1. A man presented with fever wt. loss & cough.Mantoux reads an induration of 17× 19 mm sputum cytology is –ve for AFB.Most likely diagnosis is:

a. Pul T.B.

b. fungal infection

c. viral infection

d. pneumonia

2. Tuberculous pleural effusion is characterised by all of the following features except effusion:

a haemorrhagic effusion

b pleural fluid LDH > 60% that of serum LDH

c increased deaminase

d increased mesothelial cells

3.Gold standard for the diagnosis of tb is

a. cxr

b. culture

c. sputum afb

d.bactec TB 460

4. positive mantoux test indicates….

a. induration of 6mm or more

b. induration of 10mm or more

c. induration of 15mm or more

d. induration of 20mm or more

5. Type IV hypersensitivity to Mycobacterium tuberculosis antigen may manifest as:

a. Iridocyclitis.

b. Polyarteritis nodosa.

c. Phlyctenular conjunctivitis.

d. Giant cell arteritis.

6. The standard drug regimens recommonded for tuberculosis are

a) ( INH +RCIN+ ETB) 2 months + (INH +RCIN) 7 monthsb) INH +RCIN+ ETB X 9 monthsc) (INH +RCIN + PZA + ETB) 2 months+4 months (INH + RCIN)d) RCIN+ ETB X 12months

8. Regarding TB in HIV, which statement is not true:

a) Reduced smear positivity seen with pulmonary TBb) Less cavitation and more dissentmination c) More extra pulmonary infectiond) Adverse drug reactions to anti- tubercular drugs are least seen

9. Regarding TB lymphadenitis, which statement is not true:

a) Paradoxical enlargement of lymph nodes, suppuration can occur during or after treatment

b) Constitutional features are absent in 50% of the patientsc) Supraclavicular lymphadenopathy is from mediastinal spread d) Tuberculin test is negative

10. About ethambutol which statement is not true:

a) It is bacteriostaticb) It is contraindicated below age 6 yearsc) It has no hepatotoxicity

d) It is nephrotoxic

11 . Match the following:

Diseases associated with pulmonary TB

Treatment with anti-TB drugs

1. Renal failure a. Frequent monitoring of LFT needed

2. Diabetes mellitus b. MDR seen paradoxical response or immune reconstitution phenomenon to ATT seen

3. Postrenal transplant

patient

c. Dose of OHA to be increased due to

interaction with rifampicin

4. Preexisting liver d. Rifampicin avoided, it increases

disease

clearance of

cyclosporin

5. HIV infection e. Dosage to adjust for streptomycin ethambutol and isoniazid

12. . Match the following anti-TB drugs with their side effects;

Anti- TB drug Side effect

1. Isonex a. Drug interacts on with anti-retroviral drugs

2. Rifampicin b. Ance

3. Pyrazinamide c. Photosensitivity and hyperuricemia

4. Ethambutol d. Ataxia

5. INJ. streptomycin e. Optic neuritis

6. PAS f. Convusions

7.Cyclosporine g. Neuromuscular blockade

8. Amikacin h.Dysgeusia

9.Ethionamide i.Hypothyroidism

13. Highest priority of TB central programme is:

a) DOTS therapy b) Supplying free therapy to TB patientsc) Educate public above TB awarenessd) Good quality diagnosis with sputum smear microscopy to identify infectious

cases14. During adequate treatment of tuberculosis, increase or worsening of lesion occurs due to:

a) It is an early phenomenon of unknown etiologyb) Overdosage of anti- TB drugsc) A feature commonly seen with DOTS therapyd) It is immunologically mediated complications of the disease

15. Steroids are not indicated in which tuberculosis

a) HIV with pulmonary TBb) Miliary TBc) Endobronchial TBd) TB meningitis

16. Miliary TB is caused by

a) Hematogenous spread from a primary focusb) Bronchogenic spreadc) Contiguity from tuberculous focusd) Reactivation of healed focus

17. A positive tuberculin test indicates

a) Strong immunity b) Exposure to tuberculous infectionc) Disseminated TBe) Primary complex

18. Chemoprophylaxis in TB is given to

a) Uninfected person, with risk b) Tuberculosis affected patientsc) Extrapulmonary tuberculosisd) Treatment of failure cases

19. Reinfection TB is almost exclusively a disease of the :

a.Lung b.Bones c.Joints d.brain

20. Following are the components of mycobacterium TB except….

a) mycolic acidb) tuberculostearic acidc) adenosine deaminase

d) fatty acid

21. National T.B control program is supervised by…

a) National TB institute, Banglore b) TB Research centre, Chennai c) TB Association of INDIA d) Central government of INDIA22. Following diseases predispose to TB except…

a) DMb) Pregnancyc) Silicosisd) HIV

23. Cold abscess of wall is usually due to TB of …..

a) ribs b) pleura c) intercostals muscle d) spine

24. A granuloma defined as a group of activated epithelioid macrophages surrounded

by a cuff of lymphocytes can be seen in the lung in all conditions, EXCEPT:

a. Sarcoidosis

b. Berylliosis

c. Tuberculosis

d. Asbestosis

25. Ghon’s focus can be appreciated in:

a. Primary tuberculosisb. Post primary tuberculosisc. Miliary tuberculosisd. Progressive primary tuberculosis

26. Cerebral tuberculosis focus is calleda) Assman’sb) Simmonsc) Rich’sd) Wigard’s

27. All of the following are seriously ill TB patients except:a) Pericardialb) pleural effusionc) Peritoneald) TB osteomyelitis of long bones

28. All the following second line TB drugs are bacteriocidal except:a) Capreomycinb) Cycloserinec) Kanamycind) Thiacetazone

29. Time interval for occurrence of genitourinary TB after primary infection is:a) 1-2 yrsb) 5-15 yrsc) 20-30 yrsd) >50 yrs

30. Live TB bacteria is identified by:a) Sputum smearb) BACTEC 460c) PCRd) ELISA

31. Wigard’s focus is infection of TB of:a) Brainb) Hilar Lymph nodec) Eyed) Endothelium

32. Treatment default is for :a) >1 monthb) >2 monthsc) >3monthsd) >4 months

33. Class IV DOTS regimen is for :a) Relapseb) MDRc) Chronic casesd) HIV patients

34. A chronic case of TB is diagnosed when:a) Sputum positive after 5 months of ATTb) Sputum positive after retreatment for treatment failurec) Patient who has sequelae and TB focus after ATTd) Immunosuppressed patient with positive sputum

35. A Class I DOTS patient after 3 months of ATT was subjected to sputum examination was found to be positive then you will:a) Diagnose chronic TBb) Diagnose MDR TBc) Continue ATT for 1 more month and repeat sputum examinationd) Diagnose treatment failure

36. Which among the following mycobacteria does not produce pigment when grown In light or dark?

a. M. avium intracellulare complex b. M. xenopi

c. M. scrofulaceum

d. M.marinum

37. For extrapulmonary TB pt, sputum should be examined if she/he has cough for

a. 1 wk

b. 2 wk

c. 3 wk000000000000

d. any duration

38. Counter stain used for ZN staining is:

a. carbol fuschin

b. methylene blue

c. phenopthalein

d. phenol

39. Any TB pt who is smear positive at 5 months or more after starting treatment is

a. relapse

b. failure

c. treatment after default

d. new case

40. Miliary TB spreads by which route?

a. inhalation

b. lympho-haematogenous

c. Cartilagenous

d. direct contagious

41 Occupational disease a/w TB is

a. Asbestosis

b. silicosis

c. berylosis

d. bagassosis

42 Following is the part of lymph node TB

a. lupus vulgaris

b. scrofuloderma

c. lichen scrofulosorum

d. erythma nodosum

43. Following drug is contraindicated in pregnancy

a. isoniazide

b. rifampicin

c. pyrazinamide

d. streptomycin

44. MDR TB is

a. resistance to H&R

b. resistance to H R Z E

c. resistance to H Z

d. resistance to H R E

45. TRC is situated at

a. Delhi

b. Banglore

c. Chennai

d. Kolkata

46. M. tuberculosis complex includes all except:

a. M. bovis

b. M. africanum

c. M. microti

d. M. avium intracellulare

47. Ghon’s focus is seen in

a. liver

b. lung

c. spleen

d. brain

48. what specimen is given to diagnose Pulmonary TB…

a. Blood

b. Transbronchial lavage

c. sputum

d. Transbronchial needle aspiration

49. BCG should be given at….

a. 1 wk after birth

b. at birth

c. at 6wks of birth

d. at 6 months

50. what is prevalence and incidence rate of TB infection….

a. 10 % & 10%

b. 20% & 5%

c. 30% & 4%

d. 5% & 2%

51. what is prevalence and incidence rate of TB disease……

a. 10 % & 5%

b. 10% & 1%

c. 1-2% &1.5%

d. 3% & 2%

52. what is mortality rate of Pulmonary TB…in India…

a. 1pt per day

b. 1pt per month

c. 1 pt per hour

d. 1 pt per min

53. Side effect of Rifampicin is…

a. Orange discolouration of urine

b. Nephrotoxicity

c. Ototoxicity

d. Ocular toxicity

54. Most common drug developing resistance amongst TB is…

a. Rifampicin

b. Pyrazinamide

c. INH

d. Streptomycin

55. Drug contraindicated in children below 6 years is…

a. Rifampicin

b. INH

c. Ethambutol

d. Pyrazinamide