The Center for Nanoscience & Nanotechnology

The Center for Nanoscience and N

anotechnology Scientific Report 2015–2016

The Center for Nanoscience

& NanotechnologySCIENTIFIC REPORT 2015–2016

Center forNanoscience & NanotechnologyTel Aviv University

Tel Aviv University Center forNanoscience & NanotechnologyPowering Innovation

Center forNanoscience

& Nanotechnology

SCIENTIFIC REPORTM a y 2 0 1 6

Tel Aviv University Center forNanoscience & NanotechnologyPowering Innovation

Center forNanoscience & NanotechnologyTel Aviv University

3 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY

Overview ......................................................................................................................................................................................................................6

Hubs of Innovation ..............................................................................................................................................................................................7

The Micro & Nano Characterization & Fabrication Facility (MNCF) ...................................................................................7

XIN Center ............................................................................................................................................................................................................7

Educational Activities .......................................................................................................................................................................................8

International Summer School on Nanomedicine, Tel Aviv University ............................................................................8

Autumn Innovation Forum, Beijing ......................................................................................................................................................8

Winter School on Nano-Photonics, Tel Aviv University ............................................................................................................8

The Fred Chaoul TAU 10th Annual Nano Workshop, Hagoshrim .....................................................................................9

XIN Winter School on Physics at the Edge:, Tel Aviv University ...........................................................................................9

XIN Autumn Innovation Forum, Tsinghua University, Beijing ..............................................................................................9

IEEE–Gertner Summer School on Nanomedicine, Tel Aviv University ...........................................................................9

Intersecting Pathways .................................................................................................................................................................................9

School Visits .........................................................................................................................................................................................................9

A New Building for Tel Aviv University’s Center for Nanoscience & Nanotechnology ...............................10

Researchers .............................................................................................................................................................................................................11

Dr. David Sprinzak .........................................................................................................................................................................................13

Prof. Alexander Kotlyar ..............................................................................................................................................................................14

Dr. Iftach Nachman ......................................................................................................................................................................................15

Prof. Abdussalam Azem ............................................................................................................................................................................16

Prof. Karen B. Avraham ...............................................................................................................................................................................17

Prof. Uri Ashery ...............................................................................................................................................................................................18

Prof. Itai Benhar ..............................................................................................................................................................................................19

Dr. Noam Shomron ......................................................................................................................................................................................21

Dr. Avigdor Eldar ............................................................................................................................................................................................22

Prof. Roy Beck ..................................................................................................................................................................................................23

Dr. Yael Roichman .........................................................................................................................................................................................24

Dr. Yair Shokef ..................................................................................................................................................................................................25

Prof. Tamir Tuller .............................................................................................................................................................................................26

Dr. Sharly Fleischer .......................................................................................................................................................................................27

Prof. Eli Eisenberg ..........................................................................................................................................................................................28

Dr. Amir Goldbourt ......................................................................................................................................................................................29

Prof. David Andelman ................................................................................................................................................................................30

Prof. Natan Shaked .......................................................................................................................................................................................31

Prof. Yael Hanein ............................................................................................................................................................................................32

Contents


CENTER FOR NANOSCIENCE & NANOTECHNOLOGY

Prof. Slava Krylov............................................................................................................................................................................................33

Prof. Gil Rosenman .......................................................................................................................................................................................34

Dr. Yuval Ebenstein ......................................................................................................................................................................................35

Prof. Yosi Shacham .......................................................................................................................................................................................36

Prof. Shachar Richter ...................................................................................................................................................................................37

Prof. Michael Gozin ......................................................................................................................................................................................38

Prof. Chanoch Carmeli ...............................................................................................................................................................................39

Prof. Yossi Rosenwaks .................................................................................................................................................................................40

Dr. Tal Dvir ..........................................................................................................................................................................................................41

Dr. Alexander Golberg ...............................................................................................................................................................................42

Prof. Judith Rishpon ....................................................................................................................................................................................43

Prof. Noam Eliaz .............................................................................................................................................................................................44

Dr. Oswaldo Dieguez ..................................................................................................................................................................................45

Prof. Oded Hod ...............................................................................................................................................................................................46

Dr. Amir Natan ................................................................................................................................................................................................47

Prof. Michael Urbakh ...................................................................................................................................................................................48

Prof. Haim Diamant......................................................................................................................................................................................50

Prof. Diana Golodnitsky ..........................................................................................................................................................................51

Prof. Gil Markovich........................................................................................................................................................................................52

Prof. Ori Cheshnovsky ................................................................................................................................................................................53

Prof. Emanuel Peled .....................................................................................................................................................................................54

Prof. Abraham Nitzan .................................................................................................................................................................................55

Dr. Roey J. Amir...............................................................................................................................................................................................56

Prof. Dan Peer ..................................................................................................................................................................................................57

Prof. Ronit Satchi-Fainaro .........................................................................................................................................................................58

Prof. Inna Slutsky ...........................................................................................................................................................................................59

Prof. Rimona Margalit .................................................................................................................................................................................60

Prof. Ehud Gazit ..............................................................................................................................................................................................61

Dr. Tal Ellenbogen .........................................................................................................................................................................................62

Prof. Jacob Scheuer .....................................................................................................................................................................................63

Dr. Yossi Lereah ...............................................................................................................................................................................................64

Dr. Alon Bahabad ..........................................................................................................................................................................................65

Prof. David J. Bergman ...............................................................................................................................................................................66

Prof. Ady Arie ...................................................................................................................................................................................................67

Prof. Amir Boag ...............................................................................................................................................................................................68

Dr. Moshe Goldstein ...................................................................................................................................................................................69


SCIENTIFIC REPORT 2015–2016

Prof. Yoram Dagan ........................................................................................................................................................................................70

Prof. Alexander Gerber ..............................................................................................................................................................................71

Dr. Guy Cohen .................................................................................................................................................................................................72

Prof. Alexander Palevski ............................................................................................................................................................................73

Prof. Ilan Goldfarb .........................................................................................................................................................................................74

Publications ............................................................................................................................................................................................................77

Spinoffs .....................................................................................................................................................................................................................89

Startups ...............................................................................................................................................................................................................89

License Agreements ...................................................................................................................................................................................89

Staff ..............................................................................................................................................................................................................................91

Acknowledgments ............................................................................................................................................................................................93

Scholarships ...........................................................................................................................................................................................................94



Tel Aviv University’s Center for Nanoscience & Nanotechnology was established in 2000, as the first Israeli center of its kind. Since then we have expanded and grown significantly: today the Center is affiliated with over 90 research groups, employs its own professional staff of researchers and scientists, and runs a state-of-the-art central facility.

Tel Aviv University’s Center for Nanoscience & Nanotechnology was a pioneer and leader in setting up a multidisciplinary environment, where laboratories from entirely different domains work side by side under one roof. In addition, through the synergy established between these laboratories and the Center’s Micro- and Nanofabrication Facility, a unique, campus-wide activity was created, generating a multitude of unique projects. Over the years we have also strengthened our ties with industry, providing extensive services to a growing number of companies - from small startups to large corporations.

Today, with 16 years of constant growth behind it, the Center has positioned itself as an important asset to Tel Aviv University’s researchers and the Israeli industry.

We hope you will find the information in this publication useful for identifying new partnerships, resources and ideas. Comprehensive and constantly updated information about the Center is available on our website at www.nano.tau.ac.il.

Overview



Hubs of Innovation

The Micro & Nano Characterization & Fabrication Facility (MNCF)

Tel Aviv University’s Micro & Nano Characterization & Fabrication Laboratories are the leading facilities of their kind in Israel, with regard to providing services to both academia and industry. More than 50 academic groups and over 40 companies currently use the Laboratories - which are managed by a professional team, and offer outstanding infrastructures (thanks to a multimillion dollar investment by both the Israeli government and TAU). The Laboratories provide R&D services to large Israeli corporations, as well as small startups in their earliest stages.

The TAU Center’s equipment is among the most advanced and comprehensive in Israel, spanning all types of fabrication methods, and enabling the development of full-process prototypes. Capabilities and technologies at the Labs include mask design and fabrication, optical lithography and e-beam lithography, and advanced backend techniques such as wire bonding and dicing. Our new laser-cutting and machining system is the first of its kind in Israel. The Labs’ process engineers offer researchers and corporations comprehensive prototype development services, from small-scale predefined runs to large R&D projects and full-process development, conducted jointly with the customer. Services - including characterization, device design, mask preparation, sample fabrication and backend – are continually improved and expanded, as we add standard operating procedures of more systems, and offer them online. Most of the equipment managed by MNCF is housed in two buildings, and all equipment and personnel are managed by a single financial and administrative entity.

Since 2007, we have established standardized training routines for students, local scientists and external users. We continue our effort to film training sessions on specific machines in collaboration with TEMPUS.

XIN CenterIn 2014 the elite Chinese University, Tsinghua of Beijing (THU), teamed with Tel Aviv University to launch XIN Center, a joint venture aiming to power innovation via ties between top Chinese and Israeli researchers in the fields of Nanoscience and Nanotechnology.

The XIN (meaning New in Chinese) Center focuses on collaborative, high-impact applied research, promoting over a dozen applied research programs of TAU and THU. A unique mentoring system is applied, whereby leading scientists, industrialists and business figures accompany projects throughout all stages of research, combining internal and external resources from both Israel and China.



The Center for Nanoscience & Nanotechnology organizes a range of social and scientific activities, including an annual workshop, monthly seminars, monthly “Nano-Beer” events, student exchange programs and more. Over the past two years, major activities have included:

International Summer School on Nanomedicine, June 2014, Tel Aviv University

About 100 participants, including over 40 international students, presented and discussed their novel research in nanomedicine.

Lectures were given on the following topics: RNAi delivery, nano-diagnostics, nano-neuro interfaces, nanotechnologies for regenerative medicine and tissue engineering and the

Educational Activities

path to commercialization. The School was organized by Prof. Dan Peer, Dr. Artium Khatchtouriants, Dr. Inbal Hazan-Hallevy, Prof. Karen Avraham and Prof. Yael Hanein.

Autumn Innovation Forum, October 2014, Tsinghua University, BeijingXIN Center, a joint initiative of Tel Aviv University and Tsinghua University, conducted its 2014 Autumn Forum in Beijing, China. Top academics and students from both universities, as well as entrepreneurs, investors and major government, business and industry leaders from China and Israel, joined together to discuss the universities’ new initiatives in the nano-field. Dozens of early-stage technologies originating from both universities were evaluated, and the most promising among them were selected for further development, to be conducted under the XIN Center. Additionally, collaborations between researchers and student exchanges were initiated.

Winter School on Nano-Photonics, February 2015, Tel Aviv UniversityOver a hundred students and lecturers from Tel Aviv University, Tsinghua University and other Israeli and international universities - including Prof. John Pendry from Imperial College and Prof. Nader Engheta from the University of Pennsylvania - took part in this special event. Novel topics in nano-photonics were presented and discussed, including: transformation optics, meta-materials & meta-surfaces, nano-antennas and plasmonics, quantum dots, beam shaping and nano-imaging. The Winter School was organized by Prof. Adi Arie and Dr. Koby Scheuer.

Emphasis is placed on co-projects conducted jointly by researchers from both universities. Current examples include: diagnostics and prognosis of cancer and other diseases using the CRISPR system (Dr. Yuval Ebenstein, Prof. Ting Zhu); and

small molecules for treating Parkinson’s disease (Prof. Danny Segal & Prof. Yan-Mei Li). Over a dozen PhD students from both universities have already participated in exchange visits facilitating research in the field of nanotechnology.



The Fred Chaoul TAU 10th Annual Nano Workshop, February 2015, Hagoshrim

Over one hundred of Tel Aviv University’s nanotechnology students and lecturers presented their recent research activities and enjoyed a range of social gatherings during this 3-day Workshop. Prof. Miles Padgett (University of Glasgow) gave a guest lecture on shaping light for imaging and sensing. The Workshop was organized by Dr. Tal Dvir, Dr. Tal Schwartz and Dr. Tal Ellenbogen.

XIN Winter School on Physics at the Edge: from Topological Surfaces to Oxide Interfaces, January 2016, Tel Aviv University

About 80 lecturers and students from Israel and abroad participated in the Winter School, which included intensive training by internationally renowned scientists – such as Prof. Qikun Xue (Tsinghua University), Prof. Aharon Kapitulnik (Stanford), Prof. Gabriel Aeppli (ETH), Prof. Yulin Chen (Oxford) and Prof. Yoram Dagan (TAU). Topological surfaces and oxide interfaces are an emerging scientific field, with great significance for both basic and applied research. The School was organized by Prof. Yoram Dagan and Dr. Moshe Goldstein.

XIN Autumn Innovation Forum, October 2015, Tsinghua University, Beijing

Top academics and students from Tel Aviv and Tsinghua Universities, alongside entrepreneurs, investors and major government, business and industry leaders from both China and Israel, joined together to discuss the universities’ new initiatives in the nano-field. Promising early-stage technologies introduced by the researchers were selected for further development, to be conducted under the XIN Center. Additionally, collaborations between researchers and student exchanges were initiated.

IEEE–Gertner Summer School on Nanomedicine, June 2016, Tel Aviv University

The TAU Center for Nanoscience & Nanotechnology is the proud winner of the first ever Summer School grant from IEEE Nano. The special Summer School for graduate students, also supported by a generous donation from the Gertner Institute, offers intensive training in nanomedicine. The School’s organizers are Prof. Yael Hanein, Prof. Dan Peer and Dr. Tal Dvir.

Intersecting Pathways In 2014 Tel Aviv University’s Center for Nanoscience & Nanotechnology and the Amit Foundation established the Intersecting Pathways project, bringing together outstanding Torah scholars and top academic scientists for a joint learning experience on Science & Ethics. The project builds a unique and surprising bond that facilitates curiosity, friendship and scholarship. Over 20 such meetings have already taken place, attracting more than 40 frequent attendees.

School VisitsThe Nano Center regularly hosts and guides groups from k-12 schools all over Israel, in order to enrich knowledge on nanotechnology and promote scientific excellence among the country’s younger generation. At TAU’s advanced nano facilities our young guests view cutting-edge experiments from the forefront of modern science. One especially popular demonstration is the preparation of a sensor for ionic materials, based on an aqueous colloidal solution of electro-stable gold nanoparticles.



To fulfill the growing needs of both the Center and Tel Aviv University’s research community, a new Nano Building is currently being planned. The modern building will house the Nano Characterization & Fabrication Laboratory (about 600 m2), alongside 12 core research laboratories. Altogether, about 120 engineers and researchers from academia and industry will use the building as their main hub.

A New Building for Tel Aviv University’s Center for Nanoscience & Nanotechnology

The new building will be constructed next to TAU’s Gate 2, forming a new entrance to the University. Accessible to the general public, it will invite visitors from the community to experience cutting-edge science firsthand. A special space will be dedicated to collaboration between the Center’s researchers and their guests from both academia and industry. The overall cost of the building is estimated at $30 M.

RESEARCHERS(sorted by theme of research)


RESEARCHERS

Dr. David Sprinzak

Affiliation: Life Sciences

Email: [email protected]

Web: http://www.sprinzaklab.com

Research TitleSystems developmental biology

Selected Publications:1. Khait I, Orsher Y, Golan O, Binshtok U, Gordon-Bar N, Amir-Zilberstein L,

Sprinzak D. Quantitative Analysis of Delta-like 1 Membrane Dynamics Elucidates the Role of Contact Geometry on Notch Signaling. Cell Rep. 2015 Dec 30.

2. Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB. The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome. 2015 Dec 11.

3. Yaron T., Cordova Y., Sprinzak D. Juxtacrine Signaling Is Inherently Noisy. Biophys. J. (2014) vol. 107, Issue 10, Pages 2417–2424.

4. D. Sprinzak, A. Lakhanpal, L. LeBon, J. Garcia-Ojalvo, M. B. Elowitz. Mutual inactivation of Notch receptors and ligands facilitates developmental patterning PLoS Comput. Biol. 2011 Jun;7(6).

5. D. Sprinzak, A. Lakhanpal, L. LeBon, L. A. Santat, M. E. Fontes, G. A. Anderson, J. Garcia-Ojalvo, M. B. Elowitz. Cis interactions between Notch and Delta generate mutually exclusive signaling states, Nature. 2010 May 6;465(729).

Research DescriptionThe development of a multicellular organism is a truly fantastic process. How genetically identical cells differentiate into distinct cell types in an accurate and reproducible manner remains one of the most important questions in biology. The long-term goal of our lab is to elucidate the design principles of complex developmental programs underlying organized differentiation patterns. In particular, we are interested in: 1. How the properties of intercellular signaling pathways contribute to the development of tissues and organs; 2. How cellular mechanics and cellular morphology affect, and are affected by, regulatory processes within cells and signaling between cells. To address these questions we apply an interdisciplinary approach combining synthetic biology, quantitative imaging techniques, micropatterning technology and mathematical models.


RESEARCHERS

Research DescriptionThe main goal of our work is to develop new conductive molecular nanowires based on G4-DNA and complexes of DNA with metal nanoparticles. We have synthesized nanowires composed of single self-folded poly(G) strands of thousands of bases. These G4-wires comprise a large number of stacked guanine tetrads, providing better conditions for π overlap compared to base-pairs of the canonical double-stranded DNA. A high content of guanines, which have the lowest ionization potential among DNA bases, also makes charge migration through the DNA highly probable. Indeed, we have demonstrated charge transport in G4-DNA molecules adsorbed in a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured on single G4-DNA molecules over distances ranging from tens of nanometers to more than 100 nm. These results could open a way to the realization of nanoscale transistors and devices.



Web: http://www.sashakot.com/

Research TitleDNA-based nanotechnology

Selected Publications:1. Eidelshtein, G., Fardian-Melamed, N., Gutkin, V., Basmanov, D., Klinov,

D., Rotem, D., Levi-Kalisman, Y., Porath, D. and Kotlyar, A. (2016). Synthesis and Properties of Novel Silver Containing DNA Molecules. Advanced Materials (in press).

2. Eidelshtein, G., Kotlyar, A., Hashemi, M. and Gurevich, G. (2015). Aligned deposition and electrical measurements on single DNA molecules. Nanotechnology 475102 (8pp).

3. Livshits, G.I., Stern, A., Rotem, D., Borovok, N., Eidelshtein, G., Migliore, A., Penzo, E., Wind, S.J., Di Felice, R., Skourtis, S.S., Cuevas, J.C., Gurevich. L., Kotlyar, A.B., Porath and D. (2014). Long-range charge transport in single G4-DNA molecules. Nature Nanotechnology 9, 1040-1046.

4. Livshits, G.I., Ghabboun, J., Borovok, N., Kotlyar, A.B. and Porath D. (2014). Comparative Electrostatic Force Microscopy of Tetra‐and Intra‐molecular G4‐DNA. Advanced Materials 26, 4981–4985.

5. Halamish, S., Eidelshtein, G. and Kotlyar, A. (2013) Plasmon-coupled nanostructures comprising finite number of gold particles. Plasmonics 8, 745-748.

Prof. Alexander Kotlyar


RESEARCHERS

4. Smith, Z.D., Nachman, I., Regev, A., Meissner, A. (2010). Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nature Biotechnol. May;28(5):521-6.

5. Yurkovsky, E., Nachman, I. (2013). Event timing at the single cell level. Brief Funct Genomics. 12(2):90-8.

Research DescriptionOur goal is to understand how cells within a population reach developmental decisions at the phenotypic and mechanistic level: How do cells “decide” to change their state? Why do similar cells respond differently to the same signal? What properties of the cell’s internal state affect its decision? What determines these properties and their spread in the cell population? What determines which cell states are stable? Our lab studies these fundamental questions in two model systems, using methods from live cell fluorescent imaging, microfluidics and statistical and computational analysis.



Web: inachmanlab.com

Research TitleCell fate decisions in differentiation and reprogramming

Selected Publications:1. Goldshmidt, Y., Yurkovsky, E., Reif, A., Rosner, R., Akiva, A., Nachman,

I. (2015). Control of relative timing and stoichiometry by a master regulator. PLoS One 10(5), e012733.

2. Pour, M., Pilzer, I., Rosner, R., Smith, Z.D., Meissner, A., Nachman, I. (2015). Epigenetic predisposition to reprogramming fates in somatic cells. EMBO reports 16, 370-378.

3. Aidelberg, G., Goldshmidt, Y., Nachman, I. (2012). A microfluidic device for studying multiple distinct strains. J Vis Exp, (69), e4257, doi:10.3791/4257.

Dr. Iftach Nachman

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RESEARCHERS

mitochondrial membrane and the mitochondrial matrix. The translocase of the inner membrane, TIM23 complex, with its associated proteins, is the focus of one major project in our laboratory.The second main topic of our research is the chaperonin family of proteins - the most well-known of which are the GroEL and GroES proteins of E. coli. GroEL (cpn60 or Hsp60) binds with nascent or stress-denatured proteins and facilitates their refolding with the assistance of its co-chaperonin GroES (cpn10 or Hsp10). In mitochondria, Hsp60 mediates the folding of proteins that have been translocated from the cytosol to the matrix. The importance of these chaperonins in mitochondria has been heightened by the discovery of genetic diseases caused by mutations in these proteins, as well as their extramitochondrial roles, some related to cancer development. Having studied the structure and function of mitochondrial and chloroplast chaperonins in vitro for a long time, we recently became interested in the mechanism behind genetic diseases. Modern deep-sequencing technologies have facilitated the identification of mutations responsible for recessive genetic diseases, and we use this information to delineate the molecular basis of the disease, applying a two-pronged approach. We utilize a yeast model to study the effects of the mutated protein in a biological system, while also producing and purifying the mutated protein in vitro, in order to investigate its properties and its interaction with other proteins.



Web: https://en-lifesci.tau.ac.il/profile/azema

Research TitleMolecular machines function

Selected Publications:1. Demishtein-Zohary, K., Marom, M., Neupert, W., Mokranjac, D.,

Azem, A. (2015) GxxxG Motifs hold the TIM23 Complex Together. FEBS J. 282, 2178-2186.

2. Nisemblat, S., Yaniv, O., Parnas, A., Frolow, F., Azem, A. (2015). The crystal structure of the human mitochondrial chaperonin symmetric football complex. Proc. Natl. Acad. Sci. USA. 112, 6044-6049.

3. Nisemblat, S., Parnas, A., Yaniv, O., Azem, A., Frolow, F. (2014) Crystallization and structure determination of a symmetrical football complex of the mammalian mitochondrial Hsp60-Hsp10 chaperonins. Acta Cryst. F. 70, 116-119.

4. Sharabi, M., Mandelberg, Y., Benayahu, D., Benayahu, Y., Azem, A., Haj-Ali, R. (2014) A new class of bio-composite materials of unique collagen fibers. J. Mech. Behav. Biomed. Mater. 36C, 71-81.

5. Marom, M, Azem, A and Mokranjac, D. (2011) Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: Still a long way to go. Biochem. Biophys. Acta (Biomembranes). 1808, 990-1001

Research DescriptionFor many years, our laboratory has been interested primarily in unraveling the molecular mechanisms behind the function of two groups of proteins:The first is the sophisticated machinery that mitochondria use for translocating proteins from the cytosol. Most mitochondrial proteins are encoded in the nuclear genome, synthesized in the cytosol as preproteins and then imported into mitochondria. Uptake of these preproteins into the mitochondria is mediated by a number of oligomeric protein complexes, which are found in various places: the cytosol, the outer mitochondrial membrane, intermembrane space, the inner

Prof. Abdussalam Azem


RESEARCHERS

Research DescriptionA major goal in auditory science is to understand how the cells of the inner ear develop to provide the exquisite precision of hearing. The organ of Corti, which houses the sensory cells of the inner ear, develops from sensory epithelium derived from ectoderm. Together with innervation of the sensory spiral ganglion cells, the auditory system collects sounds and transforms their mechanical forces into an electrical signal that functions throughout our lifetime. At a molecular level, the interactions of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear.The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail. Our group is asking the questions: (1) What are the genes that lead to hearing loss, and how are they involved in normal function of the inner ear? (2) How does regulation of gene expression govern the pathways that determine inner ear function, and how do alterations in regulation, on a genetic and epigenetic level, contribute to the pathology of deafness?



Web: www.tau.ac.il/~karena

Research TitleGenomics of hereditary hearing loss

Selected Publications:1. Shefer, S., Gordon, C., Avraham, K.B. and Mintz, M. (2015). Balance

deficit enhances anxiety and balance training decreases anxiety in vestibular mutant mice. Behav. Brain Res., 276:76-83.

2. Bhonker Y, Abu-Rayyan A, Ushakov U, Amir-Zilberstein A, Shaked Shivatzki S, Ofer Yizhar-Barnea O, Tal Elkan-Miller T, Einav Tayeb-Fligelman E, Kim SM, Landau M, Kanaan K, Chen P, Matsuzaki F, Sprinzak D, Avraham K.B. (2015). The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm. Genome, 27:29-46.

Prof. Karen B. Avraham


RESEARCHERS

Research DescriptionOur laboratory investigates the functions of key synaptic proteins in synaptic transmission and plasticity, both in health and in neurodegenerative diseases. The lab applies a multidisciplinary approach, pooling expertise in molecular biology, electrophysiology, biochemistry, optogenetics, high-end imaging and computer-simulation techniques, to understand how neurons communicate at the cellular and molecular levels to influence animal behavior. Recently, we integrated a novel method, termed super-resolution microscopy, enabling the detection of protein distribution at single-molecule 20-nm resolution. Using several super-resolution methods (dSTORM, STED) and combining experimental and computational capabilities, our group described how the spatial distribution of synaptic proteins from the SNARE and active zone families influences synaptic transmission (J. Biol. Chem. 2012; J. Biol. Chem. 2014; Nat. Commun. 2014). We are now using this system to investigate how the alpha synuclein protein forms aggregates, and to discover the mode of action of specific inhibitors, such as chemical chaperones and aromatic small molecules. Work is performed on brain slices, induced pluripotent stem cells and cell lines.



Web: http://www.tau.ac.il/lifesci/departments/neuro/members/ashery/ashery.html

Research TitleMolecular mechanisms of synaptic transmission

Selected Publications:1. Bar-On D, Wolter S, van de Linde S, Heilemann M, Nudelman G,

Nachliel E, Gutman M, Sauer M, Ashery U. (2012). Super-resolution Imaging Reveals the Internal Architecture of Nano-sized Syntaxin Clusters. J Biol Chem. 2012 3;287(32):27158-67

2. Bielopolski, N., Lam, A. D., Bar-On, D., Sauer, M., Stuenkel, E. L., and Ashery, U. (2014). Differential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 beta-propeller core and determines its inhibitory activity. J Biol Chem 289, 17087-17099.

3. Ehmann, N., van de Linde, S., Alon, A., Ljaschenko, D., Keung, X. Z., Holm, T., Rings, A., DiAntonio, A., Hallermann, S., Ashery, U., Heckmann, M., Sauer, M., and Kittel, R. J. (2014). Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun 5, 4650.

Prof. Uri Ashery


RESEARCHERS

it. This ability laid the ground for classical phage therapy, in which phages that kill disease-causing bacteria are isolated from their natural habitats. Our application, however, is totally different, as we do not rely on the natural ability of the virus to kill its host. Rather, we regard it as a long and thin nanoparticle that can be tailored to fulfill a specific purpose. Filamentous phages are a family of bacterial viruses that have only about 10 genes and grow in well-characterized hosts - the Gram-negative bacteria. Structurally, the filamentous phage is a particle of nanometric dimensions comprising a sheath of several thousand coat proteins in a helical array, which, during phage maturation, self-assemble around a single-stranded circular DNA molecule at the core. A few minor proteins cap the particle at each end. Our group presented a novel technology - related to the field of targeted drug delivery - in which the phages function as targeted drug-carrying phage nanoparticles. For several years now we have been developing new techniques to genetically modify these viruses to carry drugs to specific locations in the body, in order to treat various diseases, such as cancer and fungal infections. This approach is based on genetically modifying and chemically manipulating the phages: the genetic manipulation endows the phages with the ability to display a host-specificity-conferring ligand (target-specific peptide, recombinant antibody or other target-specifying entity) on their surface. Chemically, the bacteriophages are conjugated through labile linkages that are subject to controlled cleavage to a drug. These targeted drug carrying phage nanoparticles have a large drug-carrying capacity in excess of ten thousand drug molecules per target site.Previously, we evaluated the effectiveness of this



Web: http://www.tau.ac.il/lifesci/departments/biotech/members/benhar/benhar.html

Research TitleTargeted nanomedicines

Selected Publications:1. Artzy-Schnirman A, Blat D, Talmon Y, Fishler R, Gertman D, Oren R,

Wolchinsky R, Waks T, Benhar I, Eshhar Z, Sivan U, Reiter Y. (2011). Electrically controlled molecular recognition harnessed to activate a cellular response. Nano Lett. 11(11):4997-5001.

2. Vaks L, Benhar I. (2011). In vivo characteristics of targeted drug-carrying filamentous bacteriophage nanomedicines. J. Nanobiotech 9:58.

3. Saggy I, Wine Y, Shefet-Carasso L, Nahary L, Georgiou G, Benhar I (2012) Antibody isolation from immunized animals: comparison of phage display and antibody discovery via V gene repertoire.

4. Levi O, Tal B, Hileli S, Shapira A, Benhar I, Grabov P, Eliaz N (2016). Optimization of EGFR high positive cell isolation procedure by design of experiments methodology. Cytometry B Clin Cytom. 2015 Sep-Oct;88(5):338-47. doi: 10.1002/cyto.b.21246. Epub 201.

5. Halperin A, Shadkchan Y, Pisarevsky E, Szpilman AM, Sandovsky H, Osherov N, Benhar I (2016). Novel Water-Soluble Amphotericin B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy. J Med Chem. 2016 Feb 11;59(3):1197-206.

Research DescriptionFor several years we have been developing targeted drug-carrying nanomedicines, based on a core technology of genetically and chemically engineered virus particles. We developed such guided missiles to treat devastating diseases, such as life-threatening infections caused by drug-resistant bacteria, and also for potential cancer therapy. Currently, we are focusing our efforts on developing treatments of this type for pathogenic fungi that cause life-threatening lung infections in cystic fibrosis and transplant patients. In this novel work, the drug carriers are none other than genetically and chemically engineered viruses. Usually considered vicious pathogens, viruses can also be helpful to humans. In particular, viruses named bacteriophages, that attack bacteria, can be used for killing bacteria resistant to antibiotics, or other cells that bear disease. Bacteriophages (phages) thrive in bacteria, and in many cases kill the host bacteria once they have finished multiplying within

Prof. Itai Benhar


RESEARCHERS

make the drug water soluble. In a recently published article we described the drug properties of these compounds as free drugs: they are still very potent as anti fungals, but very much reduced in non-specific toxicity.Next we plan to complete the complicated task of conjugating the drug to the phages, and then test the efficiency of our drug delivery system in killing the fungus in culture and in a mouse lung infection model.

approach for the elimination of pathogenic bacteria and for cancer therapy. In our current project, we develop such phages to treat recalcitrant fungal infections. The antibodies in this case are specific for binding with the pathogenic fungus – Aspergillus fumigatus (AF) - that causes life-threatening lung infections in immunocompromised patients. The drug Amphotericin B is to be linked to the phages by means of chemical conjugation, through a genetically engineered labile linker, subject to controlled release as a result of proteolytic activity of the fungal protease Alp1. At present we are working on conjugating the drug to the phages. To this end we synthesized PEG conjugates of amphotericin B (AMB), to


RESEARCHERS

Research DescriptionThe Shomron research team focuses on the analysis of genomics, aimed at understanding human diseases. Combining high-throughput methods and bioinformatics, our team explores gene regulators, such as microRNAs, in order to reach a global systems perspective on the mechanistic roles small RNA play during disease development.Among our projects: Identifying microRNAs located at the intersection of several oncogenes; Controlling metastatic breast cancer via nanoparticles releasing microRNAs; Revealing the influence of microRNAs on pharmacogenomics and personalized medicine; Exposing pathogens in human tissues based on deep sequencing of small RNA molecules.Overall, our team pursues research that aims to deepen our understanding of the development of diseases, in order to generate a significant impact through translating ideas into clinical reality.

Affiliation: Medicine


Web: www.tau.ac.il/~nshomron

Research TitleGenomics of human diseases

Selected Publications:1. Isakov O, Perrone M, Shomron N. Exome sequencing analysis: a guide

to disease variant detection. Methods Mol Biol. 2013;1038:137-58.2. Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D,

Laitman Y, Barshack I, Friedman E, Shomron N. Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers. Breast Cancer Res Treat. 2013 Apr;138(3):753-60.

3. Mor E, Kano S, Colantuoni C, Sawa A, Navon R, Shomron N. MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. Neurobiol Dis. 2013 Jul;55:1-10.

4. Shomron N. Genetics research: jumping into the deep end of the pool. Genet Res (Camb). 2013 Feb;95(1):1-3.

5. Isakov O, Ronen R, Kovarsky J, Gabay A, Gan I, Modai S, Shomron N. Novel insight into the non-coding repertoire through deep sequencing analysis. NucleicAcids Res. 2012 Jun;40(11):e86.

Dr. Noam Shomron


RESEARCHERS

Research DescriptionOur main interest is in understanding the design principles of cooperative behavior in bacteria. More specifically, we focus on how bacterial communication (also known as quorum sensing) is involved in the regulation of cooperation. Our aim is to elucidate the impact of social structure, spatial form and phenotypic heterogeneity on the development of cooperation and its evolution. In order to study the phenomenon of cooperation in simple and complex structures we combine tools from microbiology, genetics, molecular biology, microscopy and quantitative modeling. Our main model organisms are the gram-positive soil bacteria B. subtilis and the gram-negative pathogen P. aeruginosa. These two organisms are major model systems of quorum sensing and biofilm development, allowing us to use their superb genetic tools and vast knowledge base as a starting point for our investigation.

Affiliation: Life Science


Web: http://www6.tau.ac.il/eldar/

Research TitleElucidating bacterial communication systems

Selected Publications:1. Avigdor Eldar (2011). Social conflict drives the evolutionary divergence

of quorum sensing. Proceedings of the National Academy of Science, 108 (33): 13635-13640 Partial penetrance facilitates developmental evolution in bacteria.

2. Avigdor Eldar,Vasant K. Chary, Panos Xenopoulos, Michelle E. Fontes,Oliver C. Losón, Jonathan Dworkin, Patrick J. Piggot PJ, Michael B. Elowitz. (2009). Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients Nature, 460(7254):510-4

3. Avigdor Eldar, Dalia Rosin, Ben-Zion Shilo and Naama Barkai. (2003). Robustness of the BMP morphogen gradient in Drosophila embryonic patterning Developmental Cell, Vol 5, 635-646

4. Avigdor Eldar, Ruslan Dorfman, Daniel Weiss, Hilary Ashe, Ben-Zion Shilo and Naama Barkai. (2002). Functional Roles for Noise in Genetic Circuits. Nature 419, 304-308 (2002).

5. Avigdor Eldar and Michael Elowitz. (2010). Nature, 467(7312):167-173.

Dr. Avigdor Eldar


RESEARCHERS

In order to properly study biological systems and the interactions within them, it is important to have complementary techniques covering different length and energy scales, with proximity to their natural environment. In our laboratory we purify the subunit biological building blocks, using a variety of state-of-the-art biochemical and molecular techniques. We then reassemble them in precise conditions, to extract the underlying physics pertaining to their supramolecular forces, dynamics and steady-state structures - particularly as they appear in healthy and diseased states.We use small and wide angle x-ray scattering (WAXS & SAXS) to cover length scales from 0.1-100 nm. These techniques are suitable for measuring weak scattering from biological systems in their natural environment. Detailed analysis and advanced computational techniques are regularly used to convert the reciprocal space into real-space structures, and enable studies on the nature of the interactions within the biological assemblies. SAXS, in particular, provides a ready means for determining inter-filament spacing and interactions. Recent advances in solid-state type x-ray detectors and high-flux microfocus x-ray sources allow investigation of dynamic structural events, as well as highly penetrated measurements. Conveniently, these approaches do not require staining or other modifications, and thus do not perturb our system, allowing easier access to the supramolecular forces underlying self-assembly, and simplifying data analysis.

Affiliation: Physics


Web: http://www6.tau.ac.il/beck/

Research TitleNanoscale biophysics

Selected Publications:1. G. Jacoby, K. Cohen, K. Barkan, Y. Talmon, D. Peer, R. Beck, Predetermined

and controlled metastable phase transition in lipid-based particles. Scientific Reports 5, 9481 (2015). DOI: 10.1038/srep09481

2. S. Pregent, A. Lichtenstein, R. Avinery, A. Laser-Azogui, F. Patolsky, R. Beck, Probing the interactions of intrinsically disordered proteins using nanoparticle tags. Nano Letters (2015). DOI: 10.1021/acs.nanolett.5b00073.

3. M. Kornreich, E. Malka-Gibor, A. Laser-Azogui, O. Doron, H. Herrmann, R. Beck, Composite bottlebrush mechanics: α-Internexin fine-tunes neurofilament network properties. Soft Matter 11, 5839-5849 (2015). DOI: 10.1039/C5SM00662G

4. L. Almagor, R. Avinery, J. Hirsh, R. Beck, Structural flexibility of CaV 1.2 and CaV 2.2 proximal linker fragments in solution, Biophysical Journal 104, 2392-2400 (2013), DOI: 10.1016/j.bpj.2013.04.034, PMID: 23746511

5. R. Beck, J. Deek, J.B. Jones, C.R. Safinya, Gel Expanded to Gel Condensed Transition in Neurofilament Networks revealed by Direct Force Measurements, Nature Materials 9, 40-46 (2010),PMID:19915555

Research DescriptionIn many significant biological functions the four basic building blocks (proteins, lipids, sugars and nucleic acids) aggregate to form supramolecular structures and assemblies. The forces and interactions responsible for these assemblies are composed of a set of interactions with energy scales ranging from thermal fluctuations (a few KT) to specific covalent bonds (100s of KT). Relevant length scales in biological systems also span many orders of magnitude, from the single amino acid through polypeptide chains, protein complexes and organelles, all the way up to cells and organs. These different scales present enormous challenges, both experimentally and theoretically.

Prof. Roy Beck


RESEARCHERS

Research DescriptionIn our group we are interested in understanding the principles governing the behavior of systems out of thermal equilibrium. To this end we use a combination of optical imaging and optical manipulation to probe and image soft materials and complex fluids. We believe that by studying in detail many model systems far from thermal equilibrium, we will be able to see emergent universalities. In the past few years we have studied two different systems driven out of equilibrium in different ways: optically driven colloidal suspensions, and in-vitro cytoskeleton networks containing molecular motors. Technically, the experimental work in the group is based on video microscopy, particle tracking and image velocimetry for studying the dynamics and kinetics of particles in our model systems, and microrheology for characterizing their mechanical properties. In addition, we develop optical imaging techniques with improved resolution and speed, and combine various 3D imaging techniques with optical trapping and manipulation.

Affiliation: Chemistry


Web: http://www.tau.ac.il/~roichman/

Research TitleExperimental studies of soft matter with holographic optical tweezers

Selected Publications:1. Diffusion of a nano-wire through an obstacle field, Dror Kasimov,

Tamir Admon, and Yael Roichman, PRE in press (2016)2. Tomographic phase microscopy with 180o rotation of live cells in

suspension by holographic optical tweezers, Mor Habaza, Barak Gilboa, Yael Roichman, and Natan T. Shaked, Optics Lett., 40, 1881-1884 (2015).

3. Viscoelastic respone of a complex fluid at intermediate distances, Adar Sonn-Segev, Anne bernheim-Groswasser, Haim Diamant, and Yael Roichman, Phys. Rev. Lett., 112, 088301 (2014).

4. Independent and simultaneous three-dimensional optical trapping and imaging. Maya Yevnin, Dror Kasimov, Yael Gluckman, Yuval Ebenstein, and Yael Roichman, Biomedical Optics Express, 4, 2087-2094 (2013).

5. Hydrodynamic Pair Attractions between Driven Colloidal Particles, Yulia Sokolov, Derek Frydel, David G. Grier, Haim Diamant, and Yael Roichman, Phys. Rev. Lett., 107, 158302, (2011).

Dr. Yael Roichman


RESEARCHERS

arrange themselves and behave similarly to atoms and molecules comprising materials found in nature. However, colloids and grains are large enough, and move slowly enough, to allow experiments that directly show us their dynamics at the single-particle level. The analogy with these systems thus enables us to visualize microscopic processes governing the macroscopic characteristics and dynamic properties of complex materials, which are otherwise very poorly understood.Our current research efforts focus on two main topics: jammed matter and active matter. The first involves using lattice-based models to study disordered soft materials such as powders, foams, colloids and glasses - the dynamics of which are all extremely slow and cooperative. Some of these models jam and remain disordered, due to geometric frustration - namely the inability of a system to simultaneously satisfy all of its local constraints, making it difficult for it to reach a global optimum which minimizes the relevant free energy. Other models, studied analytically and numerically, consist of kinetically constrained dynamics. Here the geometry is implemented effectively by directly defining which dynamical moves are allowed and which are forbidden, in ways that may generate jamming similar to that found in more complicated models.The second line of research includes the study of fluctuations generated in biological systems due to the presence of molecular motors within them. These motors consume chemical energy and generate mechanical forces which drive the system out of thermodynamic equilibrium. Moreover, biological materials have a very nonlinear mechanical response, and therefore the macroscopic mechanical properties of biological systems are very different from those of passive materials. Our activity along this avenue includes the use of stochastic models for the dynamics in conjunction with geometrical descriptions of the nonlinear, finite-deformation elasticity of biological materials.

Affiliation: Mechanical Engineering


Web: http://shokef.tau.ac.il/

Research TitleNon-equilibrium statistical mechanics of soft matter

Selected Publications:1. A. Ghosh, E. Teomy, and Y. Shokef, Jamming percolation in three

dimensions, Europhysics Letters 106, 16003 (2014).2. E. Teomy and Y. Shokef Finite-density effects in the Fredrickson-Andersen

and Kob-Andersen kinetically-constrained models, The Journal of Chemical Physics 141, 064110 (2014).

3. Y. Shokef and S.A. Safran, Scaling laws for the response of nonlinear elastic media with implications for cell mechanics, Physical Review Letters 108, 178103 (2012).

4. Y. Shokef, A. Souslov, and T.C. Lubensky, Order-by-disorder in the antiferromagnetic Ising model on an elastic triangular lattice, Proceedings of the National Academy of Sciences of the USA 108, 11804 (2011).

5. Y. Han, Y. Shokef, A.M. Alsayed, P. Yunker, T.C. Lubensky, and A.G. Yodh, Geometric frustration in buckled colloidal monolayers, Nature 456, 898 (2008).

Research DescriptionOur group conducts theoretical research into the dynamical behavior of soft materials, using models and concepts inspired by recent developments in the statistical mechanics of systems far from thermodynamic equilibrium. Many soft systems encountered in everyday life, such as glasses, colloidal suspensions (ink), granular media (sand), emulsions (milk) and foams (shaving cream), as well as most biological systems, are very far from thermal equilibrium. Even though they are in close contact with a thermal environment, they are either (i) strongly driven by mechanical or biological forces with a perpetual current of energy, from the driving source through the system and out into the dissipative environment, or (ii) they fall into metastable glassy states and fail to equilibrate with their surroundings. The typical energy scales of fluctuation in a sheared colloid, in the membrane of a red blood cell, or in a solution with bacteria swimming in it, are considerably higher than the thermal energy. More dramatically, for a pile of sand or flour, thermal energy is negligible compared to the energy required for a single grain to overcome gravity and hop over one of its neighbors. On top of the compelling biological and industrial interests in such materials, soft matter systems are useful as mesoscopic models of molecular systems. Nano-, micro- or millimeter- scale droplets, colloids and grains

Dr. Yair Shokef


RESEARCHERS

Research DescriptionGene expression is the process by which information encoded in the genome is used to synthesize intra-cellular molecules such as proteins, which are involved in all intra-cellular activities. The genetic code is a table that translates triplets of nucleotides (alphabet of the mRNA/DNA) to amino acids (alphabet of proteins).There is, however, redundancy in the genetic code: 61 triplets of nucleotides actually code only 20 amino acids. In this redundancy and also in the non-coding regions, some aspects of gene expression - e.g. the rate at which the proteins will be generated - can be (at least partially) encoded.Our group is working on: 1) Deciphering how gene expression is usually encoded in the transcript itself, affecting its evolution; 2) Developing and analyzing computational/ mathematical/statistical/biophysical models that represent these rules; 3) Developing novel approaches to computer-aided design (CAD), and engineering gene expression based on these models.

Affiliation: Bio-medical Engineering


Web: http://www.cs.tau.ac.il/~tamirtul/

Research TitleDeciphering, modeling and engineering gene expression

Selected Publications:1. Dana, A., Tuller, T. (2014) The effect of tRNA levels on decoding

times of mRNA codons. Nucleic Acids Res. Jul 23.2. Zur,H., Tuller, T.(2014). Exploiting Hidden Information Interleaved

in the Redundancy of the Genetic Code without Prior Knowledge. Bioinformatics. Nov 29. pii: btu797.

3. Diament,A., Pinter,R.Y., Tuller, T.(2014). Three-dimensional eukaryotic genomic organization is strongly correlated with codon usage expression and function. Nature Communications. 16 Dec 2014.

4. Ben-Yehezkel, T., Atar,S., Zur,H., Diament,A., Goz,E., Marx,T., Cohen,R., Dana,A., Feldman,A., Shapiro,E., Tuller, T. (2015) Rationally designed, heterologous S. cerevisiae transcripts expose novel expression determinants. RNA Biol. 12(9):972-84.

5. Raveh, A., Margaliot, M., Sontag, E.D. Tuller,T. (2016). A model for competition for ribosomes in the cell. J. R. Soc. Interface. Mar;13(116).

Prof. Tamir Tuller


RESEARCHERS

Research DescriptionJust as light is affected by the matter it interacts with in traditional spectroscopy, the state of matter can also be altered by light, and coherently driven to yield a desired goal. This field of research is known as ‘coherent control’.Interested in both these mutually complementary processes, we use intense femtosecond light fields in both the terahertz range (THz fields, 10^12 Hz) and the visible/near-IR range (optical fields, 10^15 Hz) to coherently control and spectroscopically study the dynamics of molecules.We develop new control schemes based on combined excitation by THz and optical fields, acting as two distinct molecular handles. We utilize these fields to induce unique angular distributions in molecular ensembles, and then study them via advanced ultrafast spectroscopic methods. With the help of intense light fields, we wish to control and study molecules of increasing size and complexity, and ultimately apply these methods to big molecules and nanostructures of chemical and biological interest.



Web: https://sites.google.com/site/terahertzandultrafastlab/

Research TitleUltrafast terahertz and optical coherent control of molecules

Selected Publications:1. Kallush, S., and Fleischer, S. (2015). Orientation dynamics of asymmetric

rotors using random phase wave functions, Phys. Rev. A 91, 063420. 2. Fleischer, S., Field, R.W, and Nelson, K. (2014), From populations to

coherences and back again – a new insight about rotating dipoles, arXiv:1405.7025.of the Genetic Code without Prior Knowledge. Bioinformatics. Nov 29. pii: btu797.

3. Fleischer, S., Field, R.W, and Nelson, K. (2012). Commensurate two quantum coherences induced by time delayed THz fields, Phys. Rev. Lett. 109, 123603.

4. Fleischer, S., Zhou, Y., Field, R.W, and Nelson, K. (2011). Molecular orientation and alignment by intense single-cycle THz pulses, Phys. Rev. Lett. 107, 163603.

5. Fleischer, S., Averbukh, I.Sh., and Prior, Y., (2007). Selective Alignment of Molecular Spin Isomers, Phys. Rev. Lett. 99, 093002.

Dr. Sharly Fleischer


RESEARCHERS

Research DescriptionWe use the bioinformatic approach and statistical modeling to analyze RNA expression data. In particular, we have developed methods for identification, quantification and analysis of A-to-I RNA editing, an endogenous process in which the RNA is enzymatically modified from its genomic blueprint.



Web: http://www.tau.ac.il/~elieis

Research TitleComputational analysis of RNA expression data, focusing on RNA editing

Selected Publications:1. Paz-Yaacov, L. Bazak, H.T.Porath, I. Buchumenski, M. Danan-Gotthold,

B.A. Knisbacher, E. Eisenberg and E.Y. Levanon. Elevated RNA Editing Activity is a Major Contributor to Transcriptomic Diversity in Tumors, Cell Reports 13, 267-276 (2015)

2. S. Alon, S.C. Garrett, E.Y. Levanon, S. Olson, B.R. Graveley, J.J.C. Rosenthal and E. Eisenberg. The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing, eLife 4, e05198 (2015).

3. L. Bazak, A. Haviv, M. Barak, J. Jacob-Hirsch, P. Deng, R. Zhang, F.J. Isaacs, G. Rechavi, J.B. Li, E. Eisenberg and E.Y. Levanon. A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes, Genome Research 24, 365-376 (2014).

4. E. Eisenberg and E.Y. Levanon. Human housekeeping genes, revisited, Trends in Genetics, 29, 569-574 (2013).

5. S. Alon, E. Mor, F. Vigneault, G. Church, F. Locatelli, F. Galeano, A. Gallo, N. Shomron and E. Eisenberg, Systematic identification of edited microRNAs in the human brain Genome Research, 22, 1533-1540 (2012).

Prof. Eli Eisenberg


RESEARCHERS

Research DescriptionResearch in our group focuses on developing and applying magic-angle spinning solid state NMR for the study of complex systems, with a particular emphasis on structural virology. One example is the family of filamentous bacteriophages: bacteria-infecting viruses that share a similar virion structure and life cycle. The virion is composed of a circular ssDNA wrapped by thousands of similar copies of a major coat protein, with several different minor coat proteins at both ends. Our group prepares, purifies and uses magic-angle spinning NMR techniques to characterize the structure of various phages in atomic-detailed resolution. Another area of interest is the NMR of metal ions, which play a crucial role in the function of enzymes. Low occupancies, dynamics and other obstacles often hinder the detailed characterization of such sites, and our group addresses this challenge. We develop and apply techniques for characterizing the structural environment of metal ions such as 11B, 51V, 7Li, 23Na and other similar nuclei exhibiting a large anisotropic interaction in the magnetic field. For example: lithium salts have been known as mood stabilizing drugs for bipolar disorder patients for over 50 years. It was hypothesized that lithium exerts its therapeutic effect by binding with the enzyme myo-inositol monophosphatase (IMPase), thereby reducing inositol levels in the blood and diminishing the hyperactive phosphatidyl-inositol cell signaling pathway. Other targets of lithium have also been proposed. Since lithium is mostly spectroscopically silent, we use magic-angle spinning NMR techniques to directly observe and characterize lithium’s binding sites in its drug targets.



Web: kuwari.tau.ac.il

Research TitleBiomolecular solid state NMR

Selected Publications:1. O. Morag, G. Abramov, A. Goldbourt (2014). Complete chemical

shift assignment of the ssDNA in the filamentous bacteriophage fd reports on its conformation and on its interface with the capsid shell, J. Am. Chem. Soc. 136, 2292-2301.

2. E. Nimerovsky, R. Gupta, J. Yehl, M. Li, T. Polenova, A. Goldbourt (2014). Phase-modulated LA-REDOR: A robust, accurate and efficient solid-state NMR technique for distance measurements between a spin-1/2 and a quadrupole spin., J. Magn. Reson. 244, 107-113.

3. O. Morag, N. G. Sgourakis, D. Baker, A. Goldbourt (2015). The NMR-Rosetta capsid model of M13 bacteriophage reveals a quadrupoled hydrophonic packing epitope, Proc. Natl. Acad. Sci. 112(4), 971-976.

4. L. Avram, A. Goldbourt, Y. Cohen (2016). Hexameric capsules studied by magic angle spinning solid state NMR Spectroscopy: Identifying solvent molecules in pyrogallol[4]arene capsules. Angew. Chem. Int. Ed. 55(3), 904-907.

5. H. Ivanir, E. Nimerovsky, PK Madhu, A. Goldbourt (2015). Site-resolved backbone and side-chain intermediate dynamics in a carbohydrate-binding module protein studied by magic-angle spinning NMR. Chem. Eur. J., 21, 10778–10785.

Dr. Amir Goldbourt


RESEARCHERS

Research DescriptionWe specialize in studying soft matter and biological systems, in collaboration with several experimental teams worldwide. In particular, we explore the properties of self-assembling polymers, and ways to manipulate them at patterned surfaces and in thin film geometries, in relation with nanolithography. Another line of research is the exploration of bio- and soft matter systems in which charges play an important role. We investigate ionic liquids at charged interfaces and membranes, and the response of ionic solutions and charged macromolecules to external electric fields.



Web: www.tau.ac.il/~andelman

Research TitleTheory of soft and biological matter

Selected Publications:1. Lamellar Diblock Copolymers on Rough Substrates: Self-consistent

Field Theory Studies, X. K. Man, J. Tang, P. Zhou, D. Yan, and D. Andelman, Macromolecules 48, 7689-7697 (2015). http://arxiv.org/abs/1506.06854.

2. Contact Angle Saturation in Electrowetting: Injection of Ions into the surrounding Media, T. Yamamoto, M. Doi, and D. Andelman, Europhys. Lett. 112, 56001.1-6 (2015). http://arxiv.org/abs/1510.00613.

3. Correlated Lateral Phase Separations in Stacks of Lipid Membranes, T. Hoshino, S. Komura, and D. Andelman, J. Chem. Phys. 143, 243124.1-9 (2015). http://arxiv.org/abs/1508.03942.

4. Surface Tension of Electrolyte Interfaces: Ionic Specificity within a Field Theory Approach, T. Markovich, D. Andelman, and R. Podgornik, J. Chem. Phys. 142, 044702.1-13 (2015). http://arxiv.org/abs/1411.5222.

5. Charge-induced Phase Separation in Lipid Membranes, H. Himeno, N. Shimokawa, S. Komura, D. Andelman, T. Hamada, and M. Takagia, Soft Matter 10, 7959-7967 (2014). http://arxiv.org/abs/1405.4650.

Prof. David Andelman


RESEARCHERS

Research DescriptionWe are interested in the development of interferometric imaging methods for nano-profiling of thin elements, such as live biological cells in vitro, lithography processes and semiconductor wafers.Specifically, we develop interferometric and tomographic phase microscopy methods that can operate outside of the optical lab, in instable environments. By using compact, low-coherence, common-path, off-axis interferometric modules, we obtain 3D imaging of live biological cells without external labeling, and record the optical path delay of light passing through the sample with sub-nanometer accuracy. Furthermore, since these interferometric methods are very sensitive to local refractive-index changes, we develop plasmonic nanoparticles, which induce local heat changes due to photothermal excitation, as new contrast agents in live cells.

Affiliation: Bio-medical Engineering


Web: www.eng.tau.ac.il/~omni

Research TitleBiomedical optical microscopy, nanoscopy and interferometry

Selected Publications:1. P. Girshovitz and N. T. Shaked, Doubling the field of view in off-axis

low-coherence interferometric imaging, Nature – Light: Science and Applications (Nature LSA), Vol. 3, e151, pp. 1-9, 2014.

2. P. Girshovitz and N. T. Shaked, Compact and portable low-coherence interferometer with off-axis geometry for quantitative phase microscopy and nanoscopy, Optics Express, Vol. 21, Issue 5, pp. 5701-5714, 2013.

3. M. Habaza, B. Gilboa, Y. Roichman, and N. T. Shaked, Tomographic phase microscopy with 180° rotation of live cells in suspension by holographic optical tweezers, Optics Letters, Vol. 40, Issue 8, pp. 1881-1884, 2015.

4. O. Blum and N. T. Shaked, “Prediction of photothermal phase signatures from arbitrary plasmonic nanoparticles and experimental verification, Nature – Light: Science and Applications (Nature LSA), Vol. 4, e322, pp. 1-8, 2015.

5. N. Turko, I. Barnea, O. Blum, R. Korenstein, and N. T. Shaked, Detection and controlled depletion of cancer cells using photothermal phase microscopy, Journal of Biophotonics, Vol. 8, Issue 9, pp. 755-763, 2015.

Prof. Natan Shaked


RESEARCHERS

Research DescriptionThe primary focus of our research is electronic devices for the recording and controlled stimulation of brain signals. These devices are designed to address neurological disorders which cannot be treated with contemporary drugs. Specifically, a nanomaterial-based artificial retina implant with outstanding performance was recently produced, offering a promising solution for blindness caused by retinal degeneration - a condition which afflicts millions of people worldwide. We are also developing skin electrode arrays for reliably recording physiological signals from humans.

Affiliation: Electrical Engineering


Web: nano.tau.ac.il/hanein

Research TitleNeuro Engineering

Selected Publications:1. Lilach Bareket, Nir Waiskopf, David Rand, Gur Lubin, Moshe David-Pur,

Jacob Ben-Dov, Soumyendu Roy, Cyril Eleftheriou, Evelyne Sernagor, Ori Cheshnovsky, Uri Banin, Yael Hanein, (2014) Semiconductor Nanorod-Carbon Nanotube Biomimetic Films for Wire-Free Photo- Stimulation of Blind Retinas, Nano Letters, 14 (11), pp 66856692 DOI: 10.1021/nl5034304.

2. Vini Gautam, David Rand, Yael Hanein and K.S. Narayan, (2013) A polymer optoelectronic interface provides visual cues to a blind retina, Advanced Materials, 10.1002/adma.201304368.

3. Yuval Yifat, Michal Eitan, Zeev Iluz, Yael Hanein, Amir Boag, Jacob Scheuer, (2014) Highly efficcient and broadband wide-angle Holography Using Patch-Dipole Nano-antenna Reflect arrays, Nano Letters, 14 (5), 24852490, 2014.

4. David-Pur M1, Bareket-Keren L, Beit-Yaakov G, Raz-Prag D, Hanein Y. (2014) All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation. Biomed Microdevices.16(1):43-53. doi: 10.1007/s10544-013-9804-6.

5. Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pitta, Eshel Ben Jacob, Hugues Berry, and Yael Hanein, Glutamate Mediated Astrocytic Filtering of Neuronal Activity (2014), PLOS Computational Biology, DOI: 10.1371/journal.pcbi.1003964.

Prof. Yael Hanein


RESEARCHERS

Over the last several years, parametrically excited microstructures were an important part of research in our lab. In electrostatic devices the actuation forces are typically time- and configuration-dependent functions that modulate the effective stiffness, and can result in parametric excitation. Our group has developed and investigated several unusual approaches to the parametric excitation of microstructures. The insights gained from the investigation of microstructures, along with the exploration of new actuation and sensing principles, serve as a basis for implementing these approaches in applications. The development of new concepts of sensors in general, and of inertial sensors (angular rate sensors and accelerometers) in particular, is essentially based on the results of more fundamental theoretical and experimental research. Recently we developed a micro accelerometer incorporating bistable elements and based on stability boundaries monitoring. The device was fabricated at TAU and its functionality was demonstrated. One of the most promising directions today is the use of polymeric materials in MEMS/NEMS. While well-established technologies based on silicon as a main structural material are widely used, and have been successfully commercialized, they are less suitable for implementation in medical micro devices. In addition, polymeric MEMS devices can be naturally integrated with flexible electronics to form a unified sensing platform. In this context, our group (in collaboration with Prof. Yosi Shacham), is currently developing a generic technology based on the design, fabrication and integration of miniature devices fabricated from electroactive or/and conductive polymers and electroactive gels. Recently these endeavors were extended to the implementation of 3D printing techniques for fabrication of micro devices.

Affiliation: Mechanical Engineering


Web: www.eng.tau.ac.il/~vadis

Research TitleDesign and modeling of micro and nano systems

Selected Publications:1. J. Shklovsky, L. Engel, Y. Sverdlov, Y. Shacham-Diamand, S. Krylov,Nano-

Imprinting Lithography of P(VDF-TrFE-CFE) for Flexible Freestanding MEMS Devices, Microelectronic Engineering, 100, 41-46, 2012.

2. Y. Gerson, D. Schreiber, H. Grau, and S. Krylov, Meso Scale MEMS Inertial Switch Fabricated using Electroplated Metal on Insulator (MOI) Process, J. Micromech. Microeng., 24, pap. 025008, 2014.

3. S. Krylov, S. Lulinsky, B. R. Ilic, I. Schneider, Collective Dynamics and Pattern Switching in an Array of Parametrically Excited Micro Cantilevers Interacting Through Fringing Electrostatic Fields, Applied Physics Letters, 105, 071909, 2014.

4. L. Medina, R. Gilat, B.R. Ilic, S. Krylov, Experimental Investigation of The Snap-Through Buckling of Electrostatically Actuated Initially Curved Pre-Stressed Microbeams, Sensors and Actuators A, 220, 323–332, 2014.

5. Y. Borisenkov, M. Kholmyansky, S. Krylov, A. Liberzon and A. Tsinober, Multi-Array Micromachined Probe for Turbulence Measurements Assembled of Suspended Hot-Film Sensors, IEEE J. of Microelectromechanical Systems, 24(5), pp. 1503-1509, 2015.

Research DescriptionOur research combines theoretical, experimental and applied aspects in the area of modeling, design, fabrication and characterization of micro- and nanoelectromechanical systems (MEMS/NEMS). Our efforts focus on the development of new approaches to actuation and sensing and their implementation in applications, as well as the study of the typically nonlinear electromechanical phenomena in microscale structures. A better understanding of physical phenomena, gained through extensive investigation, lays the foundation for the possible development of new designs and operational concepts for micro and nano devices. The dynamics and stability of micro- and nanostructures is one central direction of our current activity. One of the distinguishing features of electrostatically, magnetically or electro-thermally actuated microstructures is that they are inherently nonlinear, and can become unstable. Our research sheds light on the dynamic behavior and stability of microstructures, and inspires a generation of new concepts for using these phenomena in applications.

Prof. Slava Krylov


RESEARCHERS

Research DescriptionUltrashort aromatic and aliphatic di- and tripeptide biomolecular nanostructures of different origin and native conformation at the nanoscale are studied by monitoring their basic physical properties during a thermally induced phase transition. We show that this fundamental process, found by us in bioorganic systems, is governed by the thermally activated reconformation of biomolecules, or their spatial reconfiguration. Regardless of the origin of di- and tripeptides and their native architecture, the phase transition takes place by full refolding into another similar, irreversible, and thermodynamically stable fiber-like nanowire morphology. In this new supramolecular arrangement, newly observed bioorganic nanodots, with β-sheet structure and deep reconstruction found at all levels (molecular, electronic, peptide secondary structure, morphological, etc.) generate new physical properties and the appearance of blue/green photoluminescence.



Web: http://www.eng.tau.ac.il/~gilr

Research TitlePhysical properties of bioinspired nanomaterials

Selected Publications:1. S. Semin, A. van Etteger, N. Amdursky, L. Kulyuk, S. Lavrov, A. Sigov,

E. Mishina, G. Rosenman, and Th. Rasing, (2015). Strong Thermo-Induced Single And Two-Photon Green Luminescence In Self-Organized Peptide Microtubes, Small, 11, 1156–1160.

2. A. Handelman, G. Shalev, G. Rosenman, Symmetry of Bioinspired Peptide (2015). Nanostructures and Their Basic Physical Properties, Israel Journal of Chemistry, 55, 637–644.

3. A. Handelman, N.Kuritz, A. Natan and Gil Rosenman, (2016). Reconstructive Phase Transition in Ultrashort Peptide Nanostructures and Induced Visible Fluorescence, Invited Feature Article, Langmuir, 32 (12), 2847–2862.

4. A. Handelman, B. Apter, N.Turko and Gil Rosenman. (2016). Linear and Nonlinear Optical Waveguiding Effects in Bio-inspired Diphenylalanine Peptide Nanotubes, Acta Biomater, 30, 72–77.

5. A.Handelman, S. Lavrov, A. Kudryavtsev, S. Semin, E. Mishina and G.Rosenman, Nonlinear Optical Phenomena in Bioinspired Peptide Nanostructures and Optical Waveguide properties ,Review paper, Encyclopedia of Nanoscience and Nanotechnology, 10-volume set.

Prof. Gil Rosenman


RESEARCHERS

Research DescriptionOur lab specializes in many areas of optical imaging and spectroscopy, with emphasis on single-molecule detection and the development of imaging-based techniques. Our research focuses on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We develop new spectroscopy and microscopy methodologies that combine advanced optics with tools and reagents from the realm of nanotechnology. In addition, we have great interest in developing unique biochemistries for genomic analysis, based on chemo-enzymatic reactions.



Web: http:// www.nanobiophotonix.com

Research TitleSingle-molecule genomics

Selected Publications:1. Ebenstein, Y, Y. Michaeli, T. Shahal, D. Torchinsky, A. Grunwald, R. Hoch,

and Optical detection of epigenetic marks: Sensitive quantification and direct imaging of individual hydroxymethylcytosine bases. Chem. Commun., (2013) 49 (77), 8599 - 8601

2. Ebenstein Y., M. Levy-Sakin, Beyond Sequencing: Optical mapping of DNA in the Age of Nanotechnology and Nanoscopy. Current Opinion in Biotechnology (2013) 24, (4), 690-698.

3. Ebenstein, Y., Weiss, S., Levy-Sakin M., Grunwald A., Kim, S., Gottfried, A., Lin, R.R., Dertinger, T., Kim, A.S., Chung, S., Colyer, R.A., Weinhold, E., Towards Single-Molecule Optical Mapping of the Epigenome. ACS Nano, (2014) 8, (1), 14-26.

4. Yuval Ebenstein, Jeremy Don, Shahar Zirkin, Sivan Fishman, Hila Sharim, Yael Michaeli, Lighting Up Individual DNA Damage Sites by In Vitro Repair Synthesis. JACS (2014), 136, (21), 7771–7776.

5. Ting F. Zhu, Yuval Ebenstein, Chunbo Lou, Wenjun Jiang, Xuejin Zhao, Tslil Gabrieli, Cas9-Assisted Targeting of CHromosome segments (CATCH) enables one-step targeted cloning of large gene clusters. Nat.Comm., (2015).

Dr. Yuval Ebenstein


RESEARCHERS

cobalt alloys were found to be very useful as barrier and capping layers for Cu metallization. The most useful barrier and capping layers were made of alloys of cobalt and nickel with refractory metals (tungsten, molybdenum or rhenium) and also with phosphorus or boron. The coupling of living cells, serving as sensor elements, with microelectronic devices, provides novel opportunities for biosensors performing as stable, sensitive, specific and accurate electronic devices. Electroless Deposition methods, in which metal cations are chemically reduced by a reducing agent into a deposited metallic film, may provide a new and effective tool for the coupling of biological activities and electronic circuits. Electrical characteristics (conductivity) and structure preservation are achieved by coating the structure with a thin metal film. The main goal of our research is to study the new concept of integration of metallized whole cells with electronically interfacing biosensors. In order to miniaturize the biosensors we want to work with a single cell or a small number of cells located within a small area on a chip. To achieve this, we must be able to control the location of the cell on the electrode, and to provide electrical contact between cell and electrode. We hypothesize that by using cells metallized by electroless deposition we can achieve both goals.



Web: eng.tau.ac.il/~yosish

Research TitleInterconnect micro and nano fabrication

Selected Publications:1. Yoetz-Kopelman, T., Dror, Y., Shacham-Diamand, Y., & Freeman,

A. “Cells-on-beads”: A novel immobilization approach for the construction of whole-Cell amperometric biosensors. Sensors and Actuators B: Chemical, (2016).

2. Ram, Y., Yoetz-Kopelman, T., Dror, Y., Freeman, A., & Shacham-Diamand, Y. (2016). Impact of Molecular Surface Charge on Biosensing by Electrochemical Impedance Spectroscopy. Electrochimica Acta.

3. Hemed, N. M., Convertino, A., & Shacham-Diamand, Y. (2016). Investigation of Functionalized Silicon Nanowires by Self-Assembled Monolayer. Applied Surface Science. (Accepted for publication).

4. Yoetz-Kopelman, T., Porat-Ophir, C., Shacham-Diamand, Y., & Freeman, A. (2016). Whole-cell amperometric biosensor for screening of cytochrome P450 inhibitors. Sensors and Actuators B: Chemical, 223, 392-399.

5. Feiner, R., Engel, L., Fleischer, S., Malki, M., Gal, I., Shapira, A., Shacham-Diamand Y. & Dvir, T., Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function. Nature materials. 2016.

Research DescriptionCu interconnect requires barrier layers to prevent Cu diffusion into the dielectrics and the Si substrate. Cu lines also require capping layers to prevent oxidation and improve reliability, by reducing Cu surface electromigration - mostly at the top interface where the Cu was exposed to chemical mechanical polishing during the “Dual Damascene” fully embedded metal positive patterning process. Electroless nickel and

Prof. Yosi Shacham


RESEARCHERS

Research DescriptionIn our group we adopt a bottom-up approach to develop and explore various properties of nanomaterials, self-assembled monolayers and thin films. We start from the molecular level, and use molecular synthesis to form the desired basic structures which, in the next stage, are incorporated into our novel devices. Examples include doped proteins, chiral nanostructures and plasmonic materials. Our compounds can be formed in self-assembly fashion (the self-assembled monolayers of doped proteins), as thin films (white-emitting coating for white LEDs) or as standalone materials (biodegradable plastics and hydrogels made from renewable materials). In order to explore the properties of these materials we have developed new types of nano-devices, including nano-vertical transistors and circuits, solar cells and light emitting materials. We have also developed novel nanolithography techniques, some of which are currently undergoing commercialization processes. Our group includes students, postdocs and engineers from various disciplines - including chemistry, physics, biology and engineering.

Affiliation: Materials Science and Engineering


Web: http://www.eng.tau.ac.il/~srichter/

Research TitleBio and molecular electronics

Selected Publications:1. Sidelman, Noam, Moshik Cohen, Anke Kolbe, Zeev Zalevsky, Andreas

Herrman, and Shachar Richter. Rapid Particle Patterning in Surface Deposited Micro-Droplets of Low Ionic Content via Low-Voltage Electrochemistry and Electrokinetics. Scientific Reports 5 (2015).

2. Hendler, Netta, Elad Mentovich, Bálint Korbuly, Tamás Pusztai, László Gránásy, and Shachar Richter. Growth Control of Peptide-Nanotube Spherulitic Films: Experiments and Simulations. Nano Research 8, no. 11 (2015): 3630–38.

3. Gordiichuk, Pavlo I, Dolev Rimmerman, Avishek Paul, Daniel A Gautier, Agnieszka Gruszka, Manfred Saller, Jan Willem de Vries, et al. ,Filling the Green Gap of a Megadalton Photosystem I Complex by Conjugation of Organic Dyes. Bioconjugate Chemistry (2015).

4. Carmeli, Itai, Moshik Cohen, Omri Heifler, Yigal Lilach, Zeev Zalevsky, Vladimiro Mujica, and Shachar Richter. Spatial Modulation of Light Transmission through a Single Microcavity by Coupling of Photosynthetic Complex Excitations to Surface Plasmons.Nature Communications (2015).

5. Beilis, Edith, Bogdan Belgorodsky, Ludmila Fadeev, Hagai Cohen, and Shachar Richter. Surface-Induced Conformational Changes in Doped Bovine Serum Albumin Self-Assembled Monolayers. Journal of the American Chemical Society 136, no. 17 (2014): 6151–54.

Prof. Shachar Richter


RESEARCHERS

Research DescriptionMy group focuses on the development of novel energetic compounds and nanomaterials for various applications, including fire-extigushing gas generators and materials for deep-well oil and gas extraction. We work on synthesis and comprehensive characterization of various nitrogen-rich heterocycles, related metal complexes, energetic nanomaterials based on graphene oxide derivatives and energetic three-dimensional metal organic frameworks.



Web: https://en-exact-sciences.tau.ac.il/profile/cogozin

Research TitleChemistry of nitrogen-rich heterocycles and development of new energetic materials

Selected Publications:1. Yan, Qi-Long; Trzcinski, Waldemar A.; Cudzilo, Stanislaw; Paszula,

Jozef; Eugen, Trana; Liviu, Matache; Traian, Rotariu; Gozin, Michael. Thermobaric effects formed by aluminum foils enveloping cylindrical charges. Combustion and Flame (2016), 166, 148-157.

2. Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi; Cohen, Adva; Pang, Si-Ping. Highly energetic compositions based on functionalized carbon nanomaterials”, Nanoscale (2016), 8(9), 4799-4851.

3. Cohen, Adva; Yan, Qi-Long; Shlomovich, Avital; Aizikovich, Alexander; Petrutik, Natan; Gozin, Michael. Novel nitrogen-rich energetic macromolecules based on 3,6-dihydrazinyl-1,2,4,5-tetrazine. RSC Advances (2015), 5(129), 106971-106980.

4. Zeman, Svatopluk; Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi; Akstein, Zbynek. Thermal behavior of 1,3,5-trinitroso-1,3,5-triazinane and its melt-castable mixtures with cyclic nitramines. Thermochimica Acta (2015), 615, 51-60.

5. Aizikovich, A.; Shlomovich, A.; Cohen, A.; Gozin, M.. The nitration pattern of energetic 3,6-diamino-1,2,4,5-tetrazine derivatives containing azole functional groups. Dalton Transactions (2015), 44(31), 13939-13946.

6. Ramishetti, Srinivas; Kedmi, Ranit; Goldsmith, Meir; Leonard, Fransisca; Sprague, Andrew G.; Godin, Biana; Gozin, Michael; Cullis, Pieter R.; Dykxhoorn, Derek M.; Peer, Dan. Systemic gene silencing in primary T lymphocytes using targeted lipid nanoparticlesACS Nano (2015), 9(7), 6706-6716.

Prof. Michael Gozin


RESEARCHERS

Research DescriptionThe reaction center photosystem I (PSI) is a membrane protein-chlorophyll complex. PSI functions as a photodiode converting light quanta into electrical charges of 1V at a quantum efficiency of ~100%. We investigate the novel properties of hybrid PSI-metals - metal nanoparticles, semiconductors and nanotube devices, and study the interaction between PSI and the solids, and the efficiency of charge transfer through the fabricated electronic junctions.Oriented monolayers and multilayers of PSI are self-assembled by forming a sulfide bond between metal surfaces and unique cysteine mutants of genetically modified PSI from cyanobacteria. The dry layers generate photo potential. Covalent junctions between the protein and the solid surface form efficient electronic junctions that mediate charge transfer at a ps time scale. Oriented multilayers are fabricated by autometalization, with cross linker molecules connecting the serial layers. When placed between metal and transparent electrodes, photovoltage and a photocurrent are generated. The oriented multilayers of PSI enhance the photovoltage and photocurrent, due to the serial arrangement of the dipoles and the enhanced absorption cross section. A surface photo potential of up to 100V was recorded in PSI crystals where hundreds of layers were serially oriented. Hybrids of carbon nanotubes and PSI are fabricated by activating the nanotubes and attaching the unique cysteine in the engineered protein through small bifunctional molecules. PSI that has cysteine on both the oxidizing and reducing ends of the protein forms junctions - either between nanotubes or between nanotubes and metal electrodes. The PSI in hybrid PSI-nanotube devices thus enhances the nonotubes’ photo conductance by an order of magnitude.


Tel: 972-3- 6409826


Web: http://en-lifesci.tau.ac.il/profile/chanochc

Research TitleNanotechnology of photosynthesis

Selected Publications:1. Carmeli, I; Kumar, KS; Heifler, O; Carmeli, C., Naaman, R. Spin Selectivity

in Electron Transfer in Photosystem I. Agnew. Chem. Inter. Ed. 2014, 53, (34) 8953-8958.

2. H. Toporik, I. Carmeli, I. Volotsenko, M.Molotskii, Y. Rosenwaks, C. Carmeli and N. Nelson, Large Photovoltages Generated by Plant Photosystem I Crystals. Adv. Mater. 2012, 24, 2988–2991.

3. L. Sepunaru, I. Tsimberov, L. Forolov, C. Carmeli, I. Carmeli* and Y.Rosenwaks*, Picosecond Electron Transfer From Photosysnthetic Reaction Center Protein to GaAs Nano Lett. 2009, 9 (7) 2751-2755.

4. L. Frolov, Y. Rosenwaks, S. Richter, C. Carmeli and I. Carmeli, Photoelectric Junctions Between GaAs and Photosynthetic Reaction Center Protein, , J. Phys. Chem. C. 2008, 112, 13426-13430.

5. L. Frolov, O. Wilner, C. Carmeli and I. Carmeli, Fabrication of Oriented Multilayers of Photosystem I Proteins on Solid Surfaces by Auto-Metallization, Adv. Mater. 2008, 20, 263–266.

Prof. Chanoch Carmeli


RESEARCHERS

Research DescriptionProf. Rosenwaks leads a research group of 10 graduate students and scientists, and his current research interests include: nanoscale electrical measurements using mainly Kelvin probe force microscopy, nanowire transistors and sensors, charge carrier dynamics and transport in semiconductors, and Kelvin probe microscopy of 2D materials.



Web: http://www.eng.tau.ac.il/~yossir

Research TitleNanoscale electrical devices

Selected Publications:1. Alex Henning, Nandhini Swaminathan, Andrey Godkin, Gil Shalev,

Iddo Amit, and Yossi Rosenwaks, Tunable diameter electrostatically-formed nanowire for high sensitivity gas sensing, Nano Research, DOI 10.1007/s 12274-01, (2015).

2. A. Henning, M. Molotskii, N. Swaminathan, Y. Vaknin, A. Godkin, G. Shalev, and Y. Rosenwaks, Electrostatic Limit of Detection of Nanowire-based Sensors, Small, DOI: 10.1002/smll.201500566, (2015).

3. G. Segev, I. Amit, A. Godkin, A. Henning, and Y. Rosenwaks, Multiple State Electrostatically Formed Nanowire Transistors, IEEE Electron Device Lett. DOI: 10.1109/LED.2015.2434793, (2015).

4. I. Amit, N. Jeon, L. J. Lauhon, and Y. Rosenwaks, The Impact of Dopant Compensation on Graded p-n Junctions in Si Nanowires, ACS Applied Materials & Interfaces, 8 (1), pp 128–134, (2016).

5. Nandhini Swaminathan, Alex Henning, Yonathan Vaknin, Klimentiy Shimanovich, Andrey Godkin,Gil Shalev, and Yossi Rosenwaks, Dynamic Range Enhancement Using the Electrostatically Formed Nanowire Sensor, ACS Sensors, DOI: 10.1021/acssensors.6b00096.

Prof. Yossi Rosenwaks


RESEARCHERS

Research DescriptionOur lab develops smart bio- and nanotechnologies for engineering complex tissues. Our work focuses on engineering cardiac patches for treating patients after heart attacks, and on developing cyborg tissues that integrate micro- and nanoelectronics with living organs to control their performance.



Web: dvirlab.tau.ac.il

Research TitleTissue engineering and regenerative medicine

Selected Publications:1. Feiner R, Engel L, Fleischer S, Malki M, Gal I, Shapira A, Shacham-

Diamand Y, Dvir T. Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function. Nature Materials. 2016 Mar 14. doi: 10.1038/nmat4590.

2. Baranes K, Shevach M, Shefi O, Dvir T. Gold Nanoparticle-Decorated Scaffolds Promote Neuronal Differentiation and Maturation. Nano Letters 2015 Dec 19.

3. Fleischer S, Miller J, Hurowitz H, Shapira A, Dvir T. Effect of fiber diameter on the assembly of functional 3D cardiac patches. Nanotechnology. 2015 Jul 24;26(29):291002.

Dr. Tal Dvir


RESEARCHERS

technologies — mostly problems with lignin—raise questions regarding the actual potential of terrestrial biomass to meet the anticipated food, feed and energy challenges in a sustainable way. An alternative source of biomass for biorefineries is offshore-grown macroalgae. Macroalgae have been harvested throughout the world for centuries, both as a food source and as a commodity for the production of hydrocolloids. However, to date, macroalgae still represent only a tiny percentage of the global biomass supply: ~17∙10E6 tons fresh weight (FW) of macroalgae compared to 16∙10E11 tons of terrestrial crops, grasses and forests. A presently expanding body of evidence suggests that offshore-cultivated macroalgae, which contain very little lignin, and do not compete with food crops for arable land or potable water, can provide an alternative source of biomass for the sustainable production of food, chemicals and fuels. The goal of our laboratory is to develop a fundamental understanding of energy flows in offshore marine biorefineries, to boost the net energy return on investment, and to develop new technologies at the nano, micro and macro levels for implementing marine biorefineries for the benefit of humanity and society. To this end we are currently developing: 1) a climate simulator in silica and experimentally; 2) technologies for algae breeding “from spore to sea”, microdevices for studying seaweed-bacteria interactions; 3) a portfolio of computational and experimental tools for biomass deconstruction and fermentation.

Affiliation: Environmental Studies


Web: http://www.tau.ac.il/~agolberg/

Research TitleBioengineering for sustainability and health

Selected Publications:1. Towards marine biorefineries: Selective proteins extractions from

marine macroalgae Ulva with pulsed electric fields. Polikovsky, M, Fernand, F, Sack, M, Frey,W, Müller G, Golberg, A. Innovative Food Science & Emerging Technologies. 2016.

2. Global potential of offshore and shallow waters macroalgal biorefineries to provide for food, chemicals and energy: feasibility and sustainability, Lehahn Y, Ingle, K.N, Golberg A. Algal Research. 2016.

3. Long-term Listeria monocytogenes proliferation control in milk by intermittently delivered pulsed electric fields, implications for food security in the low-income countries. Golberg, A. Technology. 3(1):1-6, 2015.

4. Cloud-enabled microscopy and droplet microfluidic platform for specific detection of Escherichia coli in water. Golberg, A, Linshiz, G, Kravets, I, Stawski, N, Hillson, N, Yarmush ML,Marks, RS, Konry, T. Equal contributions. PLoS ONE 9(1): e86341.20.

5. Nanolayered siRNA Delivery Platforms for Local Silencing of CTGF Reduce Cutaneous Scar Contraction in Third-Degree Burns, Castleberry, SA, Golberg, A, Abu Sharkh,M, Khan,S, Almquist, BD, Austen WG Jr., Yarmush,ML, Hammond, PT. Biomaterials. 2016. 14;95:2.

Research DescriptionGlobal population growth and a rising quality of life in the era of climate change are expected to increase the demand for food, chemicals and fuels. A possible, sustainable direction for addressing this challenge is the production of biomass and the conversion of this biomass into the required products through a complex system known as a biorefinery. However, concerns over net energy balance, potable water use and environmental hazards, and uncertainty with regard to processing

Dr. Alexander Golberg


RESEARCHERS

Research DescriptionOur research is centered on the fundamentals of biological interactions at solid-liquid interfaces, with emphasis on electrochemical biosensors. Sensors for medical diagnostics, environmental pollution, food safety and veterinary uses were developed. Modification of nanoparticles, such as carbon nanotubes, gold nanotubes or peptide nanoparticles significantly increases the sensitivity of the sensors, enabling measurement of extremely low concentrations.



Web: http://www.tau.ac.il/lifesci/departments/biotech/members/rishpon/rishpon.html

Research TitleBioelectrochemistry and biosensors

Selected Publications:1. Bareket, L., Rephaeli, A., Berkovitch, G., Nudelman, A. & Rishpon .J.

Carbon nanotubes based electrochemical biosensor for detection of formaldehyde released from a cancer cell line treated with formaldehyde-releasing anticancer prodrugs. Bioelec (2011).

2. Adler-Abramovich, L., Badihi-Mossberg, M., Gazit, E. & Rishpon, J. (2010). Characterization of Peptide-Nanostructure-Modified Electrodes and Their Application for Ultrasensitive Environmental Monitoring Small 6, 825-831.

3. Vernick, S.; Freeman, A.; Rishpon, J.; et al.(2011). Electro-hemical Biosensing for Direct Biopsy Slices Screening for Colorectal Cancer Detection. JOURNAL OF THE ELECTRO-CHEMICAL SOCIETY 1581 P1-P4.

4. Rishpon, Judith; Popovtzer, Rachela; Shacham-Diamand, Yosi; et al. (2012). Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the diseasePatent Number: US 08268577. Patent Assignee: Ramot

5. Rishpon, J.; Popovtzer, R.; Shacham-Diamand, Y.; et al. (2013) Electrochemical methods of detecting cancer with 4-aminophenyl phosphate. Patent Number: US 08530179.

Prof. Judith Rishpon


RESEARCHERS

Research DescriptionThe Biomaterials & Corrosion Laboratory at Tel Aviv University strives to meet the demands of modern society by developing and studying advanced materials for a variety of applications - in biomedicine, space, harsh environments and other areas. Following are some of the lab’s internationally renowned achievements: 1) The development of a novel electrochemically-deposited hydroxyapatite and other calcium phosphate coatings for orthopedic and dental implants. Our current generation of coatings is on its way to commercial use via collaboration with a manufacturer of dental implants, and we are now working on future generations. These will incorporate biological matter and drugs to reduce infections, increase osseointegration, and improve mechanical properties. In addition, self-assembled monolayers applied to the titanium substrate will enhance the strength of adhesion. 2) Electroplating and electroless plating of rhenium-based alloys. These projects, conducted in collaboration with Prof. Eliezer Gileadi from the TAU School of Chemistry, and funded by the US AFOSR and Israel’s DoD, are intended mainly for aerospace, aircraft, and catalysis applications. Prof. Eliaz has studied the structure of such deposits at the atomic scale, using atom probe tomography (APT) and aberration-corrected transmission electron microscopy. 3) The magnetic isolation of biological matter for purposes of diagnosing diseases (such as cancer and osteoarthritis), determining the efficacy of drug treatment, and monitoring the wear of artificial joints - either at the design stage or during service in vivo. Ours is the only lab outside the US to have this capability, which is based on Bio-Ferrography.



Web: http://www.eng.tau.ac.il/~neliaz/

Research TitleFrom corrosion in space to degradation in vivo and functionality of implants

Selected Publications:1. N. Metoki, L. Liu, E. Beilis, N. Eliaz and D. Mandler. (2014) Preparation

and characterization of alkylphosphonic acid self-assembled monolayers on titanium alloy by chemisorption and electrochemical deposition. Langmuir, 30(23), 6791-6799.

2. H. Zanin, C. Rosa, N. Eliaz, P. May, F. Marciano and A. Lobo. (2015) Assisted deposition of nano-hydroxyapatite onto exfoliated carbon nanotube oxide scaffolds. Nanoscale, 7, 10218-10232.

3. O. Levi, A. Shapira, B. Tal, I. Benhar and N. Eliaz. (2015) Isolating epideral growth factor receptor overexpressing carcinoma cells from human whole blood by Bio-Ferrography. Cytometry: Part B – Clinical Cytometry, 88, 136-144.

4. O. Levi, B. Tal, S. Hileli, A. Shapira, I. Benhar, P. Grabov and N. Eliaz. (2015) Optimization of EGFR high positive cell isolation procedure by Design of Experiments methodology. Cytometry: Part B – Clinical Cytometry, 88, 338-347.

5. T. Nusbaum, B.A. Rosen, E. Gileadi and N. Eliaz. (2015) Effect of pulse on-time and peak current density on pulse plated Re-Ni alloys. J. Electrochem. Soc., 162(7), D250-D255.

Prof. Noam Eliaz


RESEARCHERS

Research DescriptionAt the Atomistic Simulation of Materials group we research materials by computationally solving the equations that their atoms follow. In this way we understand the properties of materials, perform virtual experiments under conditions that are hard to achieve in a real lab, and design new materials with tailored properties.We focus on ferroelectrics - materials with technological applications in computer memories, sensors and actuators. We aim to advance the design of ferroelectrics by understanding their properties and improving them. Current topics of interest at our lab are ferroelectric domain walls and ferroelectrics that show magnetic ordering (multiferroics). We also study other materials in collaboration with experimentalists. Over the last two years we carried out simulations in order to understand experiments in the growth of transition metal silicide nano-islands, learn about the structure of ReNi metallic alloys, and characterize the adsorption of polymers on metals in photovoltaic cells - to name several examples.



Web: http://www.eng.tau.ac.il/~dieguez/

Research TitleAtomistic simulation of materials

Selected Publications:1. Epitaxial phases of BiMnO3 from first principles; O. Diéguez and J.

Íñiguez: PHYSICAL REVIEW B 91, 184113 (2015).2. Domain walls in a perovskite oxide with two primary structural

order parameters: first-principles study of BiFeO3; O. Diéguez, P. Aguado-Puente, J. Junquera, and J. Iniguez: PHYSICAL REVIEW B 87, 024102 (2013).

3. First-Principles Investigation of Morphotropic Transitions and Phase-Change Functional Responses in BiFeO3-BiCoO3 Multiferroic SolidSolutions; O. Diéguez, and J. Iniguez: PHYSICAL REVIEW LETTERS 107, 057601 (2011).

4. First-principles predictions of low-energy phases of multiferroic BiFeO3; O. Diéguez, O.E. Gonzalez-Vazquez, J. Wojdel, and J. Iniguez: PHYSICAL REVIEW B 83, 094105 (2011).

5. The SIESTA method; developments and applicability; E. Artacho, E. Anglada, O. Diéguez, J.D. Gale, A. Garcia, J. Junquera, R.M. Martin, P. Ordejon, M.A. Pruneda, D. Sanchez-Portal, and J. Soler: JOURNAL OF PHYSICS-CONDENSED MATTER 20, 064208 (2008).

Dr. Oswaldo Dieguez


RESEARCHERS

Research DescriptionNanoscience and nanotechnology open a unique opportunity for applying highly accurate theories to realistic material science problems. Research in my group focuses on the theoretical study of the mechanical, electronic, magnetic and transport properties of systems at the nanoscale. Using first-principles computational methods, we aim to characterize both the ground state and dynamical properties of such systems. A combination of codes developed within our group, along with commercial computational chemistry packages, operating on a highly parallelizable high-performance computer cluster, allows us to address the properties and functionality of a variety of systems, ranging from carefully tailored molecular structures all the way to bulk systems. In addition to questions of basic science, we pursue the design of technologically applicable nanoscale material properties, for future applications in fields such as nano-electronics, nano-spintronics, accurate and sensitive chemical sensing and nano-mechanical devices.



Web: http://www.tau.ac.il/~odedhod/

Research TitleComputational nanomaterials science

Selected Publications:1. R. Pawlak, W. Ouyang, A. E. Filippov, L. Kalikhman-Razvozov, S. Kawai,

T. Glatzel, E. Gnecco, A. Baratoff, Q. Zheng, O. Hod, M. Urbakh, and E. Meyer, Single Molecule Tribology: Force Microscopy Manipulation of a Porphyrin Derivative on a Copper Surface, ACS Nano 10, 713-722 (2016).

2. J. E. Peralta, O. Hod, and G. E. Scuseria, Magnetization Dynamics From Time-Dependent Non-Collinear Spin Density Functional Theory Calculations, J. Chem. Theory Comput. 11, 3661-3668 (2015).

3. T. Zelovich, L. Kronik, and O. Hod, Molecule-Lead Coupling at Molecular Junctions: Relation Between the Real- and State-Space Perspectives, J. Chem. Theory Comput. 11, 4861-4869 (2015).

4. D. Krepel, J. E. Peralta, G. E. Scuseria, and O. Hod, Graphene Nanoribbons-Based Ultrasensitive Chemical Detectors, J. Phys. Chem. C 120, 3791-3797 (2016).

5. I. Oz, I. Leven, Y. Itkin, A. Buchwalter, K. Akulov, and O. Hod, Nanotubes Motion on Layered Materials: A Registry Perspective, J. Phys. Chem. C 120, 4466-4470 (2016).

Prof. Oded Hod


RESEARCHERS

Research DescriptionThe goal of our lab is to develop and use multiscale models for materials, interfaces and processes for energy applications. We also aim to bridge between atomistic quantum and classical models and larger-scale continuum equations that will eventually allow us to simulate a whole device. We develop formalism and code within the real-space PARSEC Density Functional Theory (DFT) and the time dependent DFT (TDDFT) package, and aim to achieve very fast calculations of FOCK exchange and post Hartree-Fock methods for large systems. Combining DFT and classical Molecular Dynamics (MD) we model materials and processes for future batteries and photovoltaic applications. We also use machine learning strategies and DFT to improve future MD simulations for such materials. Data mining strategies are used to search for and select new metal oxide materials, and to associate their structure with some desired properties.



Web: http://www.eng.tau.ac.il/~amirn/

Research TitleMultiscale simulations of materials and processes

Selected Publications:1. Natalia Kuritz, Michael Murat, Moran Balaish, Yair Ein-Eli, and Amir

Natan, PFC and Triglyme for Li-Air Batteries: A Molecular Dynamics Study – Journal of Physical Chemistry B (2016) DOI: 10.1021/acs.jpcb.5b12075.

2. Nicholas Boffi, Manish Jain and Amir Natan, Asymptotic behavior and interpretation of virtual states: the effects of confinement and of basis sets – J. Chem. Phys. 144, 084104 (2016).

3. M. Zuzovski, A. Boag and A. Natan, Auxilliary grid method for the calculation of electrostatic terms in Density Functional Theory on a real-space grid, PCCP, 17, 31510, (2015).

4. Yevgeny Rakita, Diana Golodnitsky, Amir Natan, Electrostatic potential of polyelectrolyte molecules grafted on charged surfaces: A Poisson-Boltzmann model, Journal of Electrochemical Society 161 (8), E3049-E3058, (2014).

5. Amir Natan, Ayelet Benjamini, Doron Naveh, Leeor Kronik, Murilo L. Tiago, Scott P. Beckman,and James R. Chelikowsky, Real Space Pseudopotential method for first principles calculations of general periodic and partially periodic systems, Phys. Rev. B 78, 075109 (2008).

Dr. Amir Natan


RESEARCHERS

• Describong thermal effects on nanoscale friction, and understanding the origin of unexpected nonmonotonic dependence of nanoscale friction on temperature

• Understanding the mechanism of wear and ripple formation in nanoscale friction

• Understanding the mechanism of onset of sliding motion for elastic sliders with extended rough interfaces

• Bridging a gap between descriptions of friction at the nano and macroscales

• Developing novel methods for controlling friction using mechanics and chemistry

A distinctive feature of research in the Michael Urbakh group is the development of minimal models which focus on a small number of the most relevant degrees of freedom of dynamical systems, but can nevertheless explain phenomena of high complexity. Moreover, the proposed minimal models have enabled predictions that were later verified experimentally. A special highlight was the remarkable prediction of the possibility of controlling friction mechanically via vibrations of small amplitude and energy. Michael Urbakh demonstrated that manipulation by mechanical excitations, when applied at the right frequency, amplitude and direction, pulls the molecules out of their potential energy minima and thereby reduces friction (at other frequencies or amplitudes the friction can be increased). This work stimulated experimental studies that confirmed the theoretical prediction, and recently this idea has been used by IBM in the development of the ultrahigh-density data storage device Millipede. The theoretical approaches developed in the field of nanoscale friction led to breakthroughs in other fields, such as single molecule force spectrosopcy and molecular motors. In particular, Michael



Web: www.tau.ac.il/~urbakh1/

Research TitleTheory and simulations of friction at the nanoscale

Selected Publications:1. Urbakh M., Klafter J., Gourdon D., Israelachvili J., The nonlinear nature

of friction, Nature 430, 525-528 (2004).2. Dudko O., Filippov A.E., Klafter J., Urbakh M., Beyond the conventional

description of dynamic force spectroscopy of adhesion bonds, Proc. National Academy of Sciences USA, 100, 11378–11381 (2003).

3. Ma M, Grey F., Shen L., Urbakh M., Wu S., Liu Z. J., Liu Y and Zheng Q. Water transport inside carbon nanotubes mediated by phonon-induced oscillating friction, Nature Nanotech., 10, 692-696 (2015).

4. Ma M., Benassi A., Vanossi A., and Urbakh M., Critical Length Limiting Superlow Friction, Phys. Rev. Lett. 114, Art. 055501 (2015).

5. W. Ouyang, M. Ma, Q. Zheng, and M. Urbakh, Frictional Properties of Nanojunctions Including Atomically Thin Sheets. Nano Letters, 16, 1878−1883 (2016).

Research DescriptionSince 1995, Michael Urbakh has been working on the theory of friction at the nano and mesoscales. Frictional motion plays a central role in diverse systems and phenomena that span a vast range of scales, from the nanometer contacts inherent in micro- and nano-machines and biological molecular motors, to the geophysical scales of earthquakes. The focus of research in the Michael Urbakh group is on a molecular level description of processes occurring between interacting surfaces in relative motion, which is needed to first understand, and later manipulate, friction. Important new results obtained by Michael Urbakh in this field include:• Understanding the mechanism of transition from stick-slip motion

to sliding• Predicting and characterizing new regimes of frictional motion, in

particular chaotic stick-slip and inverted stick-slip motion• Understanding the origin of a finite lifetime of superlubricity between

incommensurate surfaces, and suggesting novel ways to stabilize the low-friction superlubric state

• Describing friction in terms of rupture and formation of surface junctions

Prof. Michael Urbakh


RESEARCHERS

Urbakh developed a novel method for revealing molecular scale energy landscapes from the results of force unfolding experiments, which is now widely used in many experimental laboratories. Another development was a new approach to building microscopic engines on the nano and microscales, allowing efficient transformation of the fed energy into directed motion. These engines can move translationally or rotationally on surfaces, and perform useful functions such as pulling a nanoscale cargo.


RESEARCHERS

Research DescriptionOur research group attempts to understand the structure and dynamic response of soft materials and complex fluids using analytical models. Recent projects have included: instabilities in thin sheets, dynamics of driven colloidal suspensions, and correlations in confined fluids.



Web: tau.ac.il/~hdiamant

Research TitleTheory of complex fluids

Selected Publications:1. Diamant, H. (2015). Response of a polymer network to the motion

of a rigid sphere. Eur. Phys. J. 38, 32.2. Oshri, O., Brau, F., Diamant, H. (2015). Wrinkles and folds in a fluid-

supported sheet of finite size. Phys. Rev. E 91, 052408.3. Sonn-Segev, A., Blawzdziewicz, J., Wajnryb, E., Ekiel-Jezewska, M.

L., Diamant, H., Roichman, Y. (2015). Structure and dynamics of a layer of sedimented Brownian particles. J. Chem. Phys. 143, 074704.

4. Oshri, O., Diamant, H. (2016). Properties of compressible elastica from relativistic analogy. Soft Matter 12, 664-668.

5. Goldfriend, T, Diamant, H., Witten, T. A. (2015). Hydrodynamic interactions between two forced objects of arbitrary shape: I Effect on alignment. Phys. Fluids 27, 123303.

Prof. Haim Diamant


RESEARCHERS

microsensors, self-powered integrated circuits or microelectromechanical systems. Such devices need rechargeable microbatteries with dimensions on the scale of 1–10mm3, high energy density and high power capability. A 3D concentric microbattery on a Si chip or on 3D-printed polymer substrates enables the fabrication of a network of 10,000-30,000 units connected in parallel, minimizing the ion-path length between the electrodes, and providing high capacity per footprint area. This is achieved by the insertion of four consecutive thin-film battery layers into the high-aspect-ratio microchannels of the perforated chip or polymer. For the first time, the electrophoretic deposition (EPD) method is exploited for the preparation of thin-film active battery materials. Different solvents and surface-active agents are tested, with the aim of achieving well-dispersed nanoparticles in stable suspensions. Such systems are controlled by the complex interplay of concomitant phenomena, including micellization, association of the surfactant with the polymer and adsorption of the surfactant on the species. Of particular interest is the effect of these cooperative interactions on the structure and ion-transport properties of polymer electrolytes confined in the pores of ceramics. 3D-tomography tests (carried out in collaboration with Imperial College, London) provide the data sets for the calculation of the tortuosity factor at sub-100nm resolution. To produce core-shell and multiphase ceramic/alkali-metal salt nanoparticles, the method of mechanochemistry is used. Very recent subjects under investigation include redox processes in a high-energy-density all-solid-state lithiated Si/S battery (together with Prof. Emanuel Peled), and adsorption phenomena in supercapacitors based on porous silicon nanostructures.



Web: http://www2.tau.ac.il/nano/researcher.asp?id=dbjhegflh

Research TitleNanomaterials and thin films for electrochemical energy storage and conversion

Selected Publications:1. Moran Balaish, Emanuel Peled, Diana Golodnitsky and Yair Ein-Eli,

Liquid-Free Lithium-Oxygen Batteries, Angewandte Communications, 54, 2 ,436–440 (2015)

2. E. Zygadło-Monikowska, Z. Florjańczyk, J. Ostrowska, E. Peled and D. Golodnitsky Synthesis and characterization of lithium-salt complexes with difluoroalkoxyborates for application as lithium electrolytes. Electrochimica Acta, 175, 104-112 (2015)

3. K. Goldshtein, K. Freedman, D. Schneier, L. Burstein, V. Ezersky, E. Peled and D. Golodnitsky Advanced Multiphase Silicon-Based Anodes for High-Energy-Density Li-Ion Batteries, Journal of The Electrochemical Society, 162 (6) A1072-A1079 (2015)

4. E. Peled, F. Patolsky, D. Golodnitsky, K.Freedman, G. Davidi, D. Schneier Tissue-like Silicon Nanowires-Based Three-Dimensional Anodes for High-Capacity Lithium Ion Batteries, DOI: 10.1021/acs.nanolett.5b0074, Nano Lett., 2015

5. R. Blanga, L. Burstein, M. Berman, S. G. Greenbaum, and D. Golodnitsky Solid Polymer-in-Ceramic Electrolyte Formed by Electrophoretic Deposition Journal of The Electrochemical Society, 162 (11) D3084-D3089,(2015) FOCUS ISSUE ON ELECTROPHORETIC DEPOSITION

6. D. . Golodnitsky, E. Strauss, E. Peled, S. Greenbaum, Review—On Order and Disorder in Polymer Electrolytes Journal of The Electrochemical Society, 162 (14) A1-A16 (2015) invited paper.

7. D. Golodnitsky , E. Strauss, T. Ripenbein, PSi-Based Supercapacitors in the book “Porous Silicon: From Formation to Application”, v.3 Chapter 16, (2016), 345-372.

Research DescriptionMy major research activities focus on the synthesis and characterization of materials and the study of ion-transport phenomena in new nanostructured electrodes and solid electrolytes for energy-storage devices. The microelectronics industry is continually reducing the size of its products in order to produce small devices such as medical implants,

Prof. Diana Golodnitsky


RESEARCHERS

Research DescriptionThe Markovich group is working on several types of nano-systems: 1. Nanoscale chirality. Here we study the interaction of chiral biomolecules with inorganic nanostructures such as metal and semiconductor nanocrystals. These interactions may lead to induction of optical activity in plasmon and exciton resonances in the inorganic nanoparticles, and we are interested in understanding the mechanism of such interactions. We have also demonstrated that nanostructures of materials like mercury sulfide, tellurium and selenium, which have crystal structures that are intrinsically chiral, can be synthesized enantioselectively using chiral biomolecules such as cysteine and its derivatives as surface stabilizers. 2. Magnetic nanoparticles. We have performed several studies involving magnetic nanocrystals. In particular, we worked with magnetite (Fe3O4) nanocrystals and studied the magnetization dynamics of individual magnetite nanocrystals using a variable temperature STM. Using the same technique, we also studied the Verwey metal-insulator phase transition in individual magnetite nanocrystals at ~100K. Another project involving magnetic nanoparticles is the development of printable magnetic sensors based on nickel nanoparticle ink, together with Prof. Alexander Gerber’s group at TAU’s School of Physics. 3. Metal nanowire films as transparent electrodes. We are developing a simple wet chemical process for the preparation of thin gold/silver nanowire films, to be applied as transparent electrodes for various applications.



Web: http://chemistry.tau.ac.il/markovich/

Research TitleColloidal nanomaterials

Selected Publications:1. Amir Hevroni, Boris Tsukerman, Gil Markovich, Probing magnetization

dynamics in individual magnetite nanocrystals using magnetoresistive scanning tunneling microscopy, Phys. Rev. B 92, 224423 (2015).

2. Assaf Ben-Moshe, Sharon Grayer Wolf, Maya Bar Sadan, Lothar Houben, Zhiyuan Fan, Alexander O. Govorov, Gil Markovich, Enantioselective control of lattice and shape chirality in inorganic nanostructures using chiral biomolecules, Nat. Comm. 5, 4302 (2014).

3. Ben M. Maoz, Yulia Chaikin, Alexander B. Tesler, Omri Bar Elli, Zhiyuan Fan, Alexander O. Govorov, Gil Markovich, Amplification of Chiroptical Activity of Chiral Biomolecules by Surface Plasmons, Nano Lett. 13, 1203-1209 (2013).

4. Daniel Azulai, Elad Cohen, Gil Markovich, Seed concentration control of metal nanowire diameter, Nano Lett. 12, 5552-5558 (2012).

5. Assaf Ben Moshe, Daniel Szwarcman, Gil Markovich, The size dependence of chiroptical activity in colloidal quantum dots, ACS Nano 5, 9034–9043 (2011).

Prof. Gil Markovich


RESEARCHERS

Label-free super-resolution microscopyFar-field super-resolution (SR) microscopy has become an important tool in life sciences. However, it relies on, and therefore is limited by, the ability to control the fluorescence of label molecules. We introduce a new far-field label-free SR methodology that is based on the nonlinear response of the reflectance to photo-modulation. It relies on the ability to photo-excite nonlinearly spatial distribution of temperature and charge carriers inside the diffraction-limited spot, by an ultra-short pump pulse. An overlapping delayed probe pulse monitors reflectance changes. Spatial resolution within the diffraction-limited spot is enhanced due to nonlinearities in photo-modulated properties of the matter. The method is suitable for characterizing semiconductors and metals in vacuum, ambient and liquid semi-transparent and opaque systems, ultrathin and thick samples alike. The fast response of the basic methodology (picoseconds) will enable video rate scanning laser nanoscopy.We have demonstrated several examples of such resolution enhancement due to nonlinearities: The change of thermo-reflectance of VO2 upon its characteristic insulator-to-metal transition at ~340K, the heating process of nanostructured silicon or gold surfaces, and the nonlinear response of photo-modulated Raman spectra. Resolution down to 85nm is demonstrated. Based on similar ideas we focus on improving current SR methods intended for the biomedical research community.



Web: http://www3.tau.ac.il/cheshnovsky/index.php

Research TitleSingle nano-object spectroscopic microscopy

Selected Publications:1. O. Tzang, A. Pevzner, R.E. Marvel, R.F. Haglund, O. Cheshnovsky(2015).

Super-Resolution in Label-Free Photomodulated Reflectivity, Nano Letters, 15, 1362.

2. O. Tzang, O. Cheshnovsky (2015). New modes in label-free super resolution based on photo-modulated reflectivity, Optics Express, 23, 20926.

3. T. Juffmann, A. Milic, M. Mullneritsch, P. Asenbaum, A. Tsukernik, J. Tuxen, M. Mayor, O. Cheshnovsky. M. Arndt. (2012). Real time single molecule imaging of quantum interference.. Nature Nanotechnology, 7 296-299.

4. Z. Ioffe,, T. Shamai, A. Ophir, G. Noy, I. Yutsis, K. Kfir, O. Cheshnovsky, Y. Selzer.(2008). Detection of heating in current carrying molecular junctions by Raman scattering,Nature Nanotechnology 3, 727.

5. E. Flaxer, O. Sneh and O. Cheshnovsky. (1993) Molecular light emission induced by inelastic electron tunneling. Science 262, 2012-2014.

Research DescriptionSingle nano-object spectroscopic microscopySingle-molecule spectroscopic detection in fluorescent microscopy is already well established. However, not all molecules of interest fluoresce. In our laboratory we are developing a new approach to measuring the light absorption of single nano-objects, including single molecules. We use a supercontinuum laser (Fianium) and an Acousto Optical Tunable Filter to select the wavelength. The absorption detection is then carried out by an auto-balanced photodiode-pair aimed to suppress the laser noise, and a lock-in detection of a special absorption modulation technique. This is critical for enabling the detection of light absorbed by a single particle in the order of 10-4-10-7, which is orders of magnitude smaller than the intensity fluctuations of the light source. One of our long-term scientific goals is to characterize the spectroscopic properties of specially designed Si/Ge core shell nanowires (fabricated by our collaborators in the Patolsky lab), which according to theoretical predictions by A. Zunger are characterized by a direct band gap. In other projects we monitor the interaction between localized plasmons and excitons in WS2 nanorods.

Prof. Ori Cheshnovsky


RESEARCHERS

Research DescriptionOur research focuses on the development and characterization of novel and improved batteries. We have developed a molten-sodium/air battery operating at above the melting point of sodium (97.8oC). This battery, in addition to eliminating dendrite formation, can accelerate sluggish cathode reactions and lower cell impedance. We explored the key parameters that affect the performance of the electrodes and their impact on the operation of the molten-Na/air cell in glymes, PYR14TFSI ionic liquid and polyethylene oxide-based electrolytes. We have developed a very active oxygen reduction reaction (ORR). By using a core-shell nanostructure concept, we were able to reduce the amount of platinum, while at the same time increasing the activity of the ORR catalysts. We have succeeded in the development of anodes made of silicon nanowires and silicon nanoparticles coated with protective layers. These anodes demonstrate excellent performance that meets the requirements of lithium batteries for portable and electric-vehicle applications. We investigate the impact of cathode design, type of electrolyte and type of cathode binder on the cathode reactions and on battery performance of lithium-sulfur batteries. Additionally, we investigate hybrid double-layer capacitors (HDLCs) that offer at least five times more energy density than water-based double-layer capacitors (DLC).



Web: nano.tau.ac.il/peled

Research TitleNanomaterials and thin films for electrochemical energy storage and conversion

Selected Publications:1. H. Mazor, D. Golodnitsky, L. Burstein, A. Gladkich, E. Peled,

Electrophoretic deposition of lithium iron phosphate cathode for thin-film 3D-microbatteries, Journal of Power Sources 198, (2012) 264-272.

2. K. Goldshtein, D. Golodnitsky E. Peled, L. Adler-Abramovich, E. Gazit, S. Khatun, P. Stallworth, S. Greenbaum. Effect of peptide nanotubeller on structural and ion-transport properties of solid polymer electrolytes Solid State Ionics 220 (2012) 39–46

3. E. Peled. Development and Characterization of Composite YSZ-PEI Electrophoretically Deposited Membrane for Li-Ion Battery, J Phys. Chem. B, 117 (2013) (6), 1577–1584

4. E. Peled, D. Golodnitsky, R. Hadar, H. Mazor, M. Goor and L Burstein, Challenges and Obstacles in the Development of Sodium-Air Batteries, Journal of Power Sources 244 (2013) 771-776

5. E. Peled, D. Golodnitsky, R. Hadar, H. Mazor, M. Goor and L Burstein, Challenges and Obstacles in the Development of Sodium-Air Batteries, Journal of Power Sources 244 (2013) 771-776

Prof. Emanuel Peled


RESEARCHERS

Research DescriptionResearch in my group focuses on theoretical aspects of chemical dynamics. This branch of chemistry describes the nature of physical and chemical processes underlying the progress of chemical reactions, with the aim of understanding such processes and being able to predict their course of evolution. In particular, our studies deal with chemical processes involving interactions between light and matter, chemical reactions in condensed phases and at interfaces, and transport phenomena in complex systems. Our main research emphases are:• Energy transfer processes in molecular systems • Molecular dynamics in condensed phases• Ionic transport in complex environments• Optical properties and photochemistry of

adsorbed molecules• Electron transport through molecular layers and

wires • Classical and quantum thermodynamics of energy

conversion processes



Web: http://atto.tau.ac.il/~nitzan/nitzan.html

Research TitleTheoretical aspects of chemical dynamics

Selected Publications:1. A. Migliore and A. Nitzan, Irreversibility in redox molecular conduction:

single versus double metal-molecule interfaces Electrochimica Acta 160, 363–375 (2015).

2. K. Kaasbjerg and A. Nitzan, Theory of light emission from quantum noise in plasmonic contacts: above-threshold emission from higher-order electron-plasmon scattering, Phys. Rev. Letters, 114, 126803 (2015).

3. W. Dou, A. Nitzan and J. E. Subotnik, Surface hopping with a manifold of electronic states. II. Application to the many-body Anderson-Holstein model, J. Chem. Phys. 142, 084110 (2015).

4. K. Kaasbjerg and A. Nitzan, Theory of light emission from quantum noise in plasmonic contacts: above-threshold, emission from higher-order electron-plasmon scattering, Phys. Rev. Letters, 114, 126803 (2015)

5. W. Dou, A. Nitzan and J. E. Subotnik, Surface hopping with a manifold of electronic states, III: transients, broadening and the Marcus picture, J. Chem. Phys. 142, 234106 (2015).

Prof. Abraham Nitzan


RESEARCHERS

Research DescriptionStimuli-responsive nanocarriers that can disassemble to release their encapsulated cargo upon external stimuli have gained increasing attention due to their possible utilization as smart drug delivery systems. Among the various types of stimuli, enzymes offer great potential for the activation of biomedical carriers, due to their overexpression in various diseases. The design of enzyme-responsive block copolymers is highly challenging, as the enzyme must reach the enzyme-sensitive moieties - which are spread along the backbone of the polymer, and might be hidden inside the hydrophobic cores of the self-assembled structures. The polydispersity of the stimuli-responsive block raises another significant challenge for the kinetic analysis and mechanistic study of the enzymatic response, as the enzyme’s access to the enzymatically activated moieties can vary greatly - depending on their location along the polymer backbone, the length of the polymer chain, and its solubility. To address these challenges, we are developing highly modular polymeric platforms based on amphiphilic PEG-dendron hybrids. These amphiphilic hybrids can self-assemble in water into micellar nanocontainers that disassemble and release encapsulated molecular cargo upon enzymatic activation. The modularity of these PEG-dendron hybrids offers great control and tuning of the disassembly rate of the formed micelles, through simple adjustment of the PEG’s length. Such smart amphiphilic hybrids could open the way for the fabrication of nanocarriers with tunable release rates for drug delivery applications.



Web: http://chemistry.tau.ac.il/roeyamir/

Research TitleSmart polymers

Selected Publications:1. Harnoy, Assaf J.; Rosenbaum, Ido; Tirosh, Einat; Ebenstein, Yuval;

Shaharabani, Rona; Beck, Roy; Amir, Roey J., Enzyme-Responsive Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart Micellar Nanocarriers, Journal of the American Chemical Society (2014), 136, 7531-7534.

2. Rosenbaum, Ido; Harnoy, Assaf J.; Tirosh, Einat; Buzhor Marina; Segal, Merav; Frid, Liat; Shaharabani, Rona; Avinery, Ram; Beck, Roy; Amir, Roey J., Encapsulation and covalent binding of molecular payload in enzymatically activated micellar nanocarriers, Journal of the American Chemical Society (2015), 137, 2276-2284.

3. Buzhor, Marina; Harnoy, Assaf J.; Tirosh, Einat; Barak, Ayana; Schwartz, Tal; Amir, Roey J., Supramolecular translation of enzymatically triggered disassembly of micelles into tunable fluorescent responses, Chemistry - A European Journal (2015), 21, 15633–15638.

4. Amir, Roey J., Enzyme-Responsive PEG-Dendron Hybrids as Platform for Smart Nanocarriers, Synlett (2015), 26 (19), 2617-2622.

5. Buzhor, Marina; Avram, Liat; Frish, Limor; Cohen, Yoram; Amir, Roey J., Fluorinated Smart Micelles as Enzyme-responsive Probes for 19F-Magnetic Resonance, Journal of Materials Chemistry B (2016), Advance Article DOI: 10.1039/C5TB02445E.

Dr. Roey J. Amir


RESEARCHERS

Research DescriptionOur lab searches for ways to manipulate cells’ functions in order to generate novel strategies for the treatment of inflammatory diseases and cancers. In addition, we develop nanomedicines by designing highly selective targeting moieties and novel nanocarriers. Work at the lab is based on a multidisciplinary approach, which combines immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques. Our ultimate goal is translating some of our findings into drugs and therapeutics for clinical settings.We are particularly interested in:• Developing novel strategies for targeted drug

delivery• Probing and manipulating the immune system

with nanomaterials• Developing non-invasive theranostic systems for

inflammatory bowel diseases and blood cancer• Studying the role of cell cycle regulators during

inflammatory bowel diseases and blood cancers• Investigating novel cancer multidrug resistance

inhibitors• Studying novel approaches to target adult stem

cells (hematopoietic, bulge, cancer)• Harnessing RNAi as a tool for drug discovery and

therapeutic applications• Developing tools to study immuno-nanotoxicity• Investigating polysaccharides as building blocks

for nanotherapeutics



Web: http://www3.tau.ac.il/danpeer/

Research TitleNanomedicine

Selected Publications:1. S. Weinstein, I.A. Toker, R. Emmanuel, S. Ramishetti, I. Hazan-Halevy,

D. Rosenblum, M. Goldsmith, A. Abrahamc, O. Benjamini, O. Bairey, P. Raanani, A. Nagler, J. Liebermane,and D. Peer. (2016) Harnessing RNAi based-nanomedicines for therapeutic gene silencing in B cell malignancies. Proc. Natl. Acad. Sci. USA 113(1) E16-E22.

2. Dearling, J., Daka, A., Veiga, N., Peer, D., and Packard A. (2016) ImmunoPET of colitis: defining target cell populations and optimizing pharmacokinetics. Inflammatory Bowel Diseases. 22(3):529-538.

3. Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Speague AG., Godin B., Gozin M., Cullis P., Dykxhoorn DM., and Peer D (2015) Systemic Gene Silencing in Primary T lymphocytes using Targeted Lipid Nanoparticles. ACS Nano.

4. Cohen ZR, Ramishetti S, Peshes-Yaloz N, Goldsmith M, Wohl A, Zibly Z, and Peer D (2015). Localized RNAi Therapeutics of Chemo-Resistant Grade IV Glioma using Hyaluronan-Grafted Lipid-Based Nanoparticles. ACS Nano. 9(2), 1581-1591.

5. Singh M.S., Peer D. (2016) RNA nanomedicines: the next generation drugs? Current Opinion in Biotechnology 28-34.

Prof. Dan Peer


RESEARCHERS

Research DescriptionOur research focuses on the field of nanomedicine and angiogenesis (cancer and vascular biology). We have major expertise in tumor biology, tumor dormancy, angiogenesis, molecular imaging, non-invasive intravital imaging of animal models and personalized nanomedicines for cancer theranostics (therapy and diagnostics). Throughout our work we have maintained an interest in understanding the biological rationale for the design of nanomedicines suitable for transfer to clinical testing. Our multidisciplinary laboratory focuses on basic research elucidating the mechanisms underlying the switch from dormancy, leading to the discovery of new molecular targets interrupting tumor-host interactions. This research is followed by the design of highly-selective targeting molecules integrating biology, chemistry, protein engineering, molecular imaging, computational approaches, material sciences and nanotechnology, to selectively guide drugs into pathological sites.


Tel: 972-3-6407427


Web: http://medicine.mytau.org/satchi-fainaro/

Research TitleCancer angiogenesis and nanomedicine research

Selected Publications:1. Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek

P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R and Satchi-Fainaro R, Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes, ACS Nano 10(2): 2028-2045 (2016).

2. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501.

3. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501.

4. Fisusi FA, SiewPHARMACEUTICAL_Cover A, Chooi KW, Okubanjo O, Garrett N, Lalatsa K, Serrano D, Summers I, Moger J, Stapleton P, Satchi-Fainaro R, Schätzlein AG, Uchegbu IF, Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels – A Strategy for Brain Cancer Treatments, Pharmaceutical Research 33(5):1289-1303 (2016).

5. Redy-Keisar O, Ferber S, Satchi-Fainaro R, Shabat D. NIR Fluorogenic Dye as a Modular Platform for Prodrug Assembly: Real-Time in vivo Monitoring of Drug Release. ChemMedChem. 2015 10(6):999-1007.

Prof. Ronit Satchi-Fainaro


RESEARCHERS

Research DescriptionThe long-term goal of our study is to understand cellular, molecular and network-wide mechanisms underlying the transition from normal brain physiology to Alzheimer’s disease (AD) pathology. Utilizing an integrated system that combines FRET spectroscopy / 2photon-FLIM, high-resolution optical imaging, electrophysiology, molecular biology and biochemistry, we explore the casual relationships between ongoing neuronal activity, structural rearrangements within synaptic signaling complexes and plasticity of individual neurons, and the whole neural network. This integrated system has enabled us to identify new principles and novel molecular targets that critically influence synaptic and memory functions, initiating AD-associated synaptic dysfunctions. Specifically, we have identified hyperactivity of excitatory hippocampal synapses as a primary mechanism initiating synaptic dysfunctions, and have also found the mechanism underlying these synaptic changes. We believe that the integrated system we have developed to measure structure-function relationships at the single synapse level may contribute to a better understanding of the initiation of AD-related neuronal and synaptic dysfunctions, ultimately leading to a new therapeutic approach by reversing hippocampal hyperactivity in Alzheimer’s patients.



Web: http://www.slutskylab.com/

Research TitleNeuronal plasticty

Selected Publications:1. Gazit, N., Vertkin, I., Shapira, I., Helm, M., Slomowitz, E., Sheiba, M.,

Mor, Y., Rizzoli, S., and Slutsky, I. (2016) IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses, Neuron 89, 583-597.

2. Frere, S. and Slutsky, I. (2016) Targeting PTEN interactions for Alzheimers disease, Nature Neuroscience 19, 416-418.

3. Vertkin, I., Styr, B., Slomowitz, E., Ofir, N., Shapira, I., Berner, D., Fedorova, T., Laviv, T., Barak-Broner, N., Greitzer-Antes, D., Gassmann, M., Bettler, B., Lotan, I., and Slutsky, I. (2015) GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks, Proc Natl Acad Sci U S A 112, E3291-3299.

4. Slomowitz, E., Styr, B., Vertkin, I., Milshtein-Parush, H., Nelken, I., Slutsky, M., Slutsky, I. (2015). Interplay between population firing stability and single neuron dynamics in hippocampal networks. Elife 4.

Prof. Inna Slutsky


RESEARCHERS

Research DescriptionOur group applies three lipid-based particulate drug carriers for theranostics of major pathology classes - all invented and developed ‘in-house’. Four such projects are currently running at the lab, and each project includes three stages: (i) Formulation studies – making the drug-carrier systems and characterizing them through structural and physicochemical studies; (ii) In vitro studies in cultures of the relevant target and control cell lines, pursuing safety and retention of therapeutic activity of the carrier-encapsulated drug; and (iii) In vivo studies in appropriate animal models, pursuing safety and efficacy. Our current projects include: 1) Inhalational treatment of respiratory damage by aerosols of hyaluronan-liposomes encapsulating anti-inflammatory and anti-oxidant drugs - a single drug or both in the same liposome. This is currently at the in vivo stage, evaluating safety and efficacy in a mouse model for acute lung inflammation. 2) Theranostics of heart inflammation (post myocardial infarction) by macrophage-targeted liposomes encapsulating iron nanoparticles, iron complexes or steroids. This project, conducted in collaboration with Prof. J. Leor from TAU’s Faculty of Medicine, is currently at the in vitro and in vivo stages. 3) Cancer theranostics, directed at both the cancer cells and the tumor-associated macrophages, by hyaluronan-liposomes encapsulating iron complexes. This study, also in collaboration with Prof. J. Leor, is now at the in vitro and in vivo stages. 4) Treatment of osteoarthritis via local injection, by a collagen-based carrier encapsulating anti-inflammatory drugs. This is in the initial stage of formulation studies.



Web: none

Research TitleBiomaterial-based targeted carriers for theranostics of cancer and inflammation

Selected Publications:1. Ben-Mordechai T, Palevsky D, Glucksam-Galnoy Y, Elron-Gross I,

Margalit R, Leor J (2015) Targeting Macrophage Subsets for Infarct Repair. 2015). Targeting Macrophage Subsets for Infarct Repair. Journal of Cardiovascular Pharmacology and Therapeutics 20, 36-51.

2. Ilia Rivkin, Yifat Galnoy-Glucksam, Inbar Elron-Gross, Amichay Afriat, Arik Eisenkraft, Rimona Margalit (2016) Treatment of respiratory damage in mice by aerosols of drug-encapsulating targeted lipid-based particles. Journal of Cont. Rel. in publication, on line April 2016

3. Rimona Margalit and Dan Peer (2016). Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy. US patent # 9,259,474

Prof. Rimona Margalit


RESEARCHERS

Research DescriptionThe work in our group focuses on the molecular self-assembly of biological, bio-inspired and other organic building blocks, a key process in chemistry and biochemistry. We apply a minimalistic approach to define the smallest molecular recognition and assembly modules, and understand the physicochemical basis for their association. We study the organization of biological systems in diverse fields, including amyloid diseases such as Alzheimer’s disease and Parkinson’s disease, diabetes, viral diseases and metabolic disorders. We have identified the ability of very short peptides, as well as metabolites, to form typical amyloidal nano-fibrils. Our study of minimal recognition modules has led to the discovery of a family of dipeptide nanostructures of various architectures, including nanotubes, nanospheres, nanoplates and hydrogel, with nanoscale order and unique mechanical, optical, piezoelectric and semiconductive properties. These various assemblies form from remarkably simple building blocks that can potentially be synthesized in large quantities at a low cost. We demonstrated how these peptide nanostructures can be used as casting molds for the fabrication of metallic nano-wires and coaxial nanocables. We used inkjet technology as well as vapor deposition methods to coat surfaces and form peptide “nano-forests” in a highly controlled manner. We are currently employing microfluidic techniques to enable the formation of assembled products with specific size distribution, while controlling the assembly kinetics. We recently extended our studies to peptide nucleic acids (PNA), thereby converging the fields of peptide nanotechnology and DNA nanotechnology.

Affiliation: Molecular Microbiology and Biotechnology Department


Web: https://en-lifesci.tau.ac.il/profile/ehudg

Research TitleMolecular self-assembly of biological, bio-inspired and other organic building blocks

Selected Publications:1. Fichman, G., Guterman, T., Damron, J., Adler-Abramovich, L., Schmidt,

J., Kesselman, E., Shimon, L.J., Ramamoorthy, A., Talmon, Y., Gazit, E. (2016). Spontaneous structural transition and crystal formation in minimal supramolecular polymer model. Science Adv. 2, e1500827.

2. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A., Liebes-Peer, Y., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, V.T., Schwartz, T., Ebenstein, Y., Frolow, F., Shimon, L.J.W., Patolsky, F., Gazit, E. (2015). Light-Emitting Self-Assembled Peptide Nucleic Acids Exhibit Both Stacking Interactions And Watson-Crick Base Pairing. Nature Nanotech. 10, 353-360.

3. Mondal, S., Adler-Abramovich, L., Lampel, A., Bram, Y., Lipstman, S., Gazit, E. (2015). Formation Of Functional Super-Helical Assemblies By Constrained Single Heptad Repeat. Nature Commun. 6, 8615.

4. Levin, A., Mason, T.O., Adler-Abramovich, L., Buell, A.K., Meisl, G., Galvagnion, C., Bram, Y., Stratford, S.A., Dobson, C.M., Knowles, T.P.J., Gazit, E. (2014). Ostwald’S Rule Of Stages Governs Structural Transitions And Morphology Of Dipeptide Supramole.

5. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Magno, A., Caflisch, A., Frenkel, D., Gazit, E. (2012). Phenylalanine Assembly Into Toxic Fibrils Suggests Amyloid Etiology In Phenylketonuria. Nature Chem. Biol. 8, 701-706.

Prof. Ehud Gazit


RESEARCHERS

Research DescriptionWe study the fundamentals of the interaction between light and matter at the nanoscale, in order to gain a better understanding of the underlying physical mechanisms of this interaction, and use it to develop the next generation of optical and electro-optical devices. Our research involves: extensive fabrication and design of novel nanostructured materials for optical and electro-optical applications; characterization of the interaction of these materials with laser beams and incoherent light; and the development of relevant analytical or numerical models and simulations. The lab’s active lines of research and development currently include: stimulated emission effects in nano-complexes; emission control and synchronization for optical computing and lab-on-a-chip applications; nonlinear plasmonic metamaterials for optical wave mixing applications; hybrid light-matter excitations based on strongly coupled exciton-plasmon-polaritons and waveguide-exciton-polaritons as means for developing all-optical and electro-optical switches, coherent light sources and optical amplifiers; optical elements based on metamaterials and nano-antennas for consumer electronics and imaging devices; and new structured surfaces for interferometric microscopy.



Web: http://www.eng.tau.ac.il/~tal/neolab/

Research TitleNanoscale light-matter interaction

Selected Publications:1. N. Segal, S. Keren-Zur, N. Hendler, T. Ellenbogen, Controlling light with

metamaterial-based nonlinear photonic crystals, Nature Photonics 9, 180-184(2015).

2. E. Eizner, O. Avayu, R. Ditcovski, T. Ellenbogen, Aluminum Nanoantenna Complexes for Strong Coupling between Excitons and Localized Surface Plasmons, Nano Letters 15, 6215-6221(2015).

3. O. Avayu, O. Eisenbach, R. Ditcovski and T. Ellenbogen, Optical Metasurfaces for Polarization Controlled Beam Shaping, Optics Letters 39, 3892-3895 (2014).

4. Marcel Rey, Roey Elnathan, Ran Ditcovski, Karen Geisel, Michele Zanini, Miguel A Fernandez-Rodriguez, Vikrant V. Naik, Andreas Frutiger, Walter Richtering, Tal Ellenbogen, Nicolas H. Voelcker, and Lucio Isa, Fully Tunable Silicon Nanowire Arrays by Soft

5. Shay Keren-Zur, Ori Avayu, Lior Michaeli, and Tal Ellenbogen Nonlinear beam shaping with plasmonic metasurfaces, ACS Photonics 3, 117-123 (2016).

Dr. Tal Ellenbogen


RESEARCHERS

Research DescriptionNano-Photonics deals with the interaction of light and matter at the nanoscale. This research field is of fundamental scientific importance, while also providing a main route to novel technologies and applications - such as sensing, solar energy harvesting, telecommunications and optical computing. Specifically in our lab we focus on the development of nano-antennas for optical frequencies, which have applications in many different areas: solar energy harvesting, controlled self-assembly and beam shaping, nano semiconductor lasers for sensing and telecommunications, and secure communications using fiber lasers and polymer optics.



Web: www.eng.tau.ac.il/~kobys/

Research TitleNano-photonic devices and applications

Selected Publications:1. G. Kaplan, K. Aydin and J. Scheuer, Dynamically controlled plasmonic

nano-antenna phased array utilizing vanadium dioxide, Opt. Mater. Express 5, 2513-2524 (2015). (Invited).

2. E. Ben Bassat and J. Scheuer, Optimal design of radial Bragg cavities and lasers, Opt. Lett. 40, 3069-3072 (2015).

3. M. Eitan, Z. Iluz, Y. Yifat, A. Boag, Y. Hanein, and J. Scheuer, Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing, ACS Photon. 2, 615−621 (2015).

4. D. Bar-Lev, A. Arie, J. Scheuer, and I. Epstein, Efficient excitation and control of arbitrary surface plasmon polariton beams using one-dimensional metallic gratings, J. Opt. Soc. Am. B 32, 923-932 (2015).

5. J. Scheuer and Y. Yifat, Metasurfaces make it practical, Nature Nanotech. 10, 296-298 (2015).

Prof. Jacob Scheuer


RESEARCHERS

Research DescriptionRecent progress in the fabrication of artificial structures at the nanometer scale enable us to transform the established knowledge from light optics into electron beams. The transmission electron microscope contains the required optical element. However, the commercial systems are constructed for microscopy. Accordingly, it is necessary to modify the operation of the microscope via various methods, e.g. free lens control.



Web: http://www.eng.tau.ac.il/~lereah/

Research TitleApplication of TEM in quantum mechanics

Selected Publications:1. Noa Voloch-Bloch, Yossi Lereah, Yigal Lilach, Avraham Gover and Ady

Arie Generation of electron Airy beams, Nature, 494 331-335,(2013).2. A. Be’er, R. Kofman, F. Phillipp and Y. Lereah, Spontaneous

crystallographic instabilities of Pb nanoparticles in a SiO matrix, Physical Review B 76 075410 (2007).

3. Y. Lereah, R. Kofman, J.M. Penisson, G. Deutscher, P. Cheyssac, T. Ben David and A. Bourret, Time Resolved Electron Microscopy Studies of the Structure of Nanoparticles and Their Melting, Philosophical Magazine (invited paper), 81, 1801 (2001).

4. Y. Lereah, Pattern Formation and Interface Propagation in the Crystallization of Amorphous Alloys, Current Topics in Crystal Growth 7, 59 (2004). Invited paper.

5. Y. Lereah, E. Grunbaum and G. Deutscher, Formation of Dense Branching Morphology in the Crystallization of Al:Ge Amorphous Thin Films. Physical Review A 44 8316 (1991).

Dr. Yossi Lereah


RESEARCHERS

Research DescriptionOur group is interested in theoretical and experimental research in various areas of physical optics. One of our major areas of research is the generation of coherent light sources at very high photon energies (soft X-rays). For this we employ the extreme nonlinear optical process of high-harmonic-generation (HHG). HHG is driven with an intense ultra-short light pulse which ionizes a gaseous medium. The liberated electron then oscillates in the laser field, gaining kinetic energy. There is a small chance that the electron will encounter the ion from which it has been liberated and recombine with it. The excessive kinetic energy gained by the electron is released in the form of a high energy photon. During such a process hundreds of photons in the laser field can be converted into a single high-energy photon. We are interested in mediating this process by employing Plasmon-assisted field enhancement. When the laser light interacts with a metallic nanostructure, electron oscillations on the metal surface can lead to a significant field enhancement. This can be utilized to assist with the process of HHG. In addition, the geometry of the metallic nanostructure can be used to control the beam shape and polarization state of the generated high harmonic radiation.



Web: http://www.eng.tau.ac.il/~alonb/

Research TitlePhysical optics

Selected Publications:1. Itai Hadas and Alon Bahabad, Macroscopic manipulation of high-

harmonic-generation through bound-state coherent control, Physical Review Letters, 113, 253902 (2014).

2. Yaniv Eliezer and Alon Bahabad, Super-transmission: The delivery of superoscillations through the absorbing resonance of a dielectric medium, Optics Express, 22, 31212-31226 (2014).

3. Mor Konsens and Alon Bahabad, Time-to-frequency mapping of optical pulses using accelerating quasi-phase-matching, Physical Review A, 93, 023823 (2016).

4. Alon Bahabad, Margaret M. Murnane and Henry C. Kapteyn, Quasi Phase Matching of Momentum and Energy in Nonlinear Optical Processes, Nature Photonics, 4, 570-575 (2010).

5. Ron Lifshitz, Ady Arie and Alon Bahabad, Photonic quasicrystals for general purposes nonlinear optical frequency conversion, Physical Review Letters, 95, Issue 13, 133901 (2005).

Dr. Alon Bahabad


RESEARCHERS

Research DescriptionThe research in our group focuses on the followings:1. Magneto-transport and magneto-optics in metal-dielectric composite media, when the Hall resistivity in the metallic constituent is greater than the Ohmic resistivity2. Nano-plasmonics in such a medium 3. Macroscopic physical phenomena in social wasps: the exploitation of thermoelectric cooling to regulate the body temperature of the Oriental Hornet; the exploitation of ultrasonic acoustic resonances by worker hornets and worker bees in the construction of highly symmetric combs in a hornets’ nest or beehive



Web: http://www2.tau.ac.il/nano/researcher.asp?id=abddjgchk

Research TitlePhysical phenomena in composite media

Selected Publications:1. D. J. Bergman, Perfect imaging of a point charge in the quasistatic

regime, Phys. Rev. A 89, 015801 (4 pp.) (2014).2. D. J. Bergman and Y. M. Strelniker, Strong-field magneto-transport

in a two-constituent columnar composite medium where the constituents have comparable resistivity tensors, Phys. Rev. B 86, 024414 (14 pp.) (2012).

3. M. Tornow, D. Weiss, K. von Klitzing, K. Eberl, D. J. Bergman, and Y. M. Strelniker, Anisotropic Magnetoresistance of a Classical antidot array, Phys. Rev. Lett. 77, 147{150 (1996).

4. D. J. Bergman and J. S. Ishay, Do Bees and Hornets Use Acoustic Resonance in Order to Monitor and Coordinate Comb Construction? Bulletin of Mathematical Biology 69(5), 1777, 1790 (2007).

5. D. J. Bergman and M. I. Stockman, Surface plasmon amplication by stimulated emission of radiation: Quantum generation of coherent surface plasmons in Nanosystems, Phys. Rev. Letters 90, 027402-1, 027402-4 (2003).

Prof. David J. Bergman


RESEARCHERS

Research DescriptionOur group is active in several areas of research: nonlinear optics, plasmonics and electron beam shaping. In nonlinear optics, we mainly concentrate on quadratic nonlinear processes in ferroelectric crystals. The ability to modulate the quadratic nonlinear coefficient is used for shaping the spatial and spectral response of the nonlinear crystal. In plasmonics, our efforts in recent years have focused on generating special types of plasmonic beams. To this end, we have developed special types of couplers between free-space light beams and plasmonic beams, applying concepts and coding schemes developed in the field of holography. In electron beam shaping, we utilize a recent technological breakthrough, enabling us to shape the phase and amplitude of electron beams by passing them through a thin SiN membrane, patterned by focused ion beam milling.



Web: http://www.eng.tau.ac.il/~ady/

Research TitleNonlinear optics, plasmonics, electron microscopy

Selected Publications:1. Voloch-Bloch N., Lereah Y., Lilach Y., Gover A. and Arie A. (2013).

Generation of electron Airy beams, Nature 494, 331-335 .2. Suchowski H., Porat G. and Arie A. (2014). Adiabatic processes in

frequency conversion, Lasers and Photonics Reviews 8, 333-3673. Epstein I. and Arie A. (2014). Arbitrary Bending Plasmonic Light

Waves, Physical Review Letters 112, 023903.4. Remez R. and Arie A. (2015). Super-narrow frequency conversion,

Optica 2, 472-475 .5. Shapira A., Naor L. and Arie A., (2015). Nonlinear optical holograms

for spatial and spectral shaping of light waves, Science Bulletin 60, 1403-1415.

Prof. Ady Arie


RESEARCHERS

Research DescriptionThe dramatic increase in worldwide demand for electrical power makes it clear that the development of clean, renewable alternative energy sources is essential, with solar power harvesting as the leading direction. The basic properties of conventional photovoltaic solar cells are determined by their materials’ chemistry and the corresponding electronic properties. As a result, such solar cells have inherent and fundamental limitations in terms of optical bandwidth, efficiency and cost. On the other hand, power harvesting utilizing RF approaches has demonstrated high efficiency (exceeding 85%) in the radio-frequency spectral range, as well as low fabrication costs. The objective of our research is to develop new detection and power conversion schemes for optical frequencies, based on metallic rectifying nano-antennas (rectennas). A nano-rectenna includes two fundamental elements: an antenna and a rectifier. The antenna receives the EM wave and converts it into an alternating electric current (AC). The rectifier converts the AC current into a direct current (DC). We have demonstrated the ability to design, optimize and fabricate ultra-wideband nano-antenna arrays. We have measured the spectral properties of the scattered field from these antennas, and shown very good agreement with numerical simulations. We have also demonstrated preliminary success in integrating the nano-antennas with the rectifiers. We now intend to utilize these abilities to develop a new concept for solar-power harvesting, which can revolutionize the field by providing an inexpensive and efficient approach for direct EM to DC power conversion.



Web: https://www.eng.tau.ac.il/~boag/

Research TitleRectifying nano-antennas

Selected Publications:1. Z. Iluz and A. Boag, Dual-Vivaldi wide band nano-antenna with

high radiation efficiency over the infrared frequency band, Optics Letters, vol. 36, no 15, pp. 2773-2775, 2011.

2. E. Strassburg, A. Boag, Y. Rosenwaks, Reconstruction of Electrostatic Force Microscopy Images, Review of Scientific Instruments, vol.76, 083705, 28 July 2005.

3. Y. Yifat, Z. Iluz, D. Bar-Lev, M. Eitan, Y. Hanein, A. Boag, and J. Scheuer, High load-sensitivity in wideband infrared dual-Vivaldi nanoantennas, Optics Letters, vol. 38, no. 2, pp. 205–207, 2013.

4. Y. Yifat, M. Eitan, Z. Iluz, Y. Hanein, A. Boag, and J. Scheuer, Highly efficient and broadband Wide-Angle Holography Using Patch-Dipole Nano-antenna Reflectarrays, Nano Letters, March 19, 2014.

5. G. Y. Slepyan and A. Boag, Quantum non-reciprocity of nanoscale antenna arrays in timed Dicke states, Physical Review Letters, vol. 111, 023602, 11 July, 2013.

Prof. Amir Boag


RESEARCHERS

Research DescriptionMy research involves the theoretical (both analytical and numerical) study of low-dimensional/nanoscale electronic and photonic systems, in and out of equilibrium. Nanoscale systems are immensely important as the basic building blocks of future electronic devices, which may lead, among other potential applications, to the eventual realization of scalable quantum computing. They can be fabricated using a variety of materials, including semiconductor heterostructures, metallic nanowires and nanograins (normal or superconducting), carbon-based materials (graphene, nanotubes and buckyballs), the recently discovered topological insulators, and conducting polymers and single molecules. Their behavior can also be simulated with ultracold atoms in optical traps. Not less importantly, from a more fundamental perspective, nanoscale systems exhibit a variety of phenomena caused by strong electronic correlations, as well as their interplay with quantum interference effects and nonequilibrium behavior, all of which are central themes in current condensed matter research.



Web: http://www6.tau.ac.il/mgoldstein/

Research TitleTheory of low-dimensional nanoscale electronic and photonic systems

Selected Publications:1. J. I. Väyrynen, M. Goldstein, Y. Gefen, and L. I. Glazman, Resistance

of helical edges formed in a semiconductor heterostructure, Phys. Rev. B. 90, 115309 (2014), Editors’ Suggestion.

2. M. Goldstein, M. H. Devoret, M. Houzet, and L. I. Glazman, Inelastic microwave photon scattering off a quantum impurity in a Josephson-junction array”, Phys. Rev. Lett. 110, 017002 (2013).

3. B. Bradlyn, M. Goldstein, and N. Read, “Kubo formulas for viscosity: Hall viscosity, Ward identities, and the relation with conductivity, Phys. Rev. B 86, 245309 (2012), Editors’ Suggestion.

4. M. Goldstein, R. Berkovits, and Y. Gefen, Population switching and charge sensing in quantum dots: A case for a quantum phase transition, Phys. Rev. Lett. 104, 226805 (2010).

5. M. Goldstein and R. Berkovits, Duality between different geometries of a resonant level in a Luttinger liquid, Phys. Rev. Lett. 104, 106403 (2010).

Dr. Moshe Goldstein


RESEARCHERS

Research DescriptionRecent developments in thin-film fabrication techniques have enabled the deposition of newly designed and well controlled oxide interfaces. These interfaces can have properties which are significantly different from their constituent materials. Correlated electrons in oxide interfaces result in a variety of properties, such as metal-insulator transition, superconductivity and magnetism, and these phase transitions can be tuned by external stimuli such as electric and magnetic fields and pressure. The ability to tune the phase transitions makes these interfaces particularly interesting - both from the perspective of basic science, and as potential components for future electronic devices. Of particular interest are new interfaces that can be used in future applications, such as spin-controlled electronics (spintronics) and quantum computation. Other fascinating examples are interfaces where multiple orders may coexist, such as: superconductivity coexisting with magnetism, which can result in an exotic symmetry of the superconducting order-parameter, and ferromagnetism coexisting with ferroelectricity. Interface design has been proven successful in enhancing macroscopic orders, e.g. superconductivity, ferroelectricity and combining orders. Our challenge is to master these interfaces, understand them and use them as a platform for observation of exotic physical phenomena, as well as for new applications.



Web: http://minerva.tau.ac.il/dagan/index.html

Research TitleEmergent phenomena at surfaces and interfaces

Selected Publications:1. M. Ben Shalom, M. Sachs, D. Rakhmilevitch, A. Palevski and Y. Dagan,

Tuning spin-orbit coupling and superconductivity at the SrTiO3/LaAlO3 interface: a magneto-transport study, Phys. Rev. Lett. 104, 126802 (2010).

2. A. Ron and Y. Dagan, One-dimensional quantum wire formed at the boundary between two insulating LaAlO3/SrTiO3 interfaces, Phys. Rev. Lett. 112, 136801 (2014).

3. E. Lahoud, E. Maniv, M. Shaviv, M. Naamneh, A. Ribak, S. Wiedmann, L. Petaccia, Z. Salman, K. B. Chashka, Y. Dagan, A. Kanigel, Evolution of the Fermi surface of doped topological insulator with carrier concentration, Phys. Rev. B 88, 195107 (2013).

4. Itai Carmeli et al. and Yoram Dagan, Tuning the Critical Temperature of Cuprate Superconductor Films with Self‐Assembled Organic Layers, Angewandte Chemie International Edition, 51, 7162 (2012).

5. E. Maniv, M. Ben Shalom, A. Ron, M. Goldstein, A. Palevski, and Y. Dagan, Strong correlations elucidate the electronic structure and phase-diagram of LaAlO3/SrTiO3 interface , Nature Communications 6, 8239 (2015).

Prof. Yoram Dagan


RESEARCHERS

Research DescriptionSpintronics is an emerging field of basic and applied research in physics and engineering, in which the electron’s magnetic degree of freedom - its spin - may be exploited for classical and quantum information processing. Carrying information in both the charge and spin of an electron potentially enables devices with greater functional diversity.Our research focuses mainly on the spin-dependent Hall effect in a variety of artificial nanoscale materials, and on its application in a new generation of magnetic sensors, magnetic random access memories and logic devices.



Web: N/A

Research TitleHall effect spintronics

Selected Publications:1. Milner A., Gerber A., Karpovsky M. and Gladkikh A. (1996). Spin -

Dependent Electronic Transport in Granular Ferromagnets. Phys. Rev. Lett. 76, 475 - 478.

2. Gerber A. (2007). Towards Hall Effect Spintronics. Jour. Magn. Magn. Matt., 310, 2749.

3. Segal A., Gerber A. and Karpovski M. (2011). Sixteen-states magnetic memory based on the extraordinary Hall effect. J. Magn.Magn.Matt. 324, 1557.

4. Simons A., Gerber A., Korenblit I.Ya., Suslov A., Raquet B., Passacantando M., Ottaviano L., Impellizzeri G., Aronzon B. (2014). Components of strong magnetoresistance in Mn implanted Ge. J. Appl. Phys. 115, 093703

5. Winer G., Segal A., Karpovski M., Shelukhin V., and Gerber A. (2015). Probing Co/Pd interfacial alloying by the extraordinary Hall effect. J. Appl. Phys. 118, 173901.

Prof. Alexander Gerber


RESEARCHERS

Research DescriptionOur group investigates nonequilibrium phenomena in chemical and condensed matter physics. We try to understand how strongly correlated quantum systems react to dissipative environments and to external perturbations, particularly in the context of the transport properties of nanosystems. This is a deeply challenging and fundamental problem, and we therefore work on state-of-the-art computational methods such as quantum Monte Carlo algorithms. We focus on methods for circumventing the dynamical sign problem, a phenomenon which usually prevents Monte Carlo methods from accessing nonequilibrium physics and dynamics.



Web: www.tau.ac.il/~gcohen/

Research TitleComputational methods for nonequilibrium quantum many-body systems

Selected Publications:1. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., 2015. Taming the

dynamical sign problem in real-time evolution of quantum many-body problems. Phys. Rev. Lett. 115, 266802 .

2. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., 2014. Green’s Functions from Real-Time Bold-Line Monte Carlo Calculations: Spectral Properties of the Nonequilibrium Anderson Impurity Model. Phys. Rev. Lett. 112, 146802.

3. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., Rabani, E., 2013. Numerically exact long-time magnetization dynamics at the nonequilibrium Kondo crossover of the Anderson impurity model. Phys. Rev. B 87, 195108.

4. Cohen, G., Rabani, E., 2011. Memory effects in nonequilibrium quantum impurity models. Phys. Rev. B 84, 075150

5. Mocatta, D., Cohen, G., Schattner, J., Millo, O., Rabani, E., Banin, U., 2011. Heavily Doped Semiconductor Nanocrystal Quantum Dots. Science 332, 77 –81

Dr. Guy Cohen

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RESEARCHERS

Research DescriptionOur research involves quantum electronic transport in condensed matter systems at low temperatures. Topics are quite diverse, spanning many areas of modern solid state physics: superconductivity, ferromagnetism, the Quantum Hall effect and mesoscopic physics. Due to the diversity of subjects, the materials investigated also cover a broad range of solids: normal metals, ferromagnets, semiconductors, topological insulators and superconductors. The common denominator of the devices made of these material systems at our lab is low dimensionality - a vast majority of the experimentally studied electronic systems are either two- or one-dimensional. The low dimensions of the devices fabricated in the lab are achieved via state-of-the-art nanofabrication techniques, including photolithography, electron beam lithography, focused ion beam microscopy and more. In recent years research at the lab has focused mainly on the following topics: (1) Mesoscopic phenomena and superconductivity in two-dimensional electron gas formed at the interface between the two large gap insulators SrTiO3/LaAlO3 and in topological insulators BiSe3. Quantum interference effects were observed and analyzed, allowing us to establish the dephasing mechanism in these exotic systems. (2) The electronic correlations in InAs and GaAs semiconductor nanowires. The role of the electron-electron interaction was elucidated, and the so-called Luttinger liquid model was demonstrated as the adequate theory for transport in quantum nanowires. (3) Spin-orbit interaction and its effect on quantum transport in nanowires, and the role played in quantum interference phenomena in Aharonov Bohm rings. Currently we are studying the effect of the spin orbit interaction on Luttinger parameter on Berry phase in these systems.



Web: http://www.tau.ac.il/~apalev/

Research TitleQuantum electronic transport in low dimensional systems

Selected Publications:1. R. Hevroni, V. Shelukhin, M. Karpovski, M. Goldstein, E. Sela, Hadas

Shtrikman and A. Palevski (2016). Suppression of Coulomb blockade peaks by electronic correlations in InAs nanowires, Phys. Rev. B 93, 035305.

2. E. Maniv, M. Ben Shalom, A. Ron, M. Mograbi, A. Palevski, M. Goldstein, and Y. Dagan (2015). Strong correlations elucidate the electronic phase-diagram of LaAlO3/SrTiO3 interface, Nature Communications, 6, 8239.

3. Qi I. Yang, Merav Dolev, Li Zhang, Jinfeng Zhao, Alexander D. Fried, Elizabeth Schemm, Min Liu, Alexander Palevski, Ann F. Marshall, Subhash H. Risbud, and Aharon Kapitulnik (2013). Emerging weak localization effects on a topological insulator–insulating ferromagnet (Bi2Se3-EuS) interface.Phys. Rev. B 88, 081407(R).

4. Nicholas P. Breznay, Hanno Volker, Alexander Palevski, Riccardo Mazzarello, Aharon Kapitulnik, and Matthias Wuttig (2012). Weak antilocalization and disorder-enhanced electron interactions in annealed films of the phase-change compound GeSb2Te4. Phys.Rev. 73.

5. I. Sternfeld, E. Levy, M. Eshkol, A. Tsukernik, M. Karpovski, Hadas Shtrikman, A. Kretinin, and A. Palevski, (2011). Magnetoresistance Oscillations of Superconducting Al-Film Cylinders Covering InAs Nanowires below the Quantum Critical Point, Phys. Rev. Lett

Prof. Alexander Palevski


RESEARCHERS

Research DescriptionSelf-assembled nanostructures are interesting from the structural-morphological standpoint, and also due to their unusual physical properties. In my laboratory we explore the self-assembled formation and mesoscopic ordering mechanisms of epitaxial nano-island arrays on surfaces, primarily with the aid of a time-resolved scanning tunneling microscope (STM), and the way these growth mechanisms affect the resulting physical properties. For example, we have recently found that some metal-silicon compounds which are non-magnetic in their bulk form, can exhibit interesting magnetic properties when grown as self-ordered nano-islands, and that these properties can be further tuned by controlling the size and geometry of the nano-island arrays.


Tel: 972-3-6407079


Web: http://www.eng.tau.ac.il/~ilang

Research TitleEpitaxial nanostructures

Selected Publications:1. I. Goldfarb, D. A. A. Ohlberg, J. P. Strachan, M. D. Pickett, J. J. Yang,

G. Medeiros-Ribeiro, R. S. Williams, Band offsets in transition-metal oxide heterostructures, J. Phys. D - Appl. Phys. 46, 295303 (2013).

2. J.K. Tripathi, G. Markovich, I. Goldfarb, Self-Ordered Magnetic α-FeSi2 Nano-Stripes on Si(111), Appl. Phys. Lett. 102, 251604 (2013).

3. G. Cohen-Taguri, O. Sinkevich, M. Levinshtein, A. Ruzin, and I. Goldfarb, Atomic structure and electrical properties of In(Te) nano-contacts on CdZnTe(110) by scanning probe microscopy, Adv. Funct. Mater. 20(2) 215-223 (2010).

4. I. Goldfarb, Step-mediated size-selection and ordering of heteroepitaxial nanocrystals, Nanotechnology 18, 335304 (2007).

5. I. Goldfarb, Effect of strain on the appearance of subcritical nuclei of Ge nanohuts on Si(001), Phys. Rev. Lett. 95, 025501-4 (2005).

Prof. Ilan Goldfarb

PUBLICATIONS


1. Nurit Atar, Eitan Grossman, Irina Gouzman, Asaf Bolker, Vanessa J. Murray, Brooks C. Marshall, Min Qian, Timothy K. Minton, Yael Hanein, Atomic Oxygen Durable and Electrically-Conductive CNT POSS Polyimide Flexible Films for Space Applications, ACS Appl. Mater. Interfaces,5b02200,DOI:10.1021/acsami., (2015).

2. Nurit Atar, Eitan Grossman, Irina Gouzman, Asaf Bolker, and Yael Hanein, Reinforced Carbon Nanotubes as Electrically Conducting and Flexible Films for Space Applications, ACS Appl. Mater. Interfaces,505811g,DOI: 10.1021/am, (2014).

3. Ariel J. Ben-Sasson, Daniel Azulai, Hagit Gilon, Antonio Facchetti, Gil Markovich, Nir Tessler,Self-Assembled Metallic Nanowire-Based Vertical Organic Field-Effect Transistor, ACS Applied Materials and Interfaces,7,2149–2152, (2015).

4. Ayala Lampel, Yaron Bram, Anat Ezer, Ronit Shaltiel-Kario, Jamil S. Saad, Eran Bacharach, Ehud Gazit,Targeting the Early Step of Building Block Organization in Viral Capsid Assembly, ACS Chemical Biology,10,1785–1790, (2015).

5. Michal Pellach, Yoav Atsmon-Raz, Eyal Simonovsky, Hugo Gottlieb, Guy Jacoby, Roy Beck, Lihi Adler-Abramovich, Yifat Miller, Ehud Gazit,Spontaneous Structural Transition in Phospholipid-Inspired Aromatic Phosphopeptide Nanostructures, ACS nano,9,4085-4095, (2015).

6. Michal Pellach, Yoav Atsmon-Raz, Eyal Simonovsky, Hugo Gottlieb, Guy Jacoby, Roy Beck, Lihi Adler-Abramovich, Yifat Miller, Ehud Gazit,Spontaneous

Structural Transition in Phospholipid-Inspired Aromatic Phosphopeptide Nanostructures, ACS Nano,9,4085–4095, (2015).

7. Ramishetti S.*, Kedmi R.*, Goldsmith M., Leonard F., Speague AG., Godin B., Gozin M., Cullis P., Dykxhoorn DM., and Peer D ,Systemic gene silencing in primary T lymphocytes using targeted lipid nanoparticles., ACS Nano,9(7),6706-6716, (2015).

8. Cohen ZR*, Ramishetti S*, Peshes-Yaloz N*, Goldsmith M, Wohl A, Zibly Z, and Peer D ,Localized RNAi therapeutics of chemo-resistant grade IV glioma using hyaluronan-grafted lipid-based nanoparticles., ACS Nano,9(2),1581-1591, (2015).

9. O. Hazut, B.C. Huang, A. Pantzer, I. Amit, Y. Rosenwaks, A. Kohn, C.-S. Chang, Y.-P. Chiu, and R. Yerushalmi,Parallel p-n Junctions across Nanowires by One-Step Ex Situ Doping, ACS nano,8,8357–8362, (2014).

10. Ramishetti, Srinivas; Kedmi, Ranit; Goldsmith, Meir; Leonard, Fransisca; Sprague, Andrew G.; Godin, Biana; Gozin, Michael; Cullis, Pieter R.; Dykxhoorn, Derek M.; Peer, Dan ,Systemic gene silencing in primary T lymphocytes using targeted lipid nanoparticles., ACS Nano,9(7),6706-6716, (2015).

11. M. Eitan, Z. Iluz, Y. Yifat*, A. Boag, Y. Hanein, and J. Scheuer,Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing, ACS Photonics,2,615−621 , (2015).

12. Michal Eitan , Zeev Iluz , Yuval Yifat , Amir Boag , Yael Hanein , and Jacob Scheuer,Degeneracy breaking of Wood›s anomaly for enhanced refractive index sensing,

ACS Photonics,5b00091,DOI: 10.1021/acsphotonics, (2015).

13. Michal Eitan, Zeev Iluz, Yuval Yifat, Amir Boag, Yael Hanein, and Jacob Scheuer,Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing, ACS Photonics,2 (5) ,615–621, (2015).

14. A. Handelman,B. Apter, N.Turko,Gil Rosenman,Linear and Nonlinear Optical Waveguiding Effects in Bio-inspired Diphenylalanine Peptide Nanotubes, Acta Biomateriala,4,1-8, (2015).

15. G.I. Livshits, J. Ghabboun, N. Borovok, A.B. Kotlyar, D. Porath ,Comparative Electrostatic Force Microscopy of Tetra‐and Intra‐molecular G4‐DNA , Adv. Materials,26,4981-4985, (2014).

16. Dvashi Z, Shalom HJ, Shoat M, Ben-Meir D, Ferber S, Satchi-Fainaro R, Ashery-Padan R, Rosner M, Solomon AS and Lavi S,Protein Phosphatase Magnesium Dependent 1A governs the wound healing-inflammation-angiogenesis cross talk on injury, American Journal of Pathology,184,2396-2950, (2014).

17. Tatyana Polenova, Rupal Gupta, Amir Goldbourt,Magic Angle Spinning NMR Spectroscopy: A Versatile Technique for Structural and Dynamic Analysis of Solid-Phase Systems, Analytical Chemistry,87,5458-5469, (2015).

18. Yaron Bram, Ayala Lampel, Ronit Shaltiel-Karyo, Anat Ezer, Roni Scherzer-Attali, Daniel Segal, Ehud Gazit,Monitoring and Targeting the Initial Dimerization Stage of Amyloid Self-Assembly, Angewandte Chemie International Edition,54,2062–2067, (2015).

Publications


PUBLICATIONS

19. Cyrus R Safinya, Joanna Deek, Roy Beck, Jayna B Jones, Youli Li, Assembly of Biological Nanostructures: Isotropic and Liquid Crystalline Phases of Neurofilament Hydrogels, Annu. Rev. Condens. Matter Phys.,6,113-136, (2015).

20. Alex Henning, Benjamin Klein, Kris A. Bertness, Paul T. Blanchard, Norman A. Sanford, Yossi Rosenwaks,Measurement of the electrostatic edge effect in wurtzite GaN nanowires, Appl. Phys. Lett.,105,213107-9, (2014).

21. D. Permyakov, I. Sinev, D. Markovich, P. Ginzburg, A. Samusev, P. A. Belov, V. Valuckas, A. Kuznetsov, B. Luk’yanchuk, A. Miroshnichenko, D. Neshev, and Y.S. Kivshar, Probing magnetic and electric optical responses of silicon nanoparticles, Appl. Phys. Lett. ,106,171110, (2015).

22. G.Winer, A.Segal, M.Karpovski, V.Shelukhin and A.Gerber,Probing Co/Pd interfacial alloying by the extraordinary Hall effect, Appl.Phys.Lett.,N/A,N/A, (2015).

23. Freeman, A., Dror, Y., Porat, C. O., Hadar, N., & Diamand, Y. S. ,Silver-Coated Biologically Active Protein Hybrids: Antimicrobial Applications, Applied Mechanics and Materials ,749,4, (2015).

24. Ilan Goldfarb, Stanley Williams,Conduction centers in a Ta2O5-delta Fermi glass, Applied Physics A,114,287-289, (2014).

25. S. Krylov, S. Lulinsky, B. R. Ilic, I. Schneider,Collective Dynamics and Pattern Switching in an Array of Parametrically Excited Micro Cantilevers Interacting Through Fringing Electrostatic Fields, Applied Physics Letters,105,71909, (2014).

26. Shahar Shefer, Carlos Gordon, Karen B. Avraham, Matti Mintz, Balance deficit enhances anxiety and balance training decreases anxiety in vestibular mutant mice, Behav. Brain Res.,276,76-83, (2015).

27. Gal Herzog, Merav D. Shmueli, Limor Levy, Liat Engel, Ehud Gazit, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Daniel Segal,The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity, Biochemistry,54,3729–3738, (2015).

28. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, Caliceti P,A novel pullulan bioconjugate for selective breast cancer bone metastases treatment, Bioconjugate Chemistry,26(3),489-501, (2015).

29. E.Y. Levanon and E. Eisenberg,Does RNA editing compensate for Alu invasion of the primate genome?, BioEssays,37,175-181, (2015).

30. Hadas Zur, Tamir Tuller,Exploiting hidden information interleaved in the redundancy of the genetic code without prior knowledge., Bioinformatics,31,1161-8, (2015).

31. S. Alon, M. Erew and E. Eisenberg,DREAM: a webserver for the identification of editing sites in mature miRNAs using deep sequencing data, Bioinformatics,31,2568-2570, (2015).

32. Ofer Isakov, Antonio V. Bordería, David Golan, Amir Hamenahem, Gershon Celniker, Liron Yoffe, Hervé Blanc, Marco Vignuzzi and Noam Shomron,Deep sequencing analysis of viral infection and evolution allows rapid and detailed

characterization of viral mutant spectrum., Bioinformatics , Jul 1;31(13),2141-50., (2015).

33. Michal Shevach, Rotem Zax, Alona Abrahamov, Sharon Fleischer, Assaf Shapira and Tal Dvir,Omentum ECM-based hydrogel as a platform for cardiac cell delivery, Biomedical Materials,10,34106, (2015).

34. Kisin-Finfer E, Ferber S, Blau R, Satchi-Fainaro R, Shabat D,Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action, Bioorganic and Medicinal Chemistry Letters,24(11),2453-2458, (2014).

35. Yaron Tomer Cordova Yossi, Juxtacrine signaling is inherently noisy, Biophysical Journal,107,2417-24, (2014).

36. Scomparin A, Polyak D, Krivitsky A, Satchi-Fainaro R,Achieving successful delivery of oligonucleotides - From physico-chemical characterization to in vivo evaluation, Biotechnology Advances,33(6),1294–1309, (2015).

37. Alexandra Dana, Tamir Tuller,Properties and determinants of codon decoding time distributions., BMC Genomics.,Suppl 6,S13, (2014).

38. Landesman-Milo D. Ramishetti S. and Peer D. ,Nanomedicine as an emerging platform for metastatic lung cancer therapy, Cancer and Metastasis Reviews,34(2),291-301, (2015).

39. Hazan-Halevy I.*, Rosenblum D.*,Weinstein S.,Bairey O., Raanani P. and Peer D ,Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes.,


PUBLICATIONS

Cancer Letters,364(1),59-69, (2015).

40. Ferber S, Baabur-Cohen H, Blau R, Epshtein Y and Satchi-Fainaro R,Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release, Cancer Letters,352(1),81-89, (2014).

41. Ron Amon, Eliran Moshe Reuven, Shani Leviatan Ben-Arye and Vered Padler-Karavani ,Glycans in immune recognition and response, Carbohydrate Res,389,115-122, (2014).

42. Nurit Paz-Yaacov, Lily Bazak, Ilana Buchumenski, Hagit T. Porath, Miri Danan-Gotthold, Binyamin A. Knisbacher, Eli Eisenberg, Erez Y. Levanon ,Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors, Cell Reports,13,xxx, (2015).

43. Gil Nifker, Michal Levy‐Sakin, Yifat Berkov‐Zrihen, Tamar Shahal, Tslil Gabrieli, Micha Fridman, Yuval Ebenstein,One‐Pot Chemoenzymatic Cascade for Labeling of the Epigenetic Marker 5‐Hydroxymethylcytosine, ChemBioChem,16,1857-1860, (2015).

44. Kerem Goren, Jeny Karabline-Kuks, Yael Shiloni, Einav Barak-Kulbak, Scott J. Miller, Moshe Portnoy,Multivalency as a Key Factor for High Activity of Selective

45. Supported Organocatalysts for the Baylis–Hillman Reaction, Chemestry a European Journal,21,1191-1197, (2015).

46. Ayala Lampel, Efrat Elis, Tom Guterman, Sharon Shapira, Pini Marco, Eran Bacharach, Ehud Gazit,α-Aminoisobutyric acid incorporation induces

cell permeability and antiviral activity of HIV-1 major homology region fragments, Chemical Communicationsα-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments,51,12349-12352, (2015).

47. Kai Tao, Aviad Levin, Ehud Gazit,Fmoc Modified Short Peptides: Simple Biomolecules to Meet Functional Materials, Chemical Society Reviews,NA,NA, (2015).

48. Buzhor, Marina; Harnoy, Assaf J.; Tirosh, Einat; Barak, Ayana; Schwartz, Tal; Amir, Roey J.,Supramolecular translation of enzymatically triggered disassembly of micelles into tunable fluorescent responses, Chemistry - A European Journal,0,DOI: 10.1002/chem.201502988, (2015).

49. Marina Buzhor, Assaf J. Harnoy, Einat Tirosh, Ayana Barak, Tal Schwartz, Roey J. Amir,Supramolecular Translation of Enzymatically Triggered Disassembly of Micelles into Tunable Fluorescent Responses, Chemistry - A European Journal,NA,NA, (2015).

50. Hadar Ivanir-Dabora, Evgeny Nimerovsky, PK Madhu, Amir Goldbourt ,Site-Resolved Backbone and Side-Chain Intermediate Dynamics in a Carbohydrate-Binding Module Protein Studied by Magic-Angle Spinning NMR Spectroscopy, Chemistry A European Journal,21,10778-10785, (2015).

51. Orit Redy-Keisar, Sharon Ferber, Ronit Satchi-Fainaro, Doron Shabat ,NIR fluorogenic dye as a modular platform for prodrug assembly: Real-time in vivo

monitoring of drug release, ChemMedChem,10,999-1007, (2015).

52. Lior Medina, Rivka Gilat, Slava Krylov,Bouncing and dynamic trapping of a bistable curved micro beam actuated by a suddenly applied electrostatic force, Communications in Nonlinear Science and Numerical Simulation,NA,NA, (2015).

53. Galit Fichman, Tom Guterman, Lihi Adler-Abramovicha, Ehud Gazit,Synergetic functional properties of two-component single amino acid-based hydrogels, CrystEngComm,-,-, (2015).

54. Galit Fichman, Tom Guterman, Lihi Adler-Abramovich, Ehud Gazit,Synergetic functional properties of two-component single amino acid-based hydrogels, CrystEngComm,na,na, (2015).

55. Adi Laser-Azogui, Micha Kornreich, Eti Malka-Gibor, Roy Beck,Neurofilament assembly and function during neuronal development, Current opinion in cell biology,32,92-101, (215).

56. Alexander Aizikovich, Avital Shlomovich, Adva Cohen, Michael Gozin,The nitration pattern of energetic 3, 6- diamino- 1, 2, 4, 5- tetrazine derivatives containing azole functional groups., Dalton Transactions,44(31),13939-13946, (2015).

57. Jones, C., Qian, D., Kim, S.M., Li, S., Ren, D., Knapp, L., Sprinzak, D., Avraham, K.B., Matsuzaki, F., Chi, F. and Chen, P. ,Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear, Dev. Biol.,395,62-72, (2014).


PUBLICATIONS

58. Ben-Shushan D*, Markovsky E*, Gibori H*, Tiram G, Scomparin A, Satchi-Fainaro R,Overcoming obstacles in microRNA delivery towards improved cancer therapy, Drug Delivery and Translational Research,4(1),38-49, (2014).

59. Almog, R. O., Pandey, R., Sverdlov, Y., & Shacham-Diamand, Y,Gold Nanoparticle Metallization of Flexible Conducting Polymer Electrode, ECS Transactions,66(19),6, (2015).

60. A. Duhin, A. Inberg, N. Eliaz and E. Gileadi,Electroless Plating of Rhenium-Based Alloys with Nickel, Cobalt and Iron, Electrochimica Acta,174,660-666, (2015).

61. Ragones, H., Schreiber, D., Inberg, A., Berkh, O., Kósa, G., & Shacham-Diamand, Y,Processing Issues and the Characterization of Soft Electrochemical 3D Sensor, Electrochimica Acta,0,6, (2015).

62. Yoetz-Kopelman, T., Ram, Y., Freeman, A., & Shacham-Diamand, Y,Faradaic Impedance Spectroscopy for Detection of Small Molecules Binding using the Avidin-Biotin Model. , Electrochimica Acta,173,7, (2015).

63. Slomowitz, E., Styr, B., Vertkin, I., Milshtein-Parush, H., Nelken, I., Slutsky, M. and Slutsky, I. ,Interplay between population firing stability and single neuron dynamics in hippocampal networks. , eLife,nr,10.7554/eLife.04378, (2015).

64. S. Alon, S.C. Garrett, E.Y. Levanon, S. Olson, B.R. Graveley, J.J.C. Rosenthal and E. Eisenberg,The majority of transcripts in the squid nervous system are extensively recoded by A-to-I

RNA editing, eLife,4,e05198, (2015).

65. A.Handelman,S. Lavrov,A. Kudryavtsev,S. Semin,E. Mishina,G.Rosenman,Nonlinear Optical Phenomena in Bioinspired Peptide Nanostructures, Encyclopedia of Nanoscience and Nanotechnology,3,1-49, (2015).

66. Haim Diamant,Response of a polymer network to the motion of a rigid sphere, Eur Phys J E,38,32, (2015).

67. E. Bormashenko, A. Musin, G. Whyman, Z. Barkay, and M. Zinigrad,On universality of scaling law describing roughness of triple line, Eur. Phys. J. E ,38,1-9, (2015).

68. Ganoth A, Cohen K.M, and Peer D,Overcoming multidrug resistance with drug delivery strategies., Expert Opinion on Drug Delivery,12(2),223-338, (2015).

69. Micha Kornreich, Ram Avinery, Eti Malka-Gibor, Adi Laser-Azogui, Roy Beck,Order and disorder in intermediate filament proteins, FEBS letters,NA,NA, (2015).

70. Alexandra Dana, Tamir Tuller,Mean of the typical decoding rates: a new translation efficiency index based on the analysis of ribosome profiling data., G3 (Bethesda),5,73-80, (2014).

71. S. Tomaselli, F. Galeano, S. Alon, S. Raho, S. Galardi, V.A. Polito, C. Presutti, S. Vincenti, E. Eisenberg, F. Locatelli and A. Gallo,Modulation of microRNA editing, expression and processing through ADAR2 deaminase in glioblastoma, Genome Biology,16,5, (2015).

72. Reut Friedman, Natan T. Shaked,Hybrid reflective interferometric system

combining wide-field and single-point phase measurements, IEEE Photonics Journal,7,6801413, (2015).

73. Nathan Jackson, Peter Verbrugghe, Dieter Cuypers, Kenneth Adesanya, Leeya Engel, Piotr Glazer, Peter Dubruel, Yosi Shacham-Diamand, Eduardo Mendes, Paul Herijgers, Frank Stam, ,A Cardiovascular Occlusion Method based on the use of a Smart Hydrogel, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,62,7, (2015).

74. Yoram Zarai, Michael Margaliot, Tamir Tuller,Maximizing Protein Translation Rate in the Ribosome Flow Model: The Homogeneous Case., IEEE/ACM Trans Comput Biol Bioinform.,11,1184-95, (2014).

75. Mingyue Li, Jenna Yehl, Guangjin Hou, Pabitra B. Chatterjee, Amir Goldbourt, Debbie C. Crans, and Tatyana Polenova,NMR Crystallography for Structural Characterization of Oxovanadium(V) Complexes: Deriving Coordination Geometry and Detecting Weakly Coordinated Ligands at Atomic Resolution in the Solid State, Inorganic Chemistry,54,1363-1374, (2015).

76. Lior Medina, Rivka Gilat, Slava Krylov, Symmetry breaking in an initially curved pre-stressed micro beam loaded by a distributed electrostatic force, International Journal of Solids and Structures,51,2047 – 2061, (2014).

77. Zohar Arnon, Lihi Adler-Abramovich, Aviad Levin, Ehud Gazit,Solvent-Induced Self-Assembly of Highly Hydrophobic Tetra- and Pentaphenylalanine


PUBLICATIONS

Peptides, Israel Journal of Chemistry,55,756–762, (2015).

78. Luba Farberov, Eytan Herzig, Shira Modai, Ofer Isakov, Amnon Hizi, Noam Shomron ,MicroRNA-mediated regulation of p21 and TASK1 cellular restriction factors enhances HIV-1 infection., J Cell Sci. 2,Apr 15;128(8),1607-16, (2015).

79. Adar Sonn-Segev, Jerzy Blawzdziewicz, Eligius Wajnryb, Maria. L. Ekiel-Jezewska, Haim Diamant, Yael Roichman,Structure and dynamics of a layer of sedimented Brownian particles, J Chem Phys,143,74704, (2015).

80. Gilad Poker, Yoarm Zarai, Michael Margaliot, Tamir Tuller,Maximizing protein translation rate in the non-homogeneous ribosome flow model: a convex optimization approach., J R Soc Interface,11,20140713, (2014).

81. Matan Mussel, Ella Wilczynski, Uzi Eliav, Jonathan Gottesman, Michal Wilk, Uri Nevo,Dynamics of water and sodium in gels under salt-induced phase transition, J. of Polymer Science, Part B: Polymer physics.,53,1620–1628, (2015).

82. A. Handelman,A. Natan,G. Rosenman,Structural and optical properties of short peptides: nanotubes-to-nanofibers phase transformation, J. Peptide Sci,20,487-493, (2014).

83. A. Handelman,G. Shalev,G. Rosenman,Structural and optical properties of short peptides: nanotubes-to-nanofibers phase transformation, J. Peptide Science,20,487-493 , (2015).

84. Irina Volotsenko, Michel Molotskii, Anna Borovikova, Nathan Nelson, and Yossi Rosenwaks,Evidence for Deep Acceptor Centers in Plant

Photosystem I Crystals, J. Phys. Chem,119,1374-1379, (2015).

85. Naum Parkansky, Violetta Yakubov, Isak I Beilis, Raymond L Boxman and Olga Berkh,Electrode erosion during submerged arc treatment of methylene blue water solution, J. Phys. D: Appl. Phys.,48,225202 (9pp), (2015).

86. Sivan Kanner, Marta Bisio, Gilad Cohen, Miri Goldin, Marieteresa Tedesco, Yael Hanein, Eshel Ben-Jacob, Ari Barzilai, Michela Chiappalone, Paolo nifazi,Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits, J. Vis. Exp. ,e52572,doi:10.3791/52572, (2015).

87. Adar Sonn–Segev, Jerzy B lawzdziewicz, Eligiusz Wajnryb, Maria L. Ekiel–Jeżewska, Haim Diamant, and Yael Roichman,Structure and dynamics of a layer of sedimented particles, JCP ,143,74704, (2015).

88. K. Goldshtein,a K. Freedman,a D. Schneier,a L. Burstein,b V. Ezersky,c E. Peled,and D. Golodnitsky,Advanced Multiphase Silicon-Based Anodes for High-Energy-Density Li-Ion Batteries, JES,162,A1072-A1079, (2015).

89. R. Blanga L. Burstein, b M. Berman, S. G. Greenbaum, and D. Golodnitsky, Solid Polymer-in-Ceramic Electrolyte Formed by Electrophoretic

90. Deposition, JES,162,D3084-D3089, (2015).

91. D. Golodnitsky, E. Strauss,c E. Peled, and S. Greenbaum,Review—On Order and Disorder in Polymer Electrolytes , JES,162,A1-A16, (2015).

92. D. Markovich, K. Baryshnikova, A. Shalin, A. Samusev, A. Krasnok, P. Belov, and P. Ginzburg,Enhancement of artificial magnetism via resonant bianisotropy, JOSA A,-,-, (2015).

93. D. Bar-Lev, A. Arie, J. Scheuer, and I. Epstein,Efficient excitation and control of arbitrary surface plasmon polariton beams using one-dimensional metallic gratings, JOSA B,32,923-932 , (2015).

94. D. S. Filonov, P. Ginzburg, A.S. Shalin, I. Iorsh, P. A. Belov,Scattering on objects embedded in Wire Medium, JOSA B,-,-, (2015).

95. O. Y. Fajardo, F. Bresme, A. A. Kornyshev, M. Urbakh ,Electrotunable Friction with Ionic Liquid Lubricants: How Important Is the Molecular Structure of the Ions?, Journal of Physical Chemistry Letters,6,3998−4004 , (2015).

96. Tamar Ben-Mordechai, Dahlia Palevski, Yifat Glucksam-Galnoy, Inbar Elron-Gross, Rimona Margalit, Jonathan Leor,Targeting Macrophage Subsets for Infarct Repair, Journal of Cardiovascular Pharmacology and Therapeutics,20,36-51, (2015).

97. Markovich, T. Andelman, D.; Podgornik, R. ,Surface tension of electrolyte interfaces: Ionic specificity within a field-theory approach, Journal of Chemical Physics,,142,44702, (2015).

98. Juan E. Peralta, Oded Hod, and Gustavo E. Scuseria,Magnetization Dynamics from Time-Dependent Noncollinear Spin Density Functional Theory Calculations, Journal of Chemical Theory and Computation,11,3661-3668, (2015).


PUBLICATIONS

99. Density Functional Theory Calculations, Journal of Chemical Theory and Computation,11,3661-3668, (2015).

100. Markovsky E, Baabur-Cohen H, Satchi-Fainaro R, Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs, Journal of Controlled Release, 187: 145–157 (2014). (Cover feature). (9 citations, PHARMACOLOGY & PHARMACY 11/254, Impact factor 7.633). (Editorial highlight by Kinam Park, True combination therapy using synergistic drug combination, Journal of Controlled Release 187, 198 (2014), Journal of Controlled Release,187,145–157 , (2014).

101. Ilia Rivkin, Yifat Galnoy-Glucksam*, Inbar Elron-Gross, Amichay Afriat, Arik Eisenkraft, Rimona Margalit,Inhalational therapy of chlorine-exposed mice by steroid and anti-oxidant drugs formulated in hyaluronan liposomes, Journal of Hazardous Materials,not relavant yet,not relevant yet, (2015).

102. Gili Abramov, Omry Morag, Amir Goldbourt,Magic-angle spinning NMR of intact bacteriophages: Insights into the capsid, DNA and their interface, Journal of Magnetic Resonance,253,80-90, (2015).

103. Anat Haimovich, Amir Goldbourt,Characterization of lithium coordination sites with magic-angle spinning NMR, Journal of Magnetic Resonance,254,131-138, (2015).

104. Youry Borisenkov, Michael Kholmyansky, Slava Krylov, Alex Liberzon, and Arkady Tsinober,Multiarray

Micromachined Probe for Turbulence Measurements Assembled of Suspended Hot-Film Sensors, JOURNAL OF MICROELECTROMECHANICAL SYSTEMS,NA,1-7, (2015).

105. Y. Gerson, D. Schreiber, H. Grau, and S. Krylov, Meso Scale MEMS Inertial Switch Fabricated using Electroplated Metal on Insulator (MOI) Process, Journal of Micromechanics and Microengineering, 24, 025008, (2014).

106. Nili Ostrov, Galit Fichman, Lihi Adler-Abramovich, Ehud Gazit,FtsZ Cytoskeletal Filaments as a Template for Metallic Nanowire Fabrication, Journal of Nanoscience and Nanotechnology,15,556-561, (2015).

107. Shulman, Y., Stavsky, A., Fedorova, T., Mikulincer, D., Atias, M., Radinsky, I., Kahn, J., Slutsky, I., and Gitler, D. ,ATP binding to synaspsin IIa regulates usage and clustering of vesicles in terminals of hippocampal neurons., Journal of Neuroscience,35,985-998, (2015).

108. Jeny Karabline-Kuks, Palakuri Ramesh and Moshe Portnoy,Chemoselectivity improvement via partial shielding of imidazole active site in branched/dendritic homogeneous catalysts of the Baylis-Hillman reaction, Journal of Organic Chemistry,NA,NA, (2015).

109. Maria Chiara di Gregorio, Assaf Ben Moshe, Einat Tirosh, Luciano Galantini, Gil Markovich,Chiroptical Study of Plasmon-Molecule Interaction: the Case of Glutathione Interaction with Silver Nanocubes, Journal of Physical

Chemistry C,119,17111–17116, (2015).

110. Rosenbaum, Ido; Harnoy, Assaf J.; Tirosh, Einat; Buzhor Marina; Segal, Merav; Frid, Liat; Shaharabani, Rona; Avinery, Ram; Beck, Roy; Amir, Roey J.,Encapsulation and covalent binding of molecular payload in enzymatically activated micellar nanocarriers, Journal of the American Chemical Society,137,2276-2284, (2015).

111. Ido Rosenbaum, Assaf J Harnoy, Einat Tirosh, Marina Buzhor, Merav Segal, Liat Frid, Rona Shaharabani, Ram Avinery, Roy Beck, Roey J Amir,Encapsulation and covalent binding of molecular payload in enzymatically activated micellar nanocarriers, Journal of the American Chemical Society,137,2276-2284, (2015).

112. T. Nusbaum, B.A. Rosen, E. Gileadi and N. Eliaz,Effect of Pulse On-Time and Peak Current Density on Pulse Plated Re-Ni Alloys, Journal of the Electrochemical Society,162,D250-D255, (2015).

113. Doron Bar-lev, Ady Arie, Jacob Scheuer and Itai Epstein,Efficient excitation and control of arbitrary surface plasmon polariton beams using one-dimensional metallic grating, Journal of the Optical Society of America B,32,923-932, (2015).

114. R. Campos, A. Kotlyar, E.E. Ferapontova,DNA-mediated Electron Transfer in DNA Duplexes Tethered to Gold Electrodes via Phosphorothioated dA Tags , Langmuir,30,11853−11857 , (2014).

115. A.Handelman,N.Kuritz,A. Natan,Gil Rosenman,Reconstructive Phase Transition in Ultrashort


PUBLICATIONS

Peptide Nanostructures and Induced Visible Fluorescence, Langmuir,5,1-44, (2915).

116. P. Ginzburg,Accelerating Spontaneous Emission in Open Resonators, Laser & Photonics Reviews,-,-, (2015).

117. Duc Thien Trinh, Vasyl Shynkar, Ady Arie, Yan Sheng, Wieslaw Krolikowski, and Joseph Zyss,Electro-optical interferometric microscopy of periodic and aperiodic ferroelectric structures, Lasers and Photonics Reviews,9,214-223, (2015).

118. Y. Shacham-Diamand, T. Osaka, Y. Okinaka, A. Sugiyama, V. Dubin, ,30 years of electroless plating for semiconductor and polymer micro-systems, Microelectronic Engineering ,132,11, (2015).

119. T. Zelovich, L. Kronik, and O. Hod,Molecule-Lead Coupling at Molecular Junctions: Relation Between the Real- and State-Space Perspectives, NA,Submitted,Submitted, (2015).

120. Palakuri Ramesh, Jeny Karabline-Kuks, Moshe Portnoy,Towards BODIPY-cored near IR-emitting water-soluble dendritic platforms, NA,NA,NA, (2015).

121. Stive Pregent, Amir Lichtenstein, Ram Avinery, Adi Laser-Azogui, Fernando Patolsky, Roy Beck,Probing the interactions of intrinsically disordered proteins using nanoparticle tags, Nano letters,15,3080-3087, (2015).

122. Lilach Bareket, Nir Waiskopf, David Rand, Gur Lubin, Moshe David-Pur, Jacob Ben-Dov, Soumyendu Roy, Cyril Eleftheriou, Evelyne Sernagor, Ori Cheshnovsky, Uri Banin and Yael Hanein,Semiconductor nanorod-carbon nanotube biomimetic films for wire-

free photostimulation of blind retinas, Nano Letters,nl5034304,DOI: 10.1021, (2014).

123. Stefan Kuhn, Peter Asenbaum, Alon Kosloff,Mechele Sclafan, Benjamin A.Stickler, Stefan Nimmrichter, Klaus Hornberger, Ori Cheshnovsky, Fernando Patolsky, Markus Arndt,Cavity-Assisted Manipulation of Freely Rotating Silicon Nanorods in High Vacuum, nano Letters,15, 5604-5608, (2015).

124. Omer Tzang, Alexander Pevzner, Robert E Marvel, Richard Haglund, Ori Cheshnovsky,Super-Resolution in Label-Free Photomodulated Reflectivity, Nano Letters,15,1362-1367, (2015).

125. G. Marino, P. Segovia, A. V. Krasavin, P. Ginzburg, N. Olivier, G. A. Wurtz, and A. V. Zayats,Second-harmonic generation from hyperbolic plasmonic nanorod metamaterial slab, Nano Letters,-,-, (2015).

126. Hagit Peretz-Soroka, Alexander Pevzner, Reuven Tirosh, Guy Davidi, Vladimir Naddaka, Moria Kwiat and Fernando Patolsky,Monitoring and Manipulating On-Surface Biological Reactions by Light-Triggered Local pH Alterations., Nano Letters,15,4758-4768, (2015).

127. E. Peled, F. Patolsky, D. Golodnitsky, K. Freedman, G. Davidi, D. Schneier,Tissue-like Silicon Nanowires-Based Three-Dimensional Anodes for High-Capacity Lithium Ion Batteries., Nano Letters,15,3907-3916, (2015).

128. Stive Pregent, Amir Lichtenstein, Ram Avinery, Adi Laser-Azogui, Fernando Patolsky, Roy Beck,Using gold

nanoparticles tags to unveil intrinsically disordered proteins interactions in solution, Nano Letters,15,3080-3087, (2015).

129. Kuhn Stefan, Asenbaum Peter, Kosloff Alon, Sclafani Michele, Stickler Benjamin A, Nimmrichter Stefan, Hornberger Klaus, Cheshnovsky Ori, Patolsky Fernando, Arndt Markus,Cavity-Assisted Manipulation of Freely Rotating Silicon Nanorods in High Vacuum., Nano Letters,15,5604-5608, (2015).

130. Alex Henning, Nandhini Swaminathan, Andrey Godkin, Gil Shalev, Iddo Amit, and Yossi Rosenwaks,Tunable diameter electrostatically-formed nanowire for high sensitivity gas sensing, nano research,10,12274-01, (2015).

131. Hendler, N.; Mentovich, E.; Korbuly, B.; Pusztai, T.; Gránásy, L.; Richter, S. ,Controlling the Growth Forms of Peptide-Nanotube Spherulitic Films: Experiments and Simulations, Nano Research,N/A,N/A, (2015).

132. Roey Elnathan, Moria Kwiat, Fernando Patolsky and Nicolas H. Voelcker,Engineering Vertically-Aligned Silicon Nanowire Arrays for Applications in the Life Sciences., Nano Today,9,172-196, (2014).

133. Eran Edri, Saar Kirmayer, Alex Henning, Sabyasachi Mukhopadhyay, Konstantin Gartsman, Yossi Rosenwaks, Gary Hodes, David Cahen,Why Lead Methylammonium Tri-Iodide Perovskite-Based Solar Cells Require a Mesoporous Electron Transporting Scaffold (but Not Necessarily a Hole Conductor), nanoletters,14,1000-1004, (2014).

134. I. Amit, D. Englander, D. Horvitz, Y. Sasson, and Y.


PUBLICATIONS

Rosenwaks,Density and Energy Distribution of Interface-states in the Grain-boundaries of Poly-Silicon Nanowire, nanoletters,14,6190−6194, (2014).

135. Eliezer Halpern, Alexander Henning, Hadas Shtrikman, Riccardo Rurali, Xavier Cartoixà, and Yossi Rosenwaks,Room Temperature Observation of Quantum Confinement in Single InAs Nanowires, nanoletters,15,481-485, (2015).

136. Ehud Gazit,Controlling molecular self-assembly: from amyloid oligomerization and therapy to novel biomaterials and technological applications in nanomedicine., Nanomedicine ,16,2433-6, (2014).

137. H. Zanin, C. Rosa, N. Eliaz, P. May, F. Marciano and A. Lobo,Assisted Deposition of Nano-Hydroxyapatite onto Exfoliated Carbon Nanotube Oxide Scaffolds, Nanoscale,7,10218-10232, (2015).

138. Sharon Fleischer, Jacob Miller, Haley Hurowitz, Assaf Shapira and Tal Dvir,Effect of fiber diameter on the assembly of functional 3D cardiac patches, Nanotechnology,26,.., (2015).

139. A. Shamir, I. Amit, D. Englander, D. Horvitz, and Y. Rosenwaks,Potential barrier height at the grain boundaries of a poly-silicon nanowire, Nanotechnology,26,355201-6, (2015).

140. Carmeli, I.; Cohen, M.; Heifler, O.; Lilach, Y.; Zalevsky, Z.; Mujica, V.; Richter, S,Spatial Modulation of Light Transmission through a Single Microcavity by Coupling of Photosynthetic Complex Excitations to Surface Plasmons, Nat. Commun,6,734, (2015).

141. Omry Blum, Natan T. Shaked,Prediction of photothermal phase signatures from arbitrary plasmonic nanoparticles and experimental verification, Nature – Light: Science and Applications,4,e322: 1-8, (2015).

142. Ehud Gazit,Molecular self-assembly: Searching sequence space, Nature Chemistry,7,14-15, (2015).

143. Alon Diament, Ron Pinter, Tuller Tuller, Three-dimensional eukaryotic genomic organization is strongly correlated with codon usage expression and function., Nature Commun. ,5876,5, (2014).

144. Aviad Levin, Thomas O. Mason, Lihi Adler-Abramovich, Alexander K. Buell, George Meisl, Celine Galvagnion, Yaron Bram, Samuel A. Stratford, Christopher M. Dobson, Tuomas P. J. Knowles, Ehud Gazit,Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers, Nature Communications,5,5219, (2014).

145. E Maniv, M Ben Shalom, A Ron, M Mograbi, A Palevski, M Goldstein, Y Dagan,Strong correlations elucidate the electronic structure and phase diagram of LaAlO3/SrTiO3 interface, Nature Communications,6,8239, (2015).

146. Wenjun Jiang, Xuejin Zhao, Tslil Gabrieli, Chunbo Lou, Yuval Ebenstein, Ting F Zhu,Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters, Nature communications,6,1, (2015).

147. E. Maniv, M. Ben Shalom, A. Ron, M. Mograbi, A. Palevski, M.

Goldstein, and Y. Dagan,Strong correlations elucidate the electronic phase-diagram of LaAlO3/SrTiO3 interface, Nature Communications,6,8239, (2015).

148. Amir Lichtenstein, Ehud Havivi, Ronen Shacham, Ehud Hachami, Ronit Leibovich, Alexander Pevzner, Vadim Krivitski, Guy Davivi, Igor Presman, Eli Flaxer and Fernando Patolsky,Supersensitive Fingerprinting of Explosives by Chemically-Modified Nanosensors Arrays: ‹Facing Explosives›., Nature Communications,5,4195, (2014).

149. J. Scheuer ,Y. Yifat,Metasurfaces make it practical, Nature Nanotechnology,10,296-298 , (2015).

150. Or Berger, Lihi Adler-Abramovich, Michal Levy-Sakin, Assaf Grunwald, Yael Liebes-Peer, Mor Bachar, Ludmila Buzhansky, Estelle Mossou, Trevor Forsyth, Tal Schwartz, Yuval Ebenstein, Felix Frolow, Linda J. W. Shimon, Fernando Patolsky, Ehud Gazit,Light-emitting self-assembled peptide nucleic acids exhibit both stacking interactions and Watson–Crick base pairing, Nature Nanotechnology,10,353–360, (2015).

151. Ming Ma, François Grey, Luming Shen, Michael Urbakh, Shuai Wu, Jefferson Zhe Liu, Yilun Liu, Quanshui Zheng,Water transport inside carbon nanotubes mediated by phonon-induced oscillating friction, Nature Nanotechnology,10,692-695, (2015).

152. G.I. Livshits, A. Stern, D. Rotem, N. Borovok, G. Eidelshtein, A. Migliore, E. Penzo, S. J. Wind, R. Di Felice, S. S. Skourtis, J.


PUBLICATIONS

C. Cuevas, L. Gurevich, A. B. Kotlyar, D. Porath,Long-range charge transport in single G4-DNA molecules , Nature Nanotechnology ,9,1040-1046, (2014).

153. Redy-Keisar O, Kisin-Finfer E, Shiran Ferber, Satchi-Fainaro R*, and Shabat D*,Synthesis and Use of QCy7-derived Modular Probes for Detection and Imaging of Biologically Relevant Analytes, Nature Protocols,9(1),27-36, (2014).

154. Miri Danan-Gotthold, Regina Golan-Gerstl, Eli Eisenberg, Keren Meir, Rotem Karni, Erez Y. Levanon,Identification of recurrent regulated alternative splicing events across human solid tumors, Nucleic acid research,43,5130-5144, (2015).

155. Redy-Keisar O, Kisin-Finfer E, Shiran Ferber, Satchi-Fainaro R*, and Shabat D*,Synthesis and Use of QCy7-derived Modular Probes for Detection and Imaging of Biologically Relevant Analytes, Nature Protocols,9(1),27-36, (2014).

156. Miri Danan-Gotthold, Regina Golan-Gerstl, Eli Eisenberg, Keren Meir, Rotem Karni, Erez Y. Levanon,Identification of recurrent regulated alternative splicing events across human solid tumors, Nucleic acid research,43,5130-5144, (2015).

157. Tamir Tuller, Hadas Zur ,Multiple roles of the coding sequence 5› end in gene expression regulation, Nucleic Acids Res.,43,13-28, (2015).

158. D Torchinsky, Y Ebenstein,Sizing femtogram amounts of dsDNA by single-molecule counting, Nucleic Acids Research,1,1, (2015).

159. Assaf Grunwald, Moran Dahan, Anna Giesbertz, Adam Nilsson, Lena K Nyberg, Elmar

Weinhold, Tobias Ambjörnsson, Fredrik Westerlund, Yuval Ebenstein,Bacteriophage strain typing by rapid single molecule analysis, Nucleic Acids Research,1,1, (2015).

160. Roei Remez and Ady Arie,Super-narrow frequency conversion, Optica,2,472-475, (2015).

161. Omer Tzang, Doron Azoury,Ori Cheshnovsky,Super resolution methodology based on temperature dependent Raman scattering., Optics Express,23,17929-40, (2015).

162. Omer Tzang, Ori Cheshnovsky,New modes in label-free super resolution based on photo-modulated reflectivity, Optics Express,23,20926-20932, (2015).

163. Mor Habaza, Barak Gilboa, Yael Roichman, and Natan T. Shaked,Tomographic phase microscopy with 180° rotation of live cells in suspension by holographic optical tweezers. , Optics Letters,40,1881-1884, (2015).

164. O. Kotlicki, J. Scheuer,Wideband Perfect Coherent Absorber based on White Light Cavity, Optics Letters,39,6624–6627 , (2014).

165. Brenda Dana, Boris A. Malomed and Alon Bahabad,Breathing solitary-pulse pairs in a linearly coupled system, Optics Letters,39,4, (2014).

166. Ksawery Kalinowski, Asia Shapira, Ana Libster-Hershko, and Ady Arie,Nonlinear diffraction from high-order Hermite–Gauss beams, Optics letters,40,13-16, (2015).

167. Yuval Tsur, Itai Epstein and Ady Arie,Arbitrary Holographic Spectral Shaping of Plasmonic Broadband Excitations, Optics Letters,40,1615-1618, (2015).

168. Ana Libster-Hershko, Sivan Trajtenberg-Mills and Ady Arie,Dynamic Control of Light Beams in Second Harmonic Generation, Optics Letters,40,1944-1947, (2015).

169. Michael Zuzovski, Amir Boag, Amir Natan,Auxilliary grid method for the calculation of electrostatic terms in Density Functional Theory on a real-space grid, PCCP,C5CP01090J,8, (2015).

170. Amir Natan,Fock-exchange for periodic structures in the real-space formalism and the KLI approximation, PCCP,DOI: 10.1039/c5cp01093d,6, (2015).

171. Oz Oshri, Fabian Brau, Haim Diamant,Wrinkles and folds in a fluid-supported sheet of finite size, Phys Rev E,91,52408, (2015).

172. A. S. Shalin, S. V. Sukhov, A. A. Bogdanov, P. A. Belov, and P. Ginzburg, Optical pulling forces in hyperbolic metamaterials, Phys. Rev. A ,91,63830, (2015).

173. S. Lerer, N. Bachar, G. Deutscher, and Y. Dagan,Nernst effect beyond the coherence critical field of a nanoscale granular superconductor, Phys. Rev. B,90,214521, (2014).

174. A. P. Slobozhanyuk, P. Ginzburg, D. A. Powell, I. Iorsh, A. S. Shalin, P. Segovia, A. V. Krasavin, G. A. Wurtz, V.A. Podolskiy, P. A. Belov and A. V. Zayats,Purcell effect in Hyperbolic Metamaterial Resonators, Phys. Rev. B,-,-, (2015).

175. S. Yogev, and Y. Rosenwaks,Low density of gap states and unpinned Fermi level in n-channel organic thin-film transistors, Phys. Rev. B, rapid comm.,89,081409-081415, (2014).

176. A. Ron, E. Maniv, D. Graf, J.-H. Park, and Y. Dagan,Anomalous Magnetic Ground State in


PUBLICATIONS

an LaAlO3/SrTiO3 Interface Probed by Transport through Nanowires, Phys. Rev. Lett,113,216801, (2014).

177. I. V. Iorsh, A. N. Poddubny, P. Ginzburg, P.A. Belov, and Y. S. Kivshar,Compton like polariton scattering in hyperbolic metamaterials, Phys. Rev. Lett.,114,185501, (2015).

178. D. Bar-Lev, J. Scheuer, Plasmonic Meta-Surface for Efficient Ultra-Short Pulse Laser-Driven Particle Acceleration, Phys. Rev. ST Accel. Beams,17,121302, (2014).

179. Eliezer Halpern, Gilad Cohen, Shahar Gross, Alexander Henning, Max Matok, Andrey V. Kretinin, Hadas Shtrikman, and Yossi Rosenwaks,Measuring surface state density and energy distribution in InAs nanowires, Phys. Status Solidi,211,473–482, (2014).

180. D. Bartov, A. Segal, M. Karpovski, and A. Gerber,Absence of the ordinary and extraordinary Hall effects scaling in granular ferromagnets at metal-insulator transition, Phys.Rev.B,90,144423, (2014).

181. Michael Zuzovski, Amir Boag, and Amir Natan,An Auxiliary Grid Method for the Calculation of Electrostatic Terms in Density Functional Theory on a Real-Space Grid, Physical Chemistry Chemical Physics,10.1039/C5CP01090J,10.1039/C5CP01090J, (2015).

182. Brenda Dana, Alon Bahabad and Boris A. Malomed, CP symmetry in optical systems, Physical Review A,91,11, (2015).

183. Liran Naor, Shani Sharabi, Irit Juwiler and Ady Arie,Nonlinear scattering in photonic crystals having dislocations with fractional topological character and multiple dislocations,

Physical Review A,91,053841-1 - 053841-9, (2015).

184. David J. Bergman,Perfect imaging of a point charge in the quasistatic regime, Physical Review A,89,015801 (4 pp.), (2014).

185. Yakov M. Strelniker and D. J. Bergman,Strong angular magneto-induced anisotropy of Voigt effect in metal-dielectric metamaterials with periodic nanostructures, Physical Review A,89,125312 (12 pp.), (2014).

186. Asaf Farhi and David J. Bergman,Analysis of a Veselago lens in the quasistatic regime, Physical Review A,90,013806 (10 pp.), (2014).

187. Amir Hevroni, Boris Tsukerman, Gil Markovich,Probing magnetization dynamics in individual magnetite nanocrystals using magnetoresistive scanning tunneling microscopy, Physical review B, (2015).

188. Eial Teomy and Yair Shokef,The relation between the structure of blocked clusters and the relaxation dynamics in kinetically-constrained models, Physical Review E,NA,NA, (2015).

189. Roy Shiloh, Yuval Tsur, Roei Remez, Yossi Lereah, Boris A. Malomed, Vladlen Shvedov, Cyril Hnatovsky, Wieslaw Krolikowski, and Ady Arie,Unveiling the Orbital Angular Momentum and Acceleration of Electron Beams, PHYSICAL REVIEW LETTERS,114,096102-1 - 096102-5, (2015).

190. Shenhe Fu, Yuval Tsur, Jianying Zhou, Lev Shemer and Ady Arie,Propagation dynamics of Airy water wave pulses, Physical Review Letters,115,034501-1 - 034501-5, (2015).

191. Ming Ma, Andrea Benassi, Andrea Vanossi, Michael

Urbakh,Critical Length Limiting Superlow Friction, Physical Review Letters ,114,55501, (2015).

192. R. Hevroni, V. Shelukhin, M. Karpovski, M. Goldstein, E. Sela, Hadas Shtrikman and A. Palevski,Suppression of Coulomb blockade peaks by electronic correlations in InAs nanowires, Physical Review Letters ,NA,NA, (2015).

193. Ming Ma, Igor M. Sokolov, Wen Wang, Alexander E. Filippov, Quanshui Zheng, Michael Urbakh,Diffusion through Bifurcations in Oscillating Nano- and Microscale Contacts: Fundamentals and Applications, PHYSICAL REVIEW X ,5,31020, (2015).

194. S. Mahajne, D. Guetta, S. Lulinsky, S. Krylov, and Y. Linzon, ,Liquid mass sensing using resonating microplates under harsh drop and spray conditions, Physics Research International,2014,320324, (2014).

195. Naum Parkansky, Violetta Yakubov, Evelina Faktorovich Simon, Boris A. Alterkop, Raymond L. Boxman, Olga Berkh,Removal of Methylene Blue from Aging Water Solutions Treated by a Submerged Arc, Plasma Chemistry and Plasma Prpocessing,34,745-754, (2014).

196. Alon Diament, Tamir Tuller,Improving 3D Genome Reconstructions Using Orthologous and Functional Constraints., PLoS Comput Biol.,11,e1004298., (2015).

197. Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pitta, Eshel Ben Jacob, Hugues Berry, and Yael Hanein ,Glutamate Mediated Astrocytic Filtering of Neuronal Activity, PLOS


PUBLICATIONS

Computational Biology,journal.pcbi.1003964,10.1371, (2014).

198. Yifat Goldschmidt, Evgeny Yurkovsky, Amit Reif, Roni Rosner, Amit Akiva, Iftach Nachman ,Control of relative timing and stoichiometry by a master regulator, PLoS ONE,10(5),e0127339, (2015).

199. Merav D. Shmueli, Lee Schnaider, Gal Herzog, Ehud Gazit, Daniel Segal,Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome, PLOS ONE,9,e109864, (2014).

200. Vertkin, I., Styr, B., Slomowitz, E., Ofir, N., Shapira, I., Berner, D., Fedorova, T., Laviv, T., Barak-Broner, N., Greitzer-Antes, D., Gassmann, M., Bettler, B., Lotan, I., Slutsky, I. ,GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks. , PNAS,112(25),E3291-9, (2015).

201. Yakov M. Strelniker, David J. Bergman, and Anna O. Voznesenskaya,,Strong angular anisotropy of Voigt effect and other magneto-optical phenomena in ordered metal-dielectric metamaterials, Proc Int Conf Days on Diffraction, Berlin, 2014,Proceedings of the International Conference,1-6, (2014).

202. Shahar Nisemblat, Oren Yaniv, Avital Parnas, Felix Frolow, Abdussalam Azem,Crystal structure of the human mitochondrial chaperonin symmetrical football complex., Proc Natl Acad Sci U S A,112,6044-6049, (2015).

203. A. Farhi and D. J. Bergman,Non-quasi-static eigenstates of Maxwell›s equations in a two-constituent composite medium and their application to a

calculation of the local electric field of an oscillating dipole, Proc. SPIE Meeting on Optics and Photonics,9547,95471R (7 pp.), (2015).

204. D. J. Bergman and A. Farhi,Perfect Optical Imaging of a Veselago Lens: Eigenstate Based Analysis, Proc. SPIE Meeting on Optics and Photonics,9547,954706 (11 pp.), (2015).

205. Yakov M. Strelniker and D. J. Bergman,Magneto-Optical Response of a Periodic Metallic Nano-Structure, Proc. SPIE Meeting on Optics and Photonics,9547,954705 (12 pp.), (2015).

206. Parry Chen, Jacob Ben-Yakar, Yonatan Sivan, and David J. Bergman,Reinterpreting the magnetoelectric coupling of infinite cylinders using symmetry: a simple TM and TE view, Proc. SPIE Meeting on Optics and Photonics,9547,95471S (9 pp.), (2015).

207. Omry Morag, Nikolaos G. Sgourakis, David Baker, Amir Goldbourt,The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope, Proceedings of the National Academy of Sciences of the USA,112,971-976, (2015).

208. Zohar Zafrir, Tamir Tuller,Nucleotide sequence composition adjacent to intronic splice sites improves splicing efficiency via its effect on pre-mRNA local folding in fungi., RNA,21,1704-18., (2015).

209. Tuval Ben-Yehezkel, Shimshi Atar, Hadas Zur, Alon Diament, Eli Goz, Tzipy Marx, Rafael Cohen, Alexandra Dana, Anna Feldman, Ehud Shapiro, Tamir

Tuller.,Rationally designed, heterologous S. cerevisiae transcripts expose novel expression determinants., RNA Biol.,12,972-84., (2015).

210. Gagandeep Kaur, Lihi Adler-Abramovich, Ehud Gazit, Sandeep Verma,Ultrastructure of metallopeptide-based soft spherical morphologies, RSC Advances,4,64457-64465, (2014).

211. Kai Tao, Eyal Yoskovitz, Lihi Adler-Abramovicha, Ehud Gazit,Optical property modulation of Fmoc group by pH-dependent self-assembly, RSC Advances,5,73914-73918, (2015).

212. Kai Tao, Eyal Yoskovitz, Lihi Adler-Abramovich, Ehud Gazit,Optical property modulation of Fmoc group by pHdependent self-assembly, RSC Advances,5,73914, (2015).

213. Gilad Poker, Michael Margaliot, Tamir Tuller,Sensitivity of mRNA Translation., Sci Rep.,5,12795, (2015).

214. Sidelman, N.; Cohen, M.; Kolbe, A.; Zalevsky, Z.; Herrmann, A.; Richter, S. ,Rapid Particle Patterning in Surface Deposited Micro-Droplets of Low Ionic Content via Low-Voltage Electrochemistry and Electrokinetics, Sci. Rep,5,13095, (2015).

215. Shira Shaham-Niv, Lihi Adler-Abramovich, Lee Schnaider, Ehud Gazit,Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies, Science Advances,1, e1500137, (2015).

216. Guy Jacoby, Keren Cohen, Kobi Barkan, Yeshayahu Talmon, Dan Peer, Roy Beck,Metastability in lipid based particles exhibits temporally deterministic and controllable behavior, Scientific reports,5,NA, (2015).


PUBLICATIONS

217. Jacoby G.*, Cohen K.*, Tamon I., Peer D *. and Back-Barkai R*,Metastability in lipid based particles exhibits temporally deterministic and controllable behavior. , Scientific Reports,9481,5, (2015).

218. Kai Tao, Lihi Adler-Abramovich, Ehud Gazit,Controllable Phase Separation by Boc-Modified Lipophilic Acid as a Multifunctional Extractant, Scientific Reports,NA,NA, (2015).

219. Alex Dymshits, Alex Henning, Gideon Segev, Yossi Rosenwaks & Lioz Etgar,The electronic structure of metal oxide/organo metal halide perovskite junctions in perovskite based solar cells, Scientific Reports,5,8704, (2015).

220. O. Y. Fajardo, F. Bresme, A. A. Kornyshev, M. Urbakh,Electrotunable Lubricity with Ionic Liquid Nanoscale Films, Scientific Reports,5,7698, (2015).

221. A. A. Bogdanov, A. S. Shalin, and P. Ginzburg,Optical forces in nanorod metamaterial, accepted for Scientific Reports., Scientific Reports,-,-, (2015).

222. A. S. Baimuratov, I. D. Rukhlenko, R. E. Noskov, P. Ginzburg, Y. K. Gun›ko, A. V. Baranov, and A. V. Fedorov,Giant Optical Activity of Quantum Dots, Rods, and Disks with Screw Dislocations, Scientific Reports,-,-, (2015).

223. Tal Yoetz-Kopelman; Carmit Porat-Ophir,; Yosi Shacham-Diamand,; Amihay Freeman, ,Whole-Cell Amperometric Biosensor for Screening of Cytochrome P450 Inhibitors, Sensors & Actuators: B. Chemical ,N/A,8, (2015).

224. Lior Medina, Rivka Gilat, Robert Illic, Slava Krylov, Experimental investigation of the snap-through buckling of

electrostatically actuated initially curved pre-stressed micro beams, Sensors and Actuators A: Physical,220,323 – 332, (2014).

225. Carmit Porat-Ophir, Vladimir Dergachev, Anton Belkin, Sefi Vernicka, Genrietta Freynd, Mikhail Katsnelson, Viktor Chetvertnykh, Judith Rishpon, Yosi Shacham-Diamand,Chip level agitation effects on the electrochemical sensing of alkaline-phosphatase expressed from integrated liver tissue, Sensors and Actuators B: Chemical,213,9, (2015).

226. Ragones, H., Schreiber, D., Inberg, A., Berkh, O., Kósa, G., Freeman, A., & Shacham-Diamand, Y. ,Disposable electrochemical sensor prepared using 3D printing for cell and tissue diagnostics, Sensors and Actuators B: Chemical,216,9, (2015).

227. A. Henning, M. Molotskii, N. Swaminathan, Y. Vaknin, A. Godkin, G. Shalev, and Y. Rosenwaks,Electrostatic Limit of Detection of Nanowire-based Sensors, Small,10,201500566, (2015).

228. S. Semin,A. van Etteger,N. Amdursky,L. Kulyuk,S. Lavrov,A. Sigov, E. Mishina,G. Rosenman,Th. Rasing,Strong Thermo-Induced Single And Two-Photon Green Luminescence In Self-Organized Peptide Microtubes, Small,11,1156–1160 , (2015).

229. Micha Kornreich, Eti Malka-Gibor, Adi Laser-Azogui, Ofer Doron, Harald Herrmann, Roy Beck,Composite bottlebrush mechanics: α-internexin fine-tunes neurofilament network properties, Soft matter,11,5839-5849, (2015).

230. Dan Ben-Yaakov, Roman Golkov, Yair Shokef, and

Samuel A. Safran,Response of adherent cells to mechanical perturbations of the surrounding matrix, Soft Matter,11,1412, (2015).

231. Evgeny Nimerovsky, Anat Haimovich, Amir Goldbourt,An optimal double-magic flip angle for performing the distance measurement REDOR experiment on a spin S=1, Solid State Nuclear Magnetic Resonance,NA,NA, (2015).

232. Ingeborg M Storm, Micha Kornreich, Armando Hernandez-Garcia, Ilja K Voets, Roy Beck, Martien A Cohen Stuart, Frans AM Leermakers, Renko De Vries,Liquid Crystals of Self-Assembled DNA Bottlebrushes, The Journal of Physical Chemistry B,119,4084-4092, (2015).

233. Oman Walther, Itai Carmeli, Reinhard Schneider, Dagmar Gerthsen, Kurt Busch, Christian Matyssek, Ayala Shvarzman, Tsofar Maniv, Shachar Richter, Hagai Cohen,Interslit coupling via ultrafast dynamics across gold-film hole arrays, The Journal of Physical Chemistry C,118,11043-11049, (2014).


Startups• NanoLock (2015) - NanoLock’s

technology enables any solid-state memory to be physically “locked,” preventing unauthorized access at the hardware level. Furthermore, complete functionality of CPUs and MicroControllers can also be “locked” and disabled. Lead researcher: Prof. Slava Krylov

• NanoAir (2014) - A startup company developing paper-thin active cooling for thin devices. Lead researchers: Prof. Slava Krylov and Prof. Yosi Shacham

• Cine’al (2014) - A startup company developing jellyfish-derived super absorbents for fluids, with a focus on absorbing blood and proteins. Lead researcher: Prof. Shachar Richter

• Honeycomb Battery (2014) – A startup company based on 3D concentric on-chip silicon microbattery technology, enabling fabrication of 10-30K microbattery units in the perforated chip. Lead researchers: Prof. Diana Golodnitsky, Prof. Emanuel Peled and Prof. Menachem Nathan

• StoreDot Ltd. (2013) is a leader in the innovation of materials and their device applications, developing groundbreaking technologies based on a unique methodology for the design, synthesis and tuning of new organic compounds. These proprietary compounds dramatically improve the performance of a range of devices, including batteries, displays, sensors and digital memory. Lead researcher: Prof. Gil Rosenman

• NoAm ColorTech (2013) - A startup company developing novel hair coloring using unique strongly adhering coating beads. Lead researcher: Prof. Amihay Freeman

• Savicell Diagnostics (2012) - A cancer diagnostic kit. Lead researcher: Prof. Fernando Patolsky

• Quiet Therapeutics (2010) - A startup company developing a drug delivery technology. Lead researchers: Prof. Rimona Margalit and Prof. Dan Peer

• Tracense Systems (2010) - A startup company developing a nanotech-based “electronic nose” to sniff out security threats like bombs, biological warfare agents and toxic liquids. Lead researcher: Prof. Fernando Patolsky

License Agreements• Aerie Pharmaceuticals (2015)

- First-in-class therapies for anti-beta amyloid small molecules for the treatment of patients with glaucoma and dry AMD and other eye diseases. Lead researcher: Prof. Ehud Gazit

• Dexcel Pharma Technologies (2015) – Parkinson’s disease therapy, based on the identification of new beta-synuclein recognition modules. This disease-modifying treatment may enable inhibition of disease progression, in contrast to current symptomatic therapy that does not arrest disease progression. Lead researcher: Prof. Ehud Gazit

• Civan Advanced Technology (2015) - Development of a high-power laser based on the coherent

combination of fibers. Lead researcher: Prof. Shlomo Ruschin

• Variantyx Ltd. (2014) – Clinical grade, end-to-end genome analysis services for physicians and hospitals worldwide. Lead researcher: Dr. Noam Shomron

• Hall Effect Multi-bit magnetic random access memory (MRAM), signed with Samsung Global MRAM Innovation. Lead researcher: Prof. Alexander Gerber (2014)

• PEG-dendrimer hybrids as novel nano-carriers for pesticides delivery, signed with Makhteshim Chemical Works LTD. Lead researcher: Dr. Roey J. Amir (2014)

• A novel approach to fuel marking, signed with Eurocontrol Technics Group Inc. (TSX Venture: EUO). Lead researcher: Prof. Fernando Patolsky (2014)

• Discrimination of white blood cell populations with label-free digital holographic microscopy, signed with Siemens AG. Lead researcher: Dr. Natan Tzvi-Shaked (2014)

• Optical interferometry microscopy system and algorithms for non-destructive optical inspection, signed with Applied Materials Israel Ltd. Lead researcher: Dr. Natan Tzvi-Shaked (2014)

• Electrochemical deposition of hydroxyapatite on dental implants, signed with SGS International Ltd. Lead researcher: Prof. Noam Eliaz (2014)

• Nonpharma, polypeptide nanostructures for use in products of field effect transistors, signed with The Technical University of Denmark (DTU). Lead researcher: Prof. Ehud Gazit (2013)

Spinoffs


SPINOFFS

• Fluorescent nanomaterial for product authenticity verification, signed with Tata Steel Ltd. Lead researcher: Prof. Gil Markovich (2013)

• Phenylalanine fibrils antibodies related to PKU, signed with EMD Millipore Corporation. Lead researcher: Prof. Ehud Gazit. (2013)

• New drugs to treat schizophrenia and bipolar disorder, signed with Mental‐Heal Ltd. Lead researchers: Prof. Moshe Portnoy, Prof. Avi Weizman and Dr. Irit Gilad (2013)

• Targeted cancer therapy based on miR‐21, signed with Tickro Technologies. Lead researchers: Dr. Ella Sklan and Dr. Rina Rosin-Arbesfeld (2013)

• New hair coloring products based on unique coating beads which strongly adhere to the hair surface, signed with NoAm ColorTech Ltd. Lead researcher: Prof. Amihay Freeman (2013)

• Improving laser efficiency in OPO laser systems for airborne defense systems against heat-seeking missiles, signed with Elbit Systems-Elop. Lead researcher: Prof. Ady Arie (2012)

• Coral-derived collagen for tissue engineering, signed with ExceeMatrix Ltd. Lead researcher: Prof. Dafna Benayahu (2012)

• Drug-eluting composite structures, signed with Active Healing Bio Medical Ltd. Lead researcher: Prof. Meital Zilberman (2012)

• Transparent conductive coating with nanowires for flat panel applications, signed with Nepes. Lead researcher: Prof. Gil Markovich (2012)

• A new drug for Parkinson’s disease, signed with Bioline Rx. Lead researcher: Prof. Ehud Gazit (2012)

• Peptide nanotube electrodes for energy storage applications, signed with an Israeli defense industry company. Lead researchers: Prof. Ehud Gazit and Prof. Gil Rosenman (2010)

• Transparent conducting nanowires, signed with an Israeli startup in the field of photovoltaic coatings. Lead researcher: Prof. Gil Markovich (2009)


Core Staff

Prof. Yael Hanein Director

Mr. Zvi Kopolovitch Managing Director

Ms. Michal Shenhar Administrative Director

Dr. Yigal Lilach Electron & Ion Beam Lithography & Microscopy Manager

Dr. Artium Khatchatouriants Bio-AFM Laboratory Manager

Mr. Valery Gerber Process Engineer & Business Development

Dr. David Schreiber Process Engineer

Dr. Netta Handler Process Engineer

Mr. Gidon Jacob Equipment Engineer

Mr. Yoav Benjamin Equipment Engineer

Mr. Yuval Kupitz Head of International Collaborations

Dr. Inbal Halevi FTA Manager

Ms. Noa Shafir Secretary

Staff



Core Members

Prof. Shachar Richter Department of Materials Science and Engineering

Prof. Yael Hanein School of Electrical Engineering

Prof. Fernando Patolsky School of Chemistry

Prof. Koby Scheuer School of Electrical Engineering

Prof. Dan Peer Faculty of Life Sciences

Prof. Roy Beck-Barkai School of Physics & Astronomy

Scientific Committee

Prof. Ori Cheshnovsky School of Chemistry (Chairperson)

Prof. Rimona Margalit Faculty of Life Sciences

Prof. Yoram Dagan School of Physics & Astronomy

Prof. Yael Hanein School of Electrical Engineering (Director)

Prof. Fernando Patolsky School of Chemistry

Prof. Dan Peer Faculty of Life Sciences

Prof. Jacob Scheuer School of Electrical Engineering

Dr. Inna Slutsky Faculty of Medicine

Prof. Amit Kohn Department of Materials Science and Engineering


• The Chaoul Center for Nanoscale Materials and Systems

• The Marian Gertner Institute for Medical Nanosystems

• Vinci Technologies (Mr. Renaud Presberg)

• The Delaudaio Family (Argentina)

• Ms. Sara Weis (Australia)

• Mr. Shlomo Eliahu (Israel)

• Mr. Eli Horn (Brazil)

• Mr. Robert Goldberg (USA)

• James Russell DeLeon – The Center for Nanostructuring

• The Jack H. Skirball National Center for Biomedical Nanoscience

• Nanotechnology Research Fund in Cooperation with Clal Biotechnical Industries

• The Ilona Rich Institute for Nanoscale Bioscience and Biotechnologyv

• The Dr. Teodoro Jack and Dorothea Krauthamer Laboratory for Scanning Electron Microscopy

• A.V.B.A. Students Laboratory for Electron Beam Lithography

• Infrastructure Equipment for Nanotechnology Research - Wolfson Family Charitable Trust (UK)

• The Raymond and Beverly Sackler Chair in Clusters and Nanoparticles

• The Edouard Seroussi Chair for Protein Nanobiotechnology

• The Herman and Kurt Lion Chair in Nanosciences and Nanotechnologies

• The Bernard L. Schwartz Chair and Program in Nanoscale Information Technology

• Support for Nanotechnology Research donated by The Gilman Foundation

• Walanpatrias Stiftung

• Pa’amei Tikva Nanotechnology Research Fund (Israel 2004) LTD

Acknowledgments


• Mr. Ezekiel Solomon (Australia)

• The Cohen Family Doctoral Fellowship for the Study of Nanoscience

• The Buchman Heyman Foundation

• The Herb and Sharon Glaser Foundation

• Mr. Brian Lieber (UK)

• Mr. Doron Kochavi (Israel)

Since 2007 the Center is generously supported by the Israel Nanotechnology National Initiative (INNI) program, founded by TELEM (2007-2016)

Scholarships

Documents

The Center for Nanoscience & Nanotechnology