1477

Logan Donaldson and John P. Capone

Asparagine 26, glutamic acid 31, valine 45, and tyrosine 64 of Ras proteins are required for their oncogenicity.

M. S. A. Nur-E-Kamal, Andrew Size/and, Giovanna D’Abaco, and Hiroshi Maruta

X-ray structural evidence for a local helix-loop transition in a-lactalbumin

Kazuaki Harata and Michiro Muraki

Expression of the catalytic subunit of phosphorylase phosphatase (protein phosphatase-1) in Eecherichia coli.

Zhongjian Zhang, Ge Bai, Stephen Deans-Ziratty Michelle F. Browner, and Ernest Y. C. Lee

Isoprenylation of a protein kinase. Requirement of farnesylation/a-carboxyl methylation for full enzy- matic activity of rhodopsin kinase.

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James Inglese, J. Fraser Glickman, Wulfing Lorenz, Marc G. Caron, and Robert J. Lefkowitz

Different positively charged amino acids have sim- ilar effects on the topology of a polytopic transmem- brane protein in Escherichia coli.

Helena Andersson, Evert Bakker, and Gunnar von Heijne

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.

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Heike A. Wieland, Hartmut Liiddens, and Peter H. Seeburg

Inhibition of CD3-linked phospholipase C by phor- bol ester and by CAMP is associated with decreased phosphotyrosine and increased phosphoserine con- tents of PLC-yl.

Do Joon Park, Hong Ki Min, and Sue Goo Rhee Constitutive activation of the aIn-adrenergic recep- tor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

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Michael A. Kjelsberg, Susanna Cotecchia, Jacek Ostrowski, Marc G. Caron, and Robert J. Lefkowitz

Arabidopsis mutants deficient in polyunsaturated fatty acid synthesis. Biochemical and genetic char- acterization of a plant oleoyl-phosphatidylcholine desaturase.

Martine Miguel and John Browse

Rapid optimization of enzyme substrates using de- fined substrate mixtures.

Judd Berman, Michael Green, Elizabeth Sugg, Rob Anderegg, David S. Millington, Daniel L. Norwood, Jerry McGeehan, and Jeffrey Wiseman

1510 pa-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.

David D. Maenz, Catherine Chenu, Sylvie Breton, and Alfred Berteloot

ARTICLES 1517

Functional reconstitution of cytochrome P-450,, with hemin activated with Woodward’s reagent K. Formation of a hemeprotein cross-link.

Irene A. Pikuleva, Anna G. Lapko, and Vadim L. Chashchin

Patterns of prohormone processing. Order revealed by a new procholecystokinin-derived peptide.

Gert A. Eberlein, Viktor E. Eysselein, Michael T. Davis, Terry D. Lee, John E. Shively, Daniel Grandt, Wolfgang Niebel, Russel Williams, Joachim Moessner, Joerg Zeeh, Helmut E. Meyer, Harald Goebell, and Joseph R. Reeve, Jr.

Calcium channel blockers nifedipine and diltiazem inhibit Ca”+ release from intracellular stores in neu- trophils.

1522 Purification and characterization of cr-L-fucosidase from Streptomyces species.

Mutsumi Sano, Kumi Hayakawa, and Zkunoshin Kato Carlos Rosales and Eric J. Brown

1528 The NusA and NusG proteins of Escherichia coli increase the in vitro readthrough frequency of a transcriptional attenuator preceding the gene for the B subunit of RNA polymerase.

A novel sulfated structure in the carbohydrate-pro- tein linkage region isolated from porcine intestinal heparin.

Kazuyuki Sugahara, Shuhei Yamada, Keiichi Yoshida, Pieter de Waard, and Johnnnes F. G. Vliegenthart

Thomas Linn and Jack Greenblatt 1534

Molecular cloning and enzymatic analysis of the rat homolog of “PhK-yT,” an isoform of phosphorylase kinase catalytic subunit.

‘%ZzH,- and 14COz-labeling studies of the de novo synthesis of polypeptides by Nitrosomonae euro- paea during recovery from acetylene and light in- activation of ammonia monooxygenase.

Mihnil B. Calalb, Daniel T. Fox, and Steven K. Hanks Michael R. Hyman and Daniel J. Arp

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Adrenal P-450,, modulates activity of P-45011~ in liposomal and mitochondrial membranes. Impltca- tion of P-450,, in zone specificity of aldosterone biosynthesis in bovine adrenal.

Shin-ichi Zkushiro, Shiro Kominami, and Shigeki Takemori

A truncated form of fibroblast growth factor recep- tor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

Hikuru Ueno, Michael Gunn, Karen Dell, Alexander Tseng, Jr., and Lewis Williams

Regulated and constitutive secretion. Differential effects of protein synthesis arrest on transport of glycosaminoglycan chains to the two secretory path- ways.

Catherine Brion, Stephen G. Miller, and Hsiao-Ping H. Moore

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1992) J. Biol. Chem. 267,653-663, and reprints may be obtained from the editorial office.

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The purification of a Rap1 GTPase-activating pro- tein from bovine brain cytosol.

Holden, Richard J. Simpson, and Antony W. Burgess Edouurd C. Nice, Louis Fabri, Annet Hammacher, Janet

Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition.

Donald D. Anthony and William C. Merrick

Phosphorylation by CAMP-dependent protein ki- nase inhibits the degradation of Tau by calpain.

and mono(ADP-ribosy1)transferase. Specific inhibitors of poly(ADP-ribose) synthetase

Marek Banasik, Hajime Komura, Makoto Shimoyama, and Kunihiro Ueda

phocholine to l-O-alk-l’-enyl-2-acyl-sn-glycero-3- Conversion of l-O-alkyl-2-acyl-sn-glycero-3-phos-

phosphoethanolamine. A novel pathway for the me- tabolism of ether-linked phosphoglycerides.

Jay C. Strum, Adakteinn Emikson, Robert L. Wykle, and Larry W. Daniel

Mechanism of glutamate semialdehyde aminotrans- ferase. Roles of diamino- and dioxo-intermediates in the synthesis of aminolevulinate.

Ceri E. Pugh, John L. Harwood, and Robert A. John

In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plas- minogen activator with rat liver cells.

de Munk, and The0 J . C. van Berkel Johan Kuiper, Dingeman C. Rijken, Gerard A. W.

Orthophosphate-promoted ouabain binding to Na/K

preferentially binding oubain. pumps of resealed red cell ghosts. Evidence for CCP

Marisol Guerra, Marcia Steinberg, and Philip B. Dunham

Exposure of rat peritoneal macrophages to acety- lated low density lipoprotein results in release of plasma membrane cholesterol. An efficient sub- strate for esterification by acyl-CoA:cholesterol acyltransferase.

Yoshimasa Morino, and Seikoh Horiuchi Moritsugu Shinohara, Akira Miyazaki, Motoaki Shichiri,

Human gastric cathepsin E gene. Multiple tran- scripts result from alternative polyadenylation of the primary transcripts of a single gene locus at

Anne M. Bowcock, and R. Thomas Taggart Takeshl Azuma, Wanguo Liu, Douglas J. Vander Laan,

Vibrational spectroscopy of bacteriorhodopsin mu- tants. Evidence that Thr-46 and Thr-89 form part of a transient network of hydrogen bonds.

Kenneth J. Rothschild, Yi-Wu He, Sanjay Sonar, Thomas Marti, and H. Gobind Khorana

A model for the aminoacyl-tRNA binding site of eukaryotic elongation factor la.

Terri Goss Kinzy, John P. Freeman, Arthur E. Johnson, and William C. Merrick

Discrete amino acid sequences of the al-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

berg, Marc G. Caron, and Robert J . Lefkowitz Susanna Cotecchia, Jacek Ostrowski, Michael A. Kjek-

Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Caz+-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom.

Marcel Crest, Guy Jacquet, Maurice Goln, Halim Zer- rouk, Abdellnh Benslimane, Hervi Rochat, Pascal Man- suelle, and Mane-France Martin-Eauclaire

Identification and purification of DBF-A, a double- stranded DNA-binding protein from Saccharomy- ces cereuisiae.

Joel M. Litersky and Gail V. W. Johnson

lq31-q32.

Rati Verma and Judith L. Campbell

phoadenosine 6’-phosphosulfate sulfotransferase. Purification of the testicular galactolipid: 3‘-phos-

Darinka Sakac, Mary Zachos, and Clifford A. Lingwood

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A tyrosinated peptide representing the alternatively

A-chain binds specifically to cultured cells and in- spliced exon of the platelet-derived growth factor

terferes with binding of several growth factors. Levon M. Khachigian, Dwain A . Owensby, and Colin N .

Chesterman

Canalicular transport of reduced glutathione in nor- mal and mutant Eisai hyperbilirubinemic rats.

Horie, Murad Ookhtens, and Neil Kaplowitz Jose Carlos Ferncindez-Checa, Hajime Takikawa, Tohru

Molecular mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum. Effects of synthetic phospholamban pep- tides on Ca2+ pump ATPase.

Tsunehiko Kuzuya, and Michihiko Tada Tatsuya Sasaki, Makoto Inui, Yoshihiro Kimura,

The reactivity of thiols and disulfides with different redox states of myoglobin. Redox and addition re- actions and formation of thiyl radical intermediates.

Francisco J . Romero, Ishmael Ordoriez, Arduino Arduini, and Enrique Cadenas

Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.

Alfred C. Johnson, Ryoichiro Kageyama, Nicholas C. Popescu, and Ira Pastan

Post-translational modifications of Drosophila ac- etylcholinesterase. In vitro mutagenesis and expression in Xenopus oocytes.

Cholesterol is converted to 7a-hydroxy-3-oxo-4- cholestenoic acid in liver mitochondria. Evidence for a mitochondrial sterol 7a-hydroxylase.

Toll, and Kjell Wikvall Magnus Axelson, Junichi Shoda, Jan Sjovall, Anders

Cloning of the vaccinia virus ribonucleotide reduc- tase small subunit gene. Characterization of the gene product expressed in Escherichia coli.

Meredith L. Howell, Joann Sanders-Loehr, Thomas M. Loehr, Nancy A. Roseman, Christopher K. Mathews, and Mary B. Slabaugh

On the location and function of tyrosine 8331 in the catalytic site of Escherichia coli F1-ATPase.

Joachim Weber, Rita S.-F. Lee, Ernst Grell, John G. Wise, and Alan E. Senior

Contribution to ligand binding by multiple carbo- hydrate-recognition domains in the macrophage mannose receptor.

Maureen E. Taylor, Karel Bezouika, and Kurt Drickamer

Alteration by site-directed mutagenesis of the con- served lysine residue in the ATP-binding consensus sequence of the RecD subunit of the Escherichia coli RecBCD enzyme.

Enzymatic effects of a lysine-to-glutamine mutation in the ATP-binding consensus sequence in the RecD

coli. subunit of the RecBCD enzyme from Escherichia

Annick Mutero and Didier Fournier

Firouzeh Korangy and Douglas A. Julin

Firouzeh Korangy and Douglas A. Julin

Ethanol induces 2’,6’-oligoadenylate synthetase and antivirial activities through interferon+ pro- duction.

Mounira K. Chelbi-Alix and Suzanne Chousterman

Novel molecular species of sphingomyelin contain-

acids in mammalian testes and spermatozoa. ing 2-hydroxylated polyenoic very-long-chain fatty

Brenton S. Robinson, David W. Johnson, and Alf Poulos

Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a de- crease in cellular diacylglycerol levels in cultured rat hepatocytes.

Hark Jamil, Amandip K. Utal, and Dennis E. Vance Functional determinants in the autoinhibitory do- main of calcium/calmodulin-dependent protein ki- nase 11. Role of Hiszs2 and multiple basic residues.

and Thomas R. Soderling M. Kevin Smith, Roger J . Colbran, Debra A. Brickey,

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Defining the involvement of HOC1 or C1z as enzyme- generated intermediates in chloroperoxidase-cata- lyzed reactions.

R. Daniel Libby, A m y L. Shedd, A. Kathryn Phipps, Tina M. Beachy, and Susan M. Gerstberger

Competing B-Z and helix-coil conformational tran- sitions in supercoiled plasmid DNA.

Lilley Fareed Aboul-ela, Richard P. Bowater, and David M. J .

Functional and structural analysis of VLA-4 inte- grin a‘ subunit cleavage.

and Martin E. Hemler Joaquin Teixidd, Christina M. Parker, Paul D. Kassner,

Cloning and expression of a cardiachrain @ subunit of the L-type calcium channel.

Kim, Philippe Bertrand, Eric Baggstrom, Antonio E. Edward Perez-Reyes, Antonio Castellano, Haeyoung S.

Lacerda, Xiangyang Wei, and Lutz Birnbaumer

esterase activity and high affinity rolipram binding Coexpression of human CAMP-specific phosphodi-

in yeast.

Lenora B. Cieslinski, Megan M. McLuughlin, John R. Theodore J. Torphy, Jeffrey M. Stadel, Miriam Burman,

White, and George P. Livi

Retinoids and retinoid-binding protein expression in rat adipocytes.

Chiharu Tsutsumi, Masataka Okuno, Lamya Tannous, Roseann Piantedosi, Maggi Allan, De Witt S. Goodman, and William S. Blaner

Activation of phospholipase C by the a subunits of the G, and Gll proteins in transfected cos-7 cells.

Dianqing Wu, Chang Ho Lee, Sue Goo Rhee, and Melvin I. Simon

Membrane topology of the melibiose carrier of Esch- erichia coli.

and T. Hastings Wilson Martyn C. Botfield, K a z w Naguchi, Tomofusa Tsuchiya,

DNA allosterically modulates the steroid binding domain of the estrogen receptor.

Michael Fritsch, Roy D. Welch, Fern E. Murdoch, Iain Anderson, and Jack Gorski

Glucose 6-phosphate and hexokinase can be used as an ATP-regenerating system by the Ca2+-ATPase of sarcoplasmic reticulum.

Mdnica Montero-Lomeli and Leopoldo de Meis

In vitro activity of the transcription activation

intermediary factors. functions of the progesterone receptor. Evidence for

Lirim Shemshedini, Jingwei Ji, Christel Brou, Pierre Chambon, and Hinrich Gronemeyer

Insect glutathione S-transferases. Biochemical characteristics of the major forms from houseflies susceptible and resistant to insecticides.

Jean-Baptiste Berge, and Frederick W. Plapp, Jr. Didier Fournier, Jean Marc Bride, MaryEne Poirie,

Okadaic acid mimics multiple changes in early pro-

by tumor necrosis factor or interleukin-1. tein phosphorylation and gene expression induced

G. R. Guy, X . Cao, S. P. Chua, and Y. H. Tan

Primary structure of rat pulmonary surfactant pro- tein D. cDNA and deduced amino acid sequence.

Benson, Kenneth Lau, Robert J . Mason, and Dennis R. Hiroshi Shimizu, James H. Fisher, Philip Papst, Bradley

Voelker

Novel flavonol 3-sulfotransferase. Purification, ki- netic properties, and partial amino acid sequence.

Luc Varin and Ragai K. Zbrahim

A T cell nuclear factor resembling NF-AT binds to

promoter sequence “Cytokine- 1 .” an NF-KB site and to the conserved lymphokine

Patricia G. McCaffrey, Jugnu Jain, Christina Jamieson, RanJan Sen, and AnJana Rao

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Oxidative modification of Escherichia coli gluta-

stability of protein structure and specific changes mine synthetase. Decreases in the thermodynamic

in the active site conformation. Mark T. Fisher and Earl R. Stadtman

Cloning and expression in Escherichia coli of ma-

chain a-keto acid dehydrogenase complex. Mapping ture El@ subunit of bovine mitochondrial branched-

of the El@-binding region on E2. R. Max Wynn, Jacinta L. Chuang, James R. Davie,

Charles W. Fisher, Michael A. Hale, Rody P. Cox, and Davld T. Chuang

Three distinct RNAs for the surface protease gp63

Leishmania donouani chagasi promastigotes to an are differentially expressed during development of

infectious form.

Paetz, Mitra Maybodi, Sigrid C. Roberts, and Mary E. Ramesh Ramamoorthy, John E. Donelson, Katherine E.

Wikon

Characterization of endosome-endosome fusion in a cell-free system using Dictyostelium discoideum.

James M. Lenhard, Luis Mayorga, and Philip D. Stahl

Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodefi- ciency virus type 1.

Olaf Heidenreich and Fritz Eckstein

Constitutive presence of a catalytic fragment of pro- tein kinase C, in a small cell lung carcinoma cell line.

Gregory Baxter, Edwin Oto, Sarkiz Daniel-Zssakani, and Berta Strulouici

Two naturally occurring mutations at the first and second bases of codon aspartic acid 166 in the pro- posed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis.

Yuanhong Ma, Taco Bruin, Suat Tuzgol, Bonnie I. Wil- son, Ghislaine Roederer, Ming-Sun Liu, Jean Davignon, John J. P. Kastelein, John D. Brunzell, and Michael R. Hayden

Cloning and expression of two different genes from StreDtococcus dysgdactiae encoding fibronectin

”

receptors. Per-Eric Lindgren, Pietro Speziale, Martin McGavin,

Hans-Jiirg Monstein, Magnus Hook, Livia Visai, Tim0 Kostiainen, Silvia Bozzini, and Martin Lindberg

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A mutant of 7SL RNA in Yarrowia lipolytica af- fecting the synthesis of a secreted protein.

Feng He, Jean-Marie Beckerich, and Claude Gaillardin

Modulation of the carbohydrate moiety of thyro- globulin by thyrotropin and calcium in fisher rat thyroid line-6 cells.

Bruno Di Jeso, Domenico Liguoro, Pasquale Ferranti, Michele Marinaccio, Renato Acquaviva, Silvestro Formi- sano, and Eduardo Consiglw

operator binding determined by a mutational analy- The role of the N terminus in Tet repressor for tet

Hillen Christian Berens, Lothar Altschmied, and Wolfgang

Hepatitis B virus envelope L protein particles. Syn-

purification and characterization. thesis and assembly in Saccharomyces cerevisiae,

Shun’ichi Kuroda, Sachiko Otaka, Takeshi Miyazaki, Masafumi Nakao, and Yukio Fujisawa

protein E variant (cysteine at residue 142) may The functional characteristics of a human apolipo-

explain its association with dominant expression of type I11 hyperlipoproteinemia.

Weisgraber, and S tanky C. Rall, Jr. Yukw Horie, Sergio Fa&, John R. Westerlund, Karl H.

A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2.

Brian G. Gabrielli, Linda M. Roy, Jean Gautier, Michel Philippe, and James L. Maller

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Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affin- ity and enhanced conformational stability by bind- ing of a tetradecapeptide corresponding to the Pl and P,, region of the putative reactive bond loop of the inhibitor.

Paul E. Bock Ingemar Bjork, Karin Ylinenjarvi, Steven T. Olson, and

Localized Ca2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release.

Talvinder S. Sihra, Elena Bogonez, and David G. Nicholls

Reactive sites of an anticarcinogenic Bowman-Birk proteinase inhibitor are similar to other trypsin inhibitors.

Ping Chen, John Rose, Robert Love, Chin H. Wei, and Bi-Cheng Wang

TATA box-mediated polymerase I11 transcription in vitro.

Mark T. Mitchell, Grace M. Hobson, and Pamela A. Benfield

@-Adrenergic, CAMP-mediated stimulation of pro- liferation of brown fat cells in primary culture. Mediation via B1 but not via f13 adrenoceptors.

Gennady Bronnikov, Josef Ho&tCk, and Jan Nedergaard

Synthesis and assembly of the synaptic cleft protein S-laminin by cultured cells.

Todd L. Green, Dale D. Hunter, Wing Chan, John P. Merlie, and Joshua R. Sanes

Location of the ATP y-phosphate-binding sites on rat liver carbamoyl-phosphate synthetase I. Studies with the ATP analog 5‘-p-fluorosulfonylbenzoyl- adenosine.

M. Daniel Potter and Susan G. Powers-Lee

A single amino acid mutation (Ser”’ + Cys) deter- mines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability.

Michael B. Faletto, Patricia Linko, and Joyce A. Goldstein

Multidegenerate DNA recognition by the OxyR transcriptional regulator.

Louis A. Tartaglia, Carlos J. Gimeno, Gisela Storz, and Bruce N. Ames

Multiple regulatory elements control expression of the gene encoding the Saccharomvces cerevisiae cytoGhrome P458, lanosterol l4a-demethylase (ERGII).

Thomas G. Turi and John C. Loper

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Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.

Jacques-Antoine Haefliger, Roberto Bruzzone, Nancy A. Jenkins, Debra J . Gilbert, Neal G. Copeland, and David L. Paul Protein kinases negatively affect nuclear faCtOr-rB

ent stages in promyelocytic HL60 cells. activation by tumor necrosis factor-a at two differ-

Hans-Peter Hohmann, Roland Remy, Ludwig Aigner, Manfred Brockhaus, and Adolphus P. G. M. van Loon Purification and initial characterization of pepti- dyl-tRNA hydrolase from rabbit reticulocytes.

Martin Gross, Timothy K. Starn, Carolyn Rundquist, Paul Crow, John White, Annette Olin, and Thomas Wagner

dyl-tRNA hydrolase is the 3‘-AMP terminus of sus- The site of hydrolysis by rabbit reticulocyte pepti-

ceptible tRNA substrates.

Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells.

Shelton Earp, Alice Berry, Hamsa Suchindran, Elmer M. Balazs Sarkadi, Delbert Bauzon, William R. Huckle, H.

Price, John C. Olsen, Richard C. Boucher, and Gene A . Scarborough Identification of heme and copper ligands in subunit I of the cytochrome bo complex in Escherichia coli.

J u n Minagawa, Tatsushi Mogi, Robert B. Gennis, and Yasuhiro Anraku Determination of the ligands of the low spin heme of the cytochrome o ubiquinol oxidase complex using site-directed mutagenesis.

Laura J . Lemieux, Melissa W. Calhoun, Jeffrey W. Thomas, W. John Ingledew, and Robert B. Gennis

ADDITIONS AND CORRECTIONS

Martin Gross, Paul Crow, and John White

Studies on the structural requirements for the activ-

slow Ca2+ channel. Vol. 265 (1990) 11858-11863. ity of the skeletal muscle dihydropyridine receptor/

Haeyoung S. Kim, Xiangyang Wei, Peter Ruth, Edward Perez-Reyes, Veit Flockerzi, Franz Hofmann, and Lutz Birnbaumer Attenuation of CAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a CAMP-phosphodiesterase. Vol. 266 (1990) 14383- 14389.

Mario Ascoli Johannes V. Swinnen, Bruce D’Souza, Marc0 Conti, and

Cumulative author index. Numbers 1 through 3.

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The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

January 25, 1992

MINIREVIEW Voltage-sensitive Ca2+ channels.

Richard J . Miller

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Arabidopsis mutants deficient in polyunsaturated fatty acid synthesis. Biochemical and genetic char- acterization of a plant oleoyl-phosphatidylcholine desaturase.

Martine Miquel and John Browse

Purification and characterization of a-L-fucosidase from Streptomyces species.

Mutsumi Sano, Kumi Hayakawa, and Ikunoshin Kat0

A novel sulfated structure in the carbohydrate-pro- tein linkage region isolated from porcine intestinal ”

heparin.

Pieter de Waard, and Johannes F. G. Vliegenthart Kazuyuki Sugahara, Shuhei Yamada, Keiichi Yoshida,

Conversion of l-O-alkyl-2-acyl-sn-glycero-3-phos- phocholine to l-O-alk-l’-enyl-2-acyl-sn-glycero-3- phosphoethanolamine. A novel pathway for the me- tabolism of ether-linked phosphoglycerides.

and Larry W . Daniel Jay C. Strum, Adalsteinn Emilsson, Robert L. Wykle,

Novel molecular species of sphingomyelin contain- ing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa.

Brenton S. Robinson, David W. Johnson, and Alf Poulos

CELL BIOLOGY AND METABOLISM Constitutive activation of the alB-adrenergic recep- tor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

Michael A. Kjelsberg, Susanna Cotecchia, Jacek Ostrowski, Marc G. Caron, and Robert J. Lefkowitz

Calcium channel blockers nifedipine and diltiazem inhibit Ca2+ release from intracellular stores in neu- trophils.

Molecular cloning and enzymatic analysis of the rat homolog of “PhK-yT,” an isoform of phosphorylase kinase catalytic subunit.

Mihail B. Calnlb, Daniel T. Fox, and Steven K. Hanks

A truncated form of fibroblast growth factor recep- tor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

Tseng, Jr., and Lewis Williams Hikaru Ueno, Michael Gunn, Karen Dell, Alexander

Regulated and constitutive secretion. Differential effects of protein synthesis arrest on transport of glycosaminoglycan chains to the two secretory path- ways.

Moore Catherine Brion, Stephen G. Miller, and Hsiao-Ping H.

Expression of the catalytic subunit of phosphorylase

coli. phosphatase (protein phosphatase- 1) in Escherichia

Zhongjian Zhang, Ge Bai, Stephen Deans-Zirattu, Michelle F. Browner, and Ernest Y. C. Lee

bo1 ester and by CAMP is associated with decreased Inhibition of CD3-linked phospholipase C by phor-

phosphotyrosine and increased phosphoserine con- tents of PLC-71.

Carlos Rosales and Eric J. Brown

Do Joon Park, Hong Ki Min, and Sue Goo Rhee

Phosphorylation by CAMP-dependent protein ki- nase inhibits the degradation of Tau by calpain.

Joel M. Litersky and Gail V. W. Johnson

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1938

1969

In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plas- minogen activator with rat liver cells.

Johan Kuiper, Dingeman C. Rijken, Gerard A. W . de Munk, and The0 J. C. van Berkel

Exposure of rat peritoneal macrophages to acety- lated low density lipoprotein results in release of plasma membrane cholesterol. An efficient sub- strate for esterification by acyl-CoA:cholesterol acyltransferase.

Moritsugu Shinohara, Akira Miyazaki, Motoaki Shichiri, Yoshimasa Morino, and Seikoh Horiuchi

Discrete amino acid sequences of the al-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

Susanna Cotecchia, Jacek Ostrowski, Michael A . Kjels- berg, Marc G. Caron, and Robert J . Lefkowitz

Cholesterol is converted to 7a-hydroxy-3-oxo-4- cholestenoic acid in liver mitochondria. Evidence for a mitochondrial sterol 7a-hydroxylase.

Toll, and Kjell Wikvall Magnus Axelson, Junichi Shoda, Jan Sjouall, Anders

Ethanol induces 2’,5’-oligoadenylate synthetase and antivirial activities through interferon-fl pro- duction.

Mounira K. Chelbi-Alin and Suzanne Chousterman

Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a de- crease in cellular diacylglycerol levels in cultured rat hepatocytes.

Haris Jamil, Amandip K. Utal, and Dennis E. Vance

Retinoids and retinoid-binding protein expression in rat adipocytes.

Roseann Piantedosi, Maggi Allan, De Witt S. Goodman, and Chiharu Tsutsumi, Masataka Okuno, Lamya Tannous,

William S. Blaner

Activation of phospholipase C by the a subunits of the G, and GI, proteins in transfected cos-7 cells.

Dianqing Wu , Chang Ho Lee, Sue Goo Rhee, and Melvin I . Simon

Okadaic acid mimics multiple changes in early pro- tein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.

G. R. Guy, X . Cao, S. P. Chua, and Y. H. Tan

A T cell nuclear factor resembling NF-AT binds to an NF-KB site and to the conserved lymphokine promoter sequence “Cytokine- 1.”

Ranjan Sen, and Anjana Rao Patricia G. McCaffrey, Jugnu Jain, Christina Jamieson,

Characterization of endosome-endosome fusion in a cell-free system using Dictyostelium discoideum.

James M. Lenhnrd, Luis Mayorga, and Philip D. Stahl

tein kinase C, in a small cell lung carcinoma cell Constitutive presence of a catalytic fragment of pro-

line.

Berta Strulouici Gregory Baxter, Edwin Oto, Sarkiz Daniel-Issakani, and

Modulation of the carbohydrate moiety of thyro-

thyroid line-5 cells. globulin by thyrotropin and calcium in fisher rat

Bruno Di Jeso, Domenico Liguoro, Pasquale Ferranti, Michele Marinaccio, Renato Acquauiua, Siluestro Formi- sano, and Eduardo Consiglio

A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2.

Philippe, and James L. Maller Brian G. Gabrielli, Linda M. Roy, Jean Gautier, Michel

Indicates a Communication

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Localized Ca” entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release.

Talvinder S. Sihra, Elena Bogonez, and David G. Nicholls

@-Adrenergic, CAMP-mediated stimulation of pro- liferation of brown fat cells in primary culture. Mediation via 81 but not via D3 adrenoceptors.

Gennady Bronnikov, Josef Houitck, and Jan Nedergaard

Synthesis and assembly of the synaptic cleft protein S-laminin by cultured cells.

Todd L. Green, Dale D. Hunter, Wing Chan, John P. Merlie, and Joshua R. Sanes

Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.

Jacques-Antoine Haefliger, Roberto Bruzzone, Nancy A. Jenkins, Debra J . Gilbert, Neal G. Copeland, and David L. Paul

Protein kinases negatively affect nuclear factor-& activation by tumor necrosis factor-a at two differ- ent stages in promyelocytic HL60 cells.

Hans-Peter Hohmann, Roland Remy, Ludwig Aigner, Manfred Brockhuus, and Adolphus P. G. M. van Loon

Attenuation of CAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a CAMP-phosphodiesterase. Vol. 266 (1990) 14383- 14389.

Johannes V. Swinnen, Bruce D’Souza, Marc0 Conti, and Mario Ascoli

ENZYMOLOGY Rapid optimization of enzyme substrates using de- fined substrate mixtures.

Judd Berman, Michael Green, Elizabeth Sugg, Rob Anderegg, David S. Millington, Daniel L. Norwood, Jerry McGeehan, and Jeffrey Wiseman

Adrenal P-450,, modulates activity of P-45OllO in liposomal and mitochondrial membranes. Implica- tion of P-450,, in zone specificity of aldosterone biosynthesis in bovine adrenal.

Shin-ichi Ikushiro, Shiro Kominami, and Shigeki Takemori

14CzHz- and 14COz-labeling studies of the de novo synthesis of polypeptides by Nitrosomonas euro- paea during recovery from acetylene and light in- activation of ammonia monooxygenase.

Michael R. Hyman and Daniel J . Arp

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosy1)transferase.

and Kunihiro Ueda Marek Banasik, Hajime Komura, Makoto Shimoyama,

Mechanism of glutamate semialdehyde aminotrans- ferase. Roles of diamino- and dioxo-intermediates in the synthesis of aminolevulinate.

Ceri E. Pugh, John L. Harwood, and Robert A. John

Purification of the testicular galactolipid: 3’-phos- phoadenosine 5’-phosphosulfate sulfotransferase.

Darinka Sakac, Mary Zachos, and Clifford A. Lingwood

Cloning of the vaccinia virus ribonucleotide reduc- tase small subunit gene. Characterization of the gene product expressed in Escherichia coli.

Meredith L. Howell, Joann Sanders-Loehr, Thomas M. Loehr, Nancy A. Roseman, Christopher K. Mathews, and Mary B. Slabaugh

Defining the involvement of HOC1 or Clz as enzyme- generated intermediates in chloroperoxidase-cata- lyzed reactions.

R. Daniel Libby, Amy L. Shedd, A. Kathryn Phipps, Tina M. Beachy, and Susan M. Gerstberger

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Coexpression of human CAMP-specific phosphodi- esterase activity and high affinity rolipram binding in yeast.

Theodore J. Torphy, Jeffrey M. Stadel, Miriam Burman, Lenora B. Cieslinski, Megan M. McLaughlin, John R. White, and George P. Livi

Novel flavonol 3-sulfotransferase. Purification, ki- netic properties, and partial amino acid sequence.

Luc Varin and Ragai K. Ibrahim

Location of the ATP y-phosphate-binding sites on rat liver carbamoyl-phosphate synthetase I. Studies with the ATP analog 5’-p-fluorosulfonylbenzoyl- adenosine.

M. Daniel Potter and Susan G. Powers-Lee

MEMBRANES AND BIOENERGETICS pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.

David D. Maenz, Catherine Chenu, Sylvie Breton, and Alfred Berteloot

Orthophosphate-promoted ouabain binding to Na/K pumps of resealed red cell ghosts. Evidence for E*P preferentially binding oubain.

Marisol Guerra, Marcia Steinberg, and Philip B. Dunham

Vibrational spectroscopy of bacteriorhodopsin mu- tants. Evidence that Thr-46 and Thr-89 form part of a transient network of hydrogen bonds.

Kenneth J. Rothschild, Yi-Wu He, Sanjay Sonar, Thomas Marti, and H. Gobind Khorana

Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca2+-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom.

Marcel Crest, Guy Jacquet, Maurice Gola, Halim Zer- rouk, Abdellah Benslimane, HervC Rochat, Pascal Man- suelle, and Marie-France Martin-Eauclaire

Canalicular transport of reduced glutathione in nor- mal and mutant Eisai hyperbilirubinemic rats.

Jose Carlos Ferncindez-Checa, Hajime Takikawa, Tohru Horie, Murad Ookhtens, and Neil Kaplowitz

Molecular mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum. Effects of synthetic phospholamban pep- tides on Ca” pump ATPase.

Tatsuya Sasaki, Makoto Inui, Yoshihiro Kimura, Tsunehiko Kuzuya, and Michihiko Tada

On the location and function of tyrosine 8331 in the catalytic site of Escherichia coli F1-ATPase.

Joachim Weber, Rita S.-F. Lee, Ernst Grell, John G. Wise, and Alan E. Senior

Contribution to ligand binding by multiple carbo- hydrate-recognition domains in the macrophage mannose receptor.

Maureen E. Taylor, Karel Bezouika, and Kurt Drickamer

Cloning and expression of a cardiacbrain @ subunit of the L-type calcium channel.

Edward Perez-Reyes, Antonio Castellano, Haeyoung S. Kim, Philippe Bertrand, Eric Baggstrom, Antonio E. Lacerda, Xiangyang Wei, and Lutz Birnbaumer

Membrane topology of the melibiose carrier of Esch- erichia coli.

and T. Hastings Wilson Martyn C. Botfield, Kazuo Naguchi, Tomofusa Tsuchiya,

Glucose 6-phosphate and hexokinase can be used as an ATP-regenerating system by the CaZ+-ATPase of sarcoplasmic reticulum.

Mbnica Montero-Lomeli and Leopoldo de Meis

Indicates a Communication

Vlll ...

2087 Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells.

Balazs Sarkadi, Delbert Bauzon, William R. Huckle, H.

Price, John C. Olsen, Richard C. Boucher, and Gene A. Shelton Earp, Alice Berry, Hamsa Suchindran, Elmer M.

Scarborough

2096 Identification of heme and copper ligands in subunit I of the cytochrome bo complex in Escherichia coli.

J u n Minagawa, Tatsushi Mogi, Robert B. Gennis, and Yasuhiro Anraku

2105 Determination of the ligands of the low spin heme of the cytochrome o ubiquinol oxidase complex using site-directed mutagenesis.

Laura J. Lemieux, Melissa W . Calhoun, Jeffrey W . Thomas, W. John Ingledew, and Robert B. Gennis

NUCLEIC ACIDS. PROTEIN SYNTHESIS. AND

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MOLECULAR GENETICS ~ ~ '

Mammalian DNA polymerase B can substitute for DNA polymerase I during DNA replication in Esch- erichia coli.

Joann B. Sweasy and Lawrence A. Loeb

The NusA and NusG proteins of Escherichia coli increase the in vitro readthrough frequency of a transcriptional attenuator preceding the gene for the B subunit of RNA polymerase.

Thomas Linn and Jack Greenblatt

Different positively charged amino acids have sim-

brane protein in Escherichia coli. ilar effects on the topology of a polytopic transmem-

Helena Andersson, Evert B a k k r , and Gunnar uon Heijne

Analysis of 40 S and 80 S complexes with mRNA as

extension inhibition. measured by sucrose density gradients and primer

Donald D. Anthony and William C. Merrick

Human gastric cathepsin E gene. Multiple tran- scripts result from alternative polyadenylation of the primary transcripts of a single gene locus at

Takeshi Azuma, Wanguo Liu, Douglas J. Vander Laan, lq31-q32.

Anne M. Bowcock, and R. Thomas Taggart

A model for the aminoacyl-tRNA binding site of eukaryotic elongation factor la.

and William C. Merrick Terri Goss Kinzy, John P. Freeman, Arthur E. Johnson,

Identification and purification of DBF-A, a double- stranded DNA-binding protein from Saccharomy- ces cerevtsrae.

Rati Verma and Judith L. Campbell

Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.

Popescu, and Ira Pastan Alfred C. Johnson, Ryoichiro Kageyama, Nicholas C.

Alteration by site-directed mutagenesis of the con- served lysine residue in the ATP-binding consensus sequence of the RecD subunit of the Escherichia coli RecBCD enzyme.

Firouzeh Korangy and Douglas A. Julin

Enzymatic effects of a lysine-to-glutamine mutation in the ATP-binding consensus sequence in the RecD subunit of the RecBCD enzyme from Escherichia coli.

Firouzeh Korangy and Douglas A. Julin

Competing B-Z and helix-coil conformational tran- sitions in supercoiled plasmid DNA.

Lilley Fareed Aboul-ela, Richard P. Bowater, and David M . J .

In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors.

Lirim Shemshedini, Jingwei Ji, Christel Brou, Pierre Chambon, and Hinrich Gronemeyer

1840

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1924

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1945

1953

1995

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Insect glutathione S-transferases. Biochemical characteristics of the major forms from houseflies susceptible and resistant to insecticides.

Didier Fournier, Jean Marc Bride, MarylBne Poirie, Jean-Baptiste Bergk, and Frederick W . Plapp, Jr.

ture ElB subunit of bovine mitochondrial branched- Cloning and expression in Escherichia coli of ma-

chain a-keto acid dehydrogenase complex. Mapping of the ElB-binding region on E2.

R. Max Wynn, Jacinta L. Chuang, James R. Dauie, Charles W . Fisher, Michael A . Hale, Rody P. Cox, and David T. Chuang

Three distinct RNAs for the surface protease gp63

Leishmania donovani chagasi promastigotes to an are differentially expressed during development of

infectious form.

Paetz, Mitra Maybodi, Sigrid C. Roberts, and Mary E. Ramesh Ramamoorthy, John E. Donelson, Katherine E.

Wilson

Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodefi- ciency virus type 1.

Olaf Heidenreich and Fritz Eckstein

Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the pro- posed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis.

son, Ghislaine Roederer, Ming-Sun Liu, Jean Dauignon, Yuanhong Ma, Taco Bruin, Suat Tuzgol, Bonnie I. Wil-

John J . P. Kastelein, John D. Brunzell, and Michael R. Hayden

Cloning and expression of two different genes from Streptococcus dysgalactiae encoding fibronectin receptors.

Per-Eric Lindgren, Pietro Speziale, Martin McGauin, Hans-Jiirg Monstein, Magnus Hook, Livia Visai. T i n o Kostiainen, Siluia Bozzini, and Martin Lindberg

A mutant of 7SL RNA in Yarrowia lipolytica af- fecting the synthesis of a secreted protein.

Feng He, Jean-Marie Beckerich, and Claude Gaillardin

operator binding determined by a mutational analy- The role of the N terminus in Tet repressor for tet

Hillen Christian Berens, Lothar Altschmied, and Wolfgang

Hepatitis B virus envelope L protein particles. Syn-

purification and characterization. thesis and assembly in Saccharomyces cerevisiae,

Shun'ichi Kuroda, Sachiko Otaka, Takeshi Miyazaki, Masafumi Nakao, and Yukio Fujisawa

TATA box-mediated polymerase I11 transcription in vitro.

Mark T. Mitchell, Grace M. Hobson, and Pamela A. Benfield

A single amino acid mutation (Ser"' + Cys) deter- mines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability.

Goldstein Michael B. Faletto, Patricia Linko, and Joyce A.

Multidegenerate DNA recognition by the OxyR transcriptional regulator.

Bruce N. Ames Louis A. Tartaglia, Carlos J . Gimeno, Gisela Storz, and

Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14a-demethylase (ERG1 1) .

SIS.

Thomas G. Turi and John C. Loper

Purification and initial characterization of pepti- dyl-tRNA hydrolase from rabbit reticulocytes.

Martin Gross, Timothy K. Starn, Carolyn Rundquist, Paul Crow, John White, Annette O h , and Thomas Wagner

Indicates a Communication

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The site of hydrolysis by rabbit reticulocyte pepti- dyl-tRNA hydrolase is the 3‘-AMP terminus of sus- ceptible tRNA substrates.

Martin Gross, Paul Crow, and John White

Studies on the structural requirements for the activ-

slow Ca2+ channel. Vol. 265 (1990) 11858-11863. ity of the skeletal muscle dihydropyridine receptor/

Haeyoung S. Kim, Xiangyang Wei, Peter Ruth, Edward Perez-Reyes, Veit Flockerzi, Franz Hofmann, and Lutz Birnbaumer

PROTEIN CHEMISTRY AND STRUCTURE Purification and characterization of the carboxyl- terminal transactivation domain of Vmw65 from herpes simplex virus type 1.

Logan Donaldson and John P. Capone

Asparagine 26, glutamic acid 31, valine 45, and tyrosine 64 of Ras proteins are required for their oncogenicity.

D’Abaco, and Hiroshi Maruta M. S. A. Nur-E-Kamal, Andrew Sizeland, Giovanna

X-ray structural evidence for a local helix-loop transition in a-lactalbumin

Kazuaki Harata and Michiro Muraki

Isoprenylation of a protein kinase. Requirement of farnesylation/a-carboxyl methylation for full enzy- matic activity of rhodopsin kinase.

G. Caron, and Robert J. Lefkowitz James Inglese, J . Fraser Glickman, Wulfing Lorenz, Marc

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.

Heike A. Wieland, Hartmut Luddens, and Peter H. Seeburg

Functional reconstitution of cytochrome P-450,, with hemin activated with Woodward’s reagent K. Formation of a hemeprotein cross-link.

Irene A. Pikuleva, Anna G. Lapko, and Vadim L. Chashchin

Patterns of prohormone processing. Order revealed by a new procholecystokinin-derived peptide.

Gert A . Eberlein, Viktor E. Eysselein, Michael T. Davis, Terry D. Lee, John E. Shively, Daniel Grandt, Wolfgang Niebel, Russel Williams, Joachim Moessner, Joerg Zeeh, Helmut E. Meyer, Harald Goebell, and Joseph R. Reeve, Jr.

The purification of a Rap1 GTPase-activating pro- tein from bovine brain cytosol.

Edouard C. Nice, Lauis Fabri, Annet Hammacher, Janet Holden, Richard J. Simpson, and Antony W. Burgess

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A tyrosinated peptide representing the alternatively spllced exon of the latelet-derived rowth factor A-chain binds speciEcally to culture1 cells and in- terferes with binding of several growth factors.

Chesterman Levon M. Khachigian, Dwain A. Owensby, and Colin N.

The reactivity of thiols and disulfides with different redox states of myoglobin. Redox and addition re- actions and formation of thi 1 radical intermediates.

Francisco J. Romero, IshmaerOrdoriez, Arduino Arduini, and Enrique Cadenas Post-translational modifications of Drosophila ac- etylcholinesterase. In vitro mutagenesis and expression in X e n o r oocJtes. ,

Functional determinants in the autoinhibitory do- main of calcium/calmodulin-dependent protein ki- nase 11. Role of Hisza2 and multiple basic residues.

and Thomas R. Soderling M. Kevin Smith, Roger J . Colbran, Debra A . Brickey,

Functional and structural analysis of VLA-4 inte- grin a4 subunit cleavage.

and g a r t i n E . Hemler Jo uin Teirido, Christina M. Parker, Paul D. Kassner,

DNA allosterically modulates the steroid binding domain of the estrogen receptor.

Anderson, and Jack Gorskr Michael Fritsch, Roy D., Welch, Fern E. Murdoch, Iain

Primary structure of rat pulmonary surfactant pro- tein D. cDNA and deduced amino acid sequence.

Benson, Kenneth Lau, Robert J. Mason, ancf Dennis d Hiroshi Shimizu, James H. Fisher, Philip Pa st, Bradle

Voelker Oxidative modification of Escherichia coli gluta- mine synthetase. Decreases in the thermodynamic stability of protein structure and specific changes in the active site conformation.

The functional characteristics of a human apolipo- protein E variant (cysteine at residue 142) may explain its association with dominant expression of type I11 hyperlipoproteinemia.

Yukio Horie, Sergro Fazro, John R. Westerlund, Karl H. Weisgraber, and Stanley C. Rall, Jr. Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affin- ity and enhanced conformational stabihty by bind-

and P14 region of the putative reactive bond loop of ing of a tetradecapeptide corresponding to the P1

Annick Muter0 an Dldrer ournrer

Mark T. Fisher and Earl R. Stadtman

the inhibitor. Ingemar Bjork, Karin Ylinenjarvi, Steven T . Olson, and

Paul E. Bock Reactive sites of an anticarcinogenic Bowman-Birk proteinase inhibitor are similar to other trypsin inhibitors.

Bi-Cheng Wang Ping Chen, John Rose, Robert Love, Chin H. Wei, and

Indicates a Communication