The Collaborative Initiative for Paediatric HIV Education and
Research (CIPHER) Linda-Gail Bekker The implementation of this
project was made possible through an unrestricted grant from ViiV
Healthcare. The content and structure of the project has been
guided by paediatric experts convened by the IAS.
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CIPHER Vision Goal Optimizing clinical management and delivery
of services to infants, children and adolescents affected by HIV in
resource- limited settings, through advocacy and research
promotion. Objectives Addressing targeted research gaps to optimize
service delivery and clinical management Strengthening paediatric
HIV cohort collaboration to inform policy decisions Advocacy and
outreach to support evidence-informed clinical, policy and
programmatic decision making (new 2014)
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Background 2012: CIPHER founded as 2-year flagship IAS
paediatric initiative Unrestricted educational grant from ViiV
Healthcare of 1.5 M Guided by paediatric HIV experts convened by
the IAS Activities developed 2012 2013 Needs Assessment: clinical
and operational research gaps Research Grant Programme Global
Cohort Collaboration Online Paediatric HIV Cohort Database JIAS
Special Issue: Perinatally HIV-infected Adolescents End 2013:
Paediatrics an IAS priority, branded as CIPHER CIPHER re-funded for
2014-2015: 1.5 M from ViiV Healthcare 2014-2015: Continue and build
on current activities, new activities
Slide 4
Research Grant Programme Clinical and Operational research
projects with the potential to contribute to the optimization of
HIV diagnosis, prevention, treatment and care for infants, children
and adolescents affected by HIV in resource-limited settings
www.ias-cipher.org For early stage investigators Research in
resource- limited settings 75,000 USD/year - up to two years This
programme was made possible thanks to support of an unrestricted
educational grant form ViiV Healthcare.
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2014 CIPHER GRANTEES Tavitiya Sudjaritruk, Research Institute
for Health Sciences, Chang Mai University, Thailand, for research
in Thailand Liver injury and long-term metabolic complications
among perinatally HIV-infected children and adolescents receiving
antiretroviral therapy Eric McCollum, Johns Hopkins School of
Medicine, USA, for research in Malawi Bubble CPAP treatment in
hospitalized African infants failing standard pneumonia care in a
high HIV prevalence country
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CIPHER is pleased to announce a new round of PAEDIATRIC HIV
RESEARCH GRANTS For 2015 Applications open from 1 to 31 October
2014 www.iasociety.org/cipher.aspx The implementation of this
project is made possible through an unrestricted grant from ViiV
Healthcare. The content and structure is guided by experts in
paediatric HIV convened by the IAS.
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CIPHER Cohort Collaboration Paediatric HIV Cohort Investigator
Consultation, 13- 15 May 2013 Participating cohorts/networks IeDEA
(Southern, Central, West and East Africa; CCASAnet; TREAT Asia)
EPPICC (including PMTCT and Eastern European cohorts) Mdecins Sans
Frontires (MSF) Baylor International Pediatric AIDS Initiative
(BIPAI) International Maternal Pediatric Adolescent AIDS Clinical
Trials (IMPAACT) P1074 Pediatric HIV/AIDS Cohort Study (PHACS)
Optimal Models/ICAP
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CIPHER Cohort Collaboration Priority research topics Time on
first-line ART: Estimate incidence of treatment switch to
second-line ART and associated factors; describe regimen use and
durability Adolescent epidemiology: Describe the global
epidemiology of perinatally HIV-infected adolescents and compare
outcomes across regions To be studied through a new, global
pediatric cohort collaboration, supported by CIPHER (2014-2016)
Data and analysis centres CIDER (IeDEA Southen Africa), South
Africa MRC UCL (EPPICC), UK CBAR HSPH (PHACS), USA ~ 250,000
infants, children and adolescents affected by HIV
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Paediatric HIV Cohort Database Online, searchable database
Platform for cohort collaboration Source of information for
researchers, funders, policy makers Launched on World AIDS Day, Dec
2013 To date: 30 cohorts/networks, representing ~250,000 infants,
children and adolescents in 59 countries 389 unique visitors, 742
total visits, from 50 different countries Next steps and ideas:
Analysis tools: Summary tables, epidemiology tool... Additions:
Link to online paediatric HIV resource library (with UNICEF)
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Future directions and next steps Continue and build on current
programmes Grant programme Global cohort collaboration Online
database JIAS Special Issue Adolescent Working Group: Paediatric
and adult cohort investigators Viral Load Monitoring Working Group
and Early Infant Diagnosis (paediatric focus) IAS/ILF-CIPHER
Roundtable Discussions IAS 2015/ work-up to AIDS 2016