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The Chain of LogicThe Chain of Logic
►WHEN a naturally induced vaccine occurs, the WHEN a naturally induced vaccine occurs, the response is powerful, immediate and of response is powerful, immediate and of therapeutic value – to eradication in some cases therapeutic value – to eradication in some cases – we call these cases “– we call these cases “spontaneous remissionsspontaneous remissions” ”
► Extensive circumstantial evidence supports this thought Extensive circumstantial evidence supports this thought ► There are soluble inhibitors of the immune responseThere are soluble inhibitors of the immune response► These inhibitors corrupt the natural endogenous anti-These inhibitors corrupt the natural endogenous anti-
cancer vaccine processcancer vaccine process
Local ImmunosuppressionLocal Immunosuppression
Prostate Cancer
Breast Cancer
Normal
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emittingProteins :: Yong A Yu 1 '3 , Shahrokh Shabahang l , Tatyana M Timiryasova2 '3 , Qian Zhang3, Richard Beltz l, Ivaylo Gentschev4 ,Werner Goebel 4 & Aladar A Szalay 1,4,5
Known Clinical Impact ofKnown Clinical Impact ofsTNFr Removal TherapysTNFr Removal Therapy
► 6 of 16 patients had greater than 50% 6 of 16 patients had greater than 50% tumor reduction using an ultrapheresis tumor reduction using an ultrapheresis (membrane-based separation) procedure(membrane-based separation) procedure
Lentz 1989Lentz 1989
► 5 of 9 late-stage breast cancer patient had 5 of 9 late-stage breast cancer patient had measurable response with 2 full remissionsmeasurable response with 2 full remissions
Lentz 1997Lentz 1997
►Presently in clinical trial in GermanyPresently in clinical trial in Germany Biopheresis Gmbh, 2009Biopheresis Gmbh, 2009
A Different PhilosophyA Different Philosophy
Drug-based TxDrug-based Tx RevealReveal[tm] [tm] TechnologyTechnology
Supraphysiologic levelsSupraphysiologic levels Physiologic levelsPhysiologic levels
Overrides a physiologic Overrides a physiologic mechanismmechanism
Restoration of Restoration of homeostasishomeostasis
Unintended side-effectsUnintended side-effects Limited side-effectsLimited side-effects
Non-invasiveNon-invasive Minimally InvasiveMinimally Invasive
Many drugs liver/kidney Many drugs liver/kidney toxictoxic
No sustainable organ No sustainable organ toxicitytoxicity