The Italian Life Sciences Trend Analysis 2015

About Us

The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com

The Italian Life Sciences Database is a part of the global Biotechgate. www.italianbiotech.com

Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.com

Overview of the Italian Life Science Industry

2015 Statistics

Total Biotech Companies 522

Medtech companies 104

Pharma companies 87

Investor companies 5

Public / Non-Profit Organizations / Medical Facilities 156

Other life science related companies 325

Percentage of Publicly Owned Companies 2.21%

Life Sciences Venture Financing 2013 / 2014 USD 20.4m / USD 8.2m

Number of Technologies 108

Licensing Opportunities 120

Overview of the Italian Biotechnology Industry

2015 Statistics

Total Biotech Companies 522

Biotech - Therapeutics 58

Biotech – R&D Services 241

Biotech - Other 223

Percentage of SME's 76%

Percentage of Publicly Owned Companies 1.6%

Biotech Venture financing 2013 / 2014 USD 20.4m / USD 8.2m

Licensing Opportunities 104

Number of Employees

1-1039%

11-5020%

51-20017%

Greater than 200

24%

Number of Employees - Biotech

1-1024%

11-5012%

51-20024%

Greater than 200

41%

Number of Employees - Life Sciences

Company Ownership

Private / inde-pendent

81%

Public1%

Sub-sidiary17%

Life Science Companies by Ownership Status

Private / independent 74%

Public2%

Subsidiary24%

Biotechnology Companies by Ownership Status

Company Foundation Timeline

19951996

19971998

19992000

20012002

20032004

20052006

20072008

20092010

20112012

20132014

0

2

4

6

8

10

12

14

16

Number of Biotech Companies Founded by Year

Biotechnology - other Biotechnology - Therapeutics and Diagnostics Biotechnology / R&D Services

Key Activities of Biotechnology Companies

AgroBio10%

Bioinformatics and Bioelectronics3%

Contract Research and Manufacturing10%

Cosmetics6%

Diagnostics and Analytical Services16%

Drug Delivery1%

Environment4%

Food and Nutraceuticals8%

Genomics and Proteomics5%

Industrial Biotechnology2%

Other Services and Suppliers25%

Therapeutics6%

Veterinary4%

Key Biotech Activity

Biotech Products - Breakdown by Indication

Neoplasms / cancer / oncology

Infectious and parasitic diseases

other

Diseases of the nervous system

Diseases of the eye

Cardiovascular

Musculoskeletal system and connective tissue

Diseases of the blood and blood-forming organs; immune disorders

Skin and subcutaneous tissue

Respiratory

Genitourinary system

External causes of morbidity and mortality

Mental and behavioural disorders

Injury, poisoning and certain other consequences of external causes

0 10 20 30 40 50 60

Biotech Products by Indication

Products in the Pipeline as of 30.07.2015

Phase III

Phase II

Phase I

Preclinical

0 10 20 30 40 50 60

6

30

19

54

Number of Biotech Products in Development

Biotechnology Financing in Italy– 5 year report

2010 H1 2010 H2 2011 H1 2011 H2 2012 H1 2012 H2 2013 H1 2013 H2 2014 H1 2014 H2 2015 H10.00

10.00

20.00

30.00

0

1

2

3

Venture Financing of Biotech Companies

Financing Value

Number of Rounds

Fina

ncin

g Va

lue

(Mill

ion

USD)

Num

ber o

f Rou

nds

Major Biotech Financing Rounds (H2 2014 – H1 2015)

Company Sector USD M

Genenta Science s.r.l. Biotech – Therapeutics & Diagnostics 10.8

Genenta Science s.r.l. Biotech – Therapeutics & Diagnostics 7.0

Biouniversa s.r.l. Biotech – Therapeutics & Diagnostics 1.3

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The “Italian Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof.

The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions.

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