The Human Phenotypic Disease Network

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The Human Phenotypic Disease Network. Cesar A. Hidalgo Center for Complex Network Research, University of Notre Dame / Northeastern University. Collaborators. Nicholas Christakis Laurie Meneades Jason Block Dept. of Health Policy, Harvard Medical School. Christine Teutsch - PowerPoint PPT Presentation

Text of The Human Phenotypic Disease Network

  • Cesar A. HidalgoCenter for Complex Network Research, University of Notre Dame / Northeastern UniversityThe Human PhenotypicDisease Network

  • CollaboratorsNicholas ChristakisLaurie MeneadesJason Block

    Dept. of Health Policy,Harvard Medical SchoolLaszlo BarabasiNicholas BlummDeok-Sun LeeJ Park

    Center for Network Science,Northeastern UniversityChristine Teutsch

    Massachusetts General HospitalHarvard Medical School

  • Some Diseases are known to be related

  • Ectonuclide PyrophosphatePhosphodiesterase 1 High FructoseCorn SyrupSedentaryLife StyleThere are no single causes for each disease

  • Determining causes is labor and capital intensive

  • Disease 2Disease 1

  • Disease 1Disease 2Affect Same IndividualsSignificantly more than Random

  • P1P2NBuilding a Net

  • ~ 13039018 patients58.3% females,90.1% white7.5% black~ 32341348 records (hospitalizations)Up to 10 diagnosis (from ~950 cat (3digit) / ~14000 (5digit) )

  • Disease 2Disease 1

  • CHF

  • CONCLUSIONSWe introduced the concept of a phenotypic disease network.This network can be used to help explore life cycle strategies for drug companies and hospital design.This network can be used to perform comparative studies.Ultimately, the goal is to help determine disease ontology based on their comorbidity patterns

  • http://www.nd.edu/~chidalgoOr Google: CA Hidalgo

    http://www.nd.edu/~networksOr Google: CCNR