THE 13th INTERNATIONAL

SYMPOSIUM ON

MLCROENCAPSULATION

September 5-7,2001

Angers, France

SCIENTIFIC PROGRAM

Tuesday Septembre 4, 2001

6 h 30 p.m Welcome reception

Wednesday September, 5, 20018 h 30 a.m Opening comments

Prof. Jean-Pierre Benoit, University of Angers, France

Chairmen :C. Thies - Ir.H.C. Langelaan

8 h 45 a.m Plenary lecture C-IProf. Keith P. Johnston, University of Texas at Austin, USAMicroencapsulation with Compressed and supercritical fluids.

9 h 25 a.m. Oral communication O-01Biomolecules micro-encapsulation by a process using a compressed gas.Jung J., Leboeuf F., Perrut M.

9 h 45 a.m. Oral communication O-02Properties of theophylline pellets produced by a hot-melt extrusion/spheronizationprocess.McGinity J.W., Koleng J.J., Young C.R.

10 h 05 a.m. Oral communication O-03Sustained-release formulations of a herbicide by supercritical technology.Taki S., Badens E., Charbit G.

10 h 25 am. Coffee breakPosters session

Chairmen :P. Maincent - Robert O. Williams

11 h 10 a.m. Plenary lecture C-IIProf. Elias Fattal, University of Paris XI, Chatenay-Malabry, FranceBiodegradable microparticles for the mucosal delivery of antibacterial and dietaryantigens.

11 h 50 a.m. Oral communication O-04Involvement of apolipoproteins in the transport of nanoparticle-bound drugs across theblood-brain barrier.J. Kreuter, D. Shamenkov, V. Petrov, P. Ramge, K. Cybutek, C. Koch-Brandt,and R. Alyautdin.

12 h 10 a.m. Oral communication O-05Bioadhesive^potential of poly(methyl vinyl ether - CO - maleic anhydride)nanoparticles.Arbos P., Arangoa M.A., Campanero M.A., Irache J.M.

12 h 30 am. LunchPosters session

13th International Symposium on Microencapsulation

September 5-7, 2001, Angers, France

Chairmen :M. Rabiskova - M.C. Levy

2 h 00 p.m. Plenary lecture C-IIIDr. Jose M. Garcia-Anton, Lipotec S.A., Barcelona, SpainNew approches in the microencapsulation of cosmetic actives.

2 h 40 p.m. Oral communication O-06Liposomes for dermal application.Blume G., Teichmiiller E., Schafer U., Fahr A.

. 3 h 00 p.m. Oral communication O-07Optimization of topical Cidofovir penetration using microparticles.Santoyo S., Ga de Jalon E., Ygartua P., Renedo M.J., Blanco-Prieto M.J;

3 h 20p.m. Coffee breakPosters session

Chairmen :T. Whateley - E. Fattal

4 h 05 p.m. Plenary lecture C-TVProf. Michael V. Sefton, Institute of Biomaterials and Biomedical Engineering,University of Toronto, CanadaFundamentals of tissue engineering - Lessons from cell microencapsulation.

4 h 45 p.m. Oral communication O-08Jettcutter technology offers major advantages for microencapsulation : results fromentrapment of murine fibroblasts.Jahnz U., Schwinger C , Koch S., Kressler J., Rainov N.G., Wittlich P.

5 h 05 p.m. Oral communication O-09In vivo evaluation of activity of Vancomycin dispersed in biodegradablemyocardiopathies in a rabbit staphylococcus awreMsosteomyelitis experimental model.Hamel A., Laty M.K., Miegeville A.F., Le Ray A.M., Merle C , Potel G., CaillonJ.

6 h 30 p.m. Cocktail Musee Jean Lurgat

Thursday September, 6, 2001

Chairmen :M.-J. Blanco-Prieto - J. Me Ginity

8 h 45 a.m Plenary lecture C-VDr. Paul A. Burke, Amgen, Thousand Oaks, CA USAMicroencapsulation of protein therapeutics : effects of process and formulation onstability •,

9 h 25 a.m. Oral communication O-10Poly(epsilon caprolactone) / Eudragit® RS nanoparticles as a drug carrier for oraladministration of insulin in diabetic rats.Damge C , Ubrich N., Kuntz E., Kaltenbacher M.C, Attivi D., Hoffart V., PingetM., Maincent P.

13th International Symposium on Microencapsulation

September 5-7,2001, Angers, France

9 h 45 a.m. Oral communication 0-11Stability Study of multi component drug carriers for dry powder delivery.J. Guaquiere, S. Brocchini and G. Buckton

10 h 05 a.m. Oral communication 0-12Application of an Enzyme Immobilization Technique in Calcite Precipitation.Bang S.S., Williams A.E., Ramakrishnan V.

10 h 25 am. Coffee breakPosters session

Chairmen :K.-P. Johnston - R. Price

11 h 10 a.m. Plenary lecture C-VIDr. Ir.H.C. Langelaan, ATO, Wageningen, The NetherlandsMicroencapsulation for food applications using supercritical fluid technology.

11 h 50 a.m. Oral communication 0-13Microencapsulation of omega-3 polyunsaturated fatty acids for use in nutrientsupplementsMichael Yan, Shawn Moulton, Ernest Hare, Jonathan M. Curtis, Terry McKay andRaynald LeBlanc

12 h 10 a.m. Oral communication 0-14Utilization of a novel Cryogenic Spray-freezing into Liquid (SFL) Process toencapsulate Danazol.True L. Rogers, Andrew C. Nelsen, Judith N. Brown, Marazban Sarkari, Tim Young,Keith P. Johnston, and Robert O. Williams III

12 h 30 am. LunchPosters session

Chairmen :R.-E. Sparks - J.-M. Devoisselle

2 h 00 p.m. Plenary lecture C-VIIDr. Christian Mayer, University of Duisburg, GermanyCharacterisation of Nanoparticular Carriers by Nuclear Magnetic Resonance.

2 h 40 p.m. Oral communication 0-15Hydrogel deformation under shear - a new way for a solvent controlled release.Zanina A. and Budtova T.

3 h 00 p.m. Oral communication 0-16Formation of microcapsules and microparticles based on polycation - Surfactantinteractions JShlomo Magdassi and Frigita Kahana

3 h 20 p.m. Oral communication 0-17Characterization of the chemical and physical structure of the poly(urea-urethane)microcapsules using to F-SIMS and dynamic mechanical thermal analysis.Yuki Matsunami and Kimio Ichikawa

13th International Symposium on Microencapsulation

September 5-7,2001, Angers, France

3 h 40 p.m. Coffee breakPosters session

Chairmen :P. Deasy - J. Kreuter

4 h 25 p.m. Plenary lecture C-VIIIProf. Jean-Christophe Leroux, University of Montreal, CanadaPolymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery ofdrugs.

5 h 05 p.m. Oral communication O-18Nanostructured lipid matrices for improved microencapsulation of drugs.Miiller R.H., Radtke M.

5 h 25 p.m. Oral communication O-19Poly(lactic acid) microspheres for the sustained release of antiischemic agents.Dalpiaz A., Scatturin A., Pavan B., Biondi C , Vandelli M.A., Forni F.

8 h 00p.m. Gala dinner

Friday September, 7, 2001

Chairmen :S. Kas - J.-L. Pedraz-Munoz

8 h 45 a.m Plenary lecture C-IXProf. Nobuhiko Yui, Japan Advanced Institute of Science and Technology,Ishikawa, JapanSupramolecular approach to pharmaceutical functions in polymers.

9 h 25 a.m. Oral communication O-20Self sufficient microbead of lactoperoxidase system.Muriel Jacquot, A. Miclo, D. Poncelet

9 h 45 a.m. Oral communication 0-21Micron and submicron sized capsules with nano-engineered walls.Sukhorukov G.B., Radtchenko I.L., Antipov A.A., Tiourina O.P., Voigt A.,Donath E., Mohwald H.

10 h 05 a.m. Oral communication O-22Sub-micron cylinders : a novel geometry for the controlled delivery of active agents.Ronald Price, Bruce Gaber, Paul Schoen, John Santos and Patrick Deasy

10 h 25 am. Coffee breakPosters session

13th International Symposium on Microencapsulation

September 5-7,2001, Angers, France

Chairmen :R. Miiller - J.-C. Leroux

11 h 10 a.m. Plenary lecture C-XProf. Alexander T. Florence, School of Pharmacy, University of London, UKDendrimers and partial dendrimers in drug and gene delivry.

11 h 50 a.m. Oral communication 0-23Comparison of loading procedures of Iruprofen in ordered mesoporous silica.

. C. Charnay, S. Begu, L. Nicole, C. Tourne-Peteilh, D. Lerner, J.M. Devoisselle

12 h .10 a.m. Oral communication 0-24New-type apparatuses for producing microcapsules and microgranules.Vilesov A.D., Zhuravsky E.P., Vilessova M.S., Netchaeva E.A.

12 h 30 am. LunchPosters session

Chairmen :D.Poncelet-F.Henry

2 h 00 p.m. Plenary lecture C-XIDr. Gordon Nelson, Fluid Technologies, Wigan, Lancashire, UKMicroencapsulation in the Textile Industry.

2 h 40 p.m. Oral communication O-25Studies on the development of a microencapsulated delivery system for norbormide, aspecies-specific acute rodenticide.Nadian A.K. and Lindblom L.J.

3 h 00 p.m. Oral communication O-26Encapsulation of Menthol to protect honey bees from tracheal mites.J.D. Trevino, S.D. Kevan, P.G. Kevan

3 h 20 p.m. Oral communication O-27A two Steps Process of Micro-Encapsulation by Complex Coacervation in Presence ofSurfactants.J.-F. Argillier and K.S. Mayya

3 h 40 p.m. Prize giving

4 h 05 p.m Concluding commentsProf. Jean-Pierre Benoit, University of Angers, France

13th International Symposium on Microencapsulation

September 5-7,2001, Angers, France

POSTERS

P-001 Influence of some formulation parameters on lysozyme adsorption and its stability insolution.Malzert Aurelie, Renard Denis, Robert Paul, and Boury FrankINSERM ERIT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-002 Preparation an in vitro Evaluation of Piridostigmin Bromide Microparticles.N. Hegazy, M. Demirel, Y. YazanAnadolu University, Faculty of Pharmacy, 26470 ESKISEHIR, Turquie

P-003 Microencapsulation of Semisolid Ketoprofen/Polymer Microspheres.Giovanni Filippo Palmieri, Giulia Bonacucina, Piera Di Martino and Sante MartelliUniversita di Camerino, Dipartimento di Scienze Chimiche, 62032 CAMERINO(MC), Italy

P-004 Development of a boar sperm delivery device and analysis of batch seasonalvariability.M.L. Torre, M. Faustini, R. Norberti, L. Maggi, G. Maffeo, U. Conte, D. VigoUniversita di Pavia, 27100 PA VIA, Italy

P-005 Correlations between technological parameters for the development of bariumalginate cell-delivery systems.M.L. Torre, M. Faustini, R. Norberti, L. Maggi, G. Maffeo, U. Conte, D. VigoUniversity of Pavia, Dpt of Pharmaceutical Chemistry, 27100 PAVIA, Italy

P-006 Microencapsulation of cyproheptadine hydrochloride with eudragits and ethylcellulose.Yassein E. Hamza, Eman I. Soliman and Ahmed M. OsmanCairo University, Faculty of Pharmacy, CAIRO, Egypt

P-007 Evaluation of the in vitro bactericidal activity of Vancomycin, dispersed inbiodegradable poly(e-caprolactone) microparticles.Laty M.K., Le Ray A.M., Miegeville A.F., Merle C , Caillon J.Laboratoire de Pharmacie Galenique, EMI 99-03,44000 NANTES, France

P-008 Optimizing formulation factors in preparing corticosteroid-loaded chitosanmicrospheres by spray drying method.Chiang C.H., Huang Y.C., Yeh M.K.National Defense Medical Center, School of Pharmacy, TAIPEI (114) TAIWAN,ROC

P-009 Spray Dried Eudragit Microparticles as Encapsulation Devices for Vitamin C.Esposito E., Menegatti E., Nastruzzi C , Cortesi R.University of Ferrera, Department of Pharmaceutical Sciences, 44100 FERRERA,Italy

P-010 Microencapsulated additives for technical applications.Jobmann M., Nastke R., Rafler G.Fraunhofer- Institut fur, Angewandte Polymerforschung, 14476 GOLM, Germany

P-011 Influence of drug core and dissolution media on properties of pectinate microspheresprepared by emulsification technique.Wong T.W., Lee H.Y., Chan L.W., Heng P.W.S.National University of Singapore, Department of Pharmacy, SINGAPORE 119260,Singapour

P-012 Influence of polyinylpyrrolidone on aggregation propensity of spheroids coated usinghydroxypropylmethylcellulose solution.Wong T.W., Heng P.W.S., Yeo T.N., Chan L.W.National University of Singapore, Department of Pharmacy, SINGAPORE 119260,Singapour

P-013 Encapsulation of ketoprofen in MSU-type mesoporous material by direct synthesis.C. Charnay, S. Begu, L. Nicole, C. Tourne-Peteilh, D. Lerner, J.M. DevoisselleUniversite de Montpellier 1, UMR CNRS/ENSCM 5618, 34097 MONTPELLIERCedex 2, France

P-014 Use of halloysite as a novel microtubular drug delivery system.Deasy P.B., Kelly H.M., Levis S.R., Marsters S., Price R.R., Salter A.E.University of Dublin Trinity College, School of Pharmacy, DUBLIN 2 , Ireland

P-015 Caffeine microparticles obtaines by spray drying.Artusi M., Santi P., Colombo P.University of Parma, Parmacy Department, 43100 PARMA, Italy

P-016 Solvent extraction employing a static micromixer - a robust, versatile and easy-to-scale-up methode for the preparation of biodegradable microspheres.Freitas S., Merkle H.P., Gander B.Institut fur Pharmazeutische, Vissenschaften Eth., CH-8057 ZURICH, Switzerland

P-017 Tools for the production of monodisperse microbeads : minimizing size, maximizingmonodispersity.Josef P. Magvar, Stefan Schneider, Peter Walzel, and Nicolai Suter, Institute of CellBiology, CH-80093 ZURICH, Switzerland

P-018 A novel microencapsulation method based on microwave-induced emulsionpolymerization.N. Vasishtha and C.S. BrazelSouthwest Research Institute, SAN ANTONIO Texas 72238, USA

P-019 In-situ polymerization in microcapsules to produce drag reducing agents.N. Vasishtha, N. Commareddi, D. Barlow, and L. RzeznikSouthwest Research Institute, SAN ANTONIO Texas 72238, USA

P-020 Specially confined precipitation of organic molecules in hollow polymer micro- andnanocapsules.Igor L. Radtchenko, Gleb B., Sukhorukov and Helmuth MohwaldMax-Planck-Institute of Colloids and Interfaces, Department of Interfaces, D-14424

. . . POTSDAM/GOLM, Germany

P-021 Preparation of monodisperse controlled release microcapsules.Brandau ThorstenBrace GmbH, D-60439 FRANKFURT/Main, Germany

P-022 Silica/polyamide and silica/polystyrene nanocomposites synthesis via an originaldouble emulsification process.Salima Boutti, Elodie Bourgeat-Lami, Nathalie ZydowiczUniversite Claude Bernard Lyon 1, Batiment ISTIL, 69622 VILLEURBANNE,France

P-023 Preparation of oily core polyamide microcapsules via interfacial polycondensation.M.L. Soto-Portas, J.F. Argillier, F. Mechin, N. ZydowiczUniversite Claude Bernard Lyon 1, Batiment ISTIL, 69622 VILLEURBANNE,France

P-024 Microencapsulation of dehydroepiandrosterone (DHEA) with poly(ortho esters)polymers by interfacial polycondensation.Bouchemal K., Brian$on S., Chaumont P., Fessi H., Zydowicz N.Universite Claude Bernard Lyon 1, Batiment ISTIL, 69622 VILLEURBANNE,France

P-025 Influence of zinc on the properties of alginate microspheres and the investigation ofthe possible cross-linking mechanism of zinc on alginate.Chan L.W., Jin Y., Heng P.W.S.National University of Singapore, Department of Pharmacy, SINGAPORE 119260,Singapour

P-026 Production of alginate microspheres by internal gelation using an emulsificationmethod.Chan L.W., Lee H.Y., Heng P.W.S.National University of Singapore, Department of Pharmacy, SINGAPORE 119260,Singapour

P-027 The influence of four selected variables on mean size and size distribution ofspheroids produced by rotary spheronization.Gu L., Liew C.V., Heng P.W.S.National University of Singapore, Department of Pharmacy, SINGAPORE 119260,Singapour

P-028 Influence on the dring technique on theophylline pellets prepared by extrusion-spheronization.Perez J.. and Rabiskova M.University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, BRNO612 42, Czech Republic

P-029 Some variables influence the rotoagglomeration in multiprocesseur MP-1Vetchy D. and Rabiskova M.University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, BRNO612 42, Czech Republic

P-030 Design and characterization of protein-based microcapsules as a novel catamenialabsorbent system.Stern T., Lamas M.C, Kluger R. and Benita S.Hebrew University of Jerusalem, School of Pharmacy, 91120 JERUSALEM, Israel

P-031 The effects of pressure and direct compression on tabletting of microsponges.Tansel Comoglu, Nursin Goniil, Tamer BaykaraAnkara University, Faculty of Pharmacy, TANDOGAN ANKARA, Turkey

P-032 Release of Diprophylline from Minimatrices obtained by Melt Granulation with twoPolyol Behenates.Viana M., Ratsimbazafy V., Brossard C.Universite de Limoges , Faculte de Pharmacie, 87025 LIMOGES Cedex, France

P-033 Controlled release of biomolecules micro-encapsulated by a process usingcompressed gas.Jung J., Leboeuf F., Perrut M.Separex-Lavipharm, 54250 CHAMPIGNEULLES, France

P-034 Development of a novel delivery system for nicotine using yeast encapsulation.Morris K.L., Wood E.J., Wales D.S.BTTG, University of Leeds, MANCHESTER M20 2RB, U.K.

P-035 Jet milling - a new method to prepar microspheres.Nykamp G., Carstensen U., Muller B.W.Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht UniversityKiel, 24118 KIEL, Germany

P-036 Coating protein particles with lipids using a novel supercritical fluid process.J. Richard, I. Ribeiro Dos Santos, B. Pech, C. Thies and J.P. BenoitMainelab S.A., Ethypharm Group, 49100 ANGERS, France

P-037 Folate conjugated doxorubicin HCI loaded membrane vesicles for tumor targeting.P.R. Mishra and N.K. JainHamdard University, Faculty of Pharmacy, NEW-DELHI 110062, India

P-038 Microspheres of collagen/calcium phosphate prepared by the encapsulation ofcalcium phosphate particulates with collagen matrices.Cheng-Wen Lan, Feng-Huei Lin and Yng Jiin WangNational Yang Ming University, Institute of Biomedical Engineering, SHIH-PAITAIPEI, Taiwan

P-039 Creation of biopolymeric colloidal carriers dedicated to controlled releaseapplications.Denis Renard, Paul Robert, Laurence Lavenant, Dominique Melcion, YvesPopineau, Cecile Duclairoir, Evelyne Nakache, Christian Sanchez, ChristopheSchmittUnite de Physicochimie des Macromolecules, INRA, 44316 NANTES Cedex 3,France

P-040 Interaction of stearoyl-poly-N-vinylpyrrolidone with native and dioleoyl soybeanbowman-birk protease inhibitor.E.V. Malykh, A.L. Villemson, E.I. Charipova, M.I. Shtilman, N.I. LarionovaLomonosov Moscow State University, Department of Chemistry, 119899MOSCOW, Russia

P-041 Encapsulation of amphiphilic molecules by a wheat lipid transfer proteine (LTP1)Pato C. , Le Borgne M., Le Pape P., Le Baut G., Marion D. and Douliez J.P.UBTP, INRA,44316 NANTES Cedex 3, France

P-042 Characterization of supra-molecular biovectorTM/antigen interactions using surfaceplasmon resonance technology.Jean-Philippe Siguier, Michel Major, Didier Betbeder, Olivier BallandBiovector Therapeutics SA, 31676 LABEGE Cedex, France

P-043 Preparation, characterization and biocompatibility of sulfonated polyrotaxane-modified polyurethane surfaces."Park H.D., Lee W.K., Ooya T., Park K.D., Kim Y.H. Yui N.Japan Advanced Institute, of Science and Technology, ISHIKAWA 923-1292, Japan

P-044 Preparation of colloidal drug delivery systems based on poly(methylidene malonate)(PPM 2.1.2) and amphiphilic PEO-block-PPM 2.1.2 diblock copolymers.Larras V., Studer P., Breton P., Bru N., Ries G.Universite de Haute Alsace, ENSCMu,68093 MULHOUSE Cedex, France

P-045 Hydrophilic polymer encapsulated in calcium alginate spheres.R. Adra, D. Le Cerf, L. Picton, J.F. Argillier and G. MullerLaboratoire Polymeres, Biopolymeres et Membranes, 76821 MONT SAINTAIGNAN, France

P-046 Sterically stabilized pH-sensitive liposomes.Roux E., Moreau P., Leroux J.C.University of Montreal, Faculty of Pharmacy,MONTREAL (Qc) H3C 3J7, Canada

P-047 The study of the microencapsulated dye release from soybean lecithin liposomes.A.L.F. Baptista, P.J.G. Coutinho, M.E.C.D. Real Oliveira, J.I.N. Rocha GomesUniversidade do Minho, Departamento de Engenharia Textil, 4800 GUIMARAES,Portugal

P-048 Marinosomes, marine lipid - based liposomes : characterization and potentialapplication in cosmetics.Moussaoui N., Cansell M., Denizot A.Universite de Bordeaux I, ISTAB, 33403 TALENCE, France

P-049 Hirudin saturation of the destabilase complex (liposome) produced by Hirudomedicine-balls leeches.Nikonov G., Titova E., Latrille J.International Medical Leech Center, 140140 MOSCOW, Russia

P-050 Preparation and preliminary evaluation of liposomal formulations for ocular deliveryof Vancomycin.Burgalassi S., Chetoni P., Ghelardi S., Monti D., Rossi S., M.F. SaettoneUniversita degli Studi di Pisa, Dipartimento di Chimica Bioorganica e BiofarmaciaJ-56126 PISA, Italy

P-051 Investigations of new chloroethyloamine amironTchikineva N., Yavorskaya N., Golubeva I., Oborotova N., Baryshnikov A.Cancer Research Center, MOSCOW 115478, Russia

P-052 New liposomal drug formulation of cyphelin.Tchikineva N., Orlova O., Smirnova Z. , Oborotova N., Baryshnikov A.Cancer Research Center, MOSCOW 115478, Russia

P-053 Radiolabelling of injectable lipidic nanocapsules using 99mTC and 1251-biodistribution studies in rats by scintigraphy and "/-counting.

A. Cahouet, B. Denizot, F. Hindre, C. Passirani, M. Moreau, J.J. Le Jeune, J.P.BenoitINSERM ERTT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-054 Formation and characterization of chitosan nanoparticles phospholipid complex.Carvalho E.L.S., Seija B., Alonso M.J.University of S. de Compostela , Departamento de Farmacia y TecnologiaFarmaceutica, 15782 SANTIAGO de COMPOSTELA, Spain

P-055 The development of an improved carrier system for sunscreen formulations based oncrystalline lipid nanoparticles.Wissing S.A., Miiller R.H.Freie Universitat Berlin, Department of Pharmacy, 12169 BERLIN, Germany

P-056 The influence of the crystallinity of lipid nanoparticles on their occlusive properties.Wissing S.A., Miiller R.H.Freie Universitat Berlin, Department of Pharmacy, 12169 BERLIN, Germany

P-057 Characterisation of nanoparticulate systems by hydrodynamic chromatography.E. Meehan, K. Tribe, A. Williams, S. ReschPolymer Laboratories, 13009 MARSEILLE, France

P-058 Modified lipid nanoparticles prepared by the double emulsion technique : stability indigestive fluids.Garcia M., Torres D. and Alonso M.J.University of S. de Compostela Facultad de Farmacia, 15782 SANTIAGO deCOMPOSTELA, Spain

P-059 Stealth behavior of (PLA-PEG-PLA) multiblock nanospheres after IV injection.P. Hildgen and A. PanoyanUniversity of Montreal, Faculty of Pharmacy, MONTREAL (Qc) H3C 3J7, Canada

P-060 Sodium cholate : a novel surfactant in nanosphere preparation.Haas J., Lamprecht A. Bakowsky, U., Lehr C.-M.Saarland University, Department of Biopharmacy, 66123 SAARBRUCKEN,Germany

P-061 Insulin loaded nanocapsules : study of absorption in diabetic rats after oraladministration.F. Cournarie, D. Auchere, D. Chevenne, M. Montigny, B. Lacour and C. VauthierUniversite de Paris XI, Faculte de Pharmacie, 92296 CHATENAY MALABRY,France

P-062 Evaluation of the capacity of the different types of chitosan nanoparticles for theimprovement of nasal insulin absorption.Hombreiro-Perez M., Damge C, Alonso M.J.University of S. de Compostela, Departamento de Farmacia y TecnologiaFarmaceutica, 15782 SANTIAGO de COMPOSTELA, Spain

P-063 Association of tricyclic antidepressants with 6-cyclodextrin in aqueous solutionJunquera E., Romero J.C., Aicart E.Universidad Complutense, Fac. CC. Quimicas, 28040 MADRID, Spain

P-064 Electrochemical study of the chelation of Cu2+ cation by 18-crown-6-ether andhydroxybenzoic acids in aqueous solution.Junquera E., Pasero A., Aicart E.Universidad Complutense, Fac. CC. Quimicas, 28040 MADRID, Spain

P-065 Investigation of polymer erosion in microparticles produced by phase separation.Husmann M., Schenderlein S., Luck M., Lindner H., Kleinebudde P.Section Leader Technology Service, Ferring GmbH,24109 KIEL, Germany

P-066 The influence of alcohol additives on the viscosity of interphase layers ofpolymethacrylic acid at a boundary of water-methyl methacrylate.Yemelvanov D.N.Nizhny Novgorod State University, 603130 NISHNY NOVGOROD, Russia

P-067 Role of emulsifiers in the control of size and stability of microcapsules in emulsioncopolymerization of acrylates.Yemelvanov D.N., Novospasskaya N.Yu, Chernorukova Z.G.Nizhny Novgorod State University, 603130 NISHNY NOVGOROD, Russia

P-068 Molecular associations of 2-hydroxy-stearate of polyethylenglycol at thetriglycerides-water interface.Heurtault B., Saulnier P., Pech B., Proust J.E., Benoit J.P.INSERM ERIT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-069 Preparation and characterization by morphological analysis of diclofenac/PEG 4000granules obtaines using three different techniques.Rodriguez L., Cavallari C, Passerini N., Albertini B., Gonzalez-Rodriguez M.L.,Fini A.Universita di Bologna, Dipartimento di Scienze Farmaceutiche, 40127 BOLOGNA,Italy

P-070 Sequential atomic force microscopy imaging of a spontaneous nanoencapsulationprocess.M. Oliva, I. Diez, P. Gorostiza, C. Caramella, C.F. Lastra, I. Oliva, E.L. MarinoUniversity of Barcelona, Faculty of Pharmacy, 08028 BARCELONA, Spain

P-071 A fully automated micromanipulation system for measuring the mechanicalproperties of microcapsules.Y. Huang and Z. ZhangChemical Engineering School, Birmingham University, BIRMINGHAM B15 2TT,U.K.

P-072 A rheological method for the determination of the melting point of microspheres intopical formulations.Sanders C., Morlet C, Gouyette A., Merle C. and Le Ray A.-M.Stiefel Laboratories, MAIDENHEAD BERKS, U.K.

P-073 Characterisation of nifedipine solid dispersions.F. Cilurzo, P. Minghetti, A. Casiraghi, L. MontanariUniversita degli Studi di Milano, Instituto di Chimica, 20131 MILANO, Italy

P-074 Effect of preparation conditions on the properties of chitosanbased capsules -permeability and stability study.Angelova N., Hunkeler D.Department of Chemistry, IGC1, Lab. of Polyelectrolytes and BioMacromolecules,CH-1015 LAUSANNE, Switzerland

P-074 Relevance of phase diagrams for micropartide production by the polymer-polymer-incompatibility-method.Schenderlein. S., Husmann M., Luck M., Lindner H., Miiller B.W.Section Leader Technology Service, Ferring GmbH, 24109 KIEL, Germany

P-076 Drug release characteristics of calcium ion-induced gellan beads for colon-specificdrug delivery.Singh B.N., Kim K.H.Dpt of Pharmacy and Administrative Sciences, College of Pharmacy, JAMAICA NY11439, USA

P-077 Cross-linked 8-cyclodextrin microcapsules: retarding effect on drug release throughsemi-permeable membranes.N. Pariot, F. Edwards-Levy, M.C. Andry and M.-C. LevyUniversite de Reims, Faculte de Pharmacie, 51096 REIMS Cedex, France

P-078 Biodegradation and drug release rate of BSA-loaded gelatin microspheres in apresence of collagenase.Mladenovska K., Kumbaradzi F.E., Glavas D.M., Makraduli L., Goracinova K.Institute of Biopharmacy, Faculty of Pharmacy, 1000 SKOPJE, Macedonia

P-079 Oxaliplatin loaded plaga microspheres : parameters affecting the release kinetics anddesign of specific release profiles.Lagarce F., Cruaud O., Deuschel C., Bayssas M., Griffon-Etienne G., Benoit J.P.INSERM ERIT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-080 Storage stability of encapsulated retinoids.D.J. Mangold, N.F. Swynnerton, C.W. LewSouthwest Research Institute, SAN ANTONIO Texas 72238, USA

P-081 Dissolution stability of venlafaxine pellets microencapsulated with aqueous polymerdispersions.Fekete P., Palfi L., Korbely T.EGIS Pharmaceuticals Ltd, 1475 BUDAPEST 10, Hungary

P-082 Release profile of Lidocaine HC1 from topical liposomal gel formulation.M. Glavas-Dodov, K. Goracinova, K. Mladenovska and E. Fredro-Kumbaradzi.Institute of Biopharmacy, Faculty of Pharmacy, 1000 SKOPJE, Macedonia

P-083 The effet of gamma-irradiation on drug release from bioerodible microparticles : aquantitative treatment.Faisant N., Siepmann J., Laffineur V., Bruna E., Oury P., Haffner J., Benoit J.P.INSERM ERIT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-084 Floating microparticles based on foam powder: effect of the type of coatingpolymer.Streubel A., Siepmann J., Bodmeler R.Freie Universitat Berlin, College of Pharmacy, 12169 BERLIN, Germany

P-085 A new , Monte Carlo-based mathematical model quantifying drug release frombioerodible microparticles.Siepmann J., Faisant N., Haffner J., Benoit J.P.INSERM ERTT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-086 Reduced burst release from microparticles by incorporating in cubic phase formingsystem.Ahmed A.R., Dashevsky A., Bodmeier R.Freie Universitat Berlin, College of Pharmacy, 12169 BERLIN, Germany

P-087 Ciprofloxacin loaded bovine serum albumin microspheres : preparation and drug-release in vitro.Li F.Q., Hu J.H., Lu B., Yao H., Zhang W.G.Second Military Medical University, SHANGHAI 200433, China

P-088 Pectin particles as means for DNA targeting to the colon ?Peter Pietzonka, Elias FattalUniversite de Paris XI, Faculte de Pharmacie, 92296 CHATENAY MALABRY,France

P-089 Preparation and properties of slow-release microparticles containing 3,4-diaminopyridine.Bonneville A., Gibaud S., Astier A.Universite de Nancy, UPRES EA 2399, 54001 NANCY Cedex, France

P-090 Oral controlled release of diclofenac sodium using polymer-reinforced alginatemicrospheres for constant drug release.Hurbans N., Pillay V., and Dangor CM.University of Durban-Westville, School of Pharmacy and Pharmacology,TONGAAT 4400, South Africa

P-091 Stability and structure of protein-polysaccharide coacervates in presence of proteinaggregates.Christian Sanchez and Denis RenardUnite de Physicochimie des Macromolecules, INRA, 44316 NANTES Cedex 3,France

P-092 GDNF-releasing biodegradable microspheres promote striatal reinnervation, andfunctional recovery in a rat model of Parkinson's disease.C Jollivet, M.C Venier, A. Pouessel, A. Clavreul, C. Montero-Menei, J.P. Benoit, P.Menei.INSERM ERIT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-093 Effect of the solution evaporation rate on the characteristics of protein loaded PLLAand PDLLA microspheres fabricated by double-emulsion method.Tze-Wen Chung, Yu-Lin Tsai, Yi-Chih LiuChung-Yuan Christian University, Dept of Biomedical Engineering, 37033TAIWAN, ROC

P-094 Nasal immunization elicits a potent serum IgG antibody response to malariasynthetic peptide SPf66 loaded PLGA microspheres.A. Montero, R.M. Hernandez, A.R. Gascon, M. Igartua, J.E. Rosas, M.E. Patarroyo,and J.L. PedrazUniversity of the Basque Country, Facultad de Farmacia Y Tecnologia Farmaceutica,01006 VITORIA-GASTEIZ, Spain

P-095 Influence of dose and immunization route on the serum IgG antibody response toBSA loaded PLGA microspheresI. Gutierro, R.M. Hernandez, A.R. Gascon, M. Igartua, J.L. PedrazUniversity of the Basque Country, Facultad de Farmacia Y Tecnologia Farmaceutica,01006 VITORIA-GASTEIZ, Spain

P-096 Preparation of PLGA microparticles encapsulating peptide by the coacervat iontechnique and studies on the internal environment during degradation.Me Phail D., Dawson G.CeNeS Drug Delivery Ltd, IRVINE KA11 5DJ, U.K.

P-097 Microcapsules with chitosan for delivering small proteins to the intestine.Ferreira J.P., Amorim M.J.Univ. Catolica Portuguesa, Escola Superior de Biotecnologia, 4200-072 PORTO,Portugal

P-098 A novel in vitro model for assessing the biological integrity of protein upon releaseform PLGA microspheresAubert-Pouessel A., Bibby D.C., Venier-Julienne M.C, Hindre F., Benoit J.P.INSERM ERIT-M 0104, Ingenierie de la Vectorisation particulaire, 49100ANGERS, France

P-099 Alginate microparticles for enzyme peroral administration.Coppi G., Iannuccelli V., Cameroni R., Bernabei M.T.Universita di Modena e Reggio Emilia, Dipartimento di Scienze Farmaceutiche,41100 MODENA, Italy

P-100 Protection of nigrostriatal dopaminergic neurones by GDNF-loaded microspheres ina rodent model of Parkinson's desease.Gouhier C, Chalon S., Venier-Julienne M.-C, Benoit J.P., Guilloteau D.INSERM U316, Faculte des Sciences Pharmaceutiques, 37200 TOURS, France

P-101 Protein loaded multylayer polyelectrolyte microcapsules. Preparation,characterization and protein release.Volodkin D.V., Balabushevitch N.G., Larionova N.I., Sukhorukov G.B.Lomonosov Moscow State University, Department of Chemistry, 119899MOSCOW, Russia

P-102 Biodistribution of BSA-loaded gelatin microspheres after peroral application toBALB/C mice: particle size study.Mladenovska K., Ivanova J.E., Glavas D.M., Kumbaradzi F.E., Goracinova K.Institute of Biopharmacy, Faculty of Pharmacy, 1000 SKOPJE, Macedonia

P-103 Optimization of the two step microencapsulation method for cell immobilization.A. Esquisabel, T.M.S. ChangUniversity of the Basque Country, Facultad de Farmacia Y Tecnologia Farmaceutica,01006 VITORIA-GASTEIZ, Spain

P-104 Preparation of verapamil HC1 loaded microspheres with polymethacrylates whichhave different permeabilities.Miige Kilicarslan, Tamer BaykaraUniversity of Ankara, Faculty of Pharmacy, ANKARA , Turkey

P-105 Immobilisation of lactic acid bacteria in calcium alginate beads for bacteriocinproduction.E. Ivanova, E. Teunou, I. Ivanova, X. Dousset, D. PonceletENITIAA de Nantes, Departement du Genie des Precedes Alimentaires, 44322NANTES Cedex 3, France

P-106 Preliminary study on self-assembled network of plasmid DNA as new stimuli-responsive biomaterials.Kawabata Y., Ooya T., Lee W.K., Yui N.Japan Advanced Institute, of Science and Technology, ISHIKAWA 923-1292, Japan

P-107 Mechanisms of Yeast Cell Escape from Alginate Bead Matrices during GlucoseFermentation.Longden S., Webb CUniversity of Manchester, Institute of Science and Technology (UMIST),MANCHESTER M60IQD, U.K.

P-108 Development of a new technology for the stabilization of sensitive probiotic lacticcultures based on microencapsulationPicot Arnaud, Lacroix ChristopheDairy Research , Centre STELA, SAINTE FOY, PQ G1K 7P4, Canada

P-109 Optimization of PLGA microparticles for the controlled release ofoligonucleotide/polyethylenimine complexes.G. De Rosa, F. Quaglia, M. Appel, E. FattalUniversite de Paris XI, Faculte de Pharmacie, 92296 CHATENAY MALABRY,France

P-110 Microparticles prepared by Spray-drying as a vaccine delivery against brucellosis.Murillo M., Blanco-Prieto M.J., Gander B., Goni M.M., Irache J.M., Gamazo CUniversidad de Navarra, Departamento de Farmacia, 31080 PAMPLONA, Spain

P- l l l In vitro evaluation of gentamicin released from microparticles.Blanco-Prieto M.J., Lecaroz C , Renedo M.J., Kukova J., Gamazo C.Universidad de Navarra, Departamento de Farmacia, 31080 PAMPLONA, Spain

P-112 Preparation and properties of whey proteine-based microspheres for delivery of foodingredients.Rosenberg M.University of California, Davis, Dpt of Food Science and Technology, DAVIS CA95616, USA

P-113 Complexing capsules - Metal extraction and modeling of the ion transfer.Laguecir A., Frere Y., Danicher L., Loureiro J.-M., Burgard M., Institut CharlesSadron, 67083 STRASBOURG Cedex, France

P-114 Alginate beads as a matrix for slow release of pheromones.Ido Yosha, Arnon Shani and Shlomo MagdassiUniversity of the Negev, Dept. of Chemistry Ben Gurion, BEER-SHEVA 84105,Israel

P-115 New microencapsulated sunscreens : technology and comparative evaluation.Anselmi C , Centini M., Rossi C, Ricci M., Rastrelli A., Andreassi M., BuonocoreA., La Rosa C.Scuola di Specializzazione in Scienza, 53100 SIENA, Italy

P-116 Coating of fertilizers by degradable polymersM. Devassine, F. Henry, P. Guerin, X. BriandCNRS, Laboratoire de Recherche sur les Polymeres, 94320 THIAIS, France

P-117 Encapsulation of pigments with controlled radical polymerization in aqueousdispersed mediumFrancois Henry, Nguyen Anh Hung, Mickael Graton, Farah Lakkis, Florence Lecoq,Vincent Blanchart, Estelle CeulemansCNRS, Laboratoire de Recherche sur les Polymeres, 94320 THIAIS, France

P-118 Microdialysis for investigating the in situ release of bupivacaine-loadedmicrospheres following epidural administration in rabbits.Rozenn Clement, Jean Marc Malinovsky, Pascal Le Corre, Gilles Dollo, FrancoisChevanne, Roger Le VergeUniversite de Rennes 1, Faculte des Sciences Pharmaceutiques et Biologiques, 35043RENNES Cedex, France

P-119 5-FU encapsulated alginate beads for the treatment of breast cancer.Arica B., Calis S., Kas H.S., Sargon M.F., Hincal A.A.Hacettepe University, Faculty of Pharmacy, ANKARA , Turkey

P-120 Biodegradable implantable teicoplanin beads for the treatment of bone infections.I. Yenice, S. Calis, S. Kas, M. Ozalp, M. Ekizoglu, A.A. HincalHacettepe University, Faculty of Pharmacy, ANKARA , Turkey

P-121 Comparision of the mechanical strength of microcapsules made of different wallmaterials.G. Sun and Z. Zhang.Queen's University Belfast, School of Chemical Engineering, BELFAST BT9 SAG,Northern IrelandU.K.

P-122 Preparation and evaluation of multiple W/O/W emulsion based system for controlleddelivery of primaquine phosphate.Sushama Talegaonkar and S.P. VyasHamdard University, Faculty of Pharmacy, NEW-DELHI 110062, India

P-123 CPF-Process for Powder Generation from Liquids.Sabine Griiner, Frank Otto, Bernd WeinreichTU Miinchen, Adalbert-Raps-Zentrum fur Arznei-, 85350 FREISING-WEIHENSTEPHAN, Germany

P-124 Towards a better understanding of the relationship between chemical structure ofamphiphilic 6-cyclodextrins (6-CDA) and their ability to form nanoparticles.Geze A., Aous S., Baussanne L., Putaux J.-L., Wouessidjewe D.UMR 5063, Departement de Pharmacochimie Moleculaire, Universite JosephFourier, 38243 GRENOBLE, France