The Bernard M. Gordon Center for Subsurface Sensing and Imaging

Systems

Prof. Charles A. DiMarzio

Northeastern University

Portable Skin Cancer Microscope Product Development

This work was supported by in part by the Gordon Center for Subsurface Sensing and Imaging Systems, under the Engineering Research Centers Program of the National Science Foundation (Award # EEC-9986821).

5 Million Biopsies for 1 Million Cancers!

Example of Current Confocal Microscope Technology

25 m

- VivaScope 1000- Sub-Cellular Resolution- Imaging to DE Junction- Large Package- Limited Flexibility

Next Generation: NU Work

Get the Light from the Microscope to the Patient and Back

Make the Microscope Smaller

Articulated Arm and Endoscope

Gustavo Herrera (BS 2003, MS 2005), Milind Rajadhyaksha, Gary Peterson (BS, 2007)

Multiple Wavelengths:532 nm, 830 nm, and 1064 nm

√ See Poster

(capstone)

Theta Line Scanner

Peter Dwyer (BS 1989, MS 1997, Ph.D. 2005), Milind Rajadhyaksha

Confocal in One Direction, but Not in the Other for Greater Speed.Bistatic for Improved Sectioning.

-Dwyer, Peter J., Charles A. DiMarzio, James M. Zavislan, William J. Fox, and Milind Rajadhyaksha, “Confocal Reflectance Theta Line--Scanning for Imaging Human Skin in vivo,” Optics Letters, 2006. -Dwyer, P. J. , C. A. DiMarzio, and M. Rajadhyaksha, ``Confocal thetaline-scanning microscope for imaging human tissues,”Appl. Opt. 46,1 April 2007. Pp. 1843-1851.

Dual Wedge Confocal Microscope Initial Development

P1P2

α α

θ1

θ1 θ2

v1

v1

v2

Bill Warger (MS 2005, Ph.D. Candidate), and Many Undergraduate Students(Capstone Design Winner in 2004)

√ See Poster

Dual Wedge Confocal Microscope Recent Work

100 µm 100 µm

Upgraded Acquisition System to Achieve Integration time in Seconds rather than Minutes.

Operational Goal is 1/5 Second

Imaging of Business Card and Plant Material Shows Sectioning and Resolution

√ See Poster

Design Goal

Dual-Wedge Cofocal Microscope Product Development Plan

Submit Proposals NIH STTR (Close Score) R01 “Industry-University Partnerships ...

Imaging for Cancer Investigations” Submit Paper on Resolution (Done) Demonstrate Skin Imaging with Sub-

Cellular Sectioning and Resolution Develop Intermediate Generation

System (Gordon Fellowship?) Demonstrate Feasibility, and then

Design Hand-Held Instrument