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Telemedicine & physical activity
Physical Activity and Genes in
Personalised Medicine
Evidence-Based Public HealthInternational WorkshopMunich, Germany, 17th and 18th November 2010Martin Daumer
EBDiMSEvidence-Based Decision Support in MS
Results: Disability as outcome
Ebers GC., Heigenhauser L., Daumer M.,
Lederer C., Noseworthy JH. “Disability as
an outcome in MS clinical trials” Neurology,
71: 624 – 631, 2008
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CONCLUSION
Clinical surrogates of unremitting disability used in trials of
relapsing-remitting multiple sclerosis cannot be validated.
Trials have been too short or degrees of disability change too
small to measure the key outcomes. These analyses highlight
the difficulty in determining effectiveness of therapy in
chronic diseases.
Marrie RA. Neurology, 71: 620-621, 2008
4
MRI as outcome
Daumer M., Neuhaus A., Morrissey SP.,
Hintzen R., Ebers G.: “Magnetic
resonance imaging as an outcome in MS
clinical trials”, Neurology, 72, 705-711,
2009
CONCLUSION
MRI measures widely used in trials
of relapsing-remitting and
progressive multiple sclerosis add
little if anything independently to
the clinically relevant relapse and
disability outcomes.
� What is actibelt®?
� The actibelt is a three-dimensional accelerometer integrated in a belt buckle.
� It can be used for the long term monitoring of a person‘s activity, and also for gait quality and postural stability assessment in clinical trials.
� Discrete, non-invasive, portable
� Placed near the COM
Mobile accelerometry -actibelt®
Mobile accelerometry -actibelt®
� Pattern of the acceleration signal near the
body's COM while performing different
activities
Backward-forward axisLeft-right axisUp-down axis
� Towards the standardization of a gait and
balance quality assessment tool using mobile
accelerometry.
TOWARD A BIOBANK IN UK BLOOD DONORSTOWARD A BIOBANK IN UK BLOOD DONORS
ACCELEROMICS MEETS GENOMICS –Physical activity and genes for personalized
medicine
Results from an international expert panel meeting – Schloss Höhenried, Oct. 2010
• “Mobile accelerometry has great potential for improving human health by contributing to the diagnosis of gait and balance disorders in daily life and clinical practice, improving outcome measures in chronic disabling diseases as well as a tool for prescribing and monitoring exercise therapy.”
10
Selection of ProjectsBEGIN study with Bayer Schering: Betaferon treatment and Exercise data Gathering IN early MS
PerCoMed: Case study “MS Nurses” in the “Rhön -Klinik” in Bad Neustadt
Clinical study with the Masku Neurological Rehabilitation Centre in Finland: Physical activity of patients with early multiple sclerosis (MS) as monitored with a new measure – ActiBelt
Clinical trials with Lupus, Osteoporosis & MS
PhD together with the Technical University Munich: actibelt and Depression/Schizophrenia
BWiMi - Advanced Body Motion Analysis ABMA – Sport Science
FP7: VPHOP: Application of the actibelt within osteoporosis – fall risk prediction
FP7 Marie Curie ITN: Netsim: CVD/
Parabola flights in Bordeaux in November 2006, in Houston in June 2007 and Cologne in September 2007
BMBF – German Competence Network MS: IPAT integrated platform for measuring physical activity as outcome and treatment option
Physical activity assessment in osteoarthritis using actibelt®, Mayo Clinic
CardioResource – healthy blood donors
