10/12/12 2:38 PMThe Hindu : Health / Medicine & Research :
Diabetes linked to depression and other mood disorders
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Health Medicine & Research
Published: December 10, 2012 09:36 IST | Updated: December 10,
2012 09:36 IST
Diabetes linked to depression and other mood disordersDPAThe
onset of diabetes more than doubles a patients risk of suffering
depression or other mood disorders.But researchers in Australia and
Taiwan also found that metformin, the most commonly used medication
for type-2diabetes, more than halves this risk.Monash University
researcher Mark Wahlqvist, who sifted through 12 years of medical
records of adults in Taiwan, saidmetformin reduced the incidence of
dementia and Parkinsons disease as well as mood disorders,
especially when usedwith a sulfonylurea drug to increase the
production of insulin.Fortunately, we had sufficient patients not
on metformin to make the comparison, he said. We think the
keymechanism relates to mitochondrial function and cellular
bioenergetics metformin would seem to reset impairedenergy
regulation, perhaps through its action on the enzyme AMP
kinase.Professor Wahlqvist, who led a joint study by his university
in Melbourne and the National Health Research InstitutesTaiwan,
said his study was into type-2 diabetes, but the findings were
likely to be valid for type-1 diabetes as well. Hissurvey was
published in the journal BMC Medicine.Keywords: Diabetes,
depression, dementiaMore In: Medicine & Research |
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