The CART FundCoins for Alzheimer’s Research Trust

A project of Rotary Clubs of Southeast US

Rotary International District 7570

My Classmate Governor Byron (07-08) and lovely wife Kathy

Introduced by Assistant Governor Mary Miller

In Governor Byron’sDecember 2007 Newsletter, this photo and caption

appeared together.

Youth Exchange from page 1

Governor Elect Woody and First Lady Elect Lori

What we will cover today•What is Alzheimer’s

disease?•How does Alzheimer’s

affect the brain?•What is CART?•CART History

•Example CART Research Grants

Alzheimer’s DiseaseWhat you need to know

Alzheimer’s (AHLZ-high-merz) disease is brain failure

-a progressive brain disorder that gradually destroys

brain cells and affects a person's memory, ability to learn, make judgments,

communicate, and carry out basic daily activities.

Alzheimer’s is not normal aging. It is a progressive, fatal disease,

the cause is unknown and it has no cure.

New meanings for familiar Words* Sun-downing

* Wandering

*Elopement

Alzheimer’s Disease: From Basic Research to Disease Cure

The CART Fund Columbia, SC

May 7, 2008

Sanjay W. PimplikarCleveland Clinic

We do not know for sure!

Amyloid hypothesis

What causes AD?

Alzheimer’s destroys brain cells

There are 100 billion nerve cells, or neurons, creating a branching network.

Signals traveling through the neuron forest form memories, thoughts and feelings.

Alzheimer’s destroys neurons, thus also destroying memories, thoughts, impulse control, personality, etc

Aβ

AICD

AD

Alzheimer’s causes the brain to shrink

(due to the death of neurons)

History of CART.

In October 1995, the Sumter, S.C., Rotary Club initiated the effort to prove

CART works by conducting an eight month testing program which was highly

successfulJuly 1996: District 7770 in South Carolina adopted CART as a project.

April 1999: Our first grant of $100,000 is made to Emory University's Alzheimer's Research

Center under the leadership of Dr. Allan Levey. AFAR (American Federation for Aging Research).

History of CART(cont)

.

In the 18 months from January 1999 until June 2000, 10 more Rotary districts of the Carolinas and Georgia adopt CART as a project. The first

Board of Directors meeting was held in November 2000, bylaws were adopted. They state that

100% of donated funds must go to Research!!

Each district that joins the CART program has two representatives on the board and two votes.

The District Chair and the DGN

11District Team Training Seminar

Zones 33 & 34

Success to date: $3.5m

11District Team Training Seminar

Zones 33 & 34

11District Team Training Seminar

Zones 33 & 34

This is how we are related

11District Team Training Seminar

Zones 33 & 34

1999 Emory University: Allan I. Levey, M.D. Ph.D. and Jim Lau

2001 Case Western Reserve University: Karl Herrup, Ph.D. and Gary Landreth

2003 University of Pennsylvania: John Q. Trojanowski, M.D. Ph.D.

History of CART Awards

2006 University of Texas Medical Branch: Claudio Soto, Ph.D.

2007 Mayo Clinic Jacksonville: Todd E. Golde, M.D., Ph.D.

2008 The Cleveland Clinic: Sanjay W. Pimplikar, Ph.D.

2009: Mayo Clinic, Jacksonville, Fl: Dr. Malcom LeissringS, Ph.D.

History of CART Awards

2010 University of Kentucky: Paul Murphy, M.D.$250,000

2010 University of Wisconsin-Madison: Dr. Luigi Puglieli, Ph. D.

$150,0002010 University of Pennsylvania:

Dr. Kurt Brunden, Ph.D.$50,000

History of CART Awards

2011 University of Pennsylvania:Dr. Kurt Brunden

$250,000 2011 Case Western:

Dr. Gary Landreth$100,000

2011 Mass GeneralDr. Brad Hyman $50,000

History of CART Awards

2012 Dr. Maya Koronyo-HamaouiCedars Sinai, Oakland, CA.

$250,000

2012 University of WashingtonDr. Valarie Daggett, Ph. D.

$100,000

History of CART Awards

How devastating is AD on a personal level. We lose

contact with the individual that we knew.•How do we know what

they are thinking and feeling?

•How do they see themselves?

1967

1996

1996

19971997

1998

1999

2000

William Utermohlen: Self portraits

“..depict sadness, anxiety, resignation, feeling of feebleness and shame.”(NY Times, Oct 24, 2006)

You can help!! Lets find the cause, and find the

cure/prevention for this dreaded disease!!