C U R R I C U L U M V I T A E

Dr SALIM SHAFEEK

MD, FRCP, FRCP(Ed), FRCPath (Haem)

Consultant Haematologist & Clinical Director Haemato-Oncology (Worcestershire Oncology Centre)

Worcestershire Acute NHS Trust Hospital (Teaching)

Hon Senior Lecturer in Haematology (Cancer Studies)

University of Birmingham.

&

Principal Investigator for National Clinical trials (NCRI-UK) AML 18 / AML 19/ UKALL 14/ Myeloma XI+/ PACIFICO(Follicular NHL)/

RATHL(Hodgkins Lymphoma)/ ReModel-B (DLBCL) RIALTO (CLL Elderly) , FLAIR (Younger fit CLL)

Examiner MRCP(UK) (Paces) & FRCPath (Hamatology)

September 2016 (updated)

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PERSONAL DETAILS Name Salim SHAFEEK D.O.B. 26-05-1963 Nationality: British Sex Male Marital status Married Address: Consultant Haematologist & Hon Senior Lecturer(University of Birmingham) , Worcestershire Royal Hospital. Charles Hastings way, Worcester. WR5 1DD Home 30 New House Farm Drive, Bournville Park, Birmingham B31 2FN Telephone 0121 476 8090 07710210166 E-mail Salim.Shafeek@worcsacute.nhs.uk(Work) salimshafeek@nhs.net salimshafeek@btinternet.com (Home)

GMC registration: 4464727 full registration QUALIFICATIONS Dates Description of qualification Place obtained 1982 to 1989 MBBS Trivandrum Medical College 1989 to 1992 MD(Gen Med) Calicut University 1994 MRCP(UK) RCP London 1997 DipRCPath RCPathology 1998 MRCPath(Haem) RCPathology

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2004 FRCP(Ed) RCP Edinburgh 2004 FRCP RCP London DISTINCTIONS Selected for District Merit Scholarship for SSLC First Class for MBBS, Fourth rank in Kerala University Distinction for Forensic Medicine First Rank in Calicut University for MD (Gen. Medicine) First prize in Inter Collegiate Post Graduate QuizCompetition (KMC Manipal CME in 1990 &1991) Proficiency Prize for IAP Paediatric Quiz (Indian Academy of Paediatric, 1987) Honours or Prizes Best Out going Postgraduate Student in Medicine 1992 (University of Calicut, Kerala, India) Winner of G.K.Warrier Memorial Gold Medal 1992 (First Rank in Postgraduate Medicine, University of Calicut) THESIS WORK

Work return after Myocardial Infraction (as a part of MD General Medicine) MEMBERSHIPS British Society for Haematology American Society of Haematology Associations of Physicians, India Member of Royal College of Physicians London & Edinburg Member of Royal College of Pathologist , London CAREER PLAN

Special interst in Haemato-Oncology , esp Lymphoproliferative disorders Supervise County wide Clinical Haematology service, including Level 3

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Haematology care. Active Participation in teaching both undergraduates and Post graduate Students, nursing staff . Do research linking with Queen Elizabeth Hospital & Univ of Birmingham Do future Publications & Presentation

APPOINTMENTS Most recent appointment: Date Grade and Place held Specialty

06/06/2005 onwards Consultant Haematologist WRH (Worcester) 08/07/2002 onwards ‘’ Alexandra

01/05/2008 onwards Hon Senior Lecturer Univ of Birmingham & QEH

Previous appointments

Date Grade and Place held Specialty

1-10-2000 to Specialist Registrar in University Hospital Haematology Coventry & 12-04-2002 Queen Elizabeth

Hospital, Birmingham.

10-04-99 To Consultant Haematologist Borders General / (Locum) Walsgrave /

30-04-2000 Stafford District Royal Oldham Pilgrim / Grantham Hereford County Hospitals 01-10-1998 to SPR Haematology Walsgrave Hospital

09-04-1999 Coventry 01-04-1998 to SPR Haematology City Hospital 30-09-1998 Birmingham

01-10-1997 to SPR Haematology Childrens Hospital

31-04-1998 Birmingham 01-10-1996 to SPR Haematology Heartlands Hosp

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30-09-1997 Birmingham 01-12-1995 to SPR Haematology Stafford District 30-09-1996 Gen Hospital 01-09-1995 to SPR Haematology Regional Blood 30-11-1995 Transfusion 10-04-1995 to Registrar in Queen Elizabeth 30-08-1995 Haematology Birmingham 07-03-1994 to SHO Haematology Leicester Royal 09-04-1995 Infirmary

WORK EXPERIENCE (Current Job) 08-07-2002 ONWARDS CONSULTANT HAEMATOLOGIST WORCESTERSHIRE ROYAL HOSPITAL Worcestershire Royal Hospital (Full time) & Hon Senior Lecturer in Haematology , University of Birmingham from 1-05-2008 & Shared Care arrangements – Queen Elizabeth Hospital Birmingham (University Hospitals NHS Foundation trust) Level 3 & 4 Stem Cell Transplantation Countywide Haematology service for the whole of Worcestershire linking Worcester Royal hospital , Alexandra hospital & Kidderminister general. With all inpatients based at WRH in the dedicated Haematology Unit ( Laurel 3). As a Consultant, 4.5 at WRH & 2.5 at Alexandra Hospital Redditch. Mainly based at Worcestershire Royal hospital along with another Consultant, has daily responsibilities in the management of 3 Haematology clinics. Inpatients: All level 1& 2 works are based at Worcester Royal Hospital. With 1:7 commitment for fortnightly attending Physician’s role. During which period are in charge of the inpatients and all the medical referrals. Daily ward rounds with the junior medical team. Supervise all the procedures. MDT meetings: once weekly meeting discussing all new cases and problem patients in the region. Discuss all Lymphoma patients. Day Unit: Predominantly managed at Laurel 3 day unit at Worcester Royal Hospital. Also supervises the day case at Laurel 3 while working as the Attending Physician. Day case is usually nurse led. All procedures & Chemotherapy are done at the Laurel 3. Out patients: 2 regular clinics at Worcestershire Royal Hospital and one clinic at Kidderminster Treatment centre, Kidderminster. Anticoagulant : Nurse led clinics with medical inputs if needed. County Lead for anticoagulantion.

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Lead for all national Clinical trials and Phase II trials in Myeloma through University Hospital Birmingham. Currently Clinical Director for Haematology & Cancer service directorate since May 2009. Management Experience In Worcestershire Acute NHS Trust : Clinical Lead in Haematology –Cancer services Worcestershire Acute NHS Trust Since 2008 onwards as a part of Medical Directorate. Played a key role in reshaping the Worcester /Kidderminster Clinical Haematology Cover arrangements. Overcome the recruitment crisis for the Kidderminster vacancy. Worked towards the countywide structure in Haemato-Oncology. And created this new directorate for the first time in subsequent trust restructuring. Clinical Director in Haemato-Oncology : since 2009 Since officially a new directorate I was the Clinical Director since 2009. Actively involved in full centralisation of services and appointed new CNS’s to cover all three major sites. Junior doctor crisis was managed and new appointment was made 2 years ago , along with re-instating Specialist Registrar back for the rotation. 2 New Consultant posts were appointed after senior Consultant retired in 2010. With full 7 Consultants across the three main sites and peripheral clinics including Bromsgrove, Evesham & Malvern. Active working arrangements with QE and starting shared care arrangements for Autologous Transplantation service. Acute Oncology service was implemented with a robust nurse led model with 2 specialty doctors. Two new Palliative care Consultants were appointed 6 months ago. Oncology Project participation: Actively involved in the Worcestershire Oncology Project working along with Mr Adel Makar & Dr Clive Irwin, interim Oncology Lead for the trust. Fully established Oncology centre at Worcestershire , the first twin unit in the country with Coventry Oncology centre. 11 New Oncologist appointed and has been working through phase 3 implementation now with Head and neck cancer. Named as Worcestershire Oncology Centre. PREVIOUS WORK EXPERIENCE BEFORE JOINING THE CURRENT TRUST: 1-04-2002 – 05-07-2002 CONSULTANT HAEMATOLOGIST (LOCUM) DEWSBURY GENERAL & PINDERFIELD HOSPITAL MID YORKSHIRE NHS TRUST

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Before taking the substantive post worked as locum in the above trust. Main responsibility was at Dewsbury General with level 2 & 3 work based at Pinderfield hospital . Clinics & level 1 work are carried out at Dewsbury General. All haematological malignancy was treated with attachment to Leeds teaching hospitals. The centre had special interest in treating refractory CLL’s with Mab-campath. Also had a special interest in PNH related illness. All Autografts were done locally. Specialist registrars rotating from Leeds Training scheme. 1-10-2001 TO 31-03-2002 SPECIALIST REGISTRAR IN HAEMATOLOGY UNIVERSITY HOSPITAL BIRMINGHAM (QUEEN ELIZABETH HOSPITAL) (TEACHING) BIRMINGHAM Main University teaching hospital, provides health care to south Birmingham comprising of Queen Elizabeth & Selly Oak Hospitals. Total 950 beds in two sites. Hospital has Emergency admission unit. It also accommodated a range of speciality services, including Liver, Renal, Cardiac, Cardiothoracic, Neurosurgery Oncology & Radiotherapy. Clinical Haematology is part of the Haematology & Oncology Directorate, provides a general and malignant haematology service including Bone marrow transplantation, a tertiary referral centre for haemophiliacs, hereditary & acquired bleeding, and thrombotic disorder. Regional cell separator unit is situated here involved in stem cell collections, Plasmapharesis, leukopharesis & red cell exchanges. Manages Haemoglobinopathy, mainly sickle cell disease. Experience in management of General Haematology including Anaemias,

Leukaemias, myeloma, lymphomas & myelodysplasias. Regional Bone Marrow Transplant unit(Adult) includes 12 bedded unit. Busy day unit involved in blood transfusion & chemotherapy. Regional Haemophilia (Adult) centre for whole of West Midlands. Regional Thrombosis referral centre. Lab Training: Reporting abnormal blood films, marrow reporting & interpretation of abnormal clotting results. Referral lab for all specialist coagulation tests including PCR for Factor V Leiden & Prothrombin gene mutation. Co-ordinates central NEQAS program. Attending Trephine morphology meetings. Haematological Oncology / Bone Marrow Transplantation: Involved in various procedures Bone marrow aspirates, trephine, lumbar punctures. Participated in management of both Auto and Allograft patients in the unit. Experience in Volunteer unrelated donor transplants .

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Haemostasis Thrombosis : Involved in treating & managing various Haemophilic states, bleeding disorders but congenital and acquired. Management of Thrombophilic states & there investigation . Special experience in hepatic haemostasis due to the busy Regional Liver unit. 1-05-2000 TO 30-09-2001 SPECIALIST REGISTRAR (SENIOR) HAEMATOLOGY UNIVERSITY HOSPITAL COVENTRY & WARWICKSHIRE NHS TRUST, COVENTRY Level 3 DGH with 1200 beds. Hospital provides inpatient facilities including Cardiothoracic Surgery, Neurosurgery, Renal Transplantation, Radiotherapy and Oncology, Autologous Bone Marrow transplantation & Haemophilia.

Inpatient Facilities : 26 bedded ward shared with Cardiology, roughly occupying between 12 to 16 beds. Total inpatient turn over is about 250 per year. 6 isolation beds for neutropenic patient and Autologous Transplant patients. Undertake 12 cases per year. Know it is the regional centre for Warwickshire health authority. Future plan for centralising Acute Leukaemia & Lymphoma care for regional 1-10-1999 to 16-01-2000 CONSULTANT HAEMATOLOGIST (Locum) UNIVERSITY HOSPITAL COVENTRY & WARWICKSHIRE NHS TRUST health authority including South Warwickshire hospital , George Eliot Hospital & St Cross hospital Rugby. Day Unit: Undertakes all Chemotherapy, Blood transfusions & Procedures like Bone marrow aspirations, Lumbar punctures & Line insertions. Department consist of Three Full time Consultants and a part time Consultant. Two Specialist Registrar one senior and other junior& Full time Haematology SHO. Clinics.. 8 busy Haematology clinics in addition to a Joint Lymphoma Clinic & Paediatric Haematology Clinic. Specialised Haemophilia/HIV clinics & Thrombosis clinics are conducted. Anticoagulation System . Fully nurse led and computerised. Postal dosing and 5 new patient clinics run by trained nurses. Haemophilia Centre: Sub regional centre for Haemophilia care . Clinical & Lab Experience: General Haematology experience in District general level. Managment & investigation of all anaemia’s. Day to day management of all Inpatients , which included Acute Leukaemias both AML & ALL especially MRC trial baised, Chronic Leukaemia, Lymphomas & Myelomas. Supervising the

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SHO in the ward duties. Involved in the organisation of all Peripheral stem cell transplants in the county for Lymphomas, Myelomas & Leukaemias. Involved in the Intrathecal policy draft done in the trust. Procedure Experience : Bone marrow aspirate ,trephine & harvest. Hickmann line , PICC line & Vascath insertions. Clinic Experience: Involved in general haematology clinics including new & follow ups. Laboratory Experience: Broad experience in interpreting abnormal film, all bone marrow aspirates, special stains & cytospins. Day Unit: Undertakes all Chemotherapy, Blood transfusions & Procedures like Bone marrow aspirations, Lumbar punctures & Line insertions. Consultant of the week is responsible for ward rounds daily and grand rounds on a Wednesday. Current locum job was for a new full time 3rdConsultant in charge of Autologous Transplantation. Department consist of Three Full time Consultants including the new post and a part time Consultant. Two Specialist Registrar one senior and other junior& Full time Haematology SHO. Clinics: 8 busy Haematology clinics in addition to a Joint Lymphoma Clinic & Paediatric Haematology Clinic. Specialised Haemophilia/HIV clinics & Thrombosis clinics are conducted. Anticoagulation System . Fully nurse led and computerised. Postal dosing and 5 new patient clinics run by trained nurses

02-08 1999 TO 30-09-1999 CONSULTANT HAEMATOLOGIST (LOCUM) STAFFORD DISTRICT GENERAL HOSPITAL MIDSTAFFORDSIIIRE NHS TRUST STAFFORD Busy DGH with 600 beds. Level 2 for Haematology/Oncology care. With two full time Consultants. One of the training centres for SpR training in Haematology in West Midlands. PROFESSIONAL EXPERIENCE 17-01-2000 to 30-04-2000 Consultant Haematologist (Locum) Borders general hospital Melrose SCOTTISH BORDERS 19-07-1999 to 01-08-1999 CONSULTANT HAEMATOLOGIST (Locum) ROYAL OLDHAM HOSPITAL OLDHAM NHS TRUST, OLDHAM.

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5-07-1999 TO 18-07-1999 CONSULTANT HAEMATOLOGIST (LOCUM)

GRANTHAM AND DISTRICTC HOSPITAL & PILGRIM HOSPITAL, BOSTON LINCOLNSHIRE

1-05-1999 TO 02-07-1999 CONSULTANT HAEMATOLOGIST(LOCUM)

HEREFORD COUNTY HOSPITAL HEREFORD HOSPITALS NHS TRUST

10 -04-1999 TO 30-04-1999 CONSULTANT HAEMATOLOGIST (LOCUM)

WALSGRAVE NHS TRUST HOSPITAL OF ST CROSS & GEORGE ELIOT HOSPITAL NUNEATON WARWICKSHIRE

1-10-1998 TO 10-04-1999 SPECIALIST REGISTRAR IN HAEMATOLOGY WALSGRAVE GENERAL NHS TRUST COVENTRY(TEACHING) District General Hospital with 1200 beds. The hospital provides inpatient facilities including Cardiothoracic Surgery, Neurosurgery, Renal Transplantation ,Radiotherapy and Oncology, Autologous Bone marrow transplantation & Haemophilia Clinical departments: Outpatient clinics: 8 General Haematology clinics, joint Lymphoma clinics, 1 Paediatric Oncology clinic & Anticoagulation clinics. Inpatient Facilities: 26 bedded ward with 6 isolation rooms. unoccupied beds are used by Cardiologist Total in patient turn over- is about 250 per year. Haematology consultation services are provided to all other departments. This department offers sub regional Haemophilia services and under take Autologous Bone marrow Transplantation for the health authority. Recently started busy Day unit under takes procedures, transfusion & chemotherapy. Involved in daily ward rounds with SHO and once weekly joint ward rounds. Also in charge of nurse led day unit.

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Training & Teaching Experience: Recognised for MRCPath as a part of West Midlands Training Scheme for SpR's.Department is a centre for the new MRCPath final examination. Experience in teaching 4th year Medical students. Lab Training: One of the first Integrated Laboratory. Busy lab with one H2 and two Advia. Report all abnormal films, Bone marrows & Haemoglobin electrophoresis. On calls: 1 in 4 on-calls with the Consultants. 1-04-1998 TO 30-09-98: SPECIALIST REGISTRAR IN HAEMATOLOGY CITY HOSPITAL NHS TRUST(TEACHING) BIRMINGHAM District General Hospital attached to University of Birmingham involved in Teaching undergraduate medical student.Approximately 650 acute beds. Haematology laboratory provides service to all hospitals and GPs in the West Birmingham Health Authority,handling 150,000 requests annually. Official referral centre for Adult Haemoglobinopathy,including Thalassaemia &Sickle Cell Disease. ln addition to routine care of Leukaemia, Myeloma, Lymphoma, Myelodysplasia and anaemias. Auto stem cells & bone marrow Transplantations are carried out. Experience: Clinical- Wide experience in all aspects of Haemoglobinopathy management, especially Sickle cell disease and Thalassaemias. Involved in total red cell exchanges. Conducts General Haematology, Sickle clinics, Anticoagulation clinics &New Patient clinics. Involved with Antenatal Thalassaemia screening programs Anticoagulation clinics have adopted computerised Dawn AC system. Experience in teaching undergraduate medical students MLSO'S &nurses. Lab Experience: In addition to the general experience in interpretation of Routine blood counts, bone marrows, trephines and hematinics .Experience in reporting Haemoglobinopathy investigation including Gel electrophoresis & HPLC. 1-10-1997 TO 31-03-98 SPECIALIST REGISTRAR IN PAEDIATRIC HAEMATOLOGY BIRMINGHAM CHILDRENS HOSPITAL NHS TRUST (TEACHING) BIRMINGHAM Tertiary referral centre for specialist care. Only specialist children’s hospital in the West Midlands Region. Provides DCH Paediatric services, as well as Regional/ Supra- regional services in all major paediatric sub specialities. Second biggest in United Kingdom.

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Clinical Experience: Management of Childhood Leukaemias, Including ALL's AML's CML's and rare chronic Leukaemias. Active participation in all MRC Leukaemia trials. Major centre for Bone Marrow, stem cell & Cord blood Transplantation. Transplantation for Leukaemias, Lymphomas, Thalassaemia, Sickle cell Disease, rare anaemia’s including Aplastic anaemia and Congenital Immune deficiencies. HAEMOPHILIA AND THROMBOSIS HAEMOSTASIS EXPERIENCE: Regional Paediatric Haemophilia centre for the whole of West Midlands. Experience in managing Haemophilia A,B and all other bleeding disorders. Referral centre for Genetic diagnosis of Haemophilia A&B. Four Haematology clinics and one thrombosis Haemostasis clinic every week. EXPERIENCE: Wide Paediatric Haemato-Oncology experience, including management of ALL, AML, Neuroblastomas, Congenital Bone marrow disorders, aplastic anaemia & Bone marrow Transplantation. In addition I had good exposure to Thalassaemia & Sickle cell disease. Managed all different types of Haemostatic disorders including Haemophilia’s. Paediatric Anticoagulation experience was also achieved during the 6 months. 1-10-1996 TO 30-09-1997 SPECIALIST REGISTRAR IN HAEMATOLOGY BIRMINGHAM HEARTLANDS HOSPITAL NHS TRUST (TEACHING) BIRMINGHAM Clinical Work: Busy transplant unit. Mainly Peripheral stem cell Allo, Auto& MUD transplantation. Regional referral centre for MRC Leukaemia trials. Unit has 8 high dependency rooms for Bone Marrow Transplants & care of Acute Leukaemia, Lymphoma, Myeloma, Neutropaenias & other Haematological disorders. Two busy haematology clinics & 3 anticoagulant clinics per week. Participates in all haematological & Lymphoma trials. Good experience in management of Hodgkin’s & Non Hodgkin’s Lymphoma. Experience in Hickmann line (Central) & Femoral venous line insertions Day unit manages all Chemotherapy and Transfusions. Also experience in stem cell collection. Ward rounds 3 times a week, one being multidisciplinary. Pilot centre of new CLL stem transplantation.(MRC) Lab experience: Routine diagnostic and transfusion services. Fully computerised and linked to hospital information support system. Referral centre for Immunophenotyping Leukaemias & Lymphomas by Flow cytometer. On site Regional Cytogenetics & Virology labs. Reporting peripheral smears, Bone marrow & Trephine biopsy TEACHING EXPERIENCE: Involved in teaching under graduates, SHO's Laboratory & nursing staffs. Clinical Experience: Mainly Haemato-Oncology experience, by active participation all UK MRC trials. Good exposure to acute leukaemias, AML, ALL &

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Chronic Leukaemia’s with special interest in CLL management. Good on site Immunology markers lab. Lymphomas were managed mainly by the unit, active participation in the joint Lymphoma meetings. Special experience in Burkitt’s Lymphoma management. Good exposure and day to day care of all Haematology Inpatients including Bone marrow & Stem cell Transplantation, both Allografts and Autografts. Involved in DLI treatments for CML. 1-12-1995 TO 30-09-1996 SPECIALIST REGISTRAR HAEMATOLOGY STAFFORD DISTRICT GENERAL HOSPITAL STAFFORD, STAFFORDSHIRE Busy DCH with 600 beds. Haematology has four specialised isolation beds along with four general beds. Management of all general Haematology problems including management of Acute Leukaemia’s, Lymphoma, Myeloma, Chronic Leukaemias & Myelodysplasia's. Lab Work: Reporting routine Abnormal results. Bone marrows & Trephine. Experience in radioisotope techniques like Red cell mass & Schilling test. On call rota, 1 in 3 along with consultants 1-09-1995 TO 30-11-1995 REGISTRAR IN HAEMATOLOGY REGIONAL BLOOD TRANSFUSION CENTRE ,BIRMINGHAM Regional Blood Transfusion provides transfusion support to whole of Midlands. Training included one month intensive Transfusion course, which included all aspects of Transfusion Medicine. Rotated around the various departments like Blood donation centres, components separation lab, automated grouping labs, Antenatal serology lab, virology lab, research & development lab, cryobiology, Tissue typing special investigation Lab & Blood components Issue department. Some experience in Flow cytometry evaluation of platelet antibodies & Feto-Maternal bleeds. Took part in combined Rhesus foetal clinics, evaluating antenatal screening. Experience in blood donor camps, including donor selection & interview. Frozen Blood Bank is the only in the country, actively participating in world wide search. Active stern cell lab with busy schedule. R&D has started cord blood storage for future Cord Blood Transplants. Regional Tissue typing lab involved in solid organ & bone marrow transplantation. Experience in Hospital Blood banking.

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Did a project on the effect of summer temperature on donor selection by Haemoglobin 10-04-1995 - 30-8-95 REGISTRAR IN HAEMATOLOGY UNIVERSITY HOSPITAL BIRMINGHAM (QUEEN ELIZABETH HOSPITAL) (TEACHING) BIRMINGHAM Main University teaching hospital, provides health care to south Birmingham comprising of Queen Elizabeth & Selly Oak Hospitals. Total 950 beds in two sites. Hospital has Emergency admission unit. It also accommodated a range of speciality services, including Liver, Renal, Cardiac, Cardiothoracic, Neurosurgery Oncology & Radiotherapy. Clinical Haematology is part of Haematology Oncology Directorate, provides General and malignant haematology service including bone marrow transplantation. Tertiary referral centre for haemophilias, hereditary & acquired bleeding and thrombotic disorder. Regional cell separator unit is situated here involved in stem cell collections, Plasmapharesis, leukopharesis & redcell exchanges. Manages Haemoglobinopathy, mainly sickle cell disease. Experience in management of General Haematology including Anaemias, Leukaemias, myeloma, lymphomas & myelodysplasias. Bone Marrow Transplant unit includes four bedded unit. Does both Allo & Auto transplants. Busy day unit involved in blood transfusion & chemotherapy. Regional Haemophilia (Adult) centre for whole of West Midlands. Regional Thrombosis referral centre. Total of 7 clinics excluding anticoagulant clinics. 15 beds of General haematology & 4 transplant beds. Busy anticoagulation clinic Two major ward rounds. Weekly Haemophilia meeting & discussion of thrombosis clinic results .Lab Training: Reporting abnormal blood films, marrow reporting & interpretation of abnormal clotting results. Referral lab for all specialist coagulation tests including PCR for Factor V Leiden., Co-ordinates Central NEQAS program. Excellent Immunology & Genetic backup

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7-03-1994 TO 9-04-1995 SENIOR HOUSE OFFICER IN HAEMATOLOGY LEICESTER ROYAL INFIRMARY NHS TRUST (TEACHING) LEICESTER Main multispeciality hospital with Accident Emergency.1200 beds excluding 1141 day unit beds. Combined laboraroty and clinical work. Excellent lab facilities. 22 bedded Haematology ward & 5 transplant beds. Clinical experience: Managing busy day unit & inpatients. Doing all procedures, including bone marrow, trephine & line insertions. Involved actively in treating all major haematological disorders both Malignant & non malignant. Major Haemophilia centre for the region. Active participation in 8 busy out patient clinics including anticoagulant Clinics. First on-call for Haematology wards & transplant unit. Lab training: Reports all abnormal blood films. Report all marrows &Trephines Regular morphology review meetings. Regular topic discussions & Journal meetings Regular participation in Grand rounds. 20-11-93 TO 6-3-94 CLINICAL ATTACHMENT DEPARTMENT OF HAEMATOLOGY LEICESTER ROYAL INFIRMARY, NHS TRUST LEICESTER 1-12-92 TO 28-6-93 REGISTRAR IN CLINICAL HAEMATOLOGY DEPARTMENT OF HAEMATOLOGY, MEDICAL COLLEGE HOSPITAL, CALICUT, KERALA, 1-5-91 TO 30-4-92 REGISTRAR IN GENERAL MEDICINE & CLINICAL HAEMATOLOGY, MEDICAL COLLEGE HOSPITAL, CALICUT, KERALA, INDIA 1-8-90 TO 30-4-91 REGISTRAR IN MEDICAL SPECIALITIES NEPHROLOGY, CARDIOLOGY, GASTROENTEROLOGY, CHEST MEDICINE, NEUROLOGY, PHYCHIATRY,& DERMATOLOGY 1-04-90 TO 31-7-90 REGISTRAR IN GENERAL MEDICINE & INFECTIOUS DISEASE 1-12-89 TO 31-3-90 REGISTRAR IN GENERAL MEDICINE & HAEMATOLOGY 1-7-89 TO 30-11-89 REGISTRAR IN GENERAL MEDICINE Medical College Hospital, Calicut, Kerala, India. One of the five Government Medical Colleges in Kerala. Biggest teaching hospital in the state with 2500 beds. Multispeciality tertiary referral centre for five major districts. Main specialities includes Nephrology & Urology (only renal transplant centre), Cardiology, Gastroentrology & Haematology (only department in the state attached to General medicine).

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Busy Accident Emergency Department. All department attached to Calicut University. 200 students per batch Each wards contain 40 beds with side room isolation facility. In addition there are Pay Wards as well. Acquired excellent General Medical Experience through the intensive post graduate training. Including patient care responsibility, Coronary Care in-charge, Casualty Medical officer, Clinical meetings, Journal clubs & Symposiums, Case Presentations & teaching under graduates 3rd years, 4th years & final years. Regular evening case discussion three days a week. Haematology unit was attached to one of the busy medical units. Referrals whole of the state & some south Indian neighbouring states. Treat all haematology conditions. Excellent diagnostic facilities (attached to a private diagnostic firm). All treatments short of bone marrow transplantation. Involved in plenty of drug trials, pioneers in using Interferon, Interleukins, Fludarabine, GCSF, GMCSF, Cyclosporins & Erythropoietins. Experience in procedures like bone marrow, trephine & cytology. 1-4-88 to 14-4-89 RESIDENT HOUSE OFFICER IN MEDICINE, SURGERY, GYNAECOLOGY& OBSTETRICS, PAEDIATRIC & COMMUNITYMEDICINE MEDICAL COLLEGE HOSPITALS, TRIVANDRUM & CALICUT, KERALA. RESEARCH EXPERIENCE Actively participating in all NCRI clinical trials. Involved in all Acute Leukaemia Trials, BNLI trials & Myeloma trials. Principal investigator for NCRN trial for the Worcestershire Acute NHS Trust since 2006. Active trial recruitment and second biggest Haematology trial recruitment in the West Midlands region. Myeloma X1 Trial recruitment figures puts the trust in 7th position nationwide. Appointed 2 more new Clinical trial nurses through the CLRN funding and Cure Leukaemia charity funds. Close links with QE Trial unit involving in phase II & III non CLRN trials.

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PRESENTATIONS & ABSTRACTS: 1.The Quadruplet Combination of Carfilzomib, Cyclophosphamide , Lenalidomide and dexamethasone is safe and well tolerated as induction therapy for Newly diagnosed , transplant eligible Myeloma patients (Myeloma XI+ trial UK) Faith Davies , Nigel Russell, Gordon Cook , Donald Milligan , Salim Shafeek , Gareth Morgan et al EHA 12th June 2015 Oral presentation. 2.The UK & Ireland Perspective of Relapsed refractory Multiple Myeloma(PASS) treated with Lenalidomide, Bortezomib & Thalidomide. Multicenter Observational PASS study. Poster EHA 2014 Jenny Bird, Salim Shafeek, John Ashcroft, Roger Owen & Graham Jackson 3. Toxicity & Efficacy of Bendamustine in CLL & Indolent NHL – A Multicenter observational of real life experience in UK. Poster EHA 2015 Duncan Murray, Supratik Basu, Salim Shafeek, Sridhar Chaganti, Shankara Paneesha & Sebastian Francis 4.High dose ARA-C/Amsacrine as salvage therapy in Acute leukaemias- Regional transplant centre experience .S. Paneesha, S.Shafeek, P.Mahendra, C.Craddock.(BSH Poster - April 2002 )

5.Two cases of Post Transfusion Hyperhaemolysis in Sickle cell disease. S.Shafeek, M.Jabbar, M.J.Strevens,D.Bareford ,N.Smith ;British Journal of Haematology ,Suppl 1 March 2000: Page 38.

6.A baby with combined hyperlipidaemia presenting as Anaemia & Milky

Blood Salim K.A. Shafeek S, Blood Vol 76, No. 10: 46a. Suppl: November 15th 1990

7.A case of haemolysis due to excess serum copper possibly from dietary

sources in a patient having Low serum Caeruloplasmin. Salim K.A, Shafeek.S. Blood Vol 76, No 10, 46a, suppl: Nov 15th 1990.

8.Effect of short course Alpha Interferon in chronic myelogenous leukaemia.

Salim K.A, Shafeek S, Sathianathan P. Abstract – British Joumal of Haematology, August 1992 (ISH Special)

9.An unusual case of eosinophilic granuloma (Langerhans Cell Granuloma) -1991 - API Agra, India. Salim K.A, Shafeek S. Presented at Asso Physicians of India National Conference.

10.Ondansetron versus high dose metoclopramide in Chemotherapy induced

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nausea and vomiting - A preliminary report. Salim K.A., Shafeek. S, Sathyanathan P. Presented at API National Conference April 1992.

11.Mucor Mycotic Osteitis and Rhinocerebral mucormycosis in a diabetic

patient with Diabetiv Ketoacidosis. Shafeek, Salim KA- Presented at API meeting,April1992 12.A clinical profile of acute intermittent Porphyria - twelve cases. Salim K.A, Shafeek. S, Sathyanathan P, Paper Presented at API January 1993. 13.An unusual case of systemic amyloidosis and plasma cell dyscrasia in a 62 year old man. Salim K.A., Shafeek S., Sathyanathan P. Paper presented for API, January 1993. 14. Pseudotumour of right leg in a patient with haemophilia - A. Salim K.A. Shafeek, Sathyanathan P, paper presented for API January 1993. 15. Effect of ondansetron (5H3 receptor antagonist) in the relief of symptoms in malignant Carcinoid syndrome. Salim. K.A., Shafeek. S, Manoj. C. Paper presented for API January 1992. 16. Clinical effect of octreotide (Sandostatin) in controlling the symptoms of Malignant carcinoid syndrome. Salim. K.A, Shafeek. S, Manoj. S. Paper presented for API January 1993. 17.Lymes Disease - Calicut Experience. Salim. K.A, Shafeek. S. Sathyanathan.

P. Paper presented for API January 1993. PUBLICATIONS Published 1.DEFINING THE DOSE OF GEMTUZUMAB(OZOGAMICIN) IN AML A COMPARITIVE RANDOMISED STUDY MRC AML 17 TRIAL. ALAN BURNETT ,JAMIE CAVENAGH, NIGEL RUSSELL ET AL – ACKNOWLEDGEMENT SALIM SHAFEEK(WORCESTERSHIRE ROYAL TRUST. HAEMATOLOGICA FEB 2016 2.ADDITION OF GEMTUZUMAB (OZOGAMICIN) TO INDUCTION CHEMOTHERAPY IMPROVES SURVIVAL IN OLDER PATIENTS WITH AML-MRC AML TRIAL DATA- JCO 30TH JULY 2012 PROF ALAN BURNETT, CHARLIE CRADDOCK, DON MILLIGAN ET AL – ACKNOWLEGEMENT –SALIM SHAFEEK (WORCESTERSHIRE ROYAL HOSPITAL) 3.PROSPECTIVE MRD MONITORING TO PREDICT RELAPSE OF APML & TO DIRECT PREEMTIVE ARSENIC TRIOXIDE TREATMENT –MRC AML 15 TRIAL PROF DAVID GRIMWADE ET AL – ACKOWLEDGEMENT SALIM SHAFEEK (WORCESTERSHIRE ROAYL HOSPITAL) JCO 9TH FEB 2009 4.FIRST-LINE TREATMENT WITH ZOLEDRONIC ACID AS COMPARED WITH ORAL CLODRONATE IN MULTIPLE MYELOMA(MRC MYELOMA IX) AS RANDOMISED

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CONTROLLED TRIAL: LANCET 376 (0757) PP 1989-1999 GARETH MORGAN , FAITH DAVIES ET AL- SALIM SHAFEEK (WORCESTESHIRE ROYAL HOSPITAL) 5.Image in Blood Med. Pamidronate induced osteonecrosis of the jaw in a myeloma patient.

S.Paneesha,S.Shafeek,N.Barnard,U.Udeshi. https://www.bloodmed.com/education/case1.asp?id=194.

6.Image in Blood Med. Variant acute promyelocytic leukaemia presenting with massive intracerebral haemorrhage. S Paneesha, S Shafeek, C Phillips and R Stockley

https://www.bloodmed.com/education/case1.asp?id=195.

7.CLIMATIC INFLUENCE ON HAEMOGLOBIN LEVELS OF BLOOD DONORS. SHAFEEK S, BECKMAN N. SMITH N, GABRA G, TRANSFUSION TODAY, NO. 28. SEPTEMBER 1996, PAGE 6-8. 8.TREATMENT OF ANAEMIA OF PROGRESSIVE RENAL FAILURE WITH RECOMBINANT ERYTHROPOIETIN - A PRELIMINARY REPORT. SALIM K.A, SHAFEEK S, MATHEW T.J.ASSO PHYSICIANS OF INDIA, VOL 40, PAGE 42-3, JANUARY 1992. 9.CHICKENPOX INDUCED PANCYTOPENIA AND PROMPT RESPONSE TO HIGH DOSE INTRAVENOUS IMMUNOGLOBULIN. SHAFEEK. S, SALIM K.A, JAPI, VOL 40, NO. 10: PAGE 689-690 1992. 10.ANTIPHOSPHOLIPID ANTIBODY SYNDROME OF SLE PRESENTING AS DEEP THROMBOSIS. SHAFEEK.S,SALIM.K.A. JAPI,FEBRUARYL992,VOL4O,NO2,PAGE 125-126. 11.NON-HODGKIN'S LYMPHOMA PRESENTING AS PURE RED CELL APLASIA. SHAFEEK S, SALIM.K.A, JAPI, VOL. 40. NO. 11. PAGE 765 - 766. 1992 AUDIT EXPERIENCE

1. Autologous Transplantation over 10 year period , at a single centre experience . Walsgrave Hospital , Coventry

2. Hickmann line audit – Walsgrave Hospital, Coventry 3. Antifungal audit in Haematology inpatients at Worcestershire Royal

Hospital 2008.

TEACHING EXPERIENCE Actively involved in teaching Undergraduates from Leicester & Warwick University. Also have dedicated sessions for Postgraduate students. Organised Nurses training course on Chemotherapy, Myeloma & Lymphoma Given talk for Patient group in Worcestershire on Lymphoma Treatments.

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Involved in local MRCP teaching and Foundation year training and core medical training. Actively involved in teaching registrars and Staff grade doctors in Haematology Involved in update educational regional meeting in West Midlands in Myeloma and CLL Involved in Nurse prescribing courses and Anticoagulation training courses through University of Worcester Faculty in MSc Haematology course conducted by Cancer studies in University of Birmingham since 2002 annually. Actively involved in teaching 3rd, 4th & final year medical students. Involved in Postgraduate teaching for FRCPath course and regional training in Birmingham. Examiner for MRCP (UK) Paces examination for all three Royal colleges & FRCPath final exit examination.

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REFERENCES PROF CHARLES CRADDOCK DPHIL FRCP,FRCPATH PROFESSOR OF HAEMATOLOGY UNIVERSITY HOSPITAL NHS TRUST QUEEN ELIZABETH HOSPITAL EDGBASTON Birmingham B15 2TH

Dr PREM MAHENDRA MD FRCP, FRCPath Consultant Haematologist UNIVERSITY HOSPITAL NHS TRUST THE QUEEN ELIZABETH HOSPITAL EDGBASTON BIRMINGHAM B15 2TH DR A.H. SAWERS FRCP, FRCPATH CONSULTANT HAEMATOLOGIST Worcestershire Royal Hospital Charles Haisting Way Worcester WR5 1DD DR J.A. MURRAY FRCP, FRCPATH CONSULTANT HAEMATOLOGIST & CLINICAL CO-ORDINATOR UNIVERSITY HOSPITAL NHS TRUST QUEEN ELIZABETH & SELLY OAK HOSPITALS RADDLEBARN ROAD SELLY OAK BIRMINGHAM B29 6JD Dr P. REVELL FRCP (CH) MRCPath

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Consultant Haematologist Stafford District General Hospital STAFFORD ST16 3QD Dr P. ROSE FRCP, FRCPath Consultant Haematologist Warwick Hospital & Walsgrave Hospital Lakin road, Warwick CV34 5BW Ph: 01926 495321