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Table 1. Penetrance and Severity of T b 4 knockdown embryo phenotype. penetrance (% total embryos). classification of severity (% total mutants). no. of litters. no. of embryos. T b 4sh Nk. 21. 221. mild moderate severe. 36%. 30. 14%. 43. 19%. 51%. 5%. 11. 13%. T b 4sh Mlc. - PowerPoint PPT Presentation
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Table 1. Penetrance and Severity of T4 knockdown embryo phenotype
T4shMlc
no. oflitters
no. ofembryos
penetrance(% total embryos)
classification of severity(% total mutants)
mild
moderate
severe
15
T4shNk 21 221
140
5
37
12
mild
moderate
severe 11
43
30 14%
19%
5%
36%
51%
13%
9%
69%
22%9%
26%
4%
T4shNk and T4shMlc embryos were classified as mild, moderate or severe mutants based upon
presentation of the following diagnostic criteria: i) epicardial nodules, ii) myocardial non-
compaction, iii) morphologically abnormal myocardium (pale and necrotic appearance), iv)
displacement of the heart/extended OFT, v) vessel defects (transparency and/or failed branching), vi)
oedema and/or small embryonic size. Mutants were classified according to the number of criteria
satisfied: mild (1-2), moderate (3-4) or severe (5-6).