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The 5 Million Lives Campaign: “Preventing Central Line Infections”. Institute for Healthcare Improvement. The Central Line Bundle. Do Central Lines Cause Blood Stream Infections?. - PowerPoint PPT Presentation
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The 5 Million Lives Campaign:
“Preventing Central Line Infections”
Institute for Healthcare Improvement
The Central Line Bundle
© 2007 Institute for Healthcare Improvement
Do Central Lines Cause Blood Stream Infections?
➥ Central venous catheters (CVCs) disrupt the integrity of the skin, making infection with bacteria and/or fungi possible.
➥ Infection may spread to the blood stream (bacteremia) and hemodynamic changes and organ dysfunction (sepsis) may ensue.
➥ Approximately 90% of the catheter-related blood stream infections (BSIs) occur with CVCs.
Maki DG. Infections due to infusion therapy. In: Hospital Infections, Third Edition, Bennett JV, Brachman PS (eds), Little, Brown, Boston 1992.
© 2007 Institute for Healthcare Improvement
Incidence & Risk:
➥ 48% of ICU patients have central venous catheters, accounting for 15 million central venous catheter-days per year in ICUs.
➥ The case fatality rate for catheter-related blood stream infections approaches 20%.
➥ Attributable mortality ranges from 12-25% but was 3% in one meta-analysis.
Mermel LA. Ann Int Med 2000;132: 391-402Soufir L et al. Infect Control Hosp Epidemiol 1999 Jun;20(6):396-401.
© 2007 Institute for Healthcare Improvement
Incidence & Risk:
➥ Studies that control for underlying illness severity give lower estimates of attributable mortality.
➥ These data suggest that attributable mortality is between 4 and 20%.
➥ Thus, between 500-4000 U.S. patients die annually due to blood stream infections.
Pittet D, Tarara D, Wenzel RP. Jama. May 25 1994;271(20):1598-1601Soufir L et al. Infect Control Hosp Epidemiol 1999 Jun;20(6):396-401.
© 2007 Institute for Healthcare Improvement
BSI is Costly & Prolongs Care
! Attributable cost per blood stream infection is estimated to be $3,700 to $29,000.
! Nosocomial blood stream infections prolong hospitalization by a mean of 7 days.
Pittet D, Tarara D, Wenzel RP. Jama. May 25 1994;271(20):1598-1601Soufir L et al. Infect Control Hosp Epidemiol 1999 Jun;20(6):396-401.
© 2007 Institute for Healthcare Improvement
BSI Risk Factors
Risk Factors with Percutaneous or TunneledCatheters:
Site of insertion: Subclavian vein less risky than internal jugular or femoral vein.
Multiple ports/hubs: More manipulation and contamination.
Parenteral feeding: TPN and/or lipids
Infection elsewhere: Remote, e.g. UTI or wound.Mermel LA, Am J Med. Sep 16 1991;91(3B):197S-205SMcCarthy MC, J Parenter Enteral Nutr 1987; 11:259.
© 2007 Institute for Healthcare Improvement
BSI Risk Factors
Risk Factors with a Central Venous AccessDevice (C-VAD): Lower infection rates: 0.1 to 0.2 per 100 catheter days. Subcutaneous ports: 10-12 fold lower rate of infection
compared with tunneled catheters. Some risks remain:
– Colonization of catheter with organisms – IV catheterization longer than 72 hours – Inexperience of personnel inserting the C-VAD
Groeger JS, et al. Ann Intern Med 1993; 119:1168.
© 2007 Institute for Healthcare Improvement
CDC Guidelines
Major areas of emphasis: Education and training of providers who
insert lines Maximal sterile barrier precautions Use of 2% chlorhexidine for skin antisepsis Avoiding routine replacement Consider antiseptic/antibiotic impregnated
catheters if rate of infection remains high
O’Grady NP. MMWR Aug 9, 2002; 51: RR10, 1-29
© 2007 Institute for Healthcare Improvement
AHRQ-Sponsored Evidence Summary
Attributable mortality 4-20%
Analyses of costs very variable
Routine replacement does not reduce risk
Maximum barrier precautions reduce risk
CVCs coated with antiseptics or antibiotics might reduce risk but are expensive
Use of chlorhexidine skin prep reduces risk more than povidone-iodine
Saint S. http://www.ahrq.gov/clinic/evrptfiles.htm#ptsafety
© 2007 Institute for Healthcare Improvement
Opportunity Knocks
¿What if a series of interventions could markedly reduce the risk of BSI?
¿What if those interventions were already readily available in hospitals?
¿What if all of those interventions were done all of the time on each patient?
© 2007 Institute for Healthcare Improvement
Benefits of Reducing BSI
Better patient outcomes
Reduced mortality
Improved satisfaction Nursing Physician Patients and families
Financial benefits
© 2007 Institute for Healthcare Improvement
The Central Line Bundle
…is a group of interventions related to patients with intravascular central catheters that, when implemented together, result in better outcomes than when implemented individually.
© 2007 Institute for Healthcare Improvement
What is a Bundle?
A grouping of best practices with respect to a disease process that individually improve care, but when applied together result in substantially greater improvement.
The science behind the bundle is so well established that it should be considered standard of care.
Bundle elements are dichotomous and compliance can be measured: yes/no answers.
Bundles eschew the piecemeal application of proven therapies in favor of an “all or none” approach.
© 2007 Institute for Healthcare Improvement
Central Line Bundle Elements
1. Hand hygiene
2. Maximal barrier precautions
3. Chlorhexidine skin antisepsis
4. Appropriate catheter site and administration system
5. Avoidance of routine replacement
© 2007 Institute for Healthcare Improvement
But, Does it Work?
ICUs that have implemented multifaceted interventionssimilar to the central-line bundle have nearly eliminatedCR-BSIs.
Berenholtz SM, Pronovost PJ, Lipset PA, et al. Eliminating catheterrelated bloodstream infection in the intensive care unit. Critical CareMedicine. 2004; 32:2014-2020.
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Rat
e p
er 1
000
cath
day
s
© 2007 Institute for Healthcare Improvement
Outcome and Cost Impact
Rate of CR-BSIs fell from 11.3 to 0 /1000 catheter days.
Prevented annually (estimated):↳ 43 CR-BSIs↳ 8 deaths↳ 559 ICU days
Estimated savings to hospital: $1,824,447
© 2007 Institute for Healthcare Improvement
Does it Work?
Baptist Memorial Hospital-Memphis, Memphis, TN
Reduced CR-BSI and ICU length of stay:
© 2007 Institute for Healthcare Improvement
Hand Hygiene 101
Wash hands if they are obviously soiled
Wash hands or use an alcohol based waterless hand cleaner
↳ Before and after invasive procedures ↳ Between patients ↳ After removing gloves ↳ Before eating ↳ After using the bathroom ↳ If contamination is suspected
© 2007 Institute for Healthcare Improvement
What are Maximal Barrier Precautions?
• For Provider:
– Hand hygiene– Non-sterile cap and mask
• All hair should be under cap• Mask should cover nose and mouth tightly
– Sterile gown and gloves
• For the Patient:
– Cover patient’s head and body with a large sterile drape
© 2007 Institute for Healthcare Improvement
Impact of Maximal Barrier Precautions (MBR)
Author/date Design Catheter Odds Ratio for infection w/o MBR
Mermel
1990
Prospective
Cross-sectional
Swan Ganz 2.2 (p<0.03)2.2 (p<0.03)
Raad
1994
Prospective
Randomized
Central 6.3 (p<0.03)6.3 (p<0.03)
OR=odds ratio MBR= inserter washes hands and wearsmask, sterile gown, sterile gloves and patient’s head & body
are covered with a large, sterile drape.
© 2007 Institute for Healthcare Improvement
Key Change: Central Line Checklist
Have the nurse document compliance with the insertion criteria at the time of insertion.
Create a culture of safety and prevention:
empower nurses to stop line placement if improper techniques are used
Instruct nurses in use of critical communication strategies to facilitate important exchanges.
e.g. “the sterile field has been contaminated,” rather than “YouYou contaminated the catheter!”
© 2007 Institute for Healthcare Improvement
Checklist Elements
• Before the procedureBefore the procedure, did they: – Wash hands?– Sterilize procedure site?– Drape entire patient in a sterile fashion?
• During the procedureDuring the procedure, did they:– Use sterile gloves, mask and sterile gown?– Maintain a sterile field?
• Verify:Verify: did all personnel assisting with procedure
follow the above precautions?
© 2007 Institute for Healthcare Improvement
Chlorhexidine Skin Antisepsis
A. Prepare skin with antiseptic/detergent Chlorhexidine 2% in 70% isopropyl alcohol.
B. Pinch wings on the “Chloraprep” applicator to pop the ampule. Hold the applicator down to allow the solution to saturate the pad.
C. Press sponge against skin, apply chlorhexidine solution using a back and forth friction scrub for at least 30 seconds. Do not wipe or blot.
D. Allow antiseptic solution time to dry completelycompletely before puncturing the site ( ~ 2 minutes).
© 2007 Institute for Healthcare Improvement
Baseline Compliance With Best Practice
Example: At one hospital, providers were compliantwith best practice during 62% of the observedProcedures
Compliance Hand washing 62% Sterilized the procedure site 100% Draped the entire patient in a sterile fashion 85% Used a hat, mask and sterile gown 92% Used sterile gloves 100% Sterile dressing applied 100%
National compliance estimated to be 30%
Intervention:
© 2007 Institute for Healthcare Improvement
Central Line Site Care
Use line carts and dressing change kits
Standardize site care procedures
Store all equipment in the same place
© 2007 Institute for Healthcare Improvement
To Be Successful
Set an aim: “Reduce the incidence of central line catheter-related bloodstream infections using the central line bundle.”
Set a goal: “The rate of CR-BSI will decrease by 50% in one year using the central line bundle.”
Plan well: Adopt a change methodology thataccelerates improvement such
as The Model for Improvement.The Model for Improvement.
© 2007 Institute for Healthcare Improvement
Model for Improvement
Act Plan
Study Do
• What are we trying to accomplish?What are we trying to accomplish?
• How will we know that a change is an improvement?How will we know that a change is an improvement?
• What changes can we make that will result in an What changes can we make that will result in an improvement?improvement?
© 2007 Institute for Healthcare Improvement
Me and What Army?
➥ Form… a teama team↳Include a diverse staff.↳MDs, RNs, respiratory therapists.
➥ Identify… a project championa project champion ↳Someone who maintains visibility in the ICU.
➥ Identify… a process ownera process owner↳For concerns now and in the future.
© 2007 Institute for Healthcare Improvement
Identify stakeholders in intensive care.
3 groups: MDs, RNs, venous access teams.
Secure representation from each.↳ Facilitates physician buy-in.↳ Generates nursing support.
Engage Stakeholders
© 2007 Institute for Healthcare Improvement
Role of Leadership
Committed: staff cannot improve without supportive leadership.
Set the standard: “This is how we will practice.”
Resources: make time to work on testing.
Share data: to motivate staff for change.
© 2007 Institute for Healthcare Improvement
Starting the Project
➥ Is there a method in place now?
➥ Know your baseline performance:↳Randomly select 20 patients’ records who had
central lines placed. Apply the measures to them.
↳Be sure to check compliance with the total bundle as well, the “all or none” goal.
➥ Educate ICU staff (using your own data).
© 2007 Institute for Healthcare Improvement
Small Tests of Change
Small tests... 1 RN, 1 MD, 1 patient.
Move on to pilot test in one ICU:↳ Refine the process↳ Test on all shifts↳ Test on all patients with central lines
Measure your results to know if a change was an improvement.
© 2007 Institute for Healthcare Improvement
Supportive Interventions
Multidisciplinary Daily Rounds:Multidisciplinary Daily Rounds:
↳An opportunity to assess bundle related issues.↳ Invite and encourage the family to join in.
Daily Goal Sheets:Daily Goal Sheets:↳Maintenance of bundle items.
PhysiciansPhysicians NursesNurses NutritionNutrition RespiratoryRespiratory
Palliative CarePalliative Care ChaplaincyChaplaincy PharmacyPharmacy Case ManagementCase Management
© 2007 Institute for Healthcare Improvement
Measure: CR-BSI per 1000 Line Days
Central line-associated BSI rate per 1000central line-days:
Numerator: Number of central line-associated BSI x 1000.
Denominator: Number of central line-days (total number of days of exposure to central venous catheters by all patients in the selected population during the selected time period).
© 2007 Institute for Healthcare Improvement
Measure: Central Line Bundle Compliance
Central line bundle elements in place:
Numerator: Number of patients with central line bundle in place.
Denominator: Total number of pts on central lines per day of week of prevalence sample.
© 2007 Institute for Healthcare Improvement
Model for Improvement
Act Plan
Study Do
• What did we accomplish?What did we accomplish?
• Was that change an improvement?Was that change an improvement?
• What further changes will lead to more improvement?What further changes will lead to more improvement?
© 2007 Institute for Healthcare Improvement
Summary:
Central line infections are common.
Proven strategies exist to decrease CR-BSI line days.
Using the Central Line Checklist, most bundle elements are implemented.
Thousands of lives and millions of dollars saved with reliable adherence and bundle execution.