TABLE OF CONTENTS - Tech Transfer Central · 2013. 9. 3. · BG Medicine Biocon Group BioDelivery Sciences BioDrain Medical Biogen Idec BiolineRX BioMedica Life Sciences Biomedical

This brochure is published by Wildwood Ventures Ltd.

© 2013 – CurrentPartnering, a division of Wildwood Ventures Limited.

TABLE OF CONTENTS

Executive Summary

Chapter 1 – Introduction

Chapter 2 – Trends in manufacturing and supply dealmaking

2.1. Introduction 2.2. Difference between manufacturing and supply deals 2.3. Trends in manufacturing deals since 2009 2.4. Trends in supply deals since 2009

2.4.1. When supply can be useful 2.5. Attributes of pure manufacturing and supply deals 2.6. Attributes of manufacturing and supply in multi-component deals 2.7. Reasons for including manufacturing and supply options in a multicomponent deal 2.8. The future of manufacture and supply as part of multicomponent deals

Chapter 3 – Overview of manufacturing and supply deal structure

3.1. Introduction 3.2. Pure versus multi-component manufacturing deals 3.3. Pure manufacturing agreement structure

3.3.1. Example manufacturing agreements 3.3.1.a. Case study 1: Amyris Brazil – Biomin Nutricao Animal Do Brasil 3.3.1.b. Case study 2: Patheon – Orexigen Therapeutics

3.4. Manufacturing rights as part of a wider alliance agreement 3.4.1. Example multicomponent manufacturing clauses 3.4.1.a. Case study 3: Agenus Bio – NewVac 3.4.1.b. Case study 4: Elite Pharmaceuticals – Hi-Tech Pharmacal

Chapter 4 – Overview of supply deal structure

4.1. Introduction 4.2. Supply agreement structure

4.2.1. Example supply agreements 4.2.1.a. Case study 5: Omthera Pharmaceuticals – Catalent Pharma solutions 4.2.1.b. Case study 6: Endo Pharmaceuticals – Noramco

4.3. Supply rights as part of a wider alliance agreement 4.3.1. Example co-marketing right clauses 4.3.1.a. Case study 7: Auxilium Pharmaceuticals – Asahi Kasei 4.3.1.b. Case study 8: Durata Therapeutics - Hospira



Chapter 5 – Leading manufacturing deals

5.1. Introduction 5.2. Top manufacturing deals by value 5.3. Most active manufacturing dealmakers 5.4. Big pharma manufacturing deal activity 5.5. Big biotech manufacturing deal activity

Chapter 6 – Leading supply deals

6.1. Introduction 6.2. Top supply deals by value 6.3. Most active supply dealmakers 6.4. Bigpharma supply deal activity 6.4. Big biotech supply deal activity

Chapter 7 – Big pharma manufacturing and supply deals

7.1. Introduction 7.2. How to use manufacturing and supply deals 7.3. Bigpharma company manufacturing and supply deal profiles

Abbott Abbott Medical Optics Abbott Japan Abbott Laboratories Actavis (formerly knows as Watson) Allergan Amgen Astellas AstraZeneca Baxter International Bayer Biogen Idec Boehringer Ingelheim Bristol-Myers Squibb Celgene CSL Daiichi Sankyo Dainippon Sumitomo Eisai Eli Lilly Endo Pharmaceuticals



Forest Laboratories Fresenius Galderma Gilead Sciences GlaxoSmithKline Grifols Hospira Johnson & Johnson Kyowa Hakko Kirin Lundbeck Menarini Merck & Co Merck KGaA Mylan Novartis Novo Nordisk Otsuka Pfizer Pfizer Purdue Ranbaxy Laboratories Roche Sanofi Servier Shionogi Shire Takeda Teva UCB Valeant Warner Chilcott

Chapter 8 – Bigbiotech manufacturing and supply deals

8.1. Introduction 8.2. How to use bigbiotech partnering deals 8.3. Bigbiotech manufacturing and supply partnering company profiles

3SBio Acorda Therapeutics Actelion



Alkermes Alnylam Pharmaceuticals Bavarian Nordic Biocon Biogen Idec Cangene Celgene CSL Cubist Dendreon Elan Emergent BioSolutions Enzo Biochem Galapagos Genmab Gilead Sciences Grifols Ipsen Isis Pharmaceuticals LFB Group Medivation Morphosys Nektar Therapeutics Novo Nordisk NPS Pharmaceuticals Onyx Pharmaceuticals Optimer Questcor Pharmaceuticals SciClone Pharmaceuticals Seattle Genetics Spectrum Pharmaceuticals Swedish Orphan Biovitrum The Medicines Company United Therapeutics ViroPharma

Chapter 9 – Manufacturing contracts directory

9.1. Introduction 9.2. Company A-Z



Aastrom Biosciences Abbott Laboratories ACADIA Pharmaceuticals ACS Dobfar ADMA Biologics Advance Pharmaceutical Advanced Biohealing Agenus Bio Albany Molecular Research Alexza Pharmaceuticals Alimera Sciences Alkaloida Chemical Company Allergan Alliance Medical Products Alnylam Pharmaceuticals Alseres Pharmaceuticals Amgen Amicus Therapeutics Amol Pharmaceuticals Amylin Pharmaceuticals Amyris Biotechnologies Amyris Brazil Antigenics Applied DNA Sciences Arch Pharmalabs Arena Pharmaceuticals Ascend Laboratories ATEK Medical Aubrey Group Autoliv ASP Auxilium Pharmaceuticals Avanir Pharmaceuticals Bachem Baxter Healthcare Biocon Group Biomedical Advanced Research and Development Authority BioMimetic Therapeutics Biomin Nutricao Animal Do Brasil Biotage



Biotest Pharmaceuticals Biovail BioVectra BioZone Laboratories Boston Therapeutics Cadence Pharmaceuticals Caliper Life Sciences Caraco Pharmaceuticals Cardinal Health Cardium Therapeutics Catalent Pharma Solutions Cell Solutions Cell Therapeutics Cellceutix Clinical Micro Sensors Cobra Biologics Codexis Columbia Laboratories Comvita New Zealand Corgenix Medical Cornerstone Therapeutics Cryolife CSO Cubist Pharmaceuticals CytoCore Derma Sciences DPT Laboratories Durata Therapeutics Durect Eckert & Ziegler ECR Pharmaceuticals Eisai Elan Elite Pharmaceuticals Emergent BioSolutions Esaote Escalon Vascular Access Evonik Degussa Finorga



Fleet Laboratories Flextronics Genentech Generex Biotechnology GenVec Genzyme Geron Gilead Sciences Girindus GlaxoSmithKline GlaxoSmithKline Biologicals Gnosis Bioresearch GTC Biotherapeutics Hansen Medical Hi-Tech Pharmacal Horizon Pharma AG Horizon Pharma Inc Horizon Pharma USA Hospira Hovione Idenix Pharmaceuticals ImmunoGen Inspire Pharmaceuticals Integra Labs Intendis InterMune International Stem Cell Jagotec Janssen Alzheimer Immunotherapy King Pharmaceuticals KMC Systems Kythera Biopharmaceuticals Lev Pharmaceuticals LG Life Sciences LipoScience Lonza Mallinckrodt Matsuura MDS Nordion



Medigen Biotechnology Merrimack Pharmaceuticals Mglas Micromet Mikah Pharma Misonix Molecular Insight Pharmaceuticals Moxisign Mundipharma Nektar Therapeutics NerPharMa Neurobiological Technologies NewVac Nitec Pharma Nordmark Arzneimittel Norgine NovaDel Pharma Novartis Novasep Novavax Novo Nordisk NPS Pharmaceuticals NuVasive Nycomed Omthera Pharmaceuticals OPKO Health Optimer Pharmaceuticals Oramed Pharmaceuticals Orexigen Therapeutics Osiris Therapeutics Osmetech Oso Bio Pharmaceuticals Oxygen Biotherapeutics Pacira Pharmaceuticals Paradigm Medical Industries Patheon Pfizer PharmaEngine Plexus



Prana Biotechnology Printcolor Screen Progen Pharmaceuticals Prometheus Protalix BioTherapeutics Quick Med Technologies Radius Health Revolutions Medical Roquette S2 Therapeutics Sanguin Blood Supply Foundation Sanofi-Aventis Sanquin Blood Supply Foundation Santarus Schering-Plough SciClone Pharmaceuticals Seattle Genetics Serenity Pharmaceuticals Siegfried SkyePharma Solazyme-Roquette Nutritionals Solazyme Starch Medical Sun Pharmaceutical Symbollon SynCo Bio Partners Talecris Biotherapeutics Targeted Genetics Techniscan Tekmira Pharmaceuticals Tesaro The Automation Partnership ThePharmaNetwork Theravance Unicep Packaging USHIFU Usina Sao Martinho Vascular Solutions VeroScience



Vetter Viridis BioPharma Viropharma Wuxi Yushou Medical Appliances Yamasa Zeltiq Aesthetics Zoetis Zogenix

9.3. By stage of development Discovery Formulation Marketed Phase I Phase II Phase III Preclinical Regulatory

9.4. By therapeutic target Cardiovascular Central Nervous System Dermatology Gastrointestinal Genetic disorders Gynaecology Hematology Hospital care Immunology Infectives Metabolic Musculoskeletal Oncology Ophthalmics Pediatrics Respiratory

9.5. By technology type Analysis Antibodies Assays Biodefense



Biological compounds Biomarkers Biomaterials Blood products Cell culture Cell therapy Clinical testing Devices Diagnostics Discovery tools Drug delivery Enabling technology Enviromental Equipment Facilities Gene therapy Implant Industrial chemicals In vitro models Natural product Oligonucleotide Packaging Peptides Personalised medicine Processes Proteomics Radio/Chemo-therapy Recombinant DNA Research services Research supplies RNA therapeutics Screening Small molecules Software tools Stem cells Toxicity Vaccines

Chapter 10 – Supply contracts directory



10.1. Introduction 10.2. Company A-Z

3M 3M Drug Delivery Systems Aastrom Biosciences Abbott Japan Abbott Laboratories ABX-CRO Advanced Pharmaceutical Services Accellent Accentia Biopharmaceuticals Acorda Therapeutics ACS Dobfar Actavis ADMA Biologics Advance Pharmaceutical Albany Molecular Research Alchemia Alexza Pharmaceuticals Alimera Sciences Alkermes Allergan Alliance Medical Products Allos Therapeutics Alnylam Pharmaceuticals Alseres Pharmaceuticals Altair Nanotechnologies Amarillo Biosciences Amarin American Red Cross AmerisourceBergen Amersham Biosciences Amgen Amol Pharmaceuticals Amylin Pharmaceuticals Anavex Life Sciences Anika Therapeutics Antigenics Applied DNA Sciences Arch Pharmalabs



Arena Pharmaceuticals Aristos Pharmaceuticals Arius Pharmaceuticals Asahi Kasei Ascend Laboratories ASD Speciality Healthcare Astellas ATEK Medical Atlantic Healthcare Autoliv ASP Auxilium Pharmaceuticals Avanir Pharmaceuticals B Braun Bachem BASF Baxter Healthcare BG Medicine Biocon Group BioDelivery Sciences BioDrain Medical Biogen Idec BiolineRX BioMedica Life Sciences Biomedical Advanced Research and Development Authority BioMimetic Therapeutics Bioniche Pharma BioScrip Biotest Biotest Pharmaceuticals Biovail BioVectra Boston Therapeutics Cadence Pharmaceuticals Cadila Pharmaceuticals Cambridge Heart Cangene Cardinal Health Catalent Pharma Solutions Cell Therapeutics



Cellceutix Celsion CJ CheilJedang Cleveland BioLabs Codexis Colloral Columbia Laboratories CombiMatrix Comvita New Zealand Conceptus Corgenix Medical CorMedix Cornerstone Therapeutics Coronado Biosciences CP Pharmaceuticals CPL Biologicals CSO Cubist Pharmaceuticals CyDex Cyto Biotech Cytovance Biologics Delcath Systems Dendreon Department of Defense Department of Health and Human Services DePuy Mitek Derma Sciences Diosynth Durata Therapeutics Durect Eckert & Ziegler Eisai Elan Eli Lilly Elite Pharmaceuticals Emergent BioSolutions Endo Pharmaceuticals EpiCept Escalon Vascular Access



Esprit Pharma Euticals Evonik Degussa Exfluor Research Finorga Fleet Laboratories Futurebiotics GE Healthcare Generex Biotechnology Genesis BioPharma Genomatica Genzyme Geron Gilead Sciences Girindus GlaxoSmithKline GlaxoSmithKline Biologicals Gnosis Bioresearch GTC Biotherapeutics Hangzhou Zhencheng Pharmaceuticals Hansen Medical Helix BioMedix HemaCare Hi-Tech Pharmacal Hollister-Stier Labs Horizon Pharma AG Horizon Pharma Inc Horizon Pharma USA Hospira Human Genome Sciences Hyperion Therapeutics Hypertension Diagnostics Ikaria Illumina Indevus Pharmaceuticals Inspire Pharmaceuticals Intas Biopharmaceuticals Interchem Ironwood Pharmaceuticals



Isis Pharmaceuticals ISSI-Strategy Jagotec Janssen Alzheimer Immunotherapy Jazz Pharmaceuticals Jiangsu Yabang Pharmaceuticals Johann Haltermann JPI Commercial King Pharmaceuticals Kunwha Pharmaceuticals KV Pharmaceutical Kythera Biopharmaceuticals LabCorp Lev Pharmaceuticals Ligand Pharmaceuticals Lonza Luna Innovations Luna Technologies Martek Biosciences MDS Nordion Mead Johnson Nutrition Meda Medical Action Industries MediciNova Medpace Merck and Co Mglas Micromet Mikah Pharma Molecular Insight Pharmaceuticals Moxisign Mundipharma Myriant Technologies Navinta Nektar Therapeutics NerPharMa NeurogesX Nitec Pharma Noramco



Norgine Novartis Novasep Novation Novavax Novel Laboratories Novozymes Biopharma NPS Pharmaceuticals NuGlow Cosmaceuticals NuVasive Nycomed Ocean Nutrition Canada Oculus Innovative Sciences Omthera Pharmaceuticals Optimer Pharmaceuticals Oradisc Oramed Pharmaceuticals Organichem Osiris Therapeutics OvaMed Oxygen Biotherapeutics Paradigm Medical Industries Patheon Pfizer Pharmacyclics Pharming Group Piedmont Chemical Industries Poli Industria Chimica Polypeptide Laboratory Prasco Laboratories Printcolor Screen Prometheus Protalix BioTherapeutics Provista Purdue Pharma Questcor Pharmaceuticals R-Tech Ueno Radius Health Repligen



Revolutions Medical Rib-X Pharmaceuticals RTI Biologics SAFC Salix Pharmaceuticals Sanofi-Aventis Santarus SciClone Pharmaceuticals Seattle Genetics Servier Shaanxi Jiali Pharmaceuticals Shandong Yaoshan Pharmaceuticals Siegfried SIGA Technologies SkyePharma Solvay Somaxon Pharmaceuticals Sovereign Pharmaceuticals Spectrum Pharmaceuticals SPI Pharma Sucampo Pharmaceuticals Synageva BioPharma SynCo Bio Partners Synerx Pharma Takeda Pharmaceutical Talecris Biotherapeutics Targacept Tekmira Pharmaceuticals The Chemical Company ThePharmaNetwork Theravance Transcept Pharmaceuticals TTY Biopharm Uluru Unigene Laboratories University HealthSystem Consortium University of Minnesota US Army US Government



Vascular Solutions Vetter Viropharma Waste Management National Services Watson Pharmaceuticals Wilson Industrial Sales Company Wockhardt Wuxi Yushou Medical Appliances Xi’an Zaolutang Kushidai Pharmaceuticals Xoma Yakult Honsha Zimmer Zoetis Zogenix Zydus Pharmaceuticals

9.3. By stage of development Discovery Formulation Marketed Phase I Phase II Phase III Preclinical Regulatory

10.4. By therapeutic target Anaesthetics Cardiovascular Central Nervous System Dental Dermatology Gastrointestinal Genetic disorders Genitourinary Hematology Hospital care Immunology Infectives Metabolic Musculoskeletal



Oncology Ophthalmics Pediatrics Respiratory

10.5. By technology type Antibodies Assays Biodefense Biological compounds Biomarkers Biomaterials Blood products Cell culture Clinical testing Devices Diagnostics Discovery tools DNA probes Drug delivery Enabling technology Equipment Facilities Implant Industrial chemicals Nanotechnology Natural product Oligonucleotide Orphan drug Packaging Peptides Processes Proteomics Radio/Chemo-therapy Recombinant DNA Research services Research supplies RNA therapeutics Small molecules Software tools



Vaccines

About Wildwood Ventures

Current Partnering Current Agreements

Recent report titles from CurrentPartnering Order Form – Reports Order Form – Reports

View the accompanying appendices for:

Appendix 1 – Company A-Z manufacturing dealsAppendix 2 – By therapy area - manufacturingAppendix 3 – By stage of development at signing - manufacturingAppendix 4 – By technology type – manufacturingAppendix 5 – Company A-Z - supply dealsAppendix 6 – By therapy area - supplyAppendix 7 – By stage of development at signing - supplyAppendix 8 – By technology type – supplyAppendix 9 –Dealmaking referencesAppendix 10 – ResourcesAppendix 11 – Deal type definitionsAppendix 12 – Example supply contract document



TABLE OF FIGURES

Figure 1: Definition of manufacturing and supply Figure 2: Types of manufacturing agreement Figure 3: Trends in manufacturing deal announcements, 2009-2013 Figure 4: Manufacturing deals signed by phase of development, 2009-2013 Figure 5: Trends in supply deal announcements, 2009-2013 Figure 6: Supply deals signed at what phase of development, 2009-2013 Figure 7: Situations where supply deals can prove useful Figure 8: Components of the manufacturing deal structure Figure 9: Components of the supply deal structure Figure 10: Top manufacturing deals by value since 2009 Figure 11: Most active manufacturing dealmakers 2009-2013 Figure 12: Big pharma – top 50 – manufacturing deals 2009 to June 2013 Figure 13: Big pharma manufacturing deal frequency - 2009 to mid 2013 Figure 14: Big biotech – top 50 – manufacturing deals 2009 to June 2013 Figure 15: Top supply deals by value since 2009 Figure 16: Most active supply dealmakers 2009-2012 Figure 17: Bigpharma – top 50 – supply deals 2009 to 2013 Figure 18: Bigpharma supply deal frequency - 2009 to 2013 Figure 19: Big biotech – top 50 – supply deals 2009 to 2013 Figure 20: Big biotech supply deal frequency - 2009 to 2013

Documents

TABLE OF CONTENTS - Tech Transfer Central · 2013. 9. 3. · BG Medicine Biocon Group BioDelivery Sciences BioDrain Medical Biogen Idec BiolineRX BioMedica Life Sciences Biomedical