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TheFiringRate‐LFPRela1onChangesasaFunc1onofFiringRateinHumansAshwinG.Ramayya1,JeremyR.Manning1,JoshuaJacobs3,MichaelJ.Kahana2
1NeuroscienceGraduateGroupand2DepartmentofPsychology,UniversityofPennsylvania,Philadelphia,PA3Dept.ofBioengineering,DrexelUniversity,Philadelphia,PA
Introduc1onSlidingwindowanalysisrevealsnon‐linearityinFR‐LFPrela1on
Broadband+Neurons(n=453) Gamma+Neurons(n=141)
1/f“pinknoise”:calculatedasmeanofRobust‐fitline
Regressionframeworkseparatesbroadbandandgammacorrela1ons
Correlatedwithsingleneuronfiringrate
Broadbandpower(2‐150Hz)isnotanoscilla1on
References
Concave‐Up(n=285)
NotQuadra1c(n=128)
Concave‐Down(n=40)
Concave‐Up(n=68)
NotQuadra1c(n=47)
Concave‐Down(n=26)
18%
33%
48%63%
28%
8%• Extracellularrecordings20paVents• VirtualNavigaVonTask• 2,030neuronsidenVfied• SpikesremovedfromLFP• Analyzedin500msepochs
Conclusions
LFP=Summedac1vityofallneurons
FiringRate=Spikingac1vityofsingleneuron
2Modesofasingleneuron “Entrained”to
NetworkIndependentAcVvity
FiringRate
LFP
LFP
FiringRate
HighFiringRates
LowFiringRates
NetworkatRest Networkattask
LFP
FiringRate
LFP
FiringRate
LFP
FiringRate
20percenVlewindow
Power
Frequency
Broadbandpower
Narrowbandpower
NarrowbandOscillaVon
Singleneuronfiringratehasbeenwidelycorrelatedwithgammapower(30‐150Hz)ofthelocalfieldpotenVal(LFP)1.Recentevidencesuggeststhatbroadbandpower(2‐150Hz)isanotherelectrophysiologicalcorrelateofsingleneuronfiringrateinhumans2.
Firingrate
Results
Classifying+correlatedneuronswithaquadra1cfit Possiblemodelofconcave‐upneurons
+CorrelaVon
‐CorrelaVon
Firingrate(Hz)
Firingrate(Hz)
Firingrate(Hz)
Firingrate(Hz)
Firingrate(Hz)
Firingrate(Hz)
Mean=2.7
Mean=3.0
Mean=3.2
Mean=2.9
Mean=2.3
Mean=2.9
3subpopulaVonsofBB+andgamma+neurons(fig.4):1. Concave‐up:Mostcommon;FR‐LFPwellcorrelatedat
highfiringratesbutnotatlowfiringrates(seefig.5“possiblemodel”)
2. NotQuadra1c:PosiVvelycorrelatedneuronsdisplayingeitherlinearorhigherorderFR‐LFPrelaVons.
3. Concave‐down:Leastcommon;FR‐LFPwellcorrelatedatlowfiringratesbutnotathighfiringrates.Previouslydescribedinmonkeyliterature3.
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1. Whijngstall,K.andLogotheVs,N.(2009).Frequency‐BandCouplinginSurfaceEEGReflectsSpikingAcVvityinMonkeyVisualCortex.Neuron,64(2):281–289.
2.Manning,J.,Jacobs,J.,Fried,I.,andKahana,M.(2009).BroadbandshimsinLFPpowerspectraarecorrelatedwithsingle‐neuronspikinginhumans.JournalofNeuroscience,29(43):13613–13620.3.MazzoniA,WhijngstallK,BrunelN,LogotheVsNKandPanzeriS(2009).UnderstandingtherelaVonshipsbetweenspikerateanddelta/gammafrequencybandsofLFPsandEEGsusingalocalcorVcalnetworkmodel.Neuroimage,52(3):956‐972