Table. Clinical Efficacy and Safety

Ticagrelor Clopidogrel HR (95% CI) Interaction P-value

CV death, MI, or stroke

≥ 75 years 17.2 18.3 0.95 (0.78–1.13)0.22

<75 years 8.6 10.4 0.82 (0.74–0.91)

All-cause mortality

≥ 75 years 9.8 12.4 0.81 (0.65–1.03)0.78

<75 years 3.6 4.8 0.78 (0.67–0.92)

MI

≥ 75 years 9.3 9.4 0.96 (0.75-1.24)0.25

<75 years 5.4 6.6 0.81 (0.71-0.93)

CV death

≥ 75 years 8.1 10.3 0.79 (0.61-1.02)0.90

<75 years 3.3 4.2 0.81 (0.68-0.95)

Definite stent thrombosis

≥ 75 years 1.8 2.1 0.66 (0.3–1.45)0.94

<75 years 1.3 1.9 0.67 (0.49–0.93)

Overall major bleeding

≥ 75 years 14.2 13.5 1.04 (0.84–1.28)1.00

<75 years 11.2 10.8 1.04 (0.94–1.15)

Non-CABG major bleeding

≥ 75 years 8.3 7.1 1.16 (0.87–1.55)0.78

<75 years 3.9 3.2 1.22 (1.02–1.46)