Tel1: TcChr9-P

Tel1: TcChr9-P Group I

HP*

HPHP RNA

pol I

IIHP

8kb1

Telo

mer

ic R

epea

t

RHS*

RHS*

RHS

BRCA

2

N-A

cetiy

ltran

sfer

ase*

RNA

helic

ase*

ASF-

1

ATPa

se

SIRE

TS*

TS VIPE

R/SI

RE

L1Tc

VIPE

R/SI

RE

RHS*

DGF-

1

Phos

phat

e pe

rmea

se

RNA

pol I

II su

buni

t

Phos

phat

e pe

rmea

seHP

80177

HPRHS

Telomeric repeats

RHS (retrotransposon hot spot protein)

TS (trans-sialidase)

DGF-1 (dispersed gene family - 1)

Retrotransposon – SIRE, VIPER

Hypothetical protein/ other gene

RNA helicase / N-acetyltransferase

Transcription sense

* pseudogene First interstitial gene

Tel2: TcChr11-S Group I

Intersticial Region

10Kb

Telo

mer

ic

Repe

atGP

63M

ASP

VIPE

R

RHS*

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP RHS*

Glyc

ine

dehy

drog

enas

ePK HP TS RH

S

TS TS TS*

TSElon

gatio

n fa

ctor

1-g

amm

a

RHS*

DGF-

1

RHS*

HP*

DGF-

1DG

F-1

TS*

TS*

RHS*

HP TS TS*

TS*

1455281

TS*

Telomeric repeats







Transcription sense


Tel3: TcChr19-S Group I

10Kb

Telo

mer

ic re

peat

sTSRH

S*RH

S*RN

A he

licas

e*HP

*SI

RERHS

TS*

TS*

TS*

HPDGF-

1

DGF-

1

DGF-

1

RHS*

TS*

HPDGF-

1

DGF-

1DG

F-1

TS*

DGF-

1

Endo

som

al in

tegr

al m

embr

ane

prot

ein

TSRHS*

RHS*

DGF-

1

RHS*

DGF-

1HPTS

671352504588

Intersticial Region

Telomeric repeats







Transcription sense


Tel4: TcChr22-P

10kb

129059

Telo

mer

ic re

peat

RHS*

N-a

cety

ltran

sfer

ase*

RN

A he

licas

e*HP

*SI

RERH

SRH

S

AGP2

β -2

TS*

Ribo

som

al P

pro

tein

AGP

2β -1

VIPE

RHP Da

mag

e-sp

ecifi

c DN

A bi

ndin

g N

-ace

tyltr

ansf

eras

e*RN

A he

licas

e *

HP*

RHS*

PK HP*

Glyc

ine

dehy

drog

enas

e*PK TS

*

RHS

DGF-

1

DGF-

1

TS*

DGF-

1

DGF-

1

HP tRN

A sy

nthe

tase

HP Cyto

chro

me

c ox

idas

e su

buni

t 1DG

F-1

Intersticial Region

1

HPSIRE

RHS*

Group I

Telomeric repeats







Transcription sense


Tel5: TcChr25-P

8Kb

1

Telo

mer

ic r

epea

tRN

A he

licas

e*HP SI

RERH

S*

TS*

MAS

P

TS*

RHS*

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP SIRE

RHS*

RHS*

NAR

Tc

DGF-

1

DGF-

1

TS DGF-

1

TS*

TS Smal

l GTP

-bin

ding

pro

tein

Rab

18

HP*

HPHPHP HP Proh

ibiti

n

89389

Group I

Telomeric repeats







Transcription sense


Tel6: TcChr28-P

20Kb

Telo

mer

ic r

epea

tRH

SN

-ace

tyltr

ansf

eras

e *

RN

A he

licas

e*HPRH

SVI

PER/

SIRE

TSRHS*

DGF-

1TS

*RH

S*

DGF-

1

TS*β

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

VIPE

R/SI

RERH

S

TS *

TS*

RHS

SIRE

DGF-

1

TS*β

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

VIPE

R/SI

RERH

SSI

REHPDG

F-1

TSβ

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

RHS

DGF-

1*

TS*

RHS

DGF-

1*TS

*

DGF-

1*TS

*RH

S*

DGF-

1DG

F-1*

DGF-

1*TS

*

Intersticial Region

851849652990

Group I

Telomeric repeats







Transcription sense


Tel7: TcChr38-S

6Kb

1

RHS*

Telo

mer

ic r

epea

t

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP HP VI

PER/

SIRE

RHS*

Glyc

ine

dehy

drog

enas

e*

PK TS*

HP DGF-

1

HP 2-ox

oiso

vale

rate

deh

ydro

gena

se β

sub

unit

HP HP proh

ibiti

n

Tran

spor

ter

HPHP Coat

omer

zeta

subu

nit

ADP-

ribos

ylati

on fa

ctor

HPHPHPHP

63898

Group I

Telomeric repeats







Transcription sense


Tel8: TcChr31-P

7Kb

RHS*

N-a

cety

ltran

sfer

ase*

RN

A he

licas

e*

HPRHS*

TSTSRHS*

DGF-

1

DGF-

1

TS*

MAS

PHPHPHPHPHPHPHP Ri

bonu

clea

se in

hibi

tor

Telo

mer

ic r

epea

t

854700 931454

Group II

Telomeric repeats







Transcription sense


Group IITel9: TcChr35-S

PK

8Kb

Telo

mer

ic r

epea

tRH

S

N-a

cety

ltran

sfer

ase

*H

RNA

helic

ase*

HP*

DGF-

1

TS*

β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

TSRHS*

DGF-

1

RHS

RHS*

TS*

UDP-

Gal g

lyco

syltr

ansf

eras

eRH

S*RH

S*

Glyc

ine

dehy

drog

enas

e

HPRas-

rela

ted

rab-

4HPHPHP HP Pr

ofilin

1105311 1186845

Telomeric repeats







Transcription sense


Tel10: TcChr13-P Group III

4kb

Telo

mer

ic re

peat

SIRE

RHS

TS*

RHS*

ESAG

-like

*

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP*

SIRE

RHS*

ESAG

-like

*

HP HPHP HP DNA

repa

ir pr

otei

n

HSP

DnaJ

met

hyltr

ansf

eras

e

HP

1 43841

Telomeric repeats







Transcription sense


Tel11: TcChr35-P Group III

5kb

HP Mg+

+ tr

ansp

orte

r

HP HP HPHP HP HP RNA

helic

ase

HP SIRE

HP HP Profi

linHP HP Sm

all G

TP-b

indi

ng p

rote

inHPHP TS

*

HP Zinc

fing

er p

rote

inZi

nc fi

nger

pro

tein

PK Glyc

ine

dehy

drog

enas

e

RHS*

VIPE

R/SI

RE

HP RNA

helic

ase*

RHS

Telo

mer

ic r

epea

t

11419531091011

Telomeric repeats







Transcription sense


Tel12: TcChr6-S Group IV

6Kb

Telo

mer

ic r

epea

t

RHS*

TS*

RHS*

DGF-

1*

DGF-

1*

VIPE

R/SI

RETSTSβ

gala

ctof

uran

osyl

gly

cosy

ltran

sfer

ase

VIPE

R/SI

RE

RHS*

HPHP*

Tran

slatio

n in

itiati

on fa

ctor

eIF

-2B

α su

buni

tHPPr

otea

som

e β-

1 su

buni

tHPHPHPHPHPHPHP

325835 388923

Telomeric repeats







Transcription sense


Tel13: TcChr26-P Group IV

9Kb

Telo

mer

ic r

epea

tRH

SRH

S

DGF-

1

TSβ g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

eHPVI

PER/

SIRE

TSRHS*

HPTSRHS*

DGF-

1

TS*

Pyru

vate

deh

ydro

gena

se (l

ipoa

mid

e) k

inas

eVI

PER/

SIRE

HPClat

hrin

coa

t ass

embl

y pr

otei

nCo

pper

hom

eost

asis

prot

ein

HP60S

ribos

omal

pro

tein

L17

HPHPHPHPHPHPHPGuan

ine

nucl

eotid

e-bi

ndin

g pr

otei

n β

subu

nit-l

ike

prot

ein

HPGlyc

osom

al m

embr

ane

prot

ein

795830707595

Telomeric repeats







Transcription sense


Tel14: TcChr33-S Group IV

7Kb

Telo

mer

ic r

epea

t

RHS

TS*

RHS*

RHS*

DGF-

1*

VIPE

R/SI

RE

TS Calc

ium

/pot

assiu

m c

hann

el

HPHP Euka

ryoti

c in

itiati

on fa

ctor

4a

HPPK HPHP

7587129956

Telomeric repeats







Transcription sense


Tel15: TcChr34-S

SIRE

HP

7kb

102 78763

Telo

mer

ic r

epea

t

TS RHS*

TS*

AGP2

β

Ribo

som

al P

pro

tein

AGP

2β -1

60S

acid

ic ri

boso

mal

pro

tein

P2

Dam

age-

spec

ific

DNA

bind

ing

prot

ein

RHS*

TS*

RHS*

DGF-

1*

TS β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

eHP TS

*

Glut

amat

e de

hydr

ogen

ase

HP HP*

Group IV

Telomeric repeats







Transcription sense


Tel16: TcChr35-P

Elon

gatio

n fa

ctor

1

10Kb

Telo

mer

ic r

epea

tHP TS HP β

gal

acto

fura

nosy

l gly

cosy

ltran

sfer

ase*

VIPE

R/SI

RE

RHS*

RHS*

RHS*

TS*

TS β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

e*

HP Surf

ace

prot

ease

GP6

3*HP

*

TS*

TS β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

e*

RHS*

TS*

TS HP DGF-

1

TS Cycl

ic n

ucle

otide

-bin

ding

pro

tein

Cycl

ic n

ucle

otide

-bin

ding

pro

tein

HPHPHPHPHP

1161141

Group IV

Telomeric repeats







Transcription sense


Tel17: TcChr37-S

10kb

Telo

mer

ic re

peat

RHS

glyc

ine

dehy

drog

enas

e

HPprot

ein

kina

se

TS*

RHS

ESAG

-like

PK *

HP*

VIPE

R/SI

RE

L1Tc

RHS

RHS*

TS HPRHS*

DGF-

1

TS TS SIRE

HP

Intersticial Region

1 110353

Group IV

Telomeric repeats







Transcription sense


Tel18: TcChr40-P

Chol

ine-

2Fca

rniti

ne O

-acy

ltran

sfer

ase

9kb

RHS*

Telo

mer

ic r

epea

t

HPTS*

HP β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

TS*

RHS*

TS*

TS MAS

P*

VIPE

R/SI

RE

TS*

TSRHS

Pota

ssiu

m v

olta

ge-g

ated

cha

nnel

PK HP Inos

ine

mon

opho

spha

te d

ehyd

roge

nase

TS DGF-

1*

PK Pepti

dylp

roly

l iso

mer

ase-

like

HP HP

933191

HP

Group IV

Telomeric repeats







Transcription sense


https://mail.google.com/mail/?ui=2&ik=6051376c42&view=att&th=12806d8692dd2093&attid=0.1&disp=inline&realattid=f_g831p99u0&zw

Tel19: TcChr17-S Group V

5kb

Telo

mer

ic r

epea

t

TSRHS*

DGF-

1

TSRHS*

HPHP*

HPHPHPHPHPHPPKADP-

ribos

ylati

on fa

ctor

HPHPHP

648481 593698

Telomeric repeats







Transcription sense



10kb

Telo

mer

ic r

epea

t

RHS*

TS*

RHS*

DGF-

1

TS*

RHS

TS*

RHS*

TSRHS*

RHS*

TSTS*

TS*

DGF-

1

DGF-

1

RHS*

TS*

Muc

in Tc

MUC

IM

ucin

TcM

UCI

I M

ASP

Muc

in Tc

MUC

II

Dyne

in h

eavy

cha

in

Tubu

lin-t

yros

ine

ligas

eHPPKHP3-

oxoa

cyl r

educ

tase

pro

tein

HPHPHP

626403529846

Telomeric repeats







Transcription sense



6Kb

Telo

mer

ic R

epea

t

640815

RHS

TS*

RHS*

DGF-

1

TS*

DGF-

1TSHP6-

phos

phog

luco

nola

cton

ase

HPHPEuka

ryoti

c tr

ansla

tion

initi

ation

fact

or 1

AHPHPHP 50

S rib

osom

al p

rote

in L

17

703709

Telomeric repeats







Transcription sense


Tel22: TcChr 36-P Group V

5kb

Telo

mer

ic r

epea

t

RHS*

DGF-

1

TSGluc

ose-

6-ph

osph

ate

1-de

hydr

ogen

ase*

HPHPVIPE

R/SI

RE

Asco

rbat

e-de

pend

ent p

erox

idas

e

Gluc

ose-

6-ph

osph

ate

dehy

drog

enas

eGl

ucos

e-6-

phos

phat

e de

hydr

ogen

ase

HPHPHPHP HPAden

ylat

e ki

nase

Aden

ylat

e ki

nase

Mal

ate

dehy

drog

enas

e*M

alat

e de

hydr

ogen

ase

1123196 1176121

Telomeric repeats







Transcription sense


Tel23: TcChr39-P

4kb

Telo

mer

ic r

epea

t

RHS*

DGF-

1

TSHPHPKine

sin

Calc

ium

moti

ve p

-typ

e AT

Pase

HPHP60S

ribos

omal

pro

tein

L32

Anky

rin re

peat

pro

tein

,

1808447 1853149

Group V

Telomeric repeats







Transcription sense


Tel24: TcChr11-P

4kb

Telo

mer

ic r

epea

t

VIPE

R/SI

RE

RHS

TS*

RHS*

TSSyna

ptoj

anin

(N-te

rmin

al d

omai

n

Glut

athi

one-

S-tr

ansf

eras

e/gl

utar

edox

in

HPHPHPHPHPHPHP

473721 518844

Group VI

Telomeric repeats







Transcription sense


Tel25: TcChr22-S

6kb

Telo

mer

ic r

epea

t

RHS*

TSRHS*

TSβ ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

SIRE

Man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sidas

e IB

Man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sidas

e IB

Man

nosy

l-olig

osac

char

ide

1,2-

alph

a-m

anno

sidas

e IB

SIRE

Neu

tral

sphi

ngom

yelin

ase

activ

ation

ass

ocia

ted

fact

or-li

ke p

rote

in

HPHPHPHPHPProt

ohem

e IX

farn

esyl

tran

sfer

ase

Vacu

olar

pro

ton

tran

sloca

ting

ATPa

se su

buni

t A

HPSIRE

648866 700296

6 kb

Group VI

Telomeric repeats







Transcription sense


Tel26: TcChr27-P

2kb

Telo

mer

ic re

peat

s

SIRE

RHS*

RHS*

TS*

Mer

capt

opyr

uvat

e su

lfurt

rans

fera

se

Mic

rotu

bule

-ass

ocia

ted

prot

ein

HPCis-

pren

yltr

ansf

eras

e

HPHPHPHPMon

ooxy

gena

se

Cyst

eine

pro

teas

e

TSHP

820868850140

Group VI

Telomeric repeats







Transcription sense


Tel27: TcChr36-S

6Kb

Telo

mer

ic r

epea

t

TSRHS*

RHS

SIREGlyc

ine

dehy

drog

enas

e

PKTS*

TS*

HPHPHPHPSIREAsco

rbat

e-de

pend

ent p

erox

idas

e

Gluc

ose-

6-ph

osph

ate

1-de

hydr

ogen

as

HPHPHPSIRE

HPHPAden

ylat

e ki

nase

Aden

ylat

e ki

nase

Mal

ate

dehy

drog

enas

eM

itoch

ondr

ial m

alat

e de

hydr

ogen

ase

Lyso

som

al a

lpha

-man

nosid

ase

prec

urso

r

HPHP

1113691 1180641

Group VI

Telomeric repeats







Transcription sense


Tel28: TcChr15-P

3kb

RHS

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HPHPHP HPCyto

crom

o P4

50

PKHPHP HPHP HP HP HP

4209 37214

Telo

mer

ic re

peat

Group VII

Telomeric repeats







Transcription sense


Tel29: TcChr13-S

4Kb

RHS

TS*

RHS

Expr

essio

n sit

e-as

soci

ated

gen

e

HPHPHPHP DNA

repa

ir pr

otei

n

Heat

shoc

k pr

otei

n Dn

aJ

HP GMP

synt

hase

40111

Telo

mer

ic r

epea

t

11741

Group VIII

Telomeric repeats







Transcription sense


Tel30: TcChr39-S

4kb

Telo

mer

ic R

epea

t

RHS

TS*

RHS*

TS*

HPHPKine

sin

Calc

ium

moti

ve p

-typ

e AT

Pase

HPHP60S

ribos

omal

pro

tein

L32

Anky

rin re

peat

pro

tein

1806201 1853998

Group VIII

Telomeric repeats







Transcription sense


Tel31: Tcruzi_7430

1kb

Telo

mer

ic re

peat

1

GP63

*

RHS*

MAS

P*

13592

Group IX

Telomeric repeats







Transcription sense


Tel32: TcChr20-S

2kb

Telo

mer

ic r

epea

t

HP HP N-a

cety

lglu

cosa

min

e-6-

phos

phat

e de

acet

ylas

e-lik

e

PUF

RNA

bind

ing

prot

ein

1

SIRE

L-rib

ulok

inas

e

HP Stre

ss-in

duci

ble

prot

ein

STI1

-like

Leuc

ine

carb

oxyl

met

hyltr

ansf

eras

e

HPHP

26470

β ga

lact

ofur

anos

yl g

lyco

syltr

ansf

eras

e

N-a

cety

lglu

cosa

min

e-6-

phos

phat

e de

acet

ylas

e-lik

e

PUF

RNA

bind

ing

prot

ein

1

L-rib

ulok

inas

e

TS

2kb

815

Group X

Telomeric repeats







Transcription sense


Tel33: Tcruzi_8424

4kb

Telo

mer

ic R

epea

t

RHS*

TS*

HP RNA

helic

ase*

RHS*

SIRE

RHS

RHS*

RHS*

HP*

TSTS*

DGF-

1

1 46301

Group XI

Telomeric repeats







Transcription sense


Tel34: TcChr25-S

4kb

Telo

mer

ic re

peat

RHS*

DGF-

1*

DGF-

1

DGF-

1

DGF-

1

TS*

DGF-

1*

RHS*

1 38268

Group XI

Telomeric repeats







Transcription sense


Tel35: TcChr35-S Group XI

1kb

Telo

mer

ic R

epea

t

RHS

TS*

TS VIPE

R/SI

RE

1 19851

Telomeric repeats







Transcription sense


Tel36: Tcruzi_149 Group XI

100 bp1 1066

Telo

mer

ic re

peat

RHS*

Telomeric repeats







Transcription sense



100bp

RHS*

Telo

mer

ic R

epea

t

1 1231

Telomeric repeats







Transcription sense


600bp

Tel38: Tcruzi_4706

RHS*

Telo

mer

ic re

peat

1 6360

Group XI

Telomeric repeats







Transcription sense


Tel39: Tcruzi_6314

100bp

Telo

mer

ic R

epea

t

RHS*

1 1904

Group XI

Telomeric repeats







Transcription sense


Tel40: Tcruzi_6749

700bp

Telo

mer

ic R

epea

t

RHS*

17911

Group XI

Telomeric repeats







Transcription sense


1 6479

TSRHS*

600 bp

Telo

mer

ic R

epea

t


Telomeric repeats







Transcription sense


Tel42: TcChr21-P

3kb37667

Telo

mer

ic re

peat

TS

GMP

sinte

tase

HP TS

RHS*

1

Group XI

Telomeric repeats







Transcription sense


Tel43: TcChr34-P Group XI

600bp

Telo

mer

ic re

peat

TS*

1 5564

Telomeric repeats







Transcription sense


Tel44: Tcruzi_6797

2kb

RHS*

RHS*

DGF-

1

1 28340

N-A

cetiy

ltran

sfer

ase*

RNA

helic

ase*

HP*

SIRE

Telo

mer

ic R

epea

t

Group XI

Telomeric repeats







Transcription sense


Tel45: TcChr40-S

1139181

1125103

1Kb

Telo

mer

ic r

epea

t

RHS

SIRE

DGF-

1*TcChr 40S

Group XI

Telomeric repeats







Transcription sense


Tel46: TcChr19-P

5Kb

DGF-

1

DGF-

1*

RHS*

DGF-

1Te

lom

eric

rep

eat

RHS*

DGF-

1*

TS*

HPEndo

som

al in

tegr

al m

embr

ane

prot

ein

HPHPGlut

amam

yl ca

rbox

ypep

tidas

eHPAl

pha-

adap

tin-li

ke

Cyto

chro

me

c1, h

eme

prot

ein

HPGolg

i/lys

osom

e gl

ycop

rote

in

Pitr

ilysin

-like

met

allo

prot

ease

585395 526264

Group XI

Telomeric repeats







Transcription sense


Tel47: TcChr21-S

10kb

Telo

mer

ic R

epea

t

TSβ ga

lact

ofur

anos

yl g

lyco

siltr

ansf

eras

e

VIPE

R/SI

RE

RHS*

TSDGF-

1

HP*

SIRE

HPRHS*

1 99950

TcChr 21S

DGF-

1

TS TS Myo

sin h

eavy

cha

in

RHS*

RHS

Myo

sin h

eavy

cha

in*

MAS

P*

Glyc

ine

dehy

drog

ense

*

Group XI

Telomeric repeats







Transcription sense


Tel48 -TcChr27S

5 Kb

SIRE

HPTelo

mer

ic r

epea

t

RHS

RHS*

RHS

DGF-

1

VIPE

R/SI

RE

HPPhos

phoi

nositi

de-s

peci

fic p

hosp

holip

ase

C

RHS

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP*

VIPE

R/SI

RE

HP Phos

phoi

nositi

de-s

peci

fic p

hosp

holip

ase

C

HP HPHP HP GTP-

bind

ing

prot

ein

SIRE

HP HPTelo

mer

ic r

epea

t

106 53391

Group XI

Telomeric repeats







Transcription sense


VIPE

RSIR

ERH

S

RHS

Telo

mer

ic r

epea

t

Tel49: TcChr31-P

10Kb

TS TS RHS

TS TS β g

alac

tofu

rano

syl g

lyco

syltr

ansf

eras

em

anno

syl-o

ligos

acch

arid

e 1,

2-al

pha-

man

nosid

ase

IBTS

*RH

S

DGF-

1

HPHP TS HP HP*

HP RHS

N-a

cety

ltran

sfer

ase*

RNA

helic

ase*

HP TS*

TS*

HP DGF-

1

TS*

HP Dyne

in li

ght c

hain

2B,

cyt

opla

smic

HP 3-m

ethy

lcro

tony

l-CoA

car

boxy

lase

HP HP HP HP chap

eron

e Dn

aJ p

rote

in

1304 119145

Group XI

Telomeric repeats







Transcription sense


Documents

Tel1: TcChr9-P