TETRASIKLIN REV.25.07.08.ppt

8/19/2019 TETRASIKLIN REV.25.07.08.ppt

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TETRASKLIN

OLEH

dr. YASAVATI KURNIA, MS

DEPARTEMEN FARMAKOLOGI

FAKULTAS KEDOKTERAN UKRIDA


2/21

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TETRASIKLINTETRASIKLIN

ASAL :

Streptomyces aureoface!s K"ortetras#"!

Streptomyces rmosus O#stetras#"!

Tetras#"! $%uat $r K"ortetras#"! secara

semsatet# atau $ar Streptomyces terte!tu


3/21

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Sifat antimikrobaSifat antimikroba

Spe#trum a!t%a#ter "uasSpe#trum a!t%a#ter "uas

& 'a#ter Gram ( $a! ) & 'a#ter Gram ( $a! )

& Kuma! aero%# $a! a!aero%# & Kuma! aero%# $a! a!aero%#

& Spro#et* m#op"asma* r#etsa* #"am$a& Spro#et* m#op"asma* r#etsa* #"am$a

& Le+o!e"a $a! proto,oa terte!tu& Le+o!e"a $a! proto,oa terte!tu

Ut# Strepto#o#usUt# Strepto#o#us - efe#tf $+! Pe!s"! G- efe#tf $+! Pe!s"! G

Ertroms! $a% sefa"ospor!Ertroms! $a% sefa"ospor!Strepto#o#us aureusStrepto#o#us aureus %!y# t" resste! %!y# t" resste!


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Kecua" Do#ss#"! efe#tf ut# Strept. Pyo+e!es /

!eumo!ae

pe!ye%a% $ar S!usts.

Dpa#a s%+ pe!++a!t Pe!s"! p$ !fe#sO"e0 %a#ter Gram ( spt : '. a!t0racs* Eryspe"as*

1"ostr$um teta! $a! Lstera mo!ocyto+e!es

Efe#tf ut# N. +o!orr0oe* #ecua" y+ me!+0as"#a!

pe!s"!ase


5/21

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Efek antimikroba yang lainEfek antimikroba yang lain

Efe#t2tas t!++ ut# %% macam #uma! GramEfe#t2tas t!++ ut# %% macam #uma! Gram

Kecua"3 E.co"* K"e%se"a* E!tero%acter* PseuKecua"3 E.co"* K"e%se"a* E!tero%acter* Pseu

Domo!as / Proteus !$o" (Domo!as / Proteus !$o" (

Sa!+at efe#tf ut#3 Mycop"asma peumo!ae*Sa!+at efe#tf ut#3 Mycop"asma peumo!ae*

Ureop"asma urea"ytcum* 10"amy$a trac0o4Ureop"asma urea"ytcum* 10"amy$a trac0o4

Mats / %% R#ettsaMats / %% R#ettsa

Efe#tf t0$p 3 'ore""a recure!ts* Trepo!emaEfe#tf t0$p 3 'ore""a recure!ts* Trepo!ema

pa"$um* T.perte!ue / Act!omyces srae" pa"$um* T.perte!ue / Act!omyces srae"

Ka$ar t!++ me!+0m%t E. Hsto"ytcaKa$ar t!++ me!+0m%t E. Hsto"ytca


6/21

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aya antibakteri ! bakterio"tatik

RESISTENSI Terutama p$ S.5 0aemo"ytcus* E.co"* Str.

P!eumo!ae* N.+o!orr0oe* 'actero$es*S0+e""a / S. aureus

Ter6. Resste!s s"a!+ p$ semua 6e!s tetras#"!

MEKANISME KER7A

Me!+0am%at s!tesa prote! #uma! Tetras#"! ter#at p$

R%osom 89 S me!+0a"a!+ masu#!ya #omp"e#s t4RNA ) aa pa$a "o#as aa


7/21

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#armakokinetik

D%a+ 8 +o". 'er$asar#a! sfat F#!et#!ya;. Tetras#"!* K"orteras#"! / O#stetras#"!

a%sp t$# "e!+#ap* t;4? 6am

=. Demet" #"ortetras#"!

a%sp - %a#* t @ ;> 6am

8. Do#ss#"! / m!os#"! a%sp %a# se#a"* t @ ;4=9 6am

A%sp 89 ) B9C sa" cer!a* -?9C ut# $o#ss#"! / m!os#"!

A%sp $#ura!+ o"e0:

4 Ma#a!a! $"m "am%u!+* #ecua" $o#s /m!os#"!

4 pH "am%u!+ t!++ a!tas$a

4 Pem%t#a! #e"at #omp"e#s Tetra / ,at "a! y+ su#ar "arut spt3A".0$ro#s$a* +aram #a"sum / Fe


8/21

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ISTRI$USI

4 I#ata! prot.p"asma %er2aras

4 t @ $o#ss#"! t$# %eru%a0 p$ +a+a" +!6a"4 Dtm%u! $"m RES 0at*"mpa*ss.t"* $e!t! $a! ema"

4 Me"eat saar URI $a! ASI

EKRESIMe"a"u ur! $a! empe$u $a! me!+a"am sr#u"as e!tero0epat#


9/21

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E#EK SAM%IN&

Rea#s #epe#aa! #u"t erups mor%"forms* urt#ara*

$ermatts e#sfo"atf* $emam* eos!of"a*

a!+o!eurot# u$em* $a! rea#s

a!af"a#ss Rea#s to#ss / rtatf

4 Irtas "am%u!+* $are %e$a $+! y+ $se%a%#a! o"e0

super!fe#s 1".$ffc"e

4 Trom%of"e%ts %" $%er I* $a! !yer p$ tempat su!t#a!

4 T0< "ama ter6a$ +a!++ua! $ara0 3 "e#ostoss* "mfost atp# $a! trom%ostope!a


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Efek "am'ing (lan)*tan+

4 Fototo#sstas #e"a!a! #u"t

4 Hepatoto#ss ter6a$ p$ $< %esar $a! pem%era!

pare!tera" me!+0m%t #oa+u"as $ara0

4 Pertum%u0a! tu"a!+ $0m%t

tm%u" #omp"e#s #ata!Tetras#"!4tu"a!+

4 Peru%a0a! ar!a co#"at perma!e! p$ ++ susu


11/21

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44 Im%a!+ !tro+e! !e+atf / #a$ar ureum

4 Neo!atus ) te#. I!tra#ra!a" fo!ta!e"a me!o!6o"

4 est%u"ostat# 3 2ert+o* ata#sa* 2omtus %asa!ya

$se%a%#a! MINOSIKLIN4 A#%at peru%a0a! %o"o+# 3

& super!fe#s #uma! / 6amur Dare /

#a!$$ass mu"ut $"". terutama pa$a D.M.* L.E

"eu#ema* $aya ta0a! tu%u0 J* ms AIDS


12/21

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al yg 'erl* di'er-atikan

4 T$# %o"e0 $%er#a! p$ a!ta 0am"* p$ a!a#4a!a# ta!pa

!$#as #uat* pa$a +a+a" +!6a" #ecua" $o#ss#"!

4 H!$ar pe!++u!aa! s%+ prof"a#ss

4 'ua!+ ssa o%at y+ t$# terpa#a4 Dare $pt $s%#a! o"e0 3

& E!tero#o"ts o"e0 staf"o#o#us

& Ka!$$ass !test!a"

& Ko"ts pseu$o mem%ra!osa


13/21

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%engg*naan klinik

R#etsoss* K"am$a* Lmfo+ra!u"oma 2e!e4 reum p"0a!

utama* Psta#oss* Tra#oma* I!c"uso! 1o!6uct2ts

sa"ep


14/21

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%engg*naan klinik (lan)*tan+

4 e!erea" $sease: GO $a! Sf"s p"0a! #e4= sete"a0

pe!s"!

4 A#!e 2u"+ars me!+0am%at asam "ema# / se%um

4 A#t!omycoss* Fram%usa* Leptospross* I!fe#ssa".#em0 $a! sa". 1er!a

4 Top#a" 0a!ya ut# !fe#s mata sa6a


15/21

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KLRAM#ENIKL

ASAL 3 Streptomyces 2e!e,ue"ae K"oramfe!#o" /

Tamfe!#o"

SI#AT ANTIMIR$A

S'ektr*m antibakteri /

D.p!eumo!ae* Str. Pyo+e!es* Str.2r$a!s* Nesera* Haemof"us*

'ac""us spp* Lstera* 'ruce""a* Pasteure""a* 1. $p0terae*

10"amy$a* Mycop"asma* R#etsa* Trepo!ema* Km! a!aero%*

E.co"* K".p!eumo!ae / P.mra%"s


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MEKANISME KER0A

Me!+0am%at s!tesa prote! #uma! $e!+a! me!+0am%at e!,ymPEPTIDIL TRANFERASE

Daya a!t%a#ter: %a#terostat#

Ka$ar sa!+at t!++ #$+ %a#ters$

#ARMAKKINETIK A%sp3 ora" cepat* t ma = 6am t@ 8 6am* ter#at prot.p"asma Meta%o"sme3 0at $+! re#as #o!yu+as E#sres 3 ur! I!tera#s : me!+0m%t %otrasformas to"%utam$*fe!to!*

$#umaro" $""


17/21

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E#EK SAM%IN&

Rea#s 0emato"o+s:

& re#as to#s# $epres ss.t"* %er0u%.$e!+a! $oss $a!

%ersfat re2ers%e" : a!ema* ret#u"ostope!a* serum Iro!

$a! I'1* 2a#uo"sas se" $r0 mera0 mu$a

& T$# %er0u%.$+! $oss / rre2ers%e" a!ema ap"ast# $a!

pa!stope!a merupa#a! R.I$os!#ras / K"!a!

+e!et#

& Hemo"ss p$ pe!$. Defse!s G4>PD


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Rea#s A"er+ : #emera0a! #u"t* a!+o4u$em urt#ara*

a!af"a#ss* R sepert HERHEI MER ter6a$ pa$a pe!$ertaTpo$

Rea#s sa"ura! cer!a : N**D* +"osts* e!tero#o"ts

SINDROM GRA : p$ !eo!atus mu!ta0* t$# mau !yusu* per!afasa! cepat / t$# teratur*#em%u!+*sa!oss*t!6a ar!a 06au* "emas* #"t ar!a a%u4a%u*0poterma Kemata! mu!+#! o"e0 #are!a : +"u#uro!$as 0epar$a! e#sres +!6a" y+ %e"um sempur!a

Rea#s Neuro"o+s: $epres* %!+u!+* $e"rum* sa#t #epa"a*!eurts perfer / opt#


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INIKASI 1 KNTRAINIKASI

INIKASI !

44 $emam tpo$$emam tpo$ mas0 $ru+ of c0oce $+! amps"! :mas0 $ru+ of c0oce $+! amps"! :

per%a#a! #"!s cepat #arer $a! re"aps per%a#a! #"!s cepat #arer $a! re"aps

- 6ara!+- 6ara!+

44 M!!+ts puru"e!ta y+ $se%a%#a! H.!f"ue!,aM!!+ts puru"e!ta y+ $se%a%#a! H.!f"ue!,a

44 I!fe#s #m! a!aero% 3 '. fra+"sI!fe#s #m! a!aero% 3 '. fra+"s

44 R#etsoss / #uma! ya!+ "a!R#etsoss / #uma! ya!+ "a!

KNTRAINIKASI

44 Neo!atus* +a+a" faa" 0at / 0perse!st2tas Neo!atus* +a+a" faa" 0at / 0perse!st2tas


20/21

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TIAM#ENIKL

Ter0a$ap Str.pyo+e!es* p!eumo#o#us* 0aemo4 f"us /

me!!+o#o#us setara $e!+a! #"oram4 fe!#o"

Indika"i : sama $+! #"oramfe!#o"* !fe#s sa"ura! empe$u $a!

GO

#ARMAKKINETIK

4 A%sp ora" %a#* pe!etras t" / 1SS %a#

4 E#sres utu0 $uru! 0at40at ++" +!6a"

E#EK SAM%IN&

4 Depres ss. T". Re2ers%e"* 6r+ me!y%#a! ap"asa

ss.t".*$epres ertropoess* rea#s 0emato"o+# sepert*

"eu#ope!a* trom%ostope!* #$r serum Iro!


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TETRASIKLIN REV.25.07.08.ppt