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The GIANT Alliance Grenoble Innovation for Advanced New Technologies
comment les grenoblois préparent le futur
ANSTO, 8 April 2013
W.G. Stirling, CEA
Commissariat à l’énergie atomique et aux énergies alternatives
2
Members and partners of GIANT, objectives, key numbers
Centres of excellence
GIANT projects
GIANT international benchmarking
Campus building projects and urban development
Outline
4
The city benefits from the highest concentration of strategic
jobs in France after Paris, with 14% of the employments,
35,186 jobs, 45% of which specialized in design and
research.
Grenoble is also the largest research center in France after
Paris with 22,800 jobs (11,800 in public research, 7,500 in
private research and 3,500 PhD students)
Grenoble : Wikipedia 2011
5
A little history: Grenoble has been
transformed by science and technology 1967 ILL
European High Flux Reactor
1988 ESRF
European Synchrotron
Radiation Facility
2005 MINATEC
Micro and Nano-electronics
2009 GIANT
Innovation Partnership
1956 CEA (CENG)
1962 CNRS
and l’Université Joseph Fourier, Grenoble Institut Polytechnique,
Grenoble Ecole de Management …
7
Academic Members
Grenoble Ecole de Management (GEM)
Institut Polytechnique de Grenoble (G-INP)
Université Joseph Fourier (UJF)
National Research Organizations
Centre national de la recherche scientifique (CNRS)
Commissariat à l’énergie atomique et aux énergies
alternatives (CEA)
European Large-scale Research Facilities
European Molecular Biology Laboratory (EMBL)
European Synchrotron Radiation Facility (ESRF)
Institut Laue Langevin (ILL)
Underpinned by local/regional/national/international authorities
GIANT: Founding Members
8
GIANT members are involved in a large number of partnerships
with industry, e.g.
Development with Sanofi-Aventis of diabetes therapies (CNRS,
G-INP, UJF)
R&D with Renault to develop electric vehicles (CEA)
Toyota programme on catalytic convertors (ESRF)
bioMérieux worldwide research centre on GIANT campus
Industrial partners
EADS
STMicroelectronics
Schneider Electric
Alcatel-Lucent
PSA
Siemens
GIANT: Industrial Partners
Texas Instruments
IBM
bioMérieux
Sanofi-Aventis
Astra Zeneca,
GlaxoSmithKline
….
9
The GIANT members are working together with a
common set of objectives:
to respond to major societal challenges;
information, energy and health
to remove barriers to create centres of excellence
to achieve a major urban transformation by
harmonizing urban and scientific development
GIANT: Objectives
10
Jean Therme Jérôme Vitré Stephen Cusack Francesco Sette Thierry Grange Brigitte Plateau Patrick Lévy Andrew Harrison
GIANT: Organization
Presidents, directors …
CEA J Therme CNRS J Vitre
EMBL S Cusack ESRF F Sette
GEM T Grange G-INP B Plateau
ILL A Harrison UJF P Levy
11
6 000 researchers
5 000 industrial jobs
5 000 students
300 inhabitants
GIANT tomorrow GIANT today 10 000 researchers
10 000 industrial jobs
10 000 students
10 000 inhabitants
100 000 visitors annually
5 000 publications annually
500 patents filed annually
4 billion € annual economic impact
1€ = 1.23 AUD = 1.28 $ US
GIANT: Key numbers
12
MINATEC
Information
NanoBio
Biology / biotech
GreEn
Energy
EPN Science Campus
Large European
scientific infrastructures
Technology
management
Basic research:
Physics, cryogenics, instrumentation …
Three technological centres: MINATEC, GreEn, NanoBio
Three transverse centres: EPN Science Campus (EMBL, ESRF, ILL)
Basic research (CNRS, CEA, G-INP, UJF …)
Technology management (GEM)
GIANT: Removing barriers to create
centres of excellence
14
Micro and nanoscience, and technology
Research and development, prototyping/demonstrators,
higher education (PHELMA), industrial partnerships …
GIANT: Centres of excellence
MINATEC: the model
15
Nanotec 300
Photos: P. Guillaume
MEMS 200
Industrial partnerships; proof of concept → prototyping → pre-production;
24/7 operation
Research: Platforms
16
Photos: P. Guillaume
Energy storage
Battery
Platform
Fuel Cell
Platform
Production of
renewable energy
PV, biomass,
wind, hydro-
Energy management / network
management / energy efficiency
GIANT: Centres of excellence
GreEn-ER
17
Photos: P. Guillaume
GIANT: Centres of excellence
GreEn-ER
University, research (G-INP, UJF, CNRS)
23000 m²; 77 M€ project
Building delivered: summer 2015
18
NanoBio1 and 2
• Micro- and nano-technologies
• Centre for applications in
biology and health
• Proteomics
Clinatec
• Micro- and nano-technologies for medicine
GIANT: Centres of excellence
NanoBio, biotechnologies and health
Structural biology at the European level
• Partnership for Structural Biology (PSB)
• Institut de Biologie Structurale, EMBL, ESRF, ILL
19
Three European
Research Infrastructures
are based in Grenoble:
EMBL, ESRF, ILL
EPN Science Campus set
up in 2010
EPN Science Campus
20
EPN Science Campus
Institut Laue-Langevin (ILL)
operates the most intense (reactor)
neutron source in the world, feeding
a suite of 40 high-performance
instruments
European Synchrotron Radiation
Facility (ESRF) is a world-leading
synchrotron radiation source hosting
41 cutting-edge experimental
stations
EMBL Grenoble is an outstation of
the EMBL organisation (HQ in
Heidelberg), specialising in research
in structural biology (in very close
proximity to the ILL and the ESRF)
25
The Technology Platform – Grenoble (TPG)
ILL, ESRF, CEA, CNRS - close together on GIANT campus
Unique portfolio of equipment and facilities for non-
destructive characterisation and analysis of materials
and processes, for
Industrial development of advanced materials
Techniques far beyond what is possible in industrial
laboratories - major opportunity for industry → competitive
advance in R&D programmes
GIANT: Cooperative projects between the
partners - science and technology; TPG
26
Objectives:
To analyse the needs of industrial users in order to
identify the best characterisation techniques made
available by the partners
To make available advanced sample preparation and
selection methods so as to optimise the use of
instrument beamtime at the large facilities
To help the industrial users in their data treatment and
interpretation
To provide expertise on each problem and on possible
solutions
In preparation phase
GIANT: Cooperative projects between the
partners - science and technology; TPG
27
des capteurs et dispositifs embarqués
17/01/2012 27
Complementarity:
optical, neutron, X-ray radiography
Optical image X-rays Neutrons
Circuit board with chips, memories, connections… …
GIANT: Cooperative projects between the
partners - science and technology; TPG
28
GIANT: Cooperative projects between the
partners - science and technology; ERC
Actions to help candidates for European Research Council
awards (recognised as very prestigious award / important
indicator)
Three types of award ERC Starting: young researcher 1.5 M€ / 5 years
ERC Consolidator: experienced researcher 2.0 M€ / 5 years
ERC Advanced: senior researcher 2.5 M€ / 5 years
And also o ERC Synergy: team of 2 to 4 researchers 15 M€ / 6 years
o ERC Proof of concept (ERC grant-holders) 150 k€ / 1 year
marketable innovation/TT
GIANT support / advice and training days
GIANT-level consideration of candidates and projects for
ERC support
29
0
2
4
6
8
10
12
14
16
18
2007 2008 2009 2010 2011 2012
M€
8.73
ERC Income (5 year grant) by year
Total 2007 – 2012 = 40.92 M€
17.86
8.01
4.22
2.1
0
Starting Grant
Advanced Grant
Proof of Concept
GIANT: Cooperative projects between the
partners - science and technology; ERC
http://erc.europa.eu/
30
ERC grant-holders 2008 - 2012
GIANT: Cooperative projects between the
partners - science and technology; ERC
31
ERC Starting Grants (totals)
GIANT: Cooperative projects between the
partners - science and technology; ERC
http://erc.europa.eu/
32
GIANT: Cooperative projects between the
partners - finance
CPER (Contrats de Projets Etat-Régions): 2007 - 2013 Local authority funding for education / research infrastructure
All GIANT partners
~ 110 M€
CAMPUS (Opération Campus): 2008 – 2018 Renovation of university infrastructure
Grenoble Université de l’innovation
G-INP, UJF, … , CEA
~ 180 M€
Investissement de l’avenir: 2010 - 2020 French state investment – preparing the future
IRT (Institut de Recherche Technologique): most GIANT
partners (IRT Nanoélectronique) – Grenoble no. 1
Labex, Equipex: GIANT partners – variable geometry
~ 300 M€
34
GIANT: International benchmarking Objectives Major international trends (innovation campuses, R&D, …)
The position of GIANT on the international scene
Impacts of the economic crisis on R&D
Countries visited Germany, Brazil, Canada, China, Finland, France, India, Indonesia,
Israel, Japan, Mexico, Poland, Russia, Singapore, South Korea,
Switzerland, Taiwan, USA, UK (several sites/cities per country)
Organisations visited Local and central government, research support/finance organisations,
universities, private companies
Team Marcel Morabito, senior adviser CEA (Prof at Sciences Po, Paris; former Rector of the
Academy of Grenoble)
WGS
35
GIANT: Benchmarking - convergence
Strategic choices – convergence
Balance between fundamental and applied research
Global concept of innovation focused on major societal challenges:
Information/communication technologies
Health/biotechnologies
Renewable and clean energies
Growth of green technologies
Will to strengthen the links between
knowledge actors
Growth of importance of local interactions
Support to PMEs
UniversityResearchInstitute
Industry
Government
Strengthening linkage between Universities and Research Institutes
36
GIANT: international positioning
GIANT - in line with major projects/campuses whose objectives
are to:
Harmonize scientific and urban development – with science
at the heart of the city
Develop an architectural model favouring the integration of
the different stakeholders
Strengthen innovation by bringing together the different
knowledge actors – higher education, research, industry,
political authorities
Strengthen the links between fundamental and applied
research
Focus on issues of major societal interest and impact
37
GIANT: international positioning
GIANT
Compact site – rapid and easy communications
Involvement of Universities (including GEM), fundamental
research, applied research, industry
Mixture of national and international institutes/laboratories
Cosmopolitan, multi-national personnel and atmosphere
Students exposed to first class research
Strong involvement and support of local political authorities
39
Joining town centre and GIANT campus
48 M€ project
Tramline in service: winter 2013
Transport infrastructure:
Extension of tram line B
40
Transport infrastructure:
Extension of tram line B
Joining the GIANT campus to city centre to University campus
41
Micro- and nano-technologies for medicine: diagnosis
and therapy (CEA, CHU)
Advanced operating theatre
20 M€ project: 3300 m²
Building delivered: December 2011
Life sciences/health research:
CLINATEC
42
New building for life sciences institute (CEA, CNRS, UJF)
On ILL/EMBL/ESRF campus (EPN Science Campus)
9300 m²; 21 M€ project
Building delivered: autumn 2013
Life sciences/health research:
Institut de Biologie Structurale (IBS2)
44
Higher education, research:
PHELMA MINATEC 2
Technology transfer centre, lecture rooms, student space
9000 m²; 25 M€ project
Amphitheatre, 500-seat; 2000 m²
Buildings delivered: spring 2015
45
Fundamental and applied research:
ILL /ESRF Science Building
Joint scientific and technological projects
Library, theory, industrial relations, soft matter
partnership …
5000 m²; 12 M€ project
Building delivered: autumn 2013
46
Extensions to ESRF experimental hall → longer
beamlines → finer detail (nm)
13000 m²; 32 M€ project
Buildings delivered: May 2013
Fundamental and applied research:
ESRF Upgrade Programme, EX2
48
Synchrotron X-ray imaging:
Australopithecus sediba
Australopithecus sediba (~ 2 Ma) : discovered in Malapa cave (40 km
from Johannesburg) in 2008 by Matthew, the son of Prof Lee Berger
(University of Witwatersrand)
Skull, teeth, part of lower jaw, humerus, parts of spinal column, pelvis …
Two AS specimens (reconstructed) with Lucy (Australopithecus
afarensis; 3.2 Ma), centre
Wikipedia
49
Synchrotron X-ray imaging:
Australopithecus sediba
Prof. Berger: “ the many advanced
features found in the brain and
body make it possibly the best
candidate ancestor for our genus,
the genus Homo, more so than
previous discoveries such as Homo
habilis”.
X-ray microtomography at ESRF
Highest resolution X-ray scans of
cranium of early human ancestor
Resolution of ~ 45 μm (human hair
diameter ~17 - 180 μm)
Reconstructed endocast (cranium
volume) is small, 420 cm3,
compared to human (~ 1350 cm3 )
or chimpanzee ( ~ 400 cm3 )
ID19 beamline, ESRF
50
Synchrotron X-ray imaging:
Australopithecus sediba
Left: cranium from (ID17) microtomography images
Right: endocast with surrounding matrix and cranium rendered
transparent; non-destructive, surface detail visible
References: Val et al , S Afr J Sci 107, 11/12 (2011); Carlson et al, Science 333
1402 (2011); and references therein
51
Synchrotron X-ray imaging:
Australopithecus sediba
Upper: scaled endocasts: human, Au.
sediba, Au. africanus (2.4 – 3.5 Ma),
chimpanzee; from below
Front brain structure (orbitofrontal
organisation) of Au. sediba more like
human than Au. africanus
Lower: as above; side view
Similarities between the
australopithecines and chimpanzees
Overall shape of brain resembles
humans more than chimpanzees
Brain structure suggests beginning of
major changes leading to human brain
(e.g. prefrontal cortex, considered
important in reasoning, planning … in
humans)
53
Open Innovation Centre, hotel, restaurants, leisure facilities
Landscaping of river banks, parks, sports
Green mobility, tramway, bicycle tracks
Family and student housing, shops
A green neighbourhood within the city, offering excellent
living conditions and architectural coherence
GIANT: harmonizing urban and scientific
development - a vibrant community environment
54
Open Innovation Centre:
An interface between city and campus
Definition phase of project
Building delivered 2016 – 2017
56
GIANT: Investing in the future
Learning, exploring, creating, living
Building a campus of excellence, comparable to ambitious
initiatives around the world
Attracting world-class researchers, engineers, innovators
Bringing together higher education, R&D, advanced industry
57
I would like to acknowledge the support of the
GIANT network partners who provided not only
information, but also illustrations and photos.