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What is our goal? Eradication vs Remission
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The Future of HIVAIDSThe Road to a Cure
How HIV persists during therapy
Ongoing viral replication occurs in subjects on suppressive HAART (TW Chun JCI N Tobin J Virol 2005)
HIV integrate in long lived resting memory T cells and persist despite suppressive HAART (TW Chun Nat Med 1995 D Finzi Science TW Chun PNAS 1997)
Reservoir cells like other memory T cells divide very slowly to maintain the memory of the immune system (A Bosque and V Planelles)
T cell survival
Proliferation
Viral replication
Courtesy of Nicholas Chomont
What is our goal Eradication vs Remission
What strategies to controleradicate reservoirs 12 Intensification of HAART (+- other interventions) Early initiation of HAART (limit viral reservoirs) Improved Drugs (penetrating anatomical compartments)
Reactivation of HIV replication from latent reservoirs rdquoShock and Killrdquo
HIV-induced cell death
Uninfected cells
Cytokines chemical compoundshellip
Courtesy of Nicholas Chomont
What strategies to controleradicate reservoirs 22
Interfering with immunological mechanism that contribute to HIV persistence
Other therapeutic interventions (GeneMol therapy therapeutic vaccine)
T cell survival Proliferation
Antibodies cytokines gene therapy chemotherapy
Courtesy of Nicholas Chomont
While we are searching Keep patients ready by
Universal Access Early Treatment - Limit reservoirs and preserve the immune
system
Invest in research Better understanding of biological mechanism and role of the
immune system in establishing reservoirs and persistence Better tools and models
In vitro and in vivo models More precise assays and sensitive techniques
Drug development increased specificity for latently infected cells
Develop translational research
Inspired from Sharon Lewin
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
How HIV persists during therapy
Ongoing viral replication occurs in subjects on suppressive HAART (TW Chun JCI N Tobin J Virol 2005)
HIV integrate in long lived resting memory T cells and persist despite suppressive HAART (TW Chun Nat Med 1995 D Finzi Science TW Chun PNAS 1997)
Reservoir cells like other memory T cells divide very slowly to maintain the memory of the immune system (A Bosque and V Planelles)
T cell survival
Proliferation
Viral replication
Courtesy of Nicholas Chomont
What is our goal Eradication vs Remission
What strategies to controleradicate reservoirs 12 Intensification of HAART (+- other interventions) Early initiation of HAART (limit viral reservoirs) Improved Drugs (penetrating anatomical compartments)
Reactivation of HIV replication from latent reservoirs rdquoShock and Killrdquo
HIV-induced cell death
Uninfected cells
Cytokines chemical compoundshellip
Courtesy of Nicholas Chomont
What strategies to controleradicate reservoirs 22
Interfering with immunological mechanism that contribute to HIV persistence
Other therapeutic interventions (GeneMol therapy therapeutic vaccine)
T cell survival Proliferation
Antibodies cytokines gene therapy chemotherapy
Courtesy of Nicholas Chomont
While we are searching Keep patients ready by
Universal Access Early Treatment - Limit reservoirs and preserve the immune
system
Invest in research Better understanding of biological mechanism and role of the
immune system in establishing reservoirs and persistence Better tools and models
In vitro and in vivo models More precise assays and sensitive techniques
Drug development increased specificity for latently infected cells
Develop translational research
Inspired from Sharon Lewin
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
What is our goal Eradication vs Remission
What strategies to controleradicate reservoirs 12 Intensification of HAART (+- other interventions) Early initiation of HAART (limit viral reservoirs) Improved Drugs (penetrating anatomical compartments)
Reactivation of HIV replication from latent reservoirs rdquoShock and Killrdquo
HIV-induced cell death
Uninfected cells
Cytokines chemical compoundshellip
Courtesy of Nicholas Chomont
What strategies to controleradicate reservoirs 22
Interfering with immunological mechanism that contribute to HIV persistence
Other therapeutic interventions (GeneMol therapy therapeutic vaccine)
T cell survival Proliferation
Antibodies cytokines gene therapy chemotherapy
Courtesy of Nicholas Chomont
While we are searching Keep patients ready by
Universal Access Early Treatment - Limit reservoirs and preserve the immune
system
Invest in research Better understanding of biological mechanism and role of the
immune system in establishing reservoirs and persistence Better tools and models
In vitro and in vivo models More precise assays and sensitive techniques
Drug development increased specificity for latently infected cells
Develop translational research
Inspired from Sharon Lewin
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
What strategies to controleradicate reservoirs 12 Intensification of HAART (+- other interventions) Early initiation of HAART (limit viral reservoirs) Improved Drugs (penetrating anatomical compartments)
Reactivation of HIV replication from latent reservoirs rdquoShock and Killrdquo
HIV-induced cell death
Uninfected cells
Cytokines chemical compoundshellip
Courtesy of Nicholas Chomont
What strategies to controleradicate reservoirs 22
Interfering with immunological mechanism that contribute to HIV persistence
Other therapeutic interventions (GeneMol therapy therapeutic vaccine)
T cell survival Proliferation
Antibodies cytokines gene therapy chemotherapy
Courtesy of Nicholas Chomont
While we are searching Keep patients ready by
Universal Access Early Treatment - Limit reservoirs and preserve the immune
system
Invest in research Better understanding of biological mechanism and role of the
immune system in establishing reservoirs and persistence Better tools and models
In vitro and in vivo models More precise assays and sensitive techniques
Drug development increased specificity for latently infected cells
Develop translational research
Inspired from Sharon Lewin
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
What strategies to controleradicate reservoirs 22
Interfering with immunological mechanism that contribute to HIV persistence
Other therapeutic interventions (GeneMol therapy therapeutic vaccine)
T cell survival Proliferation
Antibodies cytokines gene therapy chemotherapy
Courtesy of Nicholas Chomont
While we are searching Keep patients ready by
Universal Access Early Treatment - Limit reservoirs and preserve the immune
system
Invest in research Better understanding of biological mechanism and role of the
immune system in establishing reservoirs and persistence Better tools and models
In vitro and in vivo models More precise assays and sensitive techniques
Drug development increased specificity for latently infected cells
Develop translational research
Inspired from Sharon Lewin
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
While we are searching Keep patients ready by
Universal Access Early Treatment - Limit reservoirs and preserve the immune
system
Invest in research Better understanding of biological mechanism and role of the
immune system in establishing reservoirs and persistence Better tools and models
In vitro and in vivo models More precise assays and sensitive techniques
Drug development increased specificity for latently infected cells
Develop translational research
Inspired from Sharon Lewin
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
Global Scientific Strategy Towards an HIV Cure
While the Global Fund keeps working towards Universal Access
IAS to coordinate and support the creation of an international multidisciplinary scientific advisory group on HIV Reservoirs to develop a Global Scientific Strategy laquo Towards an HIV Cure raquo
A Global Scientific Consortium laquo Towards an (functional) HIV Cure raquo
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
AcknowledgementsInternational AIDS Society Geneva
bullShirin HeidaribullMarie-Capucine PenicaudbullTamara TorribullJulie PluiesbullAnthony Flynn
With courtesy of members of IAS Core Group Towards An HIV Cure who shared their slides
1048697 Nicolas Chomont Vaccine and Gene Therapy Institute Florida USA1048697 Tae-Wook Chun National Institutes of Health USA1048697 Sharon Lewin Burnet Institute Melbourne Australia
![The effect of HIV coinfection, HAART and TB treatment on ... · IGRA have low sensitivity and specificity especially in malnutri-tioned and HIV infected individuals [8]. The fact](https://img.pdfslide.us/doc/110x75/5f568cdc487e78633a39fc52/the-effect-of-hiv-coinfection-haart-and-tb-treatment-on-igra-have-low-sensitivity.jpg)
![DO FREQUENT DOSES OF HAART BLOCK THE HIV …mysite.science.uottawa.ca/rsmith43/ViralBlips.pdf · u2 ′[]t = A10u1 −c3u ... 5.191 per day [4]. We must also keep in mind that HIV](https://img.pdfslide.us/doc/110x75/5b95983d09d3f2d7438ca782/do-frequent-doses-of-haart-block-the-hiv-u2-t-a10u1-c3u-5191.jpg)
