Tel1: TcChr9-P Group I

HP*

HP

HP

RNA

pol I

IIH

P

8kb1

Telo

mer

ic R

epea

t

RHS*

RHS*

RHS

BRCA

2

N-A

cetiy

ltran

sfer

ase*

RNA

helic

ase*

ASF-

1

ATPa

se

SIRE

TS*

TS VIPE

R/SI

RE

L1Tc

VIPE

R/SI

RE

RHS*

DG

F-1

Phos

phat

e pe

rmea

se

RNA

pol I

II su

buni

t

Phos

phat

e pe

rmea

seH

P

80177

HP

RHS

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel2: TcChr11-S Group I

Intersticial Region

10Kb

Telo

mer

ic

Repe

atG

P63

MAS

PVI

PER

RHS*

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP

RHS*

Gly

cine

deh

ydro

gena

sePK H

P

TS RHS

TS TS TS*

TSElon

gatio

n fa

ctor

1-g

amm

a

RHS*

DG

F-1

RHS*

HP*

DG

F-1

DG

F-1

TS*

TS*

RHS*

HP

TS TS*

TS*

1455281

TS*

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel3: TcChr19-S Group I

10Kb

Telo

mer

ic re

peat

sTSRH

S*RH

S*RN

A he

licas

e*H

P*SIRE

RHS

TS*

TS*

TS*

HPDG

F-1

DG

F-1

DG

F-1

RHS*

TS*

HPDG

F-1

DG

F-1

DG

F-1

TS*

DG

F-1

Endo

som

al in

tegr

al m

embr

ane

prot

ein

TSRHS*

RHS*

DG

F-1

RHS*

DG

F-1

HP

TS

671352504588

Intersticial Region

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel4: TcChr22-P

10kb

129059

Telo

mer

ic re

peat

RHS*

N-a

cety

ltran

sfer

ase*

RN

A he

licas

e*H

P*SI

RE

RHS

RHS

AGP2

β -2

TS*

Ribo

som

al P

pro

tein

AG

P2β

-1

VIPE

RH

P Dam

age-

spec

ific

DN

A bi

ndin

g N

-ace

tyltr

ansf

eras

e*RN

A he

licas

e *

HP*

RHS*

PK HP* Gly

cine

deh

ydro

gena

se*

PK TS*

RHS

DG

F-1

DG

F-1

TS*

DG

F-1

DG

F-1

HP tRN

A sy

nthe

tase

HP Cyto

chro

me

c ox

idas

e su

buni

t 1D

GF-

1

Intersticial Region

1

HP

SIRE

RHS*

Group I

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel5: TcChr25-P

8Kb

1

Telo

mer

ic r

epea

tRN

A he

licas

e*H

PSI

RERH

S*

TS*

MAS

P

TS*

RHS*

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP

SIRE

RHS*

RHS*

NAR

Tc

DG

F-1

DG

F-1

TS DG

F-1

TS*

TS Smal

l GTP

-bin

ding

pro

tein

Rab

18

HP*

HP

HP

HP

HP Proh

ibiti

n

89389

Group I

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel6: TcChr28-P

20Kb

Telo

mer

ic r

epea

tRH

SN

-ace

tyltr

ansf

eras

e *

RN

A he

licas

e*H

PRH

SVI

PER/

SIRE

TSRHS*

DG

F-1

TS*

RHS*

DG

F-1

TS*β

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

VIPE

R/SI

RERH

S

TS *

TS*

RHS

SIRE

DG

F-1

TS*β

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

VIPE

R/SI

RERH

SSI

REH

PDG

F-1

TSβ

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

RHS

DG

F-1*

TS*

RHS

DG

F-1*

TS*

DG

F-1*

TS*

RHS*

DG

F-1

DG

F-1*

DG

F-1*

TS*

Intersticial Region

851849652990

Group I

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel7: TcChr38-S

6Kb

1

RHS*

Telo

mer

ic r

epea

t

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP

HP VIPE

R/SI

RE

RHS*

Gly

cine

deh

ydro

gena

se*

PK TS*

HP DG

F-1

HP

2-ox

oiso

vale

rate

deh

ydro

gena

se β

sub

unit

HP

HP proh

ibiti

n

Tran

spor

ter

HP

HP Co

atom

er ze

ta s

ubun

itAD

P-rib

osyl

ation

fact

or

HP

HP

HP

HP

63898

Group I

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel8: TcChr31-P

7Kb

RHS*

N-a

cety

ltran

sfer

ase*

RN

A he

licas

e*

HP

RHS*

TSTSRHS*

DG

F-1

DG

F-1

TS*

MAS

PH

P

HP

HP

HP

HP

HP

HP Ribo

nucl

ease

inhi

bito

r

Telo

mer

ic r

epea

t

854700 931454

Group II

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Group IITel9: TcChr35-S

PK

8Kb

Telo

mer

ic r

epea

tRH

S

N-a

cety

ltran

sfer

ase

*H

RN

A he

licas

e*H

P*

DG

F-1

TS*

β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

TSRHS*

DG

F-1

RHS

RHS*

TS*

UD

P-G

al g

lyco

syltr

ansf

eras

eRH

S*RH

S*

Gly

cine

deh

ydro

gena

se

HPRa

s-re

late

d ra

b-4

HP

HP

HP

HP

Profi

lin

1105311 1186845

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel10: TcChr13-P Group III

4kb

Telo

mer

ic re

peat

SIRE

RHS

TS*

RHS*

ESAG

-like

*

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP*

SIRE

RHS*

ESAG

-like

*

HP

HP

HP

HP

DN

A re

pair

prot

ein

HSP

Dna

J

met

hyltr

ansf

eras

e

HP

1 43841

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel11: TcChr35-P Group III

5kb

HP Mg+

+ tr

ansp

orte

r

HP

HP

HP

HP HP

HP RN

A he

licas

e

HP

SIRE

HP

HP Profi

linH

PH

P Smal

l GTP

-bin

ding

pro

tein

HP

HP TS*

HP Zinc

fing

er p

rote

in

Zinc

fing

er p

rote

in

PK Gly

cine

deh

ydro

gena

se

RHS*

VIPE

R/SI

RE

HP RN

A he

licas

e*

RHS

Telo

mer

ic r

epea

t

11419531091011

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel12: TcChr6-S Group IV

6Kb

Telo

mer

ic r

epea

t

RHS*

TS*

RHS*

DG

F-1*

DG

F-1*

VIPE

R/SI

RETSTSβ

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

VIPE

R/SI

RE

RHS*

HP

HP*

Tran

slati

on in

itiati

on fa

ctor

eIF

-2B

α su

buni

tH

PProt

easo

me

β-1

subu

nit

HP

HP

HP

HP

HP

HP

HP

325835 388923

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel13: TcChr26-P Group IV

9Kb

Telo

mer

ic r

epea

tRH

SRH

S

DG

F-1

TSβ g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

eH

P

VIPE

R/SI

RE

TSRHS*

HP

TSRHS*

DG

F-1

TS*

Pyru

vate

deh

ydro

gena

se (l

ipoa

mid

e) k

inas

eVI

PER/

SIRE

HPClat

hrin

coa

t ass

embl

y pr

otei

nCo

pper

hom

eost

asis

pro

tein

HP60

S rib

osom

al p

rote

in L

17H

PH

PH

PH

PH

PH

P

HP

Gua

nine

nuc

leoti

de-b

indi

ng p

rote

in β

sub

unit-

like

prot

ein

HPGly

coso

mal

mem

bran

e pr

otei

n

795830707595

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel14: TcChr33-S Group IV

7Kb

Telo

mer

ic r

epea

t

RHS

TS*

RHS*

RHS*

DG

F-1*

VIPE

R/SI

RE

TS Calc

ium

/pot

assi

um c

hann

el

HP

HP Eu

kary

otic

initi

ation

fact

or 4

a

HP

PK HP

HP

7587129956

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel15: TcChr34-S

SIRE

HP

7kb

102 78763

Telo

mer

ic r

epea

t

TS RHS*

TS*

AGP2

β

Ribo

som

al P

pro

tein

AG

P2β

-160

S ac

idic

ribo

som

al p

rote

in P

2D

amag

e-sp

ecifi

c D

NA

bind

ing

prot

ein

RHS*

TS*

RHS*

DG

F-1*

TS β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

eH

P

TS*

Glu

tam

ate

dehy

drog

enas

e

HP

HP*

Group IV

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel16: TcChr35-P

Elon

gatio

n fa

ctor

1

10Kb

Telo

mer

ic r

epea

tH

PTS H

P β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

e*

VIPE

R/SI

RE

RHS*

RHS*

RHS*

TS*

TS β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

e*

HP Su

rfac

e pr

otea

se G

P63*

HP* TS*

TS β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

e*

RHS*

TS*

TS HP

DG

F-1

TS Cycl

ic n

ucle

otide

-bin

ding

pro

tein

Cycl

ic n

ucle

otide

-bin

ding

pro

tein

HP

HP

HP

HP

HP

1161141

Group IV

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel17: TcChr37-S

10kb

Telo

mer

ic re

peat

RHS

glyc

ine

dehy

drog

enas

e

HPprot

ein

kina

se

TS*

RHS

ESAG

-like

PK *

HP*

VIPE

R/SI

RE

L1Tc

RHS

RHS*

TS HPRH

S*

DG

F-1

TS TS SIRE

HP Intersticial Region

1 110353

Group IV

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel18: TcChr40-P

Chol

ine-

2Fca

rniti

ne O

-acy

ltran

sfer

ase

9kb

RHS*

Telo

mer

ic r

epea

t

HP

TS*

HP

β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

TS*

RHS*

TS*

TS MAS

P*

VIPE

R/SI

RE

TS*

TSRHS

Pota

ssiu

m v

olta

ge-g

ated

cha

nnel

PK HP Inos

ine

mon

opho

spha

te d

ehyd

roge

nase

TS DG

F-1*

PK Pepti

dylp

roly

l iso

mer

ase-

like

HP

HP

933191

HP

Group IV

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel19: TcChr17-S Group V

5kb

Telo

mer

ic r

epea

t

TSRHS*

DG

F-1

TSRHS*

HP

HP*

HP

HP

HP

HP

HP

HP

PKADP-

ribos

ylati

on fa

ctor

HP

HP

HP

648481 593698

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel20: TcChr23-S Group V

10kb

Telo

mer

ic r

epea

t

RHS*

TS*

RHS*

DG

F-1

TS*

RHS

TS*

RHS*

TSRHS*

RHS*

TSTS*

TS*

DG

F-1

DG

F-1

RHS*

TS*

Muc

in T

cMU

CIM

ucin

TcM

UCI

I M

ASP

Muc

in T

cMU

CII

Dyn

ein

heav

y ch

ain

Tubu

lin-t

yros

ine

ligas

eH

PPKH

P3-ox

oacy

l red

ucta

se p

rote

in

HP

HP

HP

626403529846

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel21: TcChr25-S Group V

6Kb

Telo

mer

ic R

epea

t

640815

RHS

TS*

RHS*

DG

F-1

TS*

DG

F-1

TSHP6-ph

osph

oglu

cono

lact

onas

eH

PH

PEuka

ryoti

c tr

ansl

ation

initi

ation

fact

or 1

AH

PH

P

HP 50

S rib

osom

al p

rote

in L

17

703709

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel22: TcChr 36-P Group V

5kb

Telo

mer

ic r

epea

t

RHS*

DG

F-1

TSGlu

cose

-6-p

hosp

hate

1-d

ehyd

roge

nase

*

HP

HP

VIPE

R/SI

RE

Asco

rbat

e-de

pend

ent p

erox

idas

e

Glu

cose

-6-p

hosp

hate

deh

ydro

gena

seG

luco

se-6

-pho

spha

te d

ehyd

roge

nase

HP

HP

HP

HP

HPAd

enyl

ate

kina

se

Aden

ylat

e ki

nase

Mal

ate

dehy

drog

enas

e*M

alat

e de

hydr

ogen

ase

1123196 1176121

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel23: TcChr39-P

4kb

Telo

mer

ic r

epea

t

RHS*

DG

F-1

TSHP

HPKine

sin

Calc

ium

moti

ve p

-typ

e AT

Pase

HP

HP60

S rib

osom

al p

rote

in L

32

Anky

rin re

peat

pro

tein

,

1808447 1853149

Group V

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel24: TcChr11-P

4kb

Telo

mer

ic r

epea

t

VIPE

R/SI

RE

RHS

TS*

RHS*

TSSyna

ptoj

anin

(N-t

erm

inal

dom

ain

Glu

tath

ione

-S-t

rans

fera

se/g

luta

redo

xin

HP

HP

HP

HP

HP

HP

HP

473721 518844

Group VI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel25: TcChr22-S

6kb

Telo

mer

ic r

epea

t

RHS*

TSRHS*

TSβ ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

SIRE

Man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sida

se IB

Man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sida

se IB

Man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sida

se IB

SIRE

Neu

tral

sph

ingo

mye

linas

e ac

tivati

on a

ssoc

iate

d fa

ctor

-like

pro

tein

HP

HP

HP

HP

HPProt

ohem

e IX

farn

esyl

tran

sfer

ase

Vacu

olar

pro

ton

tran

sloca

ting

ATPa

se s

ubun

it A

HP

SIRE

648866 700296

6 kb

Group VI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel26: TcChr27-P

2kb

Telo

mer

ic re

peat

s

SIRE

RHS*

RHS*

TS*

Mer

capt

opyr

uvat

e su

lfurt

rans

fera

se

Mic

rotu

bule

-ass

ocia

ted

prot

ein

HPCis-

pren

yltr

ansf

eras

e

HP

HP

HP

HPM

onoo

xyge

nase

Cyst

eine

pro

teas

e

TSHP

820868850140

Group VI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel27: TcChr36-S

6Kb

Telo

mer

ic r

epea

t

TSRHS*

RHS

SIREGly

cine

deh

ydro

gena

se

PKTS*

TS*

HP

HP

HP

HP

SIREAsco

rbat

e-de

pend

ent p

erox

idas

e

Glu

cose

-6-p

hosp

hate

1-d

ehyd

roge

nas

HP

HP

HP

SIRE

HP

HPAd

enyl

ate

kina

se

Aden

ylat

e ki

nase

Mal

ate

dehy

drog

enas

eM

itoch

ondr

ial m

alat

e de

hydr

ogen

ase

Lyso

som

al a

lpha

-man

nosi

dase

pre

curs

or

HP

HP

1113691 1180641

Group VI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel28: TcChr15-P

3kb

RHS

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP

HP

HP

HP

Cyto

crom

o P4

50

PKHP

HP

HP

HP

HP

HP

HP

4209 37214

Telo

mer

ic re

peat

Group VII

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel29: TcChr13-S

4Kb

RHS

TS*

RHS

Expr

essi

on s

ite-a

ssoc

iate

d ge

ne

HP

HP

HP

HP

DN

A re

pair

prot

ein

Hea

t sho

ck p

rote

in D

naJ

HP GM

P sy

ntha

se

40111

Telo

mer

ic r

epea

t

11741

Group VIII

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel30: TcChr39-S

4kb

Telo

mer

ic R

epea

t

RHS

TS*

RHS*

TS*

HP

HPKine

sin

Calc

ium

moti

ve p

-typ

e AT

Pase

HP

HP60

S rib

osom

al p

rote

in L

32

Anky

rin re

peat

pro

tein

1806201 1853998

Group VIII

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel31: Tcruzi_7430

1kb

Telo

mer

ic re

peat

1

GP6

3*

RHS*

MAS

P*

13592

Group IX

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel32: TcChr20-S

2kb

Telo

mer

ic r

epea

t

HP

HP

N-a

cety

lglu

cosa

min

e-6-

phos

phat

e de

acet

ylas

e-lik

e

PUF

RNA

bind

ing

prot

ein

1

SIRE

L-rib

ulok

inas

e

HP

Stre

ss-in

duci

ble

prot

ein

STI1

-like

Leuc

ine

carb

oxyl

met

hyltr

ansf

eras

e

HP

HP

26470

β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

N-a

cety

lglu

cosa

min

e-6-

phos

phat

e de

acet

ylas

e-lik

e

PUF

RNA

bind

ing

prot

ein

1

L-rib

ulok

inas

e

TS

2kb

815

Group X

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel33: Tcruzi_8424

4kb

Telo

mer

ic R

epea

t

RHS*

TS*

HP

RNA

helic

ase*

RHS*

SIRE

RHS

RHS*

RHS*

HP*

TSTS*

DG

F-1

1 46301

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel34: TcChr25-S

4kb

Telo

mer

ic re

peat

RHS*

DG

F-1*

DG

F-1

DG

F-1

DG

F-1

TS*

DG

F-1*

RHS*

1 38268

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel35: TcChr35-S Group XI

1kb

Telo

mer

ic R

epea

t

RHS

TS*

TS VIPE

R/SI

RE

1 19851

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel36: Tcruzi_149 Group XI

100 bp1 1066

Telo

mer

ic re

peat

RHS*

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel37: Tcruzi_2522 Group XI

100bp

RHS*

Telo

mer

ic R

epea

t

1 1231

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

600bp

Tel38: Tcruzi_4706

RHS*

Telo

mer

ic re

peat

1 6360

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel39: Tcruzi_6314

100bp

Telo

mer

ic R

epea

t

RHS*

1 1904

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel40: Tcruzi_6749

700bp

Telo

mer

ic R

epea

t

RHS*

17911

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

1 6479

TSRHS*

600 bp

Telo

mer

ic R

epea

t

Tel41: Tcruzi_7734 Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel42: TcChr21-P

3kb37667

Telo

mer

ic re

peat

TS

GM

P si

ntet

ase

HP

TS

RHS*

1

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel43: TcChr34-P Group XI

600bp

Telo

mer

ic re

peat

TS*

1 5564

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel44: Tcruzi_6797

2kb

RHS*

RHS*

DG

F-1

1 28340

N-A

cetiy

ltran

sfer

ase*

RNA

helic

ase*

HP*

SIRE

Telo

mer

ic R

epea

t

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel45: TcChr40-S

1139181

1125103

1Kb

Telo

mer

ic r

epea

t

RHS

SIRE

DG

F-1*

TcChr 40S

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel46: TcChr19-P

5Kb

DG

F-1

DG

F-1*

RHS*

DG

F-1

Telo

mer

ic r

epea

t

RHS*

DG

F-1*

TS*

HPEn

doso

mal

inte

gral

mem

bran

e pr

otei

nH

PH

PGlu

tam

amyl

car

boxy

pepti

dase

HPAlph

a-ad

aptin

-like

Cyto

chro

me

c1, h

eme

prot

ein

HP

Gol

gi/l

ysos

ome

glyc

opro

tein

Pitr

ilysi

n-lik

e m

etal

lopr

otea

se

585395 526264

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel47: TcChr21-S

10kb

Telo

mer

ic R

epea

t

TSβ ga

lact

ofur

anos

yl g

lyco

siltr

ansf

eras

e

VIPE

R/SI

RE

RHS*

TSDG

F-1

HP*

SIRE

HP

RHS*

1 99950

TcChr 21S

DG

F-1

TS TS Myo

sin

heav

y ch

ain

RHS*

RHS

Myo

sin

heav

y ch

ain*

MAS

P*

Gly

cine

deh

ydro

gens

e*

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel48 -TcChr27S

5 Kb

SIRE

HP

Telo

mer

ic r

epea

t

RHS

RHS*

RHS

DG

F-1

VIPE

R/SI

RE

HP

Phos

phoi

nosi

tide-

spec

ific

phos

phol

ipas

e C

RHS

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP*

VIPE

R/SI

RE

HP Ph

osph

oino

sitid

e-sp

ecifi

c ph

osph

olip

ase

C

HP

HP

HP

HP GTP

-bin

ding

pro

tein

SIRE

HP

HP

Telo

mer

ic r

epea

t

106 53391

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

VIPE

RSIR

ERH

S

RHS

Telo

mer

ic r

epea

t

Tel49: TcChr31-P

10Kb

TS TS RHS

TS TS β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

e

man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sida

se IB

TS*

RHS

DG

F-1

HP

HP

TS HP

HP*

HP

RHS

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP

TS*

TS*

HP

DG

F-1

TS*

HP Dyn

ein

light

cha

in 2

B, c

ytop

lasm

icH

P 3-m

ethy

lcro

tony

l-CoA

car

boxy

lase

HP

HP

HP

HP chap

eron

e D

naJ p

rote

in

1304 119145

Group XI

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene