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TATIOO: ��-f'tF BIRTHDATE: 5- 'it' SEX: /.Jc.....le-SIRE: "o'7-'> DAM: !YJ<21
STUDY: /J. ,.,,d
CLINICAL SUMMARY
ASSIGNMENT DATE: � 1' 5-AGE AT ASSIGNMENT: !/5'5 DEATH DATE: '/,JJ >s AGE AT DEATH: I�C·y-DA YS POST-ASSIGNMENT: J
J. FINAL PATHOLOGY REPORT
I. ANIMAL IDENTIFICATION:
A. TATTOO NUMBER: 1546F B. SPECIES: Canine C. DATE OF BIRTH: 89165
D. SEX: Male E. TITLE OF EXPERIMENT: Laser Treatment for Chronic Prostatic Hypertrophy F. PATHOLOGY SERIES INDEX NUMBER: DZ-25 G. DATE OF EXPOSURE: 92263 H. DAYS AFTER EXPOSURE AT DEATH: I2 I. DATE OF DEATH: 92275 J. AGE AT DEATH (DAYS): 1205 = 3.3 yr
II. FINAL ANATOMIC DIAGNOSES:
Prostate - Atrophy (gross) Prostate, left - Focal fibrosis and atrophy Prostate, right - Focal coagulative necrosis with epithelialization Prostate, urethra - Chronic urethritis Prostate, capsule - Focal necrosis Urethra - Fistula (gross) Lymph nodes, iliac, inguinal - Hypertrophy (gross)
Lung, right diaphragmatic - Congestion (gross) III. COMMENTS:
None
IV.
L. MICROSCOPIC NOTES
Dog Tattoo: 1546F 401{ . 7 OPE: 12 .{' . �I 1 P�ostate - Left: 5 section� (
Minimal, chronic nonsuppurative inflammation. One focus of fibrosis and atrophy about 2 mrn diameter, adjacent to urethra (L2).
Prostate - Right: 5 sections
A large focus of coagulation necrosis (R2) surrounded by proliferating connective tissue and an incomplete rim of sheets and nests of transitional epithelium. This epithelium appears to arise from metaplastic glandular epithelium. In the connective tissue are scattered lymphocytes and plasma cells, hemorrhage, and small deposits of hemosiderin. In the section anterior (R 1 ), the lesion extends to the capsule. Also in this section are shards of what appear to be foreign material. It does not polarize light. Posterior to section R2, there is a small focus of stroma fibrosis and epithelial atrophy. This may be the posterior edge of the necrotic lesion.
No inflammatory lesions are present in the parenchyma on the other sections (R4,5).
Prostatic Urethra: Minimal chronic inflammation.
Bladder: No slides.
Lymph Nodes: No slides.
Urethra: Chronic inflammation, marked.
GROSS NECROPSY NOTES
I. ANIMAL IDENTIFICATION: A TATTOO NUMBER: 1546F B. SPECIES: Canine C. DATE OF BIRTH: 89165 D. SEX: Male E. TITLE OF EXPERIMENT: Laser Treatment for Prostatic Hypertrophy F. PATHOLOGY SERIES INDEX NUMBER: DZ-025 G. DATE OF EXPOSURE: 92263 (9/19192)
ll. HISTORY: A MODE OF DEATH (EUTH., SAC., DIED): Sacrificed-isoflurone
anesthesia and cardiac bleed-out. B. DATE AND TIME OF DEATH: 92275 (I0/1/92) 9:05a.m. C. DATE AND TIME OF NECROPSY: 92275 (10/1192) D. AGE AT DEATH: 1205 Days� 3.3 yrs. E. DAYS AFTER EXPOSURE: 12 Days
Ill. PROSECTORS: C. Maruszak, J. Hogan IV. PATHOLOGIST IN CHARGE: Dr. Fletcher F. Hahn V. EXTERNAL APPEARANCE:
A TOTAL BODY WEIGHT AT NECROPSY: 9.6 kg B. PHYSICAL CONDITION: Excellent C. POSTMORTEM CONDITION: Excellent D. BODY OPENINGS: No Abnormal Findings (NAF) E. EXTERNAL GENITALIA: NAF F. SKIN:
Healing surgical incision in perineum over urethra. G. SUBCUTIS:
Healing surgical incision in perineum over urethra. VI. CAVITARY FINDINGS:
A THORACIC: NAF B. ABDOMINAL:
NAF - all organs in normal position. No adhesions. Vll. RESPIRATORY SYSTEM:
A. LUNG: The right diaphragmatic lobe was dark purple color and had a doughy
feeling upon palpation. Vlll. CARDIOVASCULAR SYSTEM:
A. HEART: NAF IX. ALIMENTARY SYSTEM:
A. OROPHARYNX: NAF B. STOMACH: NAF C. SMALL INTESTINE: NAF D. LARGE INTESTINE:
NAF - no lesions in colonic serosa. E. PANCREAS: NAF
F. LIVER: NAF . uniformly dark tan, sharp borders, smooth capsule.
X. UROGENITAL SYSTEM:
A. KIDNEYS: NAF - capsular surface smooth, normal cut surfaces.
B. URETERS: NAF C. URINARY BLADDER: NAF
D. URETHRA: Healing surgical incision site in urethra at ischial arch.
E. GENITAL ORGANS: I. TESTICLES: NAF 2. EPIDIDYMIS: Head of epididymis dark red, other normal. 3. PROSTATE:
9.49 g (total weight) 9.54 g (water displacement) -
The prostate was small with a distinct lobular pattern under the capsule. A 0.6 em, dark red, slightly raised focus protruded from the anterior portion of the right prostate. On section, the dark necrotic focus extended posteriorly for about 0.9 em.
XI. LYMPHATIC SYSTEM:
A. PERIPHERAL LYMPH NOES: 1. INGUINAL: Slightly enlarged and mottled.
B. VISCERAL LYMPH NODES: 1. HEPATIC: NAF 2. ANTERIOR MESENTERIC: NAF 3. ILIAC: Slightly enlarged and mottled.
C. SPLEEN: NAF - congested.
XII. ENDOCRINE SYSTEM:
A. ADRENALS: NAF XIII. PHOTOGRAPHY: Prostate XIV. PROVISIONAL DIAGNOSES:
1. Prostate: Atrophy. 2. Prostate capsule: Focal necrosis. 3. Urethra: Healing surgical incision. 4. Lymph nodes, iliac, inguinal: Hypertrophy. 5. Lung, right diaphragmatic: Marked congestion.
XVI. COMMENTS:
Tissues for histologic examination: 1) Prostate 2) Lung, RD (3, 4, 5)
15'1'-P uuf nus OltASSUi!IED
II
Gmss ::=iiitlifb diffi� 0 NOT SAMPLED FOR HISTOPATHOLOGY l
==�����==== ============================== ' , ... ,,ll.'O�/r_,-�'j'-':1"'--�Qf! .�i'fl-"'Ou_ of Necropsy
Cl;n;c;an _ _____,f3LL:r\"---'-'-1_��-
Principallnvestigator _ _]_�LJ>f_!.!...-'-----
, ... L.1:-�&.p
Stains (circle)
Number of Shdes
SKIN
BREAST
H&E
MEDIASnNALlN
CEIMCAI.l-N
ANTMESSENTERICUI
/..').05
A-R Specials
PHARYNX
ESoPHAGUS
JEJUNUM
u�
CECUM
""-�
=�� l� (J6uuJ,,j--j-jf+;;pj KIDN�:Y
SI'I.EEN /1-(lf-c... I.MIETER
FEMUR
VERTEBRAE
-·
BLOOO\I£SSEL
�·�
TONGUE
� � G
EP!OIOYMIS/OV10UCT
Tl:Sll:S/OV.O.M
·�
SPINAl. CORD
PITUITARY
"'
WEIGHTS AND MEASUREMENTS
Ht. Wt. _gm LV+S �Qm RT.V _gm
RAV _em LAV _em PV __ em AV __ cm
LVM _em RVM_cm Lung ____ gm
TBLN __ gm Adrenal __ gm Thyroid __ gm
Kidneys __ gm Liver ___ gm Spleen ___ gm
Bra in ___ gm Panc. __ X __ X __ em
Oihe' p/t?STA-rf- wr 9.'/1 f{u "'1'*"j-9,-.f �<a t'.Gc.-
PROVISIONAL ANATOMIC DIAGNOSIS
-'0/ ,_. Date �
CENTRAL RECORDS
MEDICAL HISTORY OF DOG: 1546 F
BORN o .G.i.a.rQlg & Isospora infection
Parvo titre 1 :640
Assigned "Mechanisms of Radiation Induced Cancer"
Returned to "Unassigned Colony" Assigned "Thermal Effects in the
Prostate Gland" Cystoscopy/prostatic ultrasound
Perineal urethrostomy/prostatomy
Cystoscopy/prostatic ultrasound
Cystoscopy/prostatic ultrasound
Cystoscopy/prostatic ultrasound
SACRIFICED
:adm
file: C:\HISTORY\ 1546F.MED
DATE
NOTED
89165
89251
90030
91022
91206
92255
92260
92263
92266
92269
92275
92275
CURRENT DATE
� RESOLVED
89265
TREATMENTS AND/OR DIETS OF DOG: 1546 F
89257 Metronidazole (Flagyl), I 1/2 Tablet (250 mg tablets), Oral, Sid for 5 days then re-test fecal
90064 Place on 12 oz. diet 92260 Noroxin, 100 mg (1/4 Tablet), Oral, Bid for 14 days
/adm WP FILE: c:\TREATMT\1546F.tre
HOSP!Tll ADMISSION and DISCHARGE
154 6f 89165
' U�ASSIGNED
CflZ{pQ cen�l____.___ '1/llrjq'Z.-
7111P�U1st.ll!L.Resp__:j_Welght I�. I 1<.9 ?rutntlng problem,_ __________ _
Jlfstory, ______________ _
r-nts:
b> p.g rulfe tf()r,nfQ ol'li66lfo I
llom.
1·. Attitude 2. Confonutlon 3. Hydration 4. Nutritional status 5. Super. lymph nodes 6. 11tmbrane color 7. Skin and ears 8. Eyes 9. Musculoskeletal sys.
_ 10. Respiratory sys. 11. Clrdlovucultr sys. 12. AH11tnttry sys. 13. Urinary sys. 14. Gtnlttl sys. 15. Nervous sys. 16. ·Endocrine sys. 17. Teeth and IIIIlS
Abnorm.
. ��aa� Dfagnoall:._....:.. _________________ ....;. _______ _
1:11Ddftlon et .. , ..... _____________ ...;..;. ____________ _
'lflchl,... CHnlcltn. _ _ -'-------------
Julian Date
� IL {,1 ( 'fzt .; qn'-2 Cj·J7,.'S k1nv-i
'\'1.'c<e?
h?.'Z.lt(,
17'·'"'�
�2Ut�
n,;&" lcln 7o
0 ' "
11z_zn. rl1n?, lc7 1}1
I -
0 CLINICAL CHAF-
General COtaments:
l ,,, 6 B716;i i
U'I�SS JGN D
Appe Bowels Urine T p R COMMENTS
tite
/J,ul, t , .. u. f 11 r'> 7- /1.( l)f�· f' ;./ "'�
i-JIF -d co""' I ')::; � r=£• r\,., '" 'K ,,I I 'l"SSMI ' "'� 'lil<> 1"3 � Jc...w ,.._'I �u-,<o'
10(, ·"' - "" \rr·'c, c '"' --�. U"'<V"\>. �
c--=:- r. II 0' ,,.) .r 1\1\ v c jV 5rr M.\, � 1-v<-- vAf'\k' d-h-'4 ,. "t' {I ·' .,,..,., :trk
"'""'I f, . If 0 " ....1 .,JI ,;.,, ' /" "" Gr /1.. �""'O'A.l. I Ioili. bi"l'�i'> .. W er.rl �;�..(1 ..oil '' ·, '""" -;;(
111Y'f', 1¥ wrrl . .< c;,d,cf .. A ,::.. �"<,(, H"c") I.J ri-/Ja� "' +<Y�t.c�
;,/, ...l"''""•dr.. ...,./ f,.-(&,"K . < n-S n. . U�,\7 ' ' �--+ d I, r -)/rill f .v,S•··� ,., "·,, \ :-.._,..,.,('L +d s ..... ((,"'
'1'- -iJ '\\'{y) o.A\ "' ·"·"'"'"' �"( \\_ + -.-I/,<. I{ +�u- "-• ..,(;) ) � fct c ,,,, "''' ( c«< 7 ��
I he (Ot•i' ' r='JH'Z- ..-,j I ..... . , . r"ll.nc -\ ,,.., � ... ' ,j rt.lr
h" Aj ore.-,;.,:: I rr-;
r::: .. I 11)) p "' I,,._ -H l'")i<_(\ ,r\:e ll...( �-" o ('Cd �f-lJ.._
c-cJ ,_,.,f.S �r,-.e. ,I i'"h'5 f)r "' Pre i /\( '"'""" "" . <r \ ,_, \- .._, r J 6· A) li� J
ABBREVIATIONS: Appetite: F•fair, G-good, P-poor, o--none. Bowels: N-normal, D-diarrhea, DB-diarrhea with blood, o-no feces.
-
Urine: N-normal, A-abnormal, o-none.
- - . - -
I
Cystoscopy, Prostatic Ultrasound, Anoscopy Report ( Protocol No. FY 92-044 .- ,. ' , lcjolj"J£
Tattoo: 154GF -- -i>ate:-qz -z. -r5 Body wt: 12. I SC) Dura�n of anesthesia: 3o rv..i ,_� Pre-anesthetic drugs:/...J fltr-<!p(N C:. znJ&<f""""'z,;...c Induction: !21'o :I:">of:tuc<Y'-0- /o "--
Anesthetist: M -Tbacr(2'»z---<
Anoscopy:
InterpretatiOn SZ i{J 0-
Laser Treatment for Chronic Prostatic Hypertrophy Treatment Schedule (Protocol No. FY9�-044)
Tattoo: JSLll -
Hospital Admission Date: 'lnl'ro (q/!1P/'1U Admitted By: fit 'I Ae-n fYC5h
'
Work
Julian Order Date Order Clinician Issued
I. Banamine, 0.2 ml (10 mg), IM, once, immediately post surgery
2. Noroxin (norfloxacin) 100 mg (one/.(a"+
� P,t\-M
M"'
'l1..2l<>O tablet) per os, bid (8A, 8P), ..lko days t))';t:c
9::1C!(?. 3. Cystoscopy � "l.lb/, Prostatic Ultrasound kt-"l2Ltk Anoscooy ,0.-� qz zk'1 CBC hospital orofile I� qll(Q_q 4. Cystoscopy !� "i1lloq Prostatic Ultrasound """'"
q-z:z.toq Anoscoov RA-n-qz.u.f\ CBC hosoital vrofile lp_<l-fl
"tn.7S 5. Cystoscopy BltM. ql.?..l5 Prostatic Ultrasound y,f\(1---q 1.'215 Anoscopy �t+rr-"'1.1.l� CBC hosoital orofile (? A-r1--
6. Cvstoscoov
Prostatic Ultrasound
Anoscoov
CBC hospital orofile
7. Cvstoscopy
Prostatic Ultrasound
Anoscovv
CBC hosoital orofile I Q <:'�,...,.ifirf" I ----
Completed
CJ.J'> '6 A;).;)/,�
l9;;u,;( I 'i'.u.c�
'12-z.<o q ICiv\nC\ Ci2-ZioC\
I"' 'l.(o'\ lq 721-") lq·n .. IS 1"122..15
"\:n.)z..
q�7-s
� �o����:�o�o���e���E;: �
� �o������ooo�N�� E:e:;� �
� �E�����;::�::.;:: g;
�
�
�
j
i
Cystoscopy, Prostatic Ultrasound, Anoscopy Report ; � Protocol No. FY 92-044 ·· "!.·
Tattoo: l5LfCOk
' f
·�'l:z.l.¥1 Date:'l 1 >-Sl q -.. BodyWt: Durai{Dn of anesthesia: 'IS "" :,;,. l!re-anketic drugs: I"'"'' fl±..r.,pc.a (, z oJ Aceprv,...,. Induction: 5° (n :r"ir.G.t. m ., a I o L Maintenance: (.";?"1, r...£1""' h' /nz Anesthetist: fl,< ·Tbo� Comments
Assis\am: /Jr �-r
Tattoo: IS']\i? f
Cystoscopy, Pro!:.tatic Ultrasound, Anos�py Repo1·t Protocol No. FY 92-044 · _.
:.9>.2-(olp Date:�lzz /9"2. Dura�n of anesthesia:
Body Wt:
P.re-anJthetic drugs: I.,J llfnJ{>"• £;,,I tkqvw,.z.� Induction: 3 7. :Tsctlu!fo-=e Maintenance: {, <; CZ-, -lcSo (� Anesthetist: /4-r W� Comments
Anoscopy: f!J., Y' ,__,__, (! ;-e_ � la , -c ....-14<
l::r�u?Szs��6== hklnuk
f':::;;;t:c �;a,;::i:f!:·:;;o � Endoscopist: 8d- IYL<tpfft'ahry, Dt!tU Assistant: A<f Thony:JTW· (/17(�
� j
�
� �
�
io�E��:�o�o�������:;� �
�
io�E�C��o�o���e���:;� �
;e
�E��������� �
'? &�c�;;:��i!�i:o: �
'? � �E:��;:;����o; �
;y
/,o.) SURGICAL RECORD Si'\- "-· l
Surg. Date: tj -/1-fJ---Body wt. (kq) __
Time of anesthesia� Duration 2 .Z.-7,
Pre-anesthetic drugs: At fj?�n,_.,A'd� ��
,;p,2� 5 Q, lf_t.,f,,!l>!.o! !.�., �. I nduc�tf S ·4,. Ts -.ft ...... .-- oN< Maintenan�e: 'J...'-7 Is .(f,, ""' c·
Anesthetist: l'11.A. k/cd.;,/,...e:=(L' Co11111ents : _ _ _____ _ _ _
Samples submitted: __ �v ..... · ''--"-'-"-----------------Comments: ____ _________________ _
Surgeon: /(,. � V"',?L, c� 12
�
�o�E����o�oN��:���E�: �
� �
� .
Cystoscopy, Prostatic Ultrasound, Anoscopy Report
Protocol No. FY 92-044 · _.
Tattoo: ISY (p F �\lllj'i"Z. Date: 927<rc Body Wt: ij. \ 1«1 ::; Durati,On of anesthesia: 2 SN..,·tJ
P-re-an�etic drJg�:1 A.��·�<.'eer�z..he... Induction: 9'/o I.s#"-<r"-".1 J "•
Maintenance: I. sO/o �Lev-""' / o "'-
Anesthetist: /J. ·T M=(lX,_) Comments
±zx: -bo:c A.:!:::� r;:;:Y�';;� ;7ft:;:�
�� �.Yf!i(J;�£L��ro_a 6 Prostatic �ound: !.).,"'" rz..,-< 0 -z--<;• J d-?"' q ,o,.-Cf, (c"->..._ ------------------------------------------------����� /�
Anoscopy:
� �
�
� �
;e
�o�E��:�o�oN������E�� �
"" ----,
/-,____
:,._�
�-)
� �
� �
INTEROFFICE MEMORANDUM
TO: FILE
FROM: Ms. M. A. Weinhold ,,� SUBJECT: Assignment of dogs to study
Please assign the following dogs to project FY92-044, "Thermal Effects in the Prostate Gland" and charge them to cost code 5203, effective 09/11/92 (92255):
xc Dr. B. Muggenburg Laboratory notebook #5733
1534E 1546A 1546D 1546F 1558B 1571A
INTEROFFICE MEMORANDUM
TO: FILE
FROM:
SUBJECT:
Dr. B. A. Muggenburg (,..--------Reassignment of Dogs
July 25, 1991 (91206)
The following dogs were tentatively assigned to study: 'Mechanisms of Radiation, Other Than
Immunology', Cost Code: 407t but were never used for this study. These dogs should be reassigned to their previous assignment, the ·unassigned' Colony Cost Code: 8603 effective today.
TATTOO BIRTHDATE TATTOO BIRTHOATE
15125 88111 15235 88330
1512U 88111 1523T 88330
1513C 88120 1523U 88330
15148 88133 1523V 88330
1514T 88133 15340 89089
1515T 88141 1534E 89089
1515U 88141 1546f 89165
1516U 88146 15538 89206
1517U 88160 1553T 89206
1518C 88261 1553U 89206
15180 88261 1557A 89353
1518E 88261 15588 89354
1518F 88261 1558C 89354
1521A 88279 1580A 90055
15218 88279 15808 90055
15215 88279 15805 90055
1521T 88279 1580T 90055
1521U 88279 1565A 90163
15228 88323 15658 90163
15225 88323 15655 90163
1522V 88323 1567A 90270
1522W 88330 15675 90270
15238 88330
PHYSICAL EXAMINATION (AN) (Short Form) 14.0 .. __ 1,__;:t:=§"'-""§""-, e>.._=o=---
Tattoo Number I "S'-1 CcF- (N-Normal) (A-Abnormal) A. OateC\;).\1(, i<>l;}'-�h;}., B. Weight 13� gm c. Height (Shoulder) __ ._
D. Body Temp. (rectal )l.OQ---=L E. Pulse Rate (femoral)..13d_ F. Respiration (rate/min. ).3J:._ G. General Condition:
1. Comatose 2. Poor 3. Fair 4 . �o..o<�=.._
.c5_,_EXce.�
COMMENTS:
I. Attitude 2. Conformation 3. Hydration 4. Nutritional status _ 5. Superfi cia 1 1 ymph nodes _
6. Membrane color 7. Skin and ears 8. Eyes 9. Musculoskeletal system
10. Respiratory system 11. Cardiovascular system 12. Alimentary system 13. Urinary system 14. Genital system 15. Nervous system 16. Endocrine system 17. Teeth and gums
-------------------- -
_ _ Qi____Milij ....lc\i�i:.!0::1l h.�\L_C(Ja�\�..ee,:,;,v!llu,D:l...__l!IG!.!!0Sd.·.!.:f''----- -------
·--------------------
Cl i11ician
PHYSICAl EXAMINATION (AN)
(Short Form) W.O. // I ]55 Tattoo Number /5 'f(p F
( 1 ,c;j 1. Attitude
(N-Normal) (A-Abnormal)
A. Dote (p-/ �/q / B. Weight 1)1 5o gm C. Height (Shoulder)
__ .
_
D. Body Temp. (rectal)�.j_ E. Pulse Rate (femoral)� f. Respi�atfon (rate/min. ).JK_ G. General Condition:
1. Comatose 2. Poor 3. fair
� COMMENTS:
redi\ii'i'cian
2. Conformation 3. Hydration 4. Nutritional status
_ 5. Superficial lymph nodes _ 6. Membrane color � . 7. --skin and ears
8. Eyes 9. Musculoskeletal system
10. Respiratory system 11. Cardiovascular system 12. Alimentary system 13. Urinary system 14. Genital system 15. Nervous system 16. Endocrine system 17. Teeth and gums
Clinician /
PHYSICAl EXAMINATION (AN)
(Short Form) w.o._-"0'-']�::<.,_,,;;?,.,.· _,.( c'-+l -Tattoo Number I 5 4 <9 F (N-Nonna 1) (A-Abnorma 1 )
A. Date CJ DJ 4 Q\ s/3u\'1o B. Weight I 2 ']Oo !1111
C. Height (Shoulder) __ ._
D. Body Temp. (rectal l.�W-·..!.1.. E. Pulse Rate (femoral )...1..2.d.;_; F. Respiration (rate/min.) ;:!.0 G. General Condition:
1. Comatose 2. Poor
�· COMMENTS:
·· - -.�---·-
-------
1. Attitude 2. Conformation 3. Hydration 4. Nutritional status 5. Superficial lymph nodes-6. Membrane color -:-7. ··skin and ears -8. Eyes 9. Musculoskeletal system
10. Respiratory system 11. Cardiovascular system 12. Alimentary system 13. Urinary system 14. Genital system 15. Nervous system 16. Endocrine system 17. Teeth and gums
NEW MEXICO DEPARTMENT OF AGRICULTURE
VETERINARY DIAGNOSTIC SERVICES
700 Gamino de Salud NE Albuquerque. New Me�ico 87106 Phone (505) 841·2576
Page: 2
9002061 1541T
9002062 1542B
9002063 1542S
9002064 1542T
9002065 1543S 9002066 1544A 9002067 1544B
9002068 1544S 9002069 1544T
9002070 1544U 9002071 1545T 9002072 1546A 9002073 1546B 9002074 1546C 9002075 15460 9002076 1546E 9002077 1546F 9002078 1546G
9002079 1546S 9002080 1546T 9002081 1547A 9002082 1547S 9002083 1547T 9002084 1547U 9002085 1548A 9002086 1548B 9002087 1548C 9002088 1548S 9002089 1548T 9002090 1548V 9002091 1550B 9002092 1550T 9002093 1551C 9002094 1551S 9002095 1551T 9002096 1552A 9002M7 1552B 9002098 1552S 9002099 1552T 9002100 1552U 9002101 1553A 9002102 1553B 9002103 1553S 9002104 1553T
1:640
1:160 1:160
1:160 1:40 1:80 1:80 1:20 1:20
1:40 1:40 1:1280 1:80 I :40 I :640
1:1280 I :640
1:160 1:80
1:160 1:40
1:320 1:40
I :80 1:40
1:40 1:40
1:640 I :80
1:640 I :640
I :320 1:1280
1:640 1:320
1:40 1:1280 1:640 1:160
1:80 1:160
1:80 1:80 1:160
Case: 90-02025
Species: Canine
Owner: Lovelace P090005110006 Animal Nsme:
INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY {Reason for submission)
REOUESTEO BY
0URINALYSIS COLLECTION METHOO
Compression'------------Catheterization __________ _
Cage _____________ _
Other __ ___________ _
CHEMISTRY (chemstrip-8) Sugar ____________ _::m"'g/-"'dl Albumin ___________ _:m�g/Ed l
OATE SUBMITTED
OMICROSCOPIC COMMENTS· OIRECT
Hemoglobin ERY /ug CYTOCENTRI FUGE Acetone ____________ _
Bilirubin ____________ _
Urobilinogen _ _ _ _ ___ ___ _::m2g/_:cd l
Occult blood __________ ER_Y_;_/u"'g
Nitrite Sp. G'.-------------
pH _ _ _ _ _ _ ______ ___
Calm· _____________ _
Turbidity ____________ _ TECH/PATH
MICROSCOPIC ���i¢�EQUESTEO _liil'Parasites
Date
OTrypsin ODther wBc. _ _ _ _ _ _ _ _ _ _ _ _ _ Procedure Usedi _______ _______ _
ABC _ _ _ _ _ _ ______ _
Casts: Hyaline•-------------Granular ____ ___ _____ _
WBC m ABC. ___________ _
Other-------------
Bacteria ____________ _
Renal Cells -----------Crystals -------------
• _N. 'RnL RECORDS
Results
TECH/PATH----4(1-"h'-L-- Oate tfcz,!n,/q (#a"-
OBSERVATION
IY: sf T QYifS ANIMAL ID: !5 '-/ le L d-/e re
-llate: 9/ 1'-/l )59 8'1J5J I
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St J } s�v.J
REOUESTEO BY
0 URINALYSIS COLLECTION METHOO
INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY (Reason lor submission)
OATE SUBMITTED
0MICROSCOPIC COMMENTS OIRECT
Compression ___________ _ Trfc.c+.-a Gt�rcx .. <o.. (C{"''S Catheterization __________ _
Cage _____________ _ m-e-t-ro '>'I i d a zo (e Sr d Oth"--------------
CHEMISTRY (chemstrip-8)
Sugar ____________ .::m:.":g/� dl
Albumin ___________ _:m:::g�/dl
Hemoglobin ERY/ug CYTOCENTRIFUGE
Acetone'-------------Bilirubin ____________ _
Urobilinogen __________ _:m� g'C:::/d l
Occult blood _________ __:cE::_RY:_:i2 ug
Nitrite
Sp G' -------------
pH _ _ _ _ _ _ _ _ ___ _ ___
Color _____________ _
Turbidity ____________ _
MICROSCOPIC
WBC _ __ ________ ___
ABC _ __ _ _ __ _ _ __ _
Casts
Hyaline _ ___________ _
Granular ____________ _
WBC o' ABC. ___________ _
Other-------------
Bacteria ____________ _
Renal Cells -----------CrystalS -------------
C[ NTRAL '<ECORDS
TECH/PATH Date
6lfFECAL .... )EST REQUESTED �Parasites 0 Trypsin OOther
Procedure Used ______________ _
Results
TECH/PATH----'-'(!,JJ"-"--- Oate-e ��/.l:.i�"f..�.aX"J..f..-_
INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY {Reason for submission)
REQUESTED BY
0 URINALYSIS COLLECTION METHOD
84/Y]
Compression ___________ _
Catheterization __________ _
Cage _____________ ___c
Other _____________ _
CHEMISTRY {chemstrip·8) Sugar ____________ _::m:.!!g/� dl
Albumin ____________ m::.:g/=d l
DATE SUBMITTED
OMICROSCOPIC COMMENTS DIRECT:
Hemoglobin ERY/ug CYTOCENTRIFUGE Acetone ____________ _
Bilirubin ____________ _
Urobilinogen __________ ..:_m'-' g/c::dl
Occult blood _ _ ______ _ _:;ER..:.Y..:.i u2g
Nitrite
Sp Gr -------------pH _____________ _
Color _____________ _
Turbidity ____________ _ TECH/PATH
MICROSCOPIC 0FECAL TEST REQUESTED �Parasites
Date
OTrypsin DOther wsc ___________ _ Procedure Usedl ______________ _
RBC _ _ _ _ _ _ _ _ _____ _
Casts Hyaline'-------------
Granular ____________ _
WBC or ABC. ___________ _
Other _____________ _
Bacteria ____________ _
Renal Cells ___________ _
Crystals-------------
..;EIHRAL RECORDS
Results
TECH/PATH ___ c_C:IJ:;,j...L ___ Date
All..ULUlJ� ht:>CAHL.H llll.)IIIUit ll�llMLM IIUI'I ��INE/FECAL REPORT � HISTORY(ReasonforStJbmission) .-j 0 C.
Us10Jt i.:S1� !:.� � F; JcY/6� �) ::Lotf� /.:::)- . (? � ;r; ±�fs: 4-51� To)E SUBMITTEO O' REOUESTEO BY
OURINALYSIS COLLECTION METHOO
Compression _____ ______ _
Catheterizatio[1
Cage
Other ____________ _
CHEMISTRY (chemstrip-8) mg/dl Sugar mg/dl Albumin __________ -;E:;;R:yY/ug Hemoglobin _________ __c __
Acetone ____________ _
Bitirubin ___________ -;;;m;;Mg/dl Urobilinogen ---------�ER;,Y�/;;;;ug
Occult blood
Nilrile _ -===================== Sp. Gr.
pH -----------Color _____________ _
Turbidity ____________ _
MICROSCOPIC
WBC ______ _ _ _ _ -;-RBC __________ _
Casts:
Hyaline
Granular ------------WBC or ABC _________ _ _
Other-------------
Bacteria ____________ _
Renal Cells-----------,�Crystals -------------
CENTRAL RECORDS
0MICROSCOPIC COMMENTS: OIAECT:
CYTOCENTRIFUGE:
TECH/PATH Date
Cl/�����EQUESTEO .lp Parasites 0Trypsin OOther
Procedure Used
Re9.JltS
CD Oate I?_,(Rf/C1 TECH/PATH ___ _._..._"----
TABLE 2 Cjfl_,))-
Mechnisms of Radiation Induced Cancers: Assignment of Dogs for Studies Other Than Immunology
Malefl'attoo Blrthdate Malt!f&ttoo Blrthdate
1491 B 87133 1538 B 89134
1494 D 87143 1539A 89140
1495 c 87147 1539 D 89140
1506 D 88004 1546A 89165
1507 B 88032 1546 B 89165
1508 A 88043 1546 c 89165
1510A 88081 1546D 89165
1513 B 88120 1546 E 89165
1513 c 88120 1546 F 89165
1514 B 88133 1546 G 89165
1518 c 88261 1547 A 89168
1518 D 88261 1548 A 89182
1518 E 88261 1548 B 89182
1518 F 88261 1548 c 89182
1521 A 88279 1550 B 89191
1521 B 88279 1551 c 89196
1522 B 88323 1552 A 89200
1523A 88330 1552 B 89200
1523 B 88330 1553 A 89206
1524 A 88340 1553 B 89206
1524 B 88340 1556A 89342
1524 c 88340 1557 A 89353
1525 B 88348 1558 B 89354
1532 c 89040 1558 c 89354
1533 c 89078 1560A 90055
1534 A 89089 1560 B 90055
1534 B 89089 1565 A 90163
1534 c 89089 1565 B 90163
1534 D 89089 1567 A 90270
1534 E 89089
TABLE 1
Mechanism of Radiation Induced Cancers: Assignment of Dogs for Studies Other Than Immunology
[emalrl!attoo Birthdate Fcmal!lfattoo Birthdate
1498 u 87180 1525 s 88348
1501 T 87227 1529 T 88023
1502 s 87228 1537 T 89123
1508 T 88043 1541 T 89145
1509 s 88062 1542 s 89154
1509T 88062 1545 T 89163
1509 u 88062 1546 s 89165
1511 s 88088 1546T 89165
1511 u 88088 1547 s 89168
1512 s 88111 1547 T 89168
1512 u 88111 1547 u 89168
1514 T 88133 1548 s 89182
1514 v 88133 1548 T 89182
1515 T 88141 1548 v 89182
1515 u 88141 1550 T 89191
1515 v 88141 1551 s 89196
1516 T 88146 1551 T 89196
1516 u 88146 1552 s 89200
1517 u 88160 1552 T 89200
1521 s 88279 1552 u 89200
1521 T 88279 1553 s 89206
1521 u 88279 1553 T 89206
1522 s 88323 1553 u 89206
1522 v 88323 1556 s 89342
1522 w 88323 1557 s 89353
1523 s 88330 1560 s 90055
1523 T 88330 1560 T 90055
1523 u 88330 15655 90163
1523 v 88330 1567 s 90270
1524 s 88340
INTEROFFICE MEMORANDUM January 22, 1991
TO: Dr. F. F. Hahn
FROM: Dr. B. A Muggenburg �
SUBJECT: Mechanisms of Radiation Induced Cancer: Assignment of Dogs for Studies Other than Immunology
The dogs listed in the attached tables are available for this study for exposure
after January I, 1991. We have assigned equal numbers of males (59) and females (59).
These dogs were born from May, 1987 to September, 1991. This allows for an exposure
window beginning now until October, 1991. Ten extra dogs were assigned to allow for
the exclusion of dogs that receive too much or too little plutonium aerosol.
BAM: pis WI Attachments
XC: Dr. C H. Hobbs Dr. D. G. Thomassen Dr. B. B. Boecker Dr. N. F. Johnson Dr. K. J. Nikula Dr. D. G. Burt
