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REPORT NUMBER 8

00RESEARCH EFFORT TO DEVELOP OPERATIONAL IMPROVEMENTS

TO BIOLOGICA L -RECORDS S , ~

ANNUAL REPORT1 September 72 - 30 August 73

ACT TECHNICAL STAFF

WILLIAM H. SMITH 0Principal Investigator

15 May 1976

Supported by

U.S. ARMY MEDICAL RESEARCH & DEVELOPMENT COMMANDWashington , D.C. 20314

Contract No. DADA17-68-C-8106

Advanced Computer Techniques Corporation 11501 Wilson Blvd ., Arl ington , Virginia 22209

“Approved for public release; distribution unlimited. ”

The findings in this report are not to be construed as anofficial Department of the Army position unless so designatedby other authorized documents .

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FORE WARD

The present contractual effort is a continuationof a research project initiated in August , 1967.

This research is conducted under the overall cog-nizance of Col . William E. Rothe, V.C.., Di rectorof the Division of Medicinal Chemistry, and isconducted under the imediate direction of It. Col .Kenneth E. Kinneman , Head of the Department ofBiology .

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I. INTRODUCTION

Advanced Computer Techniques (ACT) has been providing consulting servicesto Walter Reed Army Institute of Research (WRAIR) staff in the design ,implementation , and documentation of automated systems for the analysisof data resul ting from research in the Antimalarial Drug Screening ResearchProgram.

During the contractual period covered by this report the fol lowing effortswere enacted:

A. Continued conversion of current biology systems to the CDC 3500.

B. Developing a system to interface Biology and Compound InventorySystems on CDC3500 with Chemical Structures System on IBM 7090/94.

C. Design of new biology system for CDC3500

D. Providing production assistance as required .

II. OBJECTIVES

~A. Continued conversion of Biology Systems from IBM 7090/94 COBOLto ANSI COBOL for CDC3500.

B. New systems designed and implemented as required due to changesin hardware or research laboratory reporting procedures.

C. Design new biol ogy system for CDC3500 using disk storage andmul ti—programming capabilities .

III. ACCOMPLISHMENTS DURING THE YEAR

A. Conversion of current biology systms to new hardware.

1. Utility search programs converted from IBM 7090/94 COBOL toANSI COBOL for the CDC3500.

2. Update programs for following systems converted to ANSI COBOLfor the CDC3500, Rane, Radiation , Thompson, Anti foli c andLiverpool .

B. Developed system to interface Biology and Compound Inventorysystems processed on the CDC3500 wi th Chemical Structures Systemon the IBM 7090/94.

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C. Analysis and design of new biology system for the CDC3500 wasstarted .

D. Maintenance service provided for current biology systems asrequired.

E. Production assistance provided during the year.

IV . CONCLUSIONS

At the end of the contract year, the update and utility search programsfor the following systems were operational at WRAIR: Rane, Radiation ,Thompson, Antifolic and Li verpool . A new interface system was operationalat Fort Lee, Virginia. Analysis and design of new disk oriented bi ologysystem for the CDC3500 was started.

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~~~~ ~~~~~~ \Unclassifi ed~~~c~~~ I ry CLA ~ s~~ ,C.v~lCM O~ TNI~ ~~~~~~ ~~~~~~~~~~~~~~~~ ~Se.-*~ 7..~ —.—~ ‘g ,4~p

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- iw ~~~REPORT DOCUMENTATIO?4 P~~~ flEFOR ~~ COMPLLTDI r, I. ORMI. HE~~ONT NUM3ER 12. GOVT ACCESSION NO. 3. HECIP IENTS C A T A L OG NUM3Efl

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4. TITLE (med Subtiil.) 5. TYP E OF REPORT & PERIOD CovE RED

Annual Report (fo r PeriodEffort to Develop Operational I Sept. 72 - Aug. 73)

Improvements to Biologica l Programs , 6. PERFORMINGORG. REPORT NUMBER

7. AL~THOR(s ) 8. CONTRACT ON GRANT Nu,IaER(.)

William H/ Smi th ~~1~~68-C-8i~ 6 ~~9. PER~~ORMi?4 G ORGANIZAT ION NAME AND AD DRESS 20. PROGRA M ELEMENT. PROJE C T S T A S K

A~~ZA 6 WOR .< UNI T~~W~.4NERSAdvanced Computer Techniques Corporation -6VI~3A1 501 Wi l son Blvd .

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Arlington , Va. 22209 . %1~~ 3A663713D82

It. CONTROLLING OFFICE NAME AND ADDRESS 22. REPORT DATE

May 15, 1976U.S. Army Medical Research and Development

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Command , Washington , D.C. 20314ASS.~~~~ th ia report)24. MOMI TO RIP~G AGE$C~~ NAME 8 ADDRES~~ I? d l If . re,,t from Controtlina Office)

Unclassified

25.. OECL ASS FICA TIO N/DOW:i GRADINGSCH~~OUL E

IS. DISTRIB UTION STATEME NT ~‘of this R.por&t

Approved for public release; distribution unlimi ted .

17. DISTRIBUTION STATEMENT (of the abat,act entered in Block 20, II differen t from Report)

IS. SUPPLEMENTARY NOTES

IS. KEY WORDS (Continue en revere, aid. Ii n.c.a.a,y ønd identity by block number)

Biology , Information Processi ng, Chemical Structure , Compu terInformation System.

20. A 8ST R.~CT (Continue on r.ve,a. aide H n.c.a..Iy end identify by block number)

Synopsis of activities performed by Advanced Computer TechniquesCorporation in developing new biology test systems.,)

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I J A N 73 1473 EDITION OF I NOV 6 3 2 5 OBSOLETE Unclassified _________________

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DI STRLBU TIO~ LIST

4• copies HQDA (SCRD-AJ )Washington DC 20314

12 copies Defense Documentation Center (DDC)ATTN: DDC-TCACameron StationAlexandria, Virginia 22314

1 copy .

SuperintendentAcademy of Health Sciences, US ArmyATTN: AHS-COMFort Sam Houston, Texas 78234

1 copy DeanSchool of MedicineUniformed Services University of theHealth SciencesOffice of the Secretary of Defense6917 Arlington RoadBethesda, Maryland 20014

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