The Human Circulatory System

Components and Functions

Components of Blood

• Plasma• Red blood cells• White blood cells• Platelets

Plasma• Makes up 55% of the blood• Contains dissolved ions

including; Ca, Mg, Na, HCO3• Wastes and nutrients• Proteins (antibodies,

enzymes, hormones, clot factors)

• Water (91% H2O)

Red Blood Cells

• Most numerous cells • Shaped like bi-concave

discs• Produced in the bone

marrow• Mature RBC’s do NOT

contain a nucleus• Hemoglobin is an iron-

containing protein in RBC’s that binds to O2 and assist in its transport

RBCs, WBCs & Platelets

White Blood Cells

• Larger than RBC’s• Produced in the bone

marrow and lymph nodes

• Single or multi-nucleated

• Necessary to fight pathogens (ie. bacteria, viruses)

Types of White Blood Cells

• Phagocytes (engulf foreign pathogens via phagocytosis)

-Macrophage-neutrophils

-monocytes

• Lymphocytes-B cells (produce

antibodies)-T cells -T4 helper -Killer T cells

Blood Cell Origin and Differentiation

Platelets

• Assist in the clotting process• Fragments, contain no nucleus• Made in bone marrow

Blood Clotting

• Clotting involves a series of enzyme controlled reactions

• Injury to blood vessel-causes platelets to rupture-initiating clotting reactions.

• Prothrombin-Thrombin-• Fibrinogen--Fibrin, which forms a fibrous

mesh at the site of the injury.• The mesh traps blood cells, forming a clot

Coagulation Pathway

Transport Vessels

• Blood circulates through the human body within closed blood vessels

Arteries

• Carry oxygen-rich blood away from the heart to the body

• Thick, muscular walls to withstand blood pressure

• Rhythmic expansion and contraction of the arteries produced by the heart is called the pulse.

Capillaries

• Smallest branches of arteries

• One cell layer thick

• They are the site of exchange of materials between the blood and tissues

http://www.youtube.com/watch?v=hDbfkfgc1xk&feature=related

Veins

• Blood flows from the capillaries into veins

• Veins are thin walled and carry oxygen poor blood back to the heart

• Contain valves that prevent backflow of blood due to the low pressure in the veins

*Blood flow in the veins is assisted by the contraction of your muscles.

Intercellular Fluid and Lymph• Some of the plasma leaves

the capillaries and bathes the cells. This is called Intercellular Fluid (ICF).

• Excess ICF is drained into tiny vessels called lymphatic vessels. It is then called lymphatic fluid.

• Lymph fluid empties into the large veins that return blood to the heart.