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The Additive IOP-Lowering The Additive IOP-Lowering Effect of Brimonidine 0.1% Effect of Brimonidine 0.1% vs Brinzolamide 1.0% vs Brinzolamide 1.0% Adjunctive to Latanoprost Adjunctive to Latanoprost 0.005% 0.005% Douglas Day Douglas Day 1 and David Hollander and David Hollander 2 1. 1. Omni Eye Services, Atlanta, GA Omni Eye Services, Atlanta, GA ; 2. Allergan, Inc., Irvine, ; 2. Allergan, Inc., Irvine, CA CA Financial Disclosure Financial Disclosure This study was sponsored by Allergan, Inc. This study was sponsored by Allergan, Inc. D. Day has no proprietary interest in any of the study drugs or D. Day has no proprietary interest in any of the study drugs or their manufacturers. their manufacturers. D. Hollander is an employee of Allergan, Inc. D. Hollander is an employee of Allergan, Inc.

The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

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Page 1: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

The Additive IOP-Lowering Effect The Additive IOP-Lowering Effect of Brimonidine 0.1% vs of Brimonidine 0.1% vs

Brinzolamide 1.0% Adjunctive to Brinzolamide 1.0% Adjunctive to Latanoprost 0.005%Latanoprost 0.005%

Douglas DayDouglas Day11 and David Hollander and David Hollander22

1. 1. Omni Eye Services, Atlanta, GAOmni Eye Services, Atlanta, GA; 2. Allergan, Inc., Irvine, CA ; 2. Allergan, Inc., Irvine, CA

Financial DisclosureFinancial Disclosure

This study was sponsored by Allergan, Inc. This study was sponsored by Allergan, Inc. D. Day has no proprietary interest in any of the study drugs or their manufacturers. D. Day has no proprietary interest in any of the study drugs or their manufacturers.

D. Hollander is an employee of Allergan, Inc.D. Hollander is an employee of Allergan, Inc.

Page 2: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

AbstractAbstract

Purpose:Purpose: Evaluate efficacy/safety of brimonidine 0.1% vs brinzolamide Evaluate efficacy/safety of brimonidine 0.1% vs brinzolamide adjunctive to latanoprost.adjunctive to latanoprost.

Methods:Methods: Investigator-masked, randomized, parallel-group study of Investigator-masked, randomized, parallel-group study of40 patients randomized to brimonidine 0.1% or brinzolamide 1.0% TID 40 patients randomized to brimonidine 0.1% or brinzolamide 1.0% TID adjunctive to latanoprost. Subjects administered latanoprost once daily in adjunctive to latanoprost. Subjects administered latanoprost once daily in the evening and the study medication 3 times daily for 3 months. Mean the evening and the study medication 3 times daily for 3 months. Mean diurnal intraocular pressure (IOP) was calculated based on IOP diurnal intraocular pressure (IOP) was calculated based on IOP measurements at 8 measurements at 8 AMAM, 10 , 10 AMAM, and 4 , and 4 PMPM at each study visit (baseline, at each study visit (baseline,1 month, and 3 months).1 month, and 3 months).

Results:Results: Equivalent mean diurnal baseline IOPs on latanoprost (19.6, Equivalent mean diurnal baseline IOPs on latanoprost (19.6, 19.8 mm Hg; 19.8 mm Hg; PP = .846). At 3 months, the additional mean reduction from = .846). At 3 months, the additional mean reduction from latanoprost baseline for brimonidine and brinzolamide, respectively, was 3.3 latanoprost baseline for brimonidine and brinzolamide, respectively, was 3.3 and 2.1 mm Hg (and 2.1 mm Hg (PP = .028). Blurred vision ( = .028). Blurred vision (PP = .011) at 1 month and unusual = .011) at 1 month and unusual taste at 1 and 3 months were more common with brinzolamidetaste at 1 and 3 months were more common with brinzolamide((PP = .002, = .002, PP = .031, respectively). = .031, respectively).

Conclusion:Conclusion: Brimonidine 0.1% provided greater or equivalent IOP lowering Brimonidine 0.1% provided greater or equivalent IOP lowering compared with brinzolamide adjunctive to latanoprost.compared with brinzolamide adjunctive to latanoprost.

Page 3: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

IntroductionIntroduction

The once-daily prostaglandin analogs (PGAs) (bimatoprost, latanoprost, and travoprost) The once-daily prostaglandin analogs (PGAs) (bimatoprost, latanoprost, and travoprost) effectively reduce intraocular pressure (IOP) and are often used as monotherapy to treat effectively reduce intraocular pressure (IOP) and are often used as monotherapy to treat glaucoma and ocular hypertension (OHT). Many patients, however, do not achieve glaucoma and ocular hypertension (OHT). Many patients, however, do not achieve sufficiently low IOP with a single medication.sufficiently low IOP with a single medication.11 Over 20% of patients who are initiated on Over 20% of patients who are initiated on monotherapy with a once-daily PGA may be expected to require adjunctive therapy within monotherapy with a once-daily PGA may be expected to require adjunctive therapy within the next year.the next year.22

A primary consideration in choosing adjunctive medication is IOP-lowering efficacy. An A primary consideration in choosing adjunctive medication is IOP-lowering efficacy. An adjunctive therapy ideally provides at least an additional 15% reduction in IOP from baseline adjunctive therapy ideally provides at least an additional 15% reduction in IOP from baseline on the initial therapy.on the initial therapy.33 Several classes of IOP-lowering medications have been evaluated as Several classes of IOP-lowering medications have been evaluated as adjunctive therapies to PGAs. Brinzolamide is an ophthalmic suspension of a carbonic adjunctive therapies to PGAs. Brinzolamide is an ophthalmic suspension of a carbonic anhydrase inhibitor (CAI). When used as adjunctive therapy to latanoprost, brinzolamide has anhydrase inhibitor (CAI). When used as adjunctive therapy to latanoprost, brinzolamide has been demonstrated to reduce IOP as effectively as dorzolamide, the first topical CAI been demonstrated to reduce IOP as effectively as dorzolamide, the first topical CAI introduced for IOP lowering, and to be associated with less ocular discomfort.introduced for IOP lowering, and to be associated with less ocular discomfort.44 Brimonidine, Brimonidine, a highly selective alpha-adrenergic agonist, has similarly been shown to effectively reduce a highly selective alpha-adrenergic agonist, has similarly been shown to effectively reduce IOP when used in combination with PGAs including latanoprost.IOP when used in combination with PGAs including latanoprost.5-7 5-7

The purpose of the present study was to evaluate the IOP-lowering efficacy and tolerability The purpose of the present study was to evaluate the IOP-lowering efficacy and tolerability of brimonidine Puriteof brimonidine Purite®® 0.1% compared with brinzolamide 1% when used as adjunctive 0.1% compared with brinzolamide 1% when used as adjunctive therapy to latanoprost in patients with glaucoma or OHT.therapy to latanoprost in patients with glaucoma or OHT.

References: 1. Kass et al. Arch Ophthalmol. 2002;120:701-713; 2. Covert and Robin. Curr Med Res Opin. 2006;22:971-976; 3. Glaucoma Disease Management Guide. PDR 2004; 4. Tsukamoto et al. J Ocul Pharmacol Ther. 2005;21:395-399; 5. Lee and Gornbein. J Glaucoma. 2001;10:220-226;6. Konstas et al. Ophthalmology. 2005;112:603-608; 7. Netland et al. Adv Ther. 2003;20:20-30.

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Methods: Study Design and PatientsMethods: Study Design and Patients

This was a randomized, single-center, investigator-masked, parallel-group study.This was a randomized, single-center, investigator-masked, parallel-group study.

Patients diagnosed with glaucoma or OHT who were currently on latanoprost Patients diagnosed with glaucoma or OHT who were currently on latanoprost monotherapy and in need of additional IOP lowering were enrolled.monotherapy and in need of additional IOP lowering were enrolled.

Patients were required to have been on latanoprost monotherapy for at least 30 Patients were required to have been on latanoprost monotherapy for at least 30 days prior to study enrollment and to have a screening IOP of 18 mm Hg or higher days prior to study enrollment and to have a screening IOP of 18 mm Hg or higher in at least 1 eye.in at least 1 eye.

Eligible patients were randomized to 1 of 2 adjunctive treatment groups:Eligible patients were randomized to 1 of 2 adjunctive treatment groups:– Brimonidine P 0.1% TID (AlphaganBrimonidine P 0.1% TID (Alphagan®® P 0.1%; Allergan, Inc.; Irvine, CA) P 0.1%; Allergan, Inc.; Irvine, CA)

– Brinzolamide 1% TID (AzoptBrinzolamide 1% TID (Azopt®®; Alcon Laboratories, Inc.; Fort Worth, TX); Alcon Laboratories, Inc.; Fort Worth, TX)

Study drugs were dosed at 8 Study drugs were dosed at 8 AMAM, 4 , 4 PMPM, and 10 , and 10 PMPM (± 1 hour) for 3 months. (± 1 hour) for 3 months.

Marketed bottles of brimonidine P and brinzolamide were provided to patientsMarketed bottles of brimonidine P and brinzolamide were provided to patientsin identically appearing masked cartons labeled with the patient randomization in identically appearing masked cartons labeled with the patient randomization number.number.

Latanoprost was provided in its marketed bottle and was dosed in the eveningLatanoprost was provided in its marketed bottle and was dosed in the evening10 minutes apart from the instillation of study medication.10 minutes apart from the instillation of study medication.

Study visits were at baseline, month 1, and month 3.Study visits were at baseline, month 1, and month 3.

Page 5: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

Methods: Outcome Measures and Methods: Outcome Measures and AnalysisAnalysis

IOP was measured at each visit at 8 IOP was measured at each visit at 8 AMAM (morning trough, just before study drug (morning trough, just before study drug instillation), 10 instillation), 10 AMAM (peak effect) and 4 (peak effect) and 4 PMPM (before second dose of study drug). (before second dose of study drug).

Efficacy outcome measures included mean diurnal IOP at each visit and mean IOP Efficacy outcome measures included mean diurnal IOP at each visit and mean IOP at each timepoint and visit.at each timepoint and visit.

Safety measures included comfort/tolerability, ocular signs and symptoms, adverse Safety measures included comfort/tolerability, ocular signs and symptoms, adverse events, and visual acuity.events, and visual acuity.

A written questionnaire was administered at each follow-up visit to evaluate the A written questionnaire was administered at each follow-up visit to evaluate the comfort and tolerability of study drug instillation.comfort and tolerability of study drug instillation.

Analyses of IOP were based on the worse eye (the eye with the higher IOP at 8 Analyses of IOP were based on the worse eye (the eye with the higher IOP at 8 AMAM on baseline) for the intent-to-treat patient population with imputation for missing on baseline) for the intent-to-treat patient population with imputation for missing values using the last observation carried forward.values using the last observation carried forward.

Diurnal IOP for a patient was defined as the mean of the 8 Diurnal IOP for a patient was defined as the mean of the 8 AMAM, 10 , 10 AMAM, and 4 , and 4 PMPM measurements taken at a particular visit.measurements taken at a particular visit.

Baseline differences in IOP between treatment groups were evaluated using analysis Baseline differences in IOP between treatment groups were evaluated using analysis of variance (ANOVA).of variance (ANOVA).

An analysis of covariance (ANCOVA) model with baseline IOP as the covariate was An analysis of covariance (ANCOVA) model with baseline IOP as the covariate was used to evaluate differences between treatment groups at follow-up visits. used to evaluate differences between treatment groups at follow-up visits.

Page 6: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

Results: Patient Characteristics and Results: Patient Characteristics and DispositionDisposition

There were no significant differences between treatment groups in patient demographics.There were no significant differences between treatment groups in patient demographics.– Half of the patients were black, and most were diagnosed with chronic open-angle glaucoma.Half of the patients were black, and most were diagnosed with chronic open-angle glaucoma.

Thirty-four patients (85%) completed the study as planned.Thirty-four patients (85%) completed the study as planned.– In the brinzolamide group, 3 patients exited the study early because of adverse events (eye pain, pruritus, and brain In the brinzolamide group, 3 patients exited the study early because of adverse events (eye pain, pruritus, and brain

tumor) and 1 was lost to follow-up.tumor) and 1 was lost to follow-up.

– In the brimonidine P group, 1 patient discontinued due to an adverse event (hypertension) and 1 due to lack of efficacy. In the brimonidine P group, 1 patient discontinued due to an adverse event (hypertension) and 1 due to lack of efficacy.

Brimonidine P 0.1%Brimonidine P 0.1%(N = 20)(N = 20)

Brinzolamide 1%Brinzolamide 1%(N = 20)(N = 20)

Mean age (years) Mean age (years) 60.060.0 57.557.5

Sex (male/female)Sex (male/female) 45%/55%45%/55% 65%/35%65%/35%

RaceRace

BlackBlack 55%55% 45%45%

WhiteWhite 45%45% 45%45%

HispanicHispanic 0%0% 5%5%

AsianAsian 0%0% 5%5%

DiagnosisDiagnosis

OHTOHT 5%5% 10%10%

Chronic open-angle glaucomaChronic open-angle glaucoma 85%85% 75%75%

Chronic angle-closure glaucomaChronic angle-closure glaucoma 10%10% 10%10%

MixedMixed 0%0% 5%5%

Mixed diagnosis = one eye with OHT and the other with chronic open-angle glaucoma.

Page 7: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

Results: Mean Diurnal IOPResults: Mean Diurnal IOP

Baseline mean diurnal IOPs on latanoprost were similar in the 2 treatment groups Baseline mean diurnal IOPs on latanoprost were similar in the 2 treatment groups (bimatoprost: 19.6 mm Hg, travoprost: 19.8 mm Hg; (bimatoprost: 19.6 mm Hg, travoprost: 19.8 mm Hg; PP = .846). = .846).

Both brimonidine P 0.1% and brinzolamide reduced diurnal IOP substantially when Both brimonidine P 0.1% and brinzolamide reduced diurnal IOP substantially when added to ongoing latanoprost therapy.added to ongoing latanoprost therapy.

Adjunctive brimonidine P provided significantly lower mean diurnal IOP than adjunctive Adjunctive brimonidine P provided significantly lower mean diurnal IOP than adjunctive brinzolamide at both follow-up visits (brinzolamide at both follow-up visits (PP ≤ .028). ≤ .028).

At month 3, the additional mean reduction from latanoprost baseline wasAt month 3, the additional mean reduction from latanoprost baseline was3.3 mm Hg with brimonidine P vs 2.1 mm Hg with brinzolamide (3.3 mm Hg with brimonidine P vs 2.1 mm Hg with brinzolamide (PP = .028). = .028).

Mea

n (

± S

EM

) d

iurn

al I

OP

(m

m H

g)

*P ≤ .028 vs brinzolamide

Month

Brinzolamide 1% (N = 20)

Brimonidine Purite® 0.1% (N = 20)

17.8

16.3

19.8

17.919.6

16.4

14

16

18

20

0 1 2 3

* *

Page 8: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

Mean IOP (SEM) at Each Hour (mm Hg)Mean IOP (SEM) at Each Hour (mm Hg)

Baseline mean IOPs on latanoprost were similar in the 2 treatment groups at each hour.Baseline mean IOPs on latanoprost were similar in the 2 treatment groups at each hour.

Brimonidine P provided significantly lower IOP compared with brinzolamide at the Brimonidine P provided significantly lower IOP compared with brinzolamide at the 10 10 AMAM (peak effect) and 4 (peak effect) and 4 PMPM time points at both 1 and 3 months ( time points at both 1 and 3 months (PP ≤ .050). ≤ .050).

At 8 At 8 AMAM (trough effect) mean IOP was similar in the 2 treatment groups. (trough effect) mean IOP was similar in the 2 treatment groups.

The reduction from baseline IOP on latanoprost at individual time points during follow-up The reduction from baseline IOP on latanoprost at individual time points during follow-up ranged from 2.2 to 4.8 mm Hg with brimonidine P and from 1.4 to 2.9 mm Hg with ranged from 2.2 to 4.8 mm Hg with brimonidine P and from 1.4 to 2.9 mm Hg with brinzolamide. brinzolamide.

Month 1Month 1 Month 3Month 3

Brim P 0.1%Brim P 0.1%(N = 20)(N = 20)

Brinz 1.0%Brinz 1.0%(N = 20)(N = 20) P P ValueValue

Brim P 0.1%Brim P 0.1%(N = 20)(N = 20)

Brinz 1.0%Brinz 1.0%(N = 20)(N = 20) P P ValueValue

8 8 AMAM (trough) (trough) 17.8 (0.68)17.8 (0.68) 18.1 (0.60)18.1 (0.60) .896.896 18.2 (0.76)18.2 (0.76) 18.2 (0.71)18.2 (0.71) .716.716

10 10 AMAM (peak) (peak) 15.1 (0.65)15.1 (0.65) 17.6 (0.76)17.6 (0.76) .002.002 14.6 (0.63)14.6 (0.63) 17.4 (0.51)17.4 (0.51) <.001<.001

4 4 PMPM 16.2 (0.67)16.2 (0.67) 18.1 (0.78)18.1 (0.78) .035.035 16.3 (0.61)16.3 (0.61) 17.8 (0.49)17.8 (0.49) .050.050

Page 9: The Additive IOP-Lowering Effect of Brimonidine 0.1% vs Brinzolamide 1.0% Adjunctive to Latanoprost 0.005% Douglas Day 1 and David Hollander 2 1. Omni

Comfort and Tolerability of Eye Drop Comfort and Tolerability of Eye Drop Instillation: Survey Results Instillation: Survey Results

Brinzolamide-treated patients were significantly more likely than brimonidine P-treated patients Brinzolamide-treated patients were significantly more likely than brimonidine P-treated patients to report an unusual taste associated with eye drop instillation at both months 1 and 3.to report an unusual taste associated with eye drop instillation at both months 1 and 3.

Patients in the brinzolamide group were also more likely than those in the brimonidine P group Patients in the brinzolamide group were also more likely than those in the brimonidine P group to report changes in vision (usually described as blurred vision) at month 1.to report changes in vision (usually described as blurred vision) at month 1.

One patient in the brinzolamide group reported that the bitter taste associated with eye drop One patient in the brinzolamide group reported that the bitter taste associated with eye drop instillation caused him to want to discontinue his study medication. instillation caused him to want to discontinue his study medication.

Patients were asked whether they experienced an unusual taste, an unusual ocular sensation, ocular discomfort, or any change in vision after instilling their eye drop medications. All patient responses were “yes” or “no”; there were no responses of “not sure.”

Number of Patients Responding “Yes”Number of Patients Responding “Yes”(% of Total Responses)(% of Total Responses)

Month 1Month 1 Month 3Month 3

Brim P 0.1%Brim P 0.1% Brinz 1.0%Brinz 1.0% P P ValueValue Brim P 0.1%Brim P 0.1% Brinz 1.0%Brinz 1.0% P P ValueValue

Unusual tasteUnusual taste 1 (5.0%)1 (5.0%) 9 (50.0%)9 (50.0%) .002.002 2 (11.1%)2 (11.1%) 7 (43.8%)7 (43.8%) .031.031

Unusual Unusual sensation in eyesensation in eye 1 (5.0%)1 (5.0%) 1 (5.6%)1 (5.6%) .939.939 1 (5.6%)1 (5.6%) 1 (6.3%)1 (6.3%) .932.932

Ocular Ocular discomfortdiscomfort 3 (15.0%)3 (15.0%) 5 (29.4%)5 (29.4%) .289.289 3 (16.7%)3 (16.7%) 2 (12.5%)2 (12.5%) .732.732

Change in visionChange in vision 2 (10.0%)2 (10.0%) 8 (47.1%)8 (47.1%) .011.011 1 (5.6%)1 (5.6%) 2 (12.5%)2 (12.5%) .476.476

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Other Safety ParametersOther Safety Parameters

There were no significant differences between treatment There were no significant differences between treatment groups in biomicroscopic findings or changes from groups in biomicroscopic findings or changes from baseline visual acuity.baseline visual acuity.

Treatment-related adverse events were reported forTreatment-related adverse events were reported for4 patients (20%) in the brimonidine P group and 3 4 patients (20%) in the brimonidine P group and 3 patients (15%) in the brinzolamide group. patients (15%) in the brinzolamide group.

There was no significant between-group difference in the There was no significant between-group difference in the overall incidence of treatment-related adverse events or overall incidence of treatment-related adverse events or in the incidence of any individual treatment-related in the incidence of any individual treatment-related adverse event. adverse event.

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DiscussionDiscussion

In patients with inadequate IOP control on latanoprost, mean IOP at 10 In patients with inadequate IOP control on latanoprost, mean IOP at 10 AMAM and 4 and 4 PMPM and and mean diurnal IOP were significantly lower with adjunctive brimonidine P than with mean diurnal IOP were significantly lower with adjunctive brimonidine P than with brinzolamide. Mean IOP at 8 brinzolamide. Mean IOP at 8 AMAM was similar in the 2 treatment groups. was similar in the 2 treatment groups.

The difference between treatment groups in mean diurnal IOP at months 1 and 3 is likely to The difference between treatment groups in mean diurnal IOP at months 1 and 3 is likely to be clinically significant, because in the Early Manifest Glaucoma Trial, each 1 mm Hg be clinically significant, because in the Early Manifest Glaucoma Trial, each 1 mm Hg decrease in IOP was associated with a 10% decrease in the risk of glaucoma progression.decrease in IOP was associated with a 10% decrease in the risk of glaucoma progression.11

Although brimonidine P and brinzolamide are often dosed twice daily in clinical practice, they Although brimonidine P and brinzolamide are often dosed twice daily in clinical practice, they were dosed thrice daily in this study as recommended in their prescribing information.were dosed thrice daily in this study as recommended in their prescribing information.

It is unlikely that the additional afternoon dose of drugs affected the efficacy results, because It is unlikely that the additional afternoon dose of drugs affected the efficacy results, because all of the IOP measurements were taken prior to the second daily dose of medication given all of the IOP measurements were taken prior to the second daily dose of medication given in the afternoon.in the afternoon.

Transient side effects associated with eye drop instillation may cause patient discomfort and Transient side effects associated with eye drop instillation may cause patient discomfort and decrease patients’ compliance with treatment.decrease patients’ compliance with treatment.

At month 1, more brinzolamide-treated patients than brimonidine PAt month 1, more brinzolamide-treated patients than brimonidine P––treated patients reported treated patients reported blurred vision and bitter taste associated with eye drop instillation.blurred vision and bitter taste associated with eye drop instillation.

By month 3, the number of brinzolamide-treated patients who reported blurred vision had By month 3, the number of brinzolamide-treated patients who reported blurred vision had decreased, but bitter taste remained more common in patients treated with brinzolamide.decreased, but bitter taste remained more common in patients treated with brinzolamide.

Both brimonidine P and brinzolamide were well tolerated.Both brimonidine P and brinzolamide were well tolerated.

Reference: 1. Leske et al. Arch Ophthalmol. 2003;121:48-56.

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ConclusionsConclusions

Brimonidine P provided significantly lower diurnal IOP Brimonidine P provided significantly lower diurnal IOP than brinzolamide when added to latanoprost therapy.than brinzolamide when added to latanoprost therapy.

Bitter taste after eye drop instillation was significantly less Bitter taste after eye drop instillation was significantly less common with brimonidine P than with brinzolamide common with brimonidine P than with brinzolamide adjunctive therapy.adjunctive therapy.