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TTÜÜBBİİTAK TAK Turkish R&D Potential in HEALTHTurkish R&D Potential in HEALTH
A. Çınar ADALI
HEALTH NCP
Outline
• The Scientific and Technological Research Council of Turkey (TÜBİTAK)– Functions and undertakings
– Reseach in TÜBİTAK
– FP7 National Coordination Office
– TÜBİTAK in International Platform – Reseach initiatives and collaborations
• Health Reseach in Turkey– Active research bodies in health research
– Health research topics in Turkey
– Funding agencies in health research
Brief Information about TUBITAK
• Promoting, developing, organizing and coordinating scientific
research and development in Turkey in line with the national
targets of economic development and technical progress
• Primary functions� Formulating S&T policies of Turkey� Promoting, funding and monitoring academic R&D� Promoting, supporting and monitoring industrial RTD & innovations� Promoting, supporting and monitoring public RTD & innovations� Fostering academia-industry cooperation� Running R&D institutes to perform RTD activities in line with national
priorities� Operating facilities providing assistance & technical service to R&D
activities� Discovering the talents and supporting the scientists of the future� Awarding annual prizes, serving as incentives for scientific excellence� Organising and running international S&T cooperation� Publishing scientific journals and popular science books & magazines.
Research Centers and Institutes
• Marmara Research Center (MAM)– Information Technologies Research Institute– Institute of Energy– Chemistry and Environment Institute– Food Institute– Materials Institute – Earth and Marine Sciences Research Institute– Genetic Engineering and Biotechnology Research Institute– Technopark
• National Electronics and Criptology Research Institute (UEKAE)
• Defence Industry Research and Development Institute(SAGE
FP7 National Coordination Office
Mission : The mission of NCO is to increase the participation of TurkishResearchers and industrial associations that conduct R&D activities tothe EU Framework Programmes
In this regard the main activities of NCO is
• Informing• Orientating• Creating awareness• Training • Creating Partnership• Representing • Encouraging
NCO Staff• The number of the full time NCO
Staff is 35. • They are fluent in English (%85 of
them bilingual esp. German and French)
• The EU experience of the staff varies from 2 to 5 years.
• Age average is 28,2
The Institutions with Bilateral Agreements Based on Conducting Joint Projects -TÜBİTAK• ALBANIA – Ministry of Education and
Science– to be launched
• BELARUS – National Academy of Sciences of Belarus
• BULGARIA – Academy of Sciences of Bulgaria
• CHINA – Ministry of Science and Technology
• GERMANY – DFG (DeutscheForchungsgemeinschaft)
– BMBF (Ministry of Education and Research)
• GREECE – GSRT (General Secretariat for Research and Technology)
• FRANCE – CNRS (Centre National de la Recherche)
– Ministry of Foreign Affairs
• INDIA – CSIR (Council of Scientific and Industrial Research)
• ITALY – CNR (Consiglio Nazionale delle Ricerche)
– Ministry of Foreign Affairs
• HUNGARY – National Research and Technology Office (NKTH)
• MACEDONIA – Ministry of Education and Science
• MONGOLIA – Academy of Sciences
• PAKISTAN – Ministry of Science and Technology
• ROMANIA – ANSC (National Authority for Scientific Research)
• RUSSIAN FEDERATION – Russian Foundation for BasicResearch (RFBR)
• SLOVAKIA – Academy of Sciences
• SLOVENIA – Ministry of Higher Education, Science and Technology
• SOUTH KOREA – KRF (Korea Research Foundation)
• SYRIA – Ministry of Higher Education
• TUNISIA – Ministry of Higher Education,Scientific Research and Technology
• UKRAINE – NASU (Academy of Sciences)
– Ministry of Education and Science
• USA – NSF (National Science Foundation)
Total: 22 Countries/26 Institutions
Multilateral Cooperations - TÜBİTAKGLOBAL ORGANIZATIONS
• OECD (Organization for Economic Cooperation and Development)
• NATO (North Atlantic Treaty Organization)
• UN (United Nations)
• ICSU(International Council For Science)
• ICGEB (International Center for Genetic Engineering and Biotechnology)
• ECO (Economic Cooperation Organization)
• IEA (International Energy Agency)
•
EUROPEAN ORGANIZATIONS
• EU Framework Programmes (European Union Framework Programmes)
• ESA (European Space Agency)
• COST (European Cooperation in Science and Technology)
• ESF (European Science Foundation)
• EuroHORCS (European Heads of Research Councils)
• EUREKA
• EMBC (European Molecular Biology Conference)
ERA-NETS - TÜBİTAK
No Name of the Project Area No Name of the Project Area
1 HIV ERA-NET HEALTH 13 ETRANET ICT
2 ERA-ARD II KBBE 14 Urban-net HORIZONTAL
3 CROSSTEXNET NMP 15 FORSOCIETY HORIZONTAL
4 SEAS-ERA ENV 16 CORNET SME
5 CIR²CLE ENV 17 E-InfraNet INFRA
6 MATERA+ NMP 18 CORNET II SME
7 EuroNanoMed NMP 19 SEERA-EI INFRA
8 WoodWisdomNet 2 NMP 20 New INDIGO INCO
9 MNT-ERA-NET II NMP 21 SEE-ERA.NET PLUS INCO
10 ICT-AGRI HORIZONTAL 22 BS-ERA.NET INCO
11 E-RARE HEALTH 23 ERA.Net RUS INCO
12 SAFEFOODERA KBBE 24 KORANET INCO
Joint Programming Initiatives
TÜBİTAK has been actively taking part in all of the JPIs :
� JPIs recently adopted and recommended by the European Council
� JPIs recently substantiated by GPC (High Level Group for Joint Programming)
• Pilot Initative: “Joint Programming in research on
neurodegenerative diseases, in particular Alzheimer’s
disease” adopted by the European Council: TÜBİTAK is a Steering Committee member
Turkish R&D Potential in Turkish R&D Potential in HEALTHHEALTH
Type of Organisation in Health Sector
Collected by TÜBİTAK EU Framework Programme National Coordination Office
Health Research Actors in Turkey
• Most of the Health research in Turkey is being performed by Universities – both research in faculties & research in research centers founded in universities
– There are
• 64 Faculties of Medicine,
• 15 Faculties of Dentistry,
• 14 Faculties of Pharmacy,
• 36 Faculty of Health Sciences
• 5 Faculties of Health Education
in Turkey
Divisions in Faculty of Medicines
BASIC SCIENCES DIVISION
• Department of Anatomy
• Department of Biophysics
• Department of Biostatistics
• Department of Physiology
• Department of Histology and Embryology
• Department of Medical Biochemistry
• Department of Medical Biology
• Department of Medical Education and Informatics
• Department of Medical Microbiology
• Department of Medical History and Ethics
Divisions in Faculty of MedicinesMEDICAL SCIENCES DIVISION
• Department of Cardiology
• Department of Chest Diseases
• Department of Emergency Medicine
• Department of Forensic Medicine
• Department of Internal Medicine
• Department of Medical Genetics
• Department of Medical Pharmacology
• Department of Neurology
• Department of Nuclear Medicine
• Department of Pediatrics
• Department of Public Health
• Department of Radiation Oncology
• Department of Radiology
• Department of Sports Medicine
• Department of Child and Adolescent Psychiatry
• Department of Dermatology
• Department of Physical Medicine and Rehabilitation
• Department of Psychiatry
Divisions in Faculty of Medicines
SURGICAL SCIENCES DIVISION
• Department of Anesthesiology and Reanimation
• Department of Pediatric Surgery
• Department of General Surgery
• Department of Chest Surgery
• Department of Cardiovascular and Thoracıc
• Department of Ophthalmology
• Department of Obstetrics and Gynecology
• Department of Otorhinolaryngology
• Department of Neurosurgery
• Department of Orthopedics and Traumatology
• Department of Medical Pathology
• Department of Plastic Reconstructive and Aesthetic Surgery
• Department of Urology
Research Centers in Turkey
Biomedicalengineering
Biotechnology –Pharmaceutical
NanomedicineTranslational research in
diseases(Most of the universities)
FP7 HEALTH RESEARCH
Molecular biology
Public Health
TUBITAK MRC Genetic Engineering and Biotechnology Institute
Facilities
• synthesis and characterization of biodegradable microspheres
• biomaterial synthesis and tissue engineering studies
• biophysical characterization of novel non viral vectors for gene delivery (polymers and nanotubes) and their in vitro transfection and cytotoxicity tests and cellular uptake studies.
• Controlled drug/protein release from biodegradable microspheres.
Research Activities
• Non viral vectors
• Non viral gene delivery
• Nanotubes, nanoparticles for gene delivery
• Biophysical characterization of DNA/vector complexes in vitro transfection and cytotoxicity tests cellular uptake studies
• Fluorescence probes and techniques (Application of bionanomaterials for gene therapy)
• Controlled drug delivery, biomaterials,microparticles/nanoparticles
Biomedical Engineering Centres
• TUBITAK Biomedical
Technologies Centre
• Bogazici University Biomedical Engineering Institute
• Middle East Technical University Biomedical Engineering Institute
• Bilkent University Biomedical Engineering Institute
Some examples for research centers
• They are involved in two important FP6 Projects:– EUROPEAN
LEUKEMIANNET (NoE)
– EPICURE (IP)
Some examples for research centers
• Hacettepe University Pharmaceutical Biotechnology Unit
– INNOMED (IP) FP6 Project
– Prof. Dr. Turkan ELDEM : member of IMI JU
Some examples for research centers
• Gazi University Nanomedicine and Advanced Technologies Research Center: http://www.nanomed.gazi.edu.tr/
• NanoMed is a member of international organizations such as European Technology Platform on NanoMedicine, NATO Research & Technology Organization, European Foundation for Clinical Nanomedicine, American Academy of Nanomedicine, and International Academy of Nanomedicine.
• Director: Gurer G. Budak M.D
• Research Area: Regenerative Medicine, Diagnosis and Imaging, Targeted Delivery
• Actively participating to 4 programmes of FP7 and has a vast number of projects funded
Health Sector in Turkey
Pharmaceutical companies that are most remarkable in Turkey are;
– FAKO
– DEVA İLAÇ SAN.
– SANDOZ İLAÇ SAN. VE TİC. A.Ş.
– ABDİ İBRAHİM İLAÇ SAN. VE TİC.
A.S.
– MUSTAFA NEVZAT İLAÇ SAN.A.S.
– SANOVEL
– ECZACIBAŞI KIM.ÜR.SAN.TİC.A.S.
– PFIZER İLAÇLARI LTD. ŞTİ.
– BAYER
– ASTRA-ZENECA-Turkey
– GSK – Turkey
– ROCHE- Turkey
– NOVARTIS-Turkey
MAJOR PRIORITY AREAS IN TURKEY
• Diagnosis and treatment of cancer
• Diabetes and obesity
• Brain and brain-related diseases such as Parkinson’s, Alzheimer’s disease, Schizophrenia, etc.
• Infectious Diseases
• Genomics research (new gene identification, genetic epidemiology) in rare disorders with a genetic origin
• Clinical trials
• Production of domestic medical devices and kits
• Artificial tissue and organ development, natural organ and tissue transplantation
• Public Health Research
Clinical Trials• Phase I and Phase II studies are performed in the United States and
Europe.
• Clinical research centers in Turkey mostly participate in multicenter Phase II/III, Phase III, and Phase IV trials, the majority being prospective drug trials and registration-directed studies performed according to GCP guidelines.
• More focus are given on clinical trials on cardiovascular diseases, obesity, regenerative medicines, cancer treatment drugs and off-patent medicines
Brain and Brain related disorders
Public Health Research
• Ministry of Health is the main public health policy maker of Turkey. Organized and
serves in basis of public health approach and health priorities of the country.
• Refik Saydam Hygiene Center Presidency School of Public Health
(RSHCPSPH):
the branch of MoH and serves as a research center. This institution has been
conducted number of studies in collaboration with national and international partners.
Health revision project studies are conducted by RSHCPSPH. Public health
departments of medical faculties conduct public health researches in collaboration
with national and international partners and supporters. WHO, UNICEF, UNDP etc
are the international partners of medical faculties. Collaborating centers of WHO
serves as focal research points in medical faculties too.
• Research Institutions
TUBITAK (The Scientific and Technical Research Council of Turkey)
Public Health Research
NTPs related with HEALTH
• National Medicine Technology Platform initiated by
by TUBITAK in 1 August 2007
• Coordination and integration of researchers to decrease fragmentation
• Rational medicine design studies
• Development of domestic kits and medical devices
Turkish Participation in ETPs
• IMI JU– Prof. Dr. Turkan ELDEM - INNOMED (IP)
• Nanomedicine– Prof. Dr. Turkan ELDEM (Hacettepe University):
Mirror Group
– Prof. Dr. Gurer BUDAK (Gazi University –Nanomedicine Research Centre): Member
– Dr. Cem BOZKURT (Alvimedica, Vice Chair of Regenberative Medicine Working Group)
Research Studies on Health in Turkey
• Funding from– TUBITAK Health Research Grant Commitee
• More than 1100 health projects funded focused mainly on– Medicine (diagnosis)
– Cancer (Leukemia, breast cancer, lung cancer, etc...)
– Brain and brain-related diseases
– Chronic diseses such as kidney diseases
– Cardiovascular diseases
– Public health such as hospital hygene
– TUBITAK Technology and Innovation Grant Commitee
• ~300 projects funded mainly on – Prosthesis and monitoring techniques and equipments
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