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F1_M3C Number: C20307
Lock Date: 12/28/2009
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.4.2.1_003
PWG Approval Date: NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
ALIMENTARY SYSTEM
Esophagus I + + + + + + + + + 9
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + M + + + + + + + + 9Cyst X 1
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Follicle, Degeneration 2 1 2.0
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + M + + + + 9
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M + M M + M + M M + 4
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10Retrobulbar, Inflammation, Neutrophil 1 1 1.0
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 3 1 3.0
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Tongue + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10Cyst X X 2
Pituitary Gland + + + + + + + I + + 9
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M + + + M + M M M M 4
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
Skeletal Muscle + 1
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10Retina, Dysplasia 2 1 2.0
Harderian Gland + + + + + + + + + + 10Inflammation, Neutrophil 2 1 2 1.5
URINARY SYSTEM
Kidney + + + + + + + + + + 10Inflammation, Chronic 1 1 1.0
Urinary Bladder + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25%ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1 4 1.5
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25%ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
Hyperkeratosis 1 1 2 1.0Hyperplasia 2 2 2 1 2 2 1 1 2 9 1.7Inflammation, Chronic Active 1 2 1 2 2 1 1 7 1.4Hair Follicle, Hyperplasia 1 1 1 3 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 1 1 2 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Hyperplasia 2 1 2 1.5Control, Inflammation, Chronic Active 2 1 2 1.5
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
Control, Hair Follicle, Hyperplasia 2 1 2.0
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 3 2.0Hyperkeratosis 1 1 2 2 1 5 1.4Hyperplasia 2 2 3 2 1 2 1 3 1 2 10 1.9Inflammation, Chronic Active 1 2 2 2 2 2 1 2 1 2 10 1.7Hair Follicle, Hyperplasia 2 1 2 1.5
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + I + + + + + 9Centrilobular, Hypertrophy 1 2 1 3 1.3
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + I + + + + + 9
INTEGUMENTARY SYSTEM
Skin + + + + I + + + + + 9Control, Fibrosis 1 1 1.0Control, Hyperplasia 1 1 1 1 4 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Control, Inflammation, Chronic Active 1 1 2 1 4 1.3
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1 2 2 2 2 8 1.8Hyperkeratosis 1 1 2 1 2 5 1.4Hyperplasia 1 1 1 2 2 2 2 2 3 9 1.8Inflammation, Chronic Active 1 1 1 2 2 2 2 2 2 9 1.7Epidermis, Inflammation, Suppurative 1 1 1.0Hair Follicle, Hyperplasia 1 3 3 3 2.3
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Fibrosis 2 1 2 1.5Control, Hyperkeratosis 2 2 2 2.0Control, Hyperplasia 3 2 1 3 2.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
Control, Inflammation, Chronic Active 2 2 2 2.0Control, Epidermis, Inflammation, Suppurative 2 1 2.0Control, Hair Follicle, Hyperplasia 2 1 2.0
Skin, Site Of Application + + + + + + + I + + 9Fibrosis 1 2 2 2 2 1 2 1 8 1.6Hyperkeratosis 1 1 1 2 1 2 1 2 8 1.4Hyperplasia 2 3 2 3 2 3 2 2 2 9 2.3Inflammation, Chronic Active 1 1 2 2 2 2 2 2 1 9 1.7Epidermis, Inflammation, Suppurative 2 1 2.0Hair Follicle, Hyperplasia 1 1 2 1 1 1 1 7 1.1
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
ALIMENTARY SYSTEM
Esophagus + I + + + + + + + + 9
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 3 1 2 2 4 2.0
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Tongue + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + M + + 9
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M M + M + M + M + M 4
Skin + + + + + + + + + + 10Control, Fibrosis 1 2 1 2 1 5 1.4Control, Hyperkeratosis 2 2 1 1 2 5 1.6Control, Hyperplasia 2 3 2 2 2 3 2 2 8 2.3Control, Inflammation, Neutrophil 1 1 1.0Control, Inflammation, Chronic Active 2 2 2 1 2 2 2 1 8 1.8Control, Epidermis, Inflammation, Suppurative 1 1 1 1 4 1.0Control, Hair Follicle, Hyperplasia 2 1 2 2 1 5 1.6
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 2 2 2 2 2 2 2 10 2.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Hyperkeratosis 2 2 2 2 2 2 1 1 2 1 10 1.7Hyperplasia 2 3 3 3 2 3 3 3 3 3 10 2.8Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 1 1 1 1 5 1.0Hair Follicle, Hyperplasia 2 2 1 1 2 2 2 2 8 1.8
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10Inflammation, Neutrophil 1 1 1.0Inflammation, Chronic 2 1 2.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
DAY ON TEST
B6C3F1 MICE MALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
*** END OF MALE DATA ***
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + M + 9
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + M + 9
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
Vagina + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
untreatedANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + M + + + 9
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + M + + + + + + 9
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + M M + + M + + + 7
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland M + M M + + + + + M 6
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
Vagina + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
Skin, Site Of Application + + + + + + + + + + 10Ulcer 4 1 4.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
vehicleANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 1 1 1.0
Urinary Bladder + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Hyperplasia 1 1 1 1 4 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Control, Inflammation, Chronic Active 1 1 1 2 4 1.3
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1.5Hyperkeratosis 2 1 1 1 1 5 1.2Hyperplasia 3 2 2 2 2 2 2 2 2 2 10 2.1Inflammation, Chronic Active 2 2 2 1 2 2 2 1 2 2 10 1.8Hair Follicle, Hyperplasia 1 2 1 3 1.3
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Fibrosis 1 1 2 3 1.3
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
Control, Hyperkeratosis 1 1 1.0Control, Hyperplasia 2 1 2 3 1.7Control, Inflammation, Chronic Active 2 1 1 2 4 1.5
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 1 2 2 1 1 2 2 2 1 2 10 1.6Hyperkeratosis 2 1 1 1 1 5 1.2Hyperplasia 1 2 2 1 2 2 2 2 1 3 10 1.8Inflammation, Chronic Active 1 2 2 2 1 2 2 2 1 2 10 1.7Epidermis, Inflammation, Suppurative 1 1 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Control, Hyperplasia 1 1 2 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
Control, Inflammation, Chronic Active 2 1 2 1.5Control, Hair Follicle, Hyperplasia 1 1 1.0
Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 1 2 2 2 1 2 1 10 1.7Hyperkeratosis 2 2 3 2 1 2 1 2 1 1 10 1.7Hyperplasia 2 2 2 2 2 2 2 2 2 2 10 2.0Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 2 1 1 4 1.3Hair Follicle, Hyperplasia 2 3 3 3 4 2.8
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Heart I + + + + + + + + + 9
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Spleen I + + I + + + + + + 8
Thymus I I + + + + + + + + 8
INTEGUMENTARY SYSTEM
Skin I + + I + + + + + + 8Control, Hyperplasia 1 1 1 3 1.0
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Control, Inflammation, Chronic Active 1 2 1 3 1.3
Skin, Site Of Application I I I I + + + + + + 6Fibrosis 1 1 1 2 4 1.3Hyperkeratosis 2 1 2 2 2 2 6 1.8Hyperplasia 3 3 2 2 2 2 6 2.3Inflammation, Chronic Active 2 2 2 2 2 2 6 2.0Ulcer 2 1 2.0Epidermis, Inflammation, Suppurative 1 1 1 2 4 1.3Hair Follicle, Hyperplasia 3 1 2 3 2.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10
Oral Mucosa + + + + + + + + + + 10
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Tongue + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Parathyroid Gland + + + + + M + + M + 8Cyst X 1
Pituitary Gland + + + + + I + + + + 9
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Vagina + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node + 1
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10Atrophy 2 2 2 2.0
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Control, Fibrosis 2 2 1 1 1 2 6 1.5Control, Hyperkeratosis 2 1 2 2 2 2 3 7 2.0Control, Hyperplasia 3 1 2 3 2 1 2 1 3 3 10 2.1Control, Inflammation, Chronic Active 2 1 2 2 2 2 2 2 8 1.9Control, Ulcer 2 1 2.0Control, Epidermis, Inflammation, Suppurative 1 1 2 2 2 2 1 2 8 1.6Control, Hair Follicle, Hyperplasia 1 2 3 3 2.0
Skin, Site Of Application + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Fibrosis 3 2 2 2 1 2 2 2 2 9 2.0Hyperkeratosis 3 2 1 3 2 1 2 2 2 3 10 2.1Hyperplasia 3 3 3 3 3 3 2 2 3 3 10 2.8Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 1 2 1 2 1 1 7 1.3Hair Follicle, Hyperplasia 1 1 2 2 1 3 2 2 3 3 10 2.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Larynx + + + + + + + + + + 10
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10Retrobulbar, Inflammation, Neutrophil 1 1 1.0
Harderian Gland + + + + + + + + + + 10
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 42
DAY ON TEST
B6C3F1 MICE FEMALE
0092
0092
0092
0092
0092
0092
0092
0092
0092
0092
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
*** END OF REPORT ***
TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E
Super)Time Report Requested: 12:17:04
Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 43
