Table S1. Distribution of discrimination scores (DSs) for pathway cross-talks.

Pathway cross-talks DS scores

Role of NFAT in Regulation of the Immune Response Prostanoid Biosynthesis 0.212938 G Protein Signaling Mediated by Tubby 0.004802 Graft-versus-Host Disease Signaling 0.004756 Antigen Presentation Pathway 0.004756 Glutamate Receptor Signaling 0.004802 Activation of IRF by Cytosolic Pattern Recognition Receptors 0.111934 Eicosanoid Signaling 0.212938 Antiproliferative Role of Somatostatin Receptor 2 0.004802 CCR5 Signaling in Macrophages 0.004802 T Helper Cell Differentiation 0.004756 IL-4 Signaling 0.004756 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.004756 Ephrin B Signaling 0.004802 Crosstalk between Dendritic Cells and Natural Killer Cells 0.004756 _-Adrenergic Signaling 0.004802 G Beta Gamma Signaling 0.004802 SAPK/JNK Signaling 0.004802 IL-1 Signaling 0.004802 iCOS-iCOSL Signaling in T Helper Cells 0.004756 Type I Diabetes Mellitus Signaling 0.004756 fMLP Signaling in Neutrophils 0.004802 G_s Signaling 0.004802 CD28 Signaling in T Helper Cells 0.004756 Androgen Signaling 0.004802 PKC_ Signaling in T Lymphocytes 0.004756 CCR3 Signaling in Eosinophils 0.004802 P2Y Purigenic Receptor Signaling Pathway 0.004802 G_i Signaling 0.004802 Cardiac _-adrenergic Signaling 0.004802 Relaxin Signaling 0.004802 G_q Signaling 0.004802 Tec Kinase Signaling 0.004802 CXCR4 Signaling 0.004802 Dendritic Cell Maturation 0.004756 EIF2 Signaling 0.182708 CREB Signaling in Neurons 0.004802 RhoGDI Signaling 0.004802 Ephrin Receptor Signaling 0.004802 Role of NFAT in Cardiac Hypertrophy 0.004802 IL-8 Signaling 0.004802 Breast Cancer Regulation by Stathmin1 0.004802 Thrombin Signaling 0.004802 Huntington's Disease Signaling 0.004802 Cardiac Hypertrophy Signaling 0.004802 Phospholipase C Signaling 0.004802 Prostanoid Biosynthesis G Protein Signaling Mediated by Tubby 0.094553 Graft-versus-Host Disease Signaling 0.099319 Antigen Presentation Pathway 0.099319 Glutamate Receptor Signaling 0.094553 Activation of IRF by Cytosolic Pattern Recognition Receptors 0.043788 Eicosanoid Signaling 0 Antiproliferative Role of Somatostatin Receptor 2 0.094553 CCR5 Signaling in Macrophages 0.094553 T Helper Cell Differentiation 0.099319 IL-4 Signaling 0.099319 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.099319 Ephrin B Signaling 0.094553

2

Crosstalk between Dendritic Cells and Natural Killer Cells 0.099319 _-Adrenergic Signaling 0.094553 G Beta Gamma Signaling 0.094553 SAPK/JNK Signaling 0.094553 IL-1 Signaling 0.094553 iCOS-iCOSL Signaling in T Helper Cells 0.099319 Type I Diabetes Mellitus Signaling 0.099319 fMLP Signaling in Neutrophils 0.094553 G_s Signaling 0.094553 CD28 Signaling in T Helper Cells 0.099319 Androgen Signaling 0.094553 PKC_ Signaling in T Lymphocytes 0.099319 CCR3 Signaling in Eosinophils 0.094553 P2Y Purigenic Receptor Signaling Pathway 0.094553 G_i Signaling 0.094553 Cardiac _-adrenergic Signaling 0.094553 Relaxin Signaling 0.004802 G_q Signaling 0.094553 Tec Kinase Signaling 0.094553 CXCR4 Signaling 0.094553 Dendritic Cell Maturation 0.099319 EIF2 Signaling 0.012722 CREB Signaling in Neurons 0.094553 RhoGDI Signaling 0.094553 Ephrin Receptor Signaling 0.094553 Role of NFAT in Cardiac Hypertrophy 0.094553 IL-8 Signaling 0.094553 Breast Cancer Regulation by Stathmin1 0.094553 Thrombin Signaling 0.094553 Huntington's Disease Signaling 0.094553 Cardiac Hypertrophy Signaling 0.094553 Phospholipase C Signaling 0.094553 G Protein Signaling Mediated by Tubby Graft-versus-Host Disease Signaling 0.004811 Antigen Presentation Pathway 0.004811 Glutamate Receptor Signaling 0 Activation of IRF by Cytosolic Pattern Recognition Receptors 0.050976 Eicosanoid Signaling 0.094553 Antiproliferative Role of Somatostatin Receptor 2 0 CCR5 Signaling in Macrophages 0 T Helper Cell Differentiation 0.004811 IL-4 Signaling 0.004811 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.004811 Ephrin B Signaling 0 Crosstalk between Dendritic Cells and Natural Killer Cells 0.004811 _-Adrenergic Signaling 0 G Beta Gamma Signaling 0 SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0.004802

3

G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Graft-versus-Host Disease Signaling Antigen Presentation Pathway 0 Glutamate Receptor Signaling 0.004811 Activation of IRF by Cytosolic Pattern Recognition Receptors 0.055773 Eicosanoid Signaling 0.099319 Antiproliferative Role of Somatostatin Receptor 2 0.004811 CCR5 Signaling in Macrophages 0.004811 T Helper Cell Differentiation 0 IL-4 Signaling 0 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0 Ephrin B Signaling 0.004811 Crosstalk between Dendritic Cells and Natural Killer Cells 0 _-Adrenergic Signaling 0.004811 G Beta Gamma Signaling 0.004811 SAPK/JNK Signaling 0.004811 IL-1 Signaling 0.004811 iCOS-iCOSL Signaling in T Helper Cells 0 Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004802 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 Antigen Presentation Pathway Glutamate Receptor Signaling 0.004811 Activation of IRF by Cytosolic Pattern Recognition Receptors 0.055773

4

Eicosanoid Signaling 0.099319 Antiproliferative Role of Somatostatin Receptor 2 0.004811 CCR5 Signaling in Macrophages 0.004811 T Helper Cell Differentiation 0 IL-4 Signaling 0 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0 Ephrin B Signaling 0.004811 Crosstalk between Dendritic Cells and Natural Killer Cells 0 _-Adrenergic Signaling 0.004811 G Beta Gamma Signaling 0.004811 SAPK/JNK Signaling 0.004811 IL-1 Signaling 0.004811 iCOS-iCOSL Signaling in T Helper Cells 0 Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004802 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 Glutamate Receptor Signaling Activation of IRF by Cytosolic Pattern Recognition Receptors 0.050976 Eicosanoid Signaling 0.094553 Antiproliferative Role of Somatostatin Receptor 2 0 CCR5 Signaling in Macrophages 0 T Helper Cell Differentiation 0.004811 IL-4 Signaling 0.004811 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.004811 Ephrin B Signaling 0 Crosstalk between Dendritic Cells and Natural Killer Cells 0.004811 _-Adrenergic Signaling 0 G Beta Gamma Signaling 0 SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0

5

P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0.004802 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Activation of IRF by Cytosolic Pattern Recognition Receptors Eicosanoid Signaling 0.043788 Antiproliferative Role of Somatostatin Receptor 2 0.050976 CCR5 Signaling in Macrophages 0.050976 T Helper Cell Differentiation 0.055773 IL-4 Signaling 0.055773 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.055773 Ephrin B Signaling 0.050976 Crosstalk between Dendritic Cells and Natural Killer Cells 0.055773 _-Adrenergic Signaling 0.050976 G Beta Gamma Signaling 0.050976 SAPK/JNK Signaling 0.050976 IL-1 Signaling 0.050976 iCOS-iCOSL Signaling in T Helper Cells 0.055773 Type I Diabetes Mellitus Signaling 0.055773 fMLP Signaling in Neutrophils 0.050976 G_s Signaling 0.050976 CD28 Signaling in T Helper Cells 0.055773 Androgen Signaling 0.050976 PKC_ Signaling in T Lymphocytes 0.055773 CCR3 Signaling in Eosinophils 0.050976 P2Y Purigenic Receptor Signaling Pathway 0.050976 G_i Signaling 0.050976 Cardiac _-adrenergic Signaling 0.050976 Relaxin Signaling 0.004802 G_q Signaling 0.050976 Tec Kinase Signaling 0.050976 CXCR4 Signaling 0.050976 Dendritic Cell Maturation 0.055773 EIF2 Signaling 0.031084 CREB Signaling in Neurons 0.050976 RhoGDI Signaling 0.050976 Ephrin Receptor Signaling 0.050976 Role of NFAT in Cardiac Hypertrophy 0.050976 IL-8 Signaling 0.050976 Breast Cancer Regulation by Stathmin1 0.050976 Thrombin Signaling 0.050976 Huntington's Disease Signaling 0.050976 Cardiac Hypertrophy Signaling 0.050976 Phospholipase C Signaling 0.050976 Eicosanoid Signaling Antiproliferative Role of Somatostatin Receptor 2 0.094553

6

CCR5 Signaling in Macrophages 0.094553 T Helper Cell Differentiation 0.099319 IL-4 Signaling 0.099319 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.099319 Ephrin B Signaling 0.094553 Crosstalk between Dendritic Cells and Natural Killer Cells 0.099319 _-Adrenergic Signaling 0.094553 G Beta Gamma Signaling 0.094553 SAPK/JNK Signaling 0.094553 IL-1 Signaling 0.094553 iCOS-iCOSL Signaling in T Helper Cells 0.099319 Type I Diabetes Mellitus Signaling 0.099319 fMLP Signaling in Neutrophils 0.094553 G_s Signaling 0.094553 CD28 Signaling in T Helper Cells 0.099319 Androgen Signaling 0.094553 PKC_ Signaling in T Lymphocytes 0.099319 CCR3 Signaling in Eosinophils 0.094553 P2Y Purigenic Receptor Signaling Pathway 0.094553 G_i Signaling 0.094553 Cardiac _-adrenergic Signaling 0.094553 Relaxin Signaling 0.094553 G_q Signaling 0.094553 Tec Kinase Signaling 0.094553 CXCR4 Signaling 0.094553 Dendritic Cell Maturation 0.099319 EIF2 Signaling 0.012722 CREB Signaling in Neurons 0.094553 RhoGDI Signaling 0.094553 Ephrin Receptor Signaling 0.094553 Role of NFAT in Cardiac Hypertrophy 0.094553 IL-8 Signaling 0.094553 Breast Cancer Regulation by Stathmin1 0.094553 Thrombin Signaling 0.094553 Huntington's Disease Signaling 0.094553 Cardiac Hypertrophy Signaling 0.094553 Phospholipase C Signaling 0.094553 Antiproliferative Role of Somatostatin Receptor 2 CCR5 Signaling in Macrophages 0 T Helper Cell Differentiation 0.004811 IL-4 Signaling 0.004811 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.004811 Ephrin B Signaling 0 Crosstalk between Dendritic Cells and Natural Killer Cells 0.004811 _-Adrenergic Signaling 0 G Beta Gamma Signaling 0 SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0

7

Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 CCR5 Signaling in Macrophages T Helper Cell Differentiation 0.004811 IL-4 Signaling 0.004811 Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0.004811 Ephrin B Signaling 0 Crosstalk between Dendritic Cells and Natural Killer Cells 0.004811 _-Adrenergic Signaling 0 G Beta Gamma Signaling 0 SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 T Helper Cell Differentiation IL-4 Signaling Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0 Ephrin B Signaling 0.004811 Crosstalk between Dendritic Cells and Natural Killer Cells 0 _-Adrenergic Signaling 0.004811 G Beta Gamma Signaling 0.004811 SAPK/JNK Signaling 0.004811 IL-1 Signaling 0.004811 iCOS-iCOSL Signaling in T Helper Cells 0

8

Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 IL-4 Signaling Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 0 Ephrin B Signaling 0.004811 Crosstalk between Dendritic Cells and Natural Killer Cells 0 _-Adrenergic Signaling 0.004811 G Beta Gamma Signaling 0.004811 SAPK/JNK Signaling 0.004811 IL-1 Signaling 0.004811 iCOS-iCOSL Signaling in T Helper Cells 0 Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811

9

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis Ephrin B Signaling 0.004811 Crosstalk between Dendritic Cells and Natural Killer Cells 0 _-Adrenergic Signaling 0.004811 G Beta Gamma Signaling 0.004811 SAPK/JNK Signaling 0.004811 IL-1 Signaling 0.004811 iCOS-iCOSL Signaling in T Helper Cells 0 Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 Ephrin B Signaling Crosstalk between Dendritic Cells and Natural Killer Cells 0.004811 _-Adrenergic Signaling 0 G Beta Gamma Signaling 0 SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0

10

IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Crosstalk between Dendritic Cells and Natural Killer Cells _-Adrenergic Signaling 0.004811 G Beta Gamma Signaling 0.004811 SAPK/JNK Signaling 0.004811 IL-1 Signaling 0.004811 iCOS-iCOSL Signaling in T Helper Cells 0 Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 Adrenergic Signaling G Beta Gamma Signaling 0 SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0

11

Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 G Beta Gamma Signaling SAPK/JNK Signaling 0 IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 SAPK/JNK Signaling IL-1 Signaling 0 iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0

12

IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 IL-1 Signaling iCOS-iCOSL Signaling in T Helper Cells 0.004811 Type I Diabetes Mellitus Signaling 0.004811 fMLP Signaling in Neutrophils 0 G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 iCOS-iCOSL Signaling in T Helper Cells Type I Diabetes Mellitus Signaling 0 fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811

13

Type I Diabetes Mellitus Signaling fMLP Signaling in Neutrophils 0.004811 G_s Signaling 0.004811 CD28 Signaling in T Helper Cells 0 Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 fMLP Signaling in Neutrophils G_s Signaling 0 CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 G_s Signaling CD28 Signaling in T Helper Cells 0.004811 Androgen Signaling 0 PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0

14

Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 CD28 Signaling in T Helper Cells Androgen Signaling 0.004811 PKC_ Signaling in T Lymphocytes 0 CCR3 Signaling in Eosinophils 0.004811 P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 Androgen Signaling PKC_ Signaling in T Lymphocytes 0.004811 CCR3 Signaling in Eosinophils 0 P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 PKC_ Signaling in T Lymphocytes CCR3 Signaling in Eosinophils 0.004811

15

P2Y Purigenic Receptor Signaling Pathway 0.004811 G_i Signaling 0.004811 Cardiac _-adrenergic Signaling 0.004811 Relaxin Signaling 0.004811 G_q Signaling 0.004811 Tec Kinase Signaling 0.004811 CXCR4 Signaling 0.004811 Dendritic Cell Maturation 0 EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 CCR3 Signaling in Eosinophils P2Y Purigenic Receptor Signaling Pathway 0 G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 P2Y Purigenic Receptor Signaling Pathway G_i Signaling 0 Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 G_i Signaling Cardiac _-adrenergic Signaling 0 Relaxin Signaling 0

16

G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Cardiac-adrenergic Signaling Relaxin Signaling 0 G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Relaxin Signaling G_q Signaling 0 Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 G_q Signaling Tec Kinase Signaling 0 CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0

17

Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Tec Kinase Signaling CXCR4 Signaling 0 Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 CXCR4 Signaling Dendritic Cell Maturation 0.004811 EIF2 Signaling 0.08193 CREB Signaling in Neurons 0 RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Dendritic Cell Maturation EIF2 Signaling 0.086707 CREB Signaling in Neurons 0.004811 RhoGDI Signaling 0.004811 Ephrin Receptor Signaling 0.004811 Role of NFAT in Cardiac Hypertrophy 0.004811 IL-8 Signaling 0.004811 Breast Cancer Regulation by Stathmin1 0.004811 Thrombin Signaling 0.004811 Huntington's Disease Signaling 0.004811 Cardiac Hypertrophy Signaling 0.004811 Phospholipase C Signaling 0.004811 EIF2 Signaling CREB Signaling in Neurons 0.08193 RhoGDI Signaling 0.08193 Ephrin Receptor Signaling 0.08193 Role of NFAT in Cardiac Hypertrophy 0.08193 IL-8 Signaling 0.08193 Breast Cancer Regulation by Stathmin1 0.08193 Thrombin Signaling 0.08193 Huntington's Disease Signaling 0.08193 Cardiac Hypertrophy Signaling 0.08193 Phospholipase C Signaling 0.08193 CREB Signaling in Neurons RhoGDI Signaling 0 Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0

18

Phospholipase C Signaling 0 RhoGDI Signaling Ephrin Receptor Signaling 0 Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Ephrin Receptor Signaling Role of NFAT in Cardiac Hypertrophy 0 IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Role of NFAT in Cardiac Hypertrophy IL-8 Signaling 0 Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 IL-8 Signaling Breast Cancer Regulation by Stathmin1 0 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Breast Cancer Regulation by Stathmin1 Thrombin Signaling 0 Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Thrombin Signaling Huntington's Disease Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Huntington's Disease Signaling Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling 0 Cardiac Hypertrophy Signaling 0 Phospholipase C Signaling