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CPL The Convergence of Bioinformatics and Medical Informatics -- PL Chang, M.D.

The Convergence of Bioinformatics and Medical Informatics

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The Convergence of Bioinformatics and Medical Informatics. -- PL Chang, M.D. Total Genes – 28939 (07-28-2006) – Build 36.1. Protein Synthesis. 38320 Structures (Aug 22, 2006). Protein 3D structure. Informatics United: Combining Medical Informatics and Bioinformatics. - PowerPoint PPT Presentation

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Page 1: The Convergence of Bioinformatics and Medical Informatics

CPL

The Convergence of Bioinformatics and Medical Informatics

The Convergence of Bioinformatics and Medical Informatics

-- PL Chang, M.D.-- PL Chang, M.D.

Page 2: The Convergence of Bioinformatics and Medical Informatics

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Total Genes – 28939(07-28-2006) – Build 36.1

Total Genes – 28939(07-28-2006) – Build 36.1

Chromosome Genes Chromosome Genes Chromosome Genes

1 2776 9 1207 17 1442

2 1866 10 1094 18 438

3 1473 11 1841 19 1624

4 1164 12 1355 20 717

5 1281 13 556 21 367

6 1528 14 1220 22 756

7 1474 15 961 X 1344

8 1025 16 1108 Y 322

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Protein SynthesisProtein Synthesis

Protein 3D structureProtein 3D structure

38320 Structures (Aug 22, 2006)38320 Structures (Aug 22, 2006)

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Informatics United: Combining Medical Informatics and Bioinformatics

Informatics United: Combining Medical Informatics and Bioinformatics

• The use of image processing techniques for the analysis of

the dynamics of cell nuclei

• The application of medical informatics tools for data

mining in bioinformatics

• Clinical decision support systems based on bioinformatics

have the potential to improve medical diagnostics and lead

to a personalized delivery of healthcare

• The use of image processing techniques for the analysis of

the dynamics of cell nuclei

• The application of medical informatics tools for data

mining in bioinformatics

• Clinical decision support systems based on bioinformatics

have the potential to improve medical diagnostics and lead

to a personalized delivery of healthcare

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Clinical ApplicationsClinical Applications

• Diagnostic tools– Gene chips, protein chips– Early detection of infectious agent, congenital

disorders, susceptibility to disease and, eventually, idiosyncrasy

• Drug Discovery/Development– Gene expression profile– Protein structure and candidate molecules

• Diagnostic tools– Gene chips, protein chips– Early detection of infectious agent, congenital

disorders, susceptibility to disease and, eventually, idiosyncrasy

• Drug Discovery/Development– Gene expression profile– Protein structure and candidate molecules

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Clinical BioinformaticsClinical Bioinformatics

GenomicsGenomics

Personalized medicinePersonalized medicine

Medical informaticsMedical informatics

Bio-decision support systemBio-decision support system

Systems biologySystems biology

Bioinformatics Bioinformatics in cancer researchin cancer research

PharmacogenomicsPharmacogenomics

Structure databasesStructure databases

ProteomicsProteomics

MicroarrayMicroarray

Comparative Comparative genome analysisgenome analysis

Clinical Applications

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CGMH EHR

EHR Clinical Bioinformatics

Genes ProteinsSNPs

Pathways

Diseases電子病歷

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How Will the Medicine of the How Will the Medicine of the 2121stst Century Be Like? Century Be Like?

BioMedical informatics Medical informatics and bioinformatics

Intelligent representation, storage, retrieval and application Data and Text mining

Personalized medicine Diagnosis, treatment, and prognosis ba

sed on bioinformatics

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