T · H · E

~ OHIO

SIA1E UNIVERSITY

NEWS For release

on r eceipt

TRUSTEES MAKE PERSONNEL APPOINTMENTS

News Services 1125 Kinnear Road Columbus, O H 43212-1153 Phone 614-292-27 11

4- 6- 90

(LO)

COLUMBUS -- The Ohio State University Board of Trustees

Friday {4/6) reappointed two deans, appointed six chairpersons

and directors, and reappointed seven others.

The board appointed William L. Hayton as chairperson of the Division of Pharmaceutics and Pharmaceutical Chemistry in the College of Pharmacy. His term begins May 1 and runs through september 1993.

Hayton is a professor of pharmacy at Washington State University. where he chairs the Pharmacology/Toxicology Graduate Program. He has taught at Washington State since 1975.

Hayton has a bachelor's degree in pharmacy from the University of Washington and a doctorate in pharmaceutics from the State University of New York at Buffalo.

He will replace Robert Notari. a professor who retired in 1988. sylvan G. Frank has been serving as the acting chairperson.

I · H · t

O~·IIO SlATE UNIVERSITY

NEWS News Services 1125 Kinnear Road Columbus, OH 43212-1153 Phone 614-292-2711 FAX 614-292-0154

For release on receipt

(LO)

COLLEGE OF PHARMACY FACULTY RECEIVE NATIONAL RECOGNITION

COLUMBUS -- Four members of The Ohio state University

College of Pharmacy have been named Fellows of the American

Association of Pharmaceutical Scientists.

The awards recognize outstanding research d an scholarship in

the pharmaceutical sciences. The four recipients are:

William L. Hayton of Columbus (43235), professor and chairpe rson, Department of Pharmaceutics and Pharmaceutical Chemistry. Hayton is an aquatic toxicologist who specializes in the uptake and accumula tion of water-borne chemicals by fish. Among other accomplishments, hi s work led to an understanding of the factors that influence the uptake of dissolved pollutants as they pass over the gills of fish.

"This is the highest recognition given to pharmaceutical

scientists by the ir national scientific organization," said John

Cassady, dean o f the College of Pharmacy. "It i s unprecedented

to have four fellows come from one institution in one year."

The Ame rican Association of Pharmaceutical Sci e ntis t s

recognizes the achievements of pharmaceutical scientists and

fosters further development of t he pharmaceutical scien ces .

The awards were granted during a program held November 15 in

San Antonio, Texas .

..

CURRICULUM VITAE

William l. Hayton College of Pharmacy

The Ohio State University 500 West 12th Avenue

Columbus, Ohio

Telephone No.: Social Security Number:

(614)292-1288 538-40-8929

Education:

University of Washington State Univ. of NY at Buffalo

Major Professor: Dr. Gerhard Levy

Experience:

Washington State University

Assistant Professor of Pharmacy Associate Professor of Pharmacy Professor of Pharmacy Elected to WSU Graduate Faculty

1962-67 1967-71

Chair, Pharmacology (Toxicology Graduate Program Acting Dean, College of Pharmacy, January-October

The Ohio State University

Professor and Chairman, Division of Pharmaceutics and Pharmaceutical Chemistry

Professional leaves:

BS PhD

Pharmacy Pharmaceutics

1971-1977 1977-1984 1984-1990 1975 1982-1990 1987

1990-present

July 1, 1984 - June 30, 1985: Design and execution of preclinical and clinical pharmacokinetic studies performed in new drug development; F. Hoffmann-La Roche and Co., Basel, Switzerland.

Scientific, Professional, and Scholarly Societies:

American Association of Pharmaceutical Scientists American Association for the Advancement of Science American Association of Colleges of Pharmacy Society of Toxicology American Society for Pharmacology and Experimental Therapeutics Society of Environmental Toxicology and Chemistry Rho Chi Pharmacy Honorary Sigma Xi Kappa Psi Pharmaceutical Fraternity

2

Professional Service

Outside University:

1982 ad hoc member, Pharmacology Study Section, NIH, June 15-17 1983 ad hoc member, Pharmacology Study Section, NIH, June 21-23 1987 Special Review Committee, "Acid Rain- Adverse Health Effects of Aluminum," NIEHS, March

19-20 1990 Member, Panel to Review Medaka Carcinogenesis Model Research at the United States

Environmental Protection Agency Environmental Research Lab at Duluth, MN, July 16-19 1990 Member, Panel on "Metabolism Studies and Data Requirements for Aquaculture Species,"

Fifth IR-4/FDA Workshop for Minor Use Drugs: Focus on Aquaculture, at Bethesda, MD, October 15-16

Reviewer for:

Journal of Pharmaceutical Sciences Journal of Pharmacokinetics and Biopharmaceutics International Journal of Pharmaceutics Aquatic Toxicology Biopharmaceutics and Drug Disposition Pharmaceutical Research Toxicology and Applied Pharmacology Molecular Pharmacology

Committee Service at WSU (selected):

1977-82Wegner Hall Building Committee (Chair) 1981-83Senator, University Senate 1986-90 Graduate Studies Committee (Chair, 1989-90)

Committee Service at OSU:

College 1990

1991

Dean's Advisory Committee on Affirmative Action Accreditation Steering Committee Accreditation Mission and Goals Subcommittee Accreditation Organization and Administration Subcommittee Executive Committee Long Range Planning Committee

Tenure and Promotion Committee Executive Committee Dean's Advisory Committee on Affirmative Action Executive Committee Program Review Self Study Committee

Graduate Students Directed:

Ph.D. Students, Thesis Title, Year:

1. Duane C. Bloedow, Bioavailability of lipophilic drugs in lipid vehicles, 1974. 2. Michael E. Brady, Gastrointestinal drug absorption in rats exposed to 60Co gamma radiation, 1976. 3. Joseph A. Grisafe, Intestinal absorption of lipophilic drugs administered with lipids, 1977.

3

4. Juzar S. Kaka, Comparative pharmacokinetics of ketamine, 1979. 5. Chu-Fang (Julia) Lin, Bioavailability of orally administered drugs in senescent rat, 1981. 6. Adel H.Y. Karara, A pharmacokinetic analysis of the effect of temperature on the accumulation kinetics of

di-2-ethylhexyl phthalate in fish, 1983. 7. Brian D. Tarr, Squoxin toxicity and phthalate accumulation kinetics in fish, 1985. · 8. Mace G. Barron, Toxicokinetics of Di-2-ethylhexyl phthalate in rainbow troU1, 1986. 9. Guy R. Stehly, Metabolism and pharmacokinetics of pentachlorophenol in fish, 1987. 1 o. Atiqur Rahman, Drug distribution and biliary elimination, 1987. 11. Abdur Rashid, Biliary excretion of xenobiotics, 1987. 12. Irwin R. Schultz, Body size effects and species differences in the pharmacokinetics oftrifluralin in fish,

1990. 13. Todd M. Ott 14. Suresh Doddapaneni 15. Richat Abbas

M.S. Students, Thesis Title, Year:

1. Juzar S. Kaka, The effect of temperature on the absorption of drugs in goldfish, 1976. 2. 1-Hui Lo, Effects of pH on the accumulation of sulfonamides by fish, 1980. 3. Meichwen Chen, Effect of dissolved oxygen concentration on the accumulation of trifturalin by fish

(Cyprinodon variegatus), 1981. 4. Eva F. Sabu, (no thesis), 1983. 5. lb Christensen, (no thesis), 1983. 6. Peter L. Bonate, Pharmacokinetics of trichloroethylene and its metabolttes in the rat, 1990.

Research Support {direct costs for entire project period):

1. $61,081 from WSU Graduate School for various small projects, 1972-86. 2.$35,106 from PHS NationallnstttU1e on Aging, "Effects of Aging on Drug Bioavailability," principal

investigator, 1977-80, 5 R23 AG00674. 3. $103,573 from PHS NationallnstitU1e of Environmental Health Sciences, "Environmental Effects on

Xenobiotic Kinetics in Fish," principal investigator, 1979-1981, 1 R01 ES01995. 4. $92,175 from PHS National Institute of General Medical Sciences, "Rate Limiting Barriers in Intestinal

Drug Absorption," principal investigator, 1980-83, 5 R01 GM27924. 5. $167,257 from PHS NationallnstttU1e on Aging, "Aging and Diazepam's Binding and Effects on Behavior,"

co-investigator wah H.L. Komiskeywhowasthe PI, 1981-84, 1 R01 AG03327. 6. $137,385 from PHS National lnstitU1e on Environmental Health Sciences, "Environmental Effects on

Xenobiotic Kinetics in Fish," principal investigator, 1982-85, 2 R01 ES01995. 7. $131,300 from EPA; "Scaling Xenobiotic Pharmacokinetic Models in Fish," Project Manager, 4/28/86 to

10/31/89, R812818010. 8. $18,500 from Hoffmann-La roche & Co., "Studies of Ceftriaxone Biliary Excretion," 1986-87. 9. $74,611 from PHS National lnstttU1e on Alcohol Abuse and Alcoholism, "Ethanol Induction of UDP­

Giucuronyltransferase," co-investigator wtth G.S. Yost who was the PI, 1986-87, AA06555. 10. $180,544 from NASA. "Differential Pharmacokinetics and Toxicology of Iodine and Iodide," co­

investigator wtth R.J. Bull who is the PI, 1987-89, NASA 9-226. 11. $240,006 from PHS National lnstttU1e of Environmental Health Sciences, "Chlorinated Acetic Acid

Hepatocarcinogenesis," co-investigator with R.J. Bull who is the PI, 9/1/86 to 8/31/91, 1 R01 ES04848.

12. $205,527 from Air Force Office of Scientific Research, "Xenobiotic Kinetics and Toxictty Among Fish and Mammals," principal investigator, 9/15/88 to 1/31/92, 88-NL-180.

13. $195,714 from EPA, "Hemoglobin Adducts as Dosimeters for Exposure to Taxies," principal investigator, 11/1/88 to 10/31/91, CR-815216-01-0. (This is a part of a multi-investigator "program project" headed by R.J. Bull; the budget listed is for W.L. Hayton's part.)

14. $63,000 from Bonneville Power Administration, "FDA-Approved Registration of Erythromycin for Treatment of Bacterial Kidney Disease in Juvenile and Adult Chinook Salmon," 3/15/89 to

4

3/14/90, DE-PS79-89BP96247, co-investigator with C.M. Moffitt who was the principal investigator; the budget listed is for W.L Hayton's part.

15. $160,132 from the Environmental Protection Agency, "Scaling Xenobiotic Pharmacokinetic Models in Fish," Project Manager, 7/23/90 to 7/22/93, R816879-Q1-Q.

PENDING

$365,769 from NIH, "Carcinogenic events from benzofluoranthenes in finfish," Principal Investigator, 12/01/91 to 11/30/94, 1 R01 ES05819-01.

$612,101 from NIH, "Risk Assessment Model of Pesticides in Primates," Co-Investigator, Dr. L.J. LaFrado is PI, 12/01/91 to 11/30/94.

fl. Jt~$736,337 from FDA, ''Total Residue Depletion and Metabolic Profile of Selected Drugs in Catfish," Principal ~ Investigator, 9/91 to 5/94. .

PLANNED

Environmental Protection Agency, "Rate Limiting Barriers to Xenobiotic Uptake by the Fish Gill," Project Manager.

Publications

1. N.A. Hall and W.L. Hayton. Absorption of Ethanol by the Common Guppy (Lebistes reticulatus). J. Pharm. Sci. 56:304-306 (1967).

2. W. L. Hayton and N.A. Hall. Apparent pH Dependence of Ethanol Absorption Rate in the Common Guppy. J. Pharm. Sci. 57:158-161 (1968).

3. W.L. Hayton, D. E. Guttman and G. Levy. Enhancement of Steroid Absorption by Dialkylamides. J. Pharm. Sci. 59:575-576 (1970).

4. W.L. Hayton and G. Levy. Effect of SKF 525-A on Drug Absorption in Rats. Life Sciences Part 110:691-697 (1971).

5. W.L. Hayton, D.E. Guttman and G. Levy. Effect of Complex Formation on Drug Absorption XI: Complexation of Prednisone and Prednisolone with Dialkylpropionamides and its Effect on Prednisone Transfer Through an Artificial Lipoid Barrier. J. Pharm. Sci. 61:356-361 (1972).

6. W.L. Hayton and G. Levy. Effect of Complex Formation on Drug Absorption XII: Enhancement of Intestinal Absorption of Prednisone and Prednisolone by Dialkylpropionamides in Rats. J. Pharm. Sci. 61:362-366 (1972).

7. W.L. Hayton and G. Levy. Effect of Complex Formation on Drug Absorption XIII: Effect of Constant Concentrations of N,N-Di-n-propylpropionamide on Prednisolone Absorption from the Rat Small Intestine. J. Pharm. Sci. 61:367-371 (1972).

8. W.L Hayton, G. Levy and C. G. Regardh. Effect of Complex Formation on Drug Absorption XIV: Effect of N,N-Di-n-propylpropionamide on Intestinal Absorption of Certain Nonsteroid Drugs in the Rat. J. Pharm. Sci. 61:473-474 (1972).

9. M. Gibaldi, G. Levy and W.L. Hayton. Tubocurarine and Renal Failure. Br. J. Anaesth. 44:163-165 (1972).

10. M. Gibaldi, G. Levy and W.L Hayton. Kinetics of the Elimination+ and Neuromuscular Blocking Effect of D-Tubocurarine in Man. Anesthesiology 36:213-218 (1972).

11. W.L. Hayton and G. Levy. Effect of Complex Formation on Drug Absorption XV: Structural Requirements for Enhancement of Intestinal Absorption of Steroids by N,N-Di-n­propylpropionamide. J. Pharm. Sci. 61:649-651 (1972).

12. M.A. Schwartz and W.L Hayton. Relative Stability of Hetacillin and Ampicillin in Solution. J. Pharm. Sci. 61:906-909 (1972).

13. G. Levy and W.L. Hayton. Pharmacokinetic Aspects of Placental Drug Transfer. Fetal Pharmacology, L. Boreus, Ed., Raven Press, New York (1973), pp. 29-39.

14. D.L. Giusti and W.L Hayton. Dosage Regimen Adjustments in. Renal Impairment. Drug Intelligence & Clinical Pharmacy, 7:382-387 (1973).

15. W.L. Hayton. Effect of gamma-Radiation on Intestinal Absorption of Sulfanilamide. J. Pharm. Sci. 63:645 {1974).

5

16. W.L. Hayton. Effects of Normal Alcohols on Intestinal Absorption of Salicylic Acid, Sulfapyridine, and Prednisolone in Rats. J. Pharm. Sci. 64:1450-1456 {1975).

17. D.C. Bloedow and W.L. Hayton. Saturable First-pass Metabolism of Sulfisoxazole N 1-Acetyl in Rats. J. Pharm. Sci. 65:334-338 {1976).

18. D.C. Bloedow and W.L. Hayton. Effects of Lipids on Bioavailability of Sulfisoxazole Acetyl, Dicumarol, and Griseofulvin in Rats. J. Pharm. Sci. 65:328-333 {1976).

19. W.L. Hayton. Propellant-powered Nebulizers. J. APhA, NS16:201-207 {1976). 20. W.L. Hayton and J. Grisafe. Pharmacokinetic Evaluation of Dosing Regimens for Insulin in Diabetic

Ketoacidosis. Diabetes 25:771-775 {1976). 21. M.E. Brady and W.L. Hayton. Gl Drug Absorption in Rats Exposed to 60co gamma-Radiation 1: Extent

of Absorption. J. Pharm. Sci. 66:361-365 {1977). 22. M.E. Brady and W.L. Hayton. Gl Drug Absorption in Rats Exposed to 60co gamma-Radiation II: In vivo

Rate of Absorption. J. Pharm. Sci. 66:366-370 {1977). 23. M.E. Brady and W.L. Hayton. Effects of 60co gamma-Radiation on Hexobarbfial-induced Sleeping

Times in Rats. Rad. Research 69:594-597 {1977). 24. M.E. Brady and W.L. Hayton. Gl Drug Absorption in Rats Exposed to 60co gamma-Radiation Ill: In

Situ Intestinal Absorption. J. Pharm. Sci. 66:680-683 {1977). 25. W.A. Colburn, W.L. Hayton and M. Gibaldi. Pharmacokinetic Studies of the Hypoglycemic Effects of

Insulin in the Treatment of Diabetic Ketoacidosis. Int. J. Pharm. 1:121-126 {1978). 26. R.S. Lott and W.L. Hayton. Estimation of Creatinine Clearance from Serum Creatinine Concentration:

A Review. Drug Intelligence and Clinical Pharmacy 12:140-150 {1978). 27. J.S. Kaka and W.L. Hayton. Temperature and Surfactant Dependence of the Accumulation of 4-

Aminoantipyrine and Ethanol in Fish. J. Pharm. Sci. 67:1558-1563 {1978). 28. J.A. Grisafe and W.L. Hayton. Intestinal Absorption of Griseofulvin from a Triolein Digestion Mixture in

the Rat. J. Pharm. Sci. 67:895-899 {1978). 29. J.A. Grisafe and W.L. Hayton. Effects of Short- and Medium-Chain Fatty Acids on the Absorption of

Lipophilic Drugs from the Perfused Rat Intestine. J. Pharm. Sci. 67:1211-1215 {1978). 30. J.S. Kaka, P.A. Klavano and W.L. Hayton. Ketamine Pharmacokinetics in the Horse. Am. J. Vet. Res.

40:978-981 (1979). 31. P.O. Hansten and W.L. Hayton. Effect of Antacid and Ascorbic Acid on Serum Salicylate

Concentration. J. Clin. Pharmacal. 20:326-331 {1980). 32. J.S. Kaka and W.L. Hayton. Pharmacokinetics of Ketamine and Two Metabolites in the Dog. J.

Pharmacok. Biopharm. 8:193-202 {1980). 33. W.L. Hayton. Rate Limiting Barriers to Intestinal Drug Absorption: A Review. J. Pharmacok. Biopharm.

8:321-334 {1980). 34. 1-H. Lo and W.L. Hayton. Effects of pH on the Accumulation of Sulfonamides by Fish. J. Pharmacok.

Biopharm. 9:389-405 {1981 ). 35. H.L. Komiskey, T.M. Cook, C-F. Lin and W.L. Hayton. Impairment of Learning or Memory in the Mature

and Old Rat by Diazepam. Psychopharmacology 73:304-305, 1981. 36. W.L. Hayton and T. Chen. Correction of Perfusate Concentration for Sample Removal. J. Pharm. Sci.

71:820-821 {1982). 37. C-F. Lin and W.L. Hayton. Gl Motility and Subepfihelial Blood Flow in Mature and Senescent Rats. Age

6:46-51, 1963. 38. C-F. Lin and W.L. Hayton. Absorption of Polyethylene Glycol 400 Administered Orally to Mature and

Senescent Rats. Age 6:52-56 {1983). 39. D.M. Sylvester, W.L. Hayton, R.L. Morgan and J.L. Way. Effects o!Thiosulfate on Cyanide

Pharmacokinetics in Dogs. Toxicol. Appl. Pharmacal. 69:265-271 {1963). 40. W.L. Hayton and G.R. Stehly. pH Control of Weak Electrolyte Toxicfiy to Fish. Environm. Toxicol.

Chern. 2:325-328 {1963). 41. C. F. Lin and W.L. Hayton. Bioavailability of Orally Administered Sulfisoxazole Acetyl, Riboflavin,

Tetracycline, and Bretylium in Mature and Senescent Rats. Age 7:48-57 {1964). 42. R.H. Zobrist, H.L. Komiskey, T.F. Murray and W.L. Hayton. Aging: Effect on Carboline Binding in

Hippocampal Subfields. Neurobiol. Aging 5:49-53 {1964).

43. A. H. Karara, W.L. Hayton and B. G. Archer. A Separation and Purification Procedure for [14C]Di-2-Ethylhexylphthalate (DEHP) in Fish. J. Analyt. Toxicol. 8:141-145 (1984).

6

44. A. H. Karara and W.L. Hayton. Pharmacokinetic Model for the Uptake and Disposition of Di-2-Ethylhexylphthalate in Sheepshead Minnow Cyprinodon variegateus. Aquatic Toxicology 5:181-195 (1984).

45. B.D. Tarr, L.J. Winters, M.P. Moore, R.L. Cowell and W.L. Hayton. Low Dose Ethanol in the Treatment of Ethylene Glycol Poisoning. J. Vet. Pharmacal. Exp. Therap. 8:254-262 (1985).

46. U.B. Schaad, W.L. Hayton and K. Stoeckel. Single-dose Ceftriaxone Kinetics in the Newborn. Clin. Pharmacal. Therap. 37:522-528 (1985).

47. W.L. Hayton and P. Haefelfinger. Steady-state Volume of Distribution after Multiple Doses. J. Pharm. Sci. 74:1134 (1985).

48. H.L. Komiskey, A. Rahman, W.P. Weisenburger, W.L. Ha,t;on, R.H. Zobrist and W. Silvius. Extraction, Separation, and Detections of 14C-Diazepam and 1 C-Metabolites from Brain Tissue of Mature and Old Rats. J. Analyt. Toxicol. 9:131"133 (1985).

49. W.L. Hayton and K. Stoeckel. Age-associated Changes in Ceftriaxone Pharmacokinetics. Clin. Pharmacok. 11:76-86 (1986).

50. W.L. Hayton, R. Schandalik and K. Stoeckel. Ceftriaxone Biliary Excretion and Pharmacokinetics after Cholecystectomy. Eur. J. Clin. Pharmacal. 30:445-451 (1986).

51. A. Rahman, H.L. Komiskey, W.L. Hayton and W.P. Weisenburger. Aging: Changes in Distribution of Diazepam and Metabolites in the Rat. Drug Metab. Disp. 14:299-302 (1986).

52. W. Hayton and K. Stoeckel. Biliary-Excretion of Ceftriaxone. Eur. J. Clin. Pharmacal. 31:123-124 (1986).

53. M.G. Barron, B.D. Tarr and W.L. Hayton. Temperature Dependence of Di-2-Ethylhexyl Phthalate (DEHP) Kinetics in Rainbow Trout. Toxicol. Appl. Pharmacal. 88:305-312 (1987).

54. M.G. Barron, B.D. Tarr and W.L. Hayton. Temperature Dependence of Cardiac Output and Regional Blood Flow in Rainbow Trout (Salmo gairdneri Richardson). J. Fish. Bioi. 31:735-744 (1987).

55. A. H. Karara and W.L. Hayton. Metabolic Inhibition and Di-2- Ethylhexyl Phthalate Pharmacokinetics in Fish. Drug Metab. Disp. 16:146-150 (1988).

56. G.R. Stehly and W.L. Hayton. Detection of Pentachlorophenol and Its Glucuronide and Sulfate Conjugates in Fish Bile and Exposure Water. J Environm Sci and Hlth, Part B. B23:355-366 (1988).

57. A. H. Karara and W.L. Hayton. A Pharmacokinetic Analysis of the Effect of Temperature on the Accumulation of Di-2-Ethylhexyl Phthalate (DEHP) in Sheepshead Minnow. Aquatic Toxicology 15:27-36 (1989).

58. G.R. Stehly and W.L. Hayton. Errors in the Use of the Accelerated Bioconcentration Test, in Aquatic Toxicology and Environmental Fate, Volume 11. ASTM STP 1007, G.W. Suter II and M.A. Lewis, Eds., American Society for Testing and Materials, Philadelphia, 1989, pp. 573-584.

59. M.G. Barron, I.R. Schultz and W.L. Hayton. Presystemic Branchial Metabolism Limits Di-2-ethylhexyl Phthalate Accumulation in Fish. Toxicol. Appl. Pharmacal. 98:49-57(1989).

60. G.R. Stehly and W.L. Hayton. Metabolism of Pentachlorophenol by Fish. Xenobiotica 19:75-81 (1989). 61. W.L. Hayton. lnterspecies Scaling Pharmacokinetic Models. Health Physics 57: Suppl. 1, 159-164

(1989). 62. G.R. Stehly and W.L. Hayton. Disposition of Pentachlorophenol in Rainbow Trout (Salmo gairdneri):

Effect of Inhibition of Metabolism. Aquatic Toxicology 14:131-148 (1989). 83. M. Yokokawa, R. Nishigaki, K. Umemura and W.L. Hayton. Intestinal Absorption Kinetics Using a

Laminar Flow Model. J. Pharmacobiodyn. 12:332-340 (1989). 64. M.S. Dey, R.G. Breeze, W.L. Hayton, A. H. Karara and R.l Krieger. Paraquat Pharmacokinetics Using a

Subcutaneous Toxic Low Dose in the Rat. Fund. Appl. Toxicol. 14:208-216 (1990). 65. W.L. Hayton and M.G. Barron. Rate Limiting Barriers to Xenobiotic Uptake by the Fish Gill. Environ.

Toxicol. Chern. 9:151-157 (1990). 66. G.R. Stehly and W.L. Hayton. Effect of pH on the Accumulation Kinetics of Pentachlorophenol in

Goldfish. Arch. Environm. Contam. Toxicol. 19:464-470 (1990). 67. B.D. Tarr, M.G. Barron and W.L. Hayton. Effect of Body Size on the Uptake and Bioconcentration of Di-

2-Ethylhexyl Phthalate in Rainbow Trout. Environmental Toxicology and Chemistry 9:989-995 (1990).

' '

7

68. W.L. Hayton, J. Kneer, R.A. Blouin and K. Stoeckel. Pharmacokinetics of Intravenous Cefetamet and Oral Cefetamet Pivoxil in Patients with Hepatic Cirrhosis. Antimicrob. Agents Chemother. 34:1318-1322 (1990)

69. M.G. Barron, G.R. Stehly and W.L Hayton. Pharmacokinetic Modeling in Aquatic Animals. 1. Models and Concepts. Aquatic Toxicology 17;187-212 (1990).

70. W.L Hayton. Symbol-and-Arrow Diagrams in Teaching Pharmacokinetics. Am. J. Pharm. Ed. 54:290-292 (1990).

71. W.L Hayton, V. Vlahov, N. Bacracheva, I. Viachki, R. Portmann, G. Muirhead, K. Stoeckel and E. Weidekamm. Pharmacokinetics and Biliary Concentrations of Fleroxacin in Cholecystectomized Patients. Antimicrob. Agents Chemother. 34:2375-2380 (1990).

72. W.L Hayton, R.A. Walstad, E. Thurmann-Nielsen, T. Kufass, J. Kneer, R.J. Ambros, H.E. Rugstad, E, Monn, E. Bodd, and K. Stoeckel. Pharmacokinetics of Intravenous Cefetamet and Oral Cefetamet Pivoxil in Children. Antimicrob. Agents Chemother. 35:720-725 (1991).

73. S.S. Narayan, W.L Hayton and G.S. Yost Chronic Ethanol Consumption Causes Increased Glucuronidation of Morphine in Rabbits. Xenobiotica 21 :515-524 (1991 ).

74. W.L Hayton and I.R. Schultz. Scaling Bioconcentration and Pharmacokinetic Parameters for Body Size and Environmental Variables in Fish. accepted for Proceedings of the 14th Symposium on Aquatic Toxicology and Risk Assessment, American Society for Testing and Materials, April, 1990.

75. I.R. Schultz and W.L. Hayton. Experimental Design for Pharmacokinetic Data Analysis Using Compartmental Pharmacokinetic Models. accepted for Proceedings of the 14th Symposium on Aquatic Toxicology and Risk Assessment, American Society for Testing and Materials, April, 1990.

76. W.L Hayton and P.L Collins. STELLA: Simulation Software for the Pharmacokinetics Classroom. Am. J. Pharm. Ed. 55:131-134 (1991).

77. A Rahman and W.L Hayton. Influence of Alcohol on bile Flow and Biliary Clearance of Ceftriaxone in Rat J. Pharm. Sci., submitted.

Non-refereed:

1. W.L Hayton. Sulfisoxazole Bioavailability Monograph. J. APhA NS16:617-620 (1976). 2. T.M. ~ook, H.L. Komiskey and W.L. Hayton. The Influence of Ethanol Withdrawal on the Binding Site of

H-Dopamine. Proc. West Pharmacal. Soc.23:157-158 (1980). 3. D.M. Sylvester, C. Sander, W.L Hayton and J.L Way. Alteration of the Pharmacokinetics of Sodium

Cyanide by Sodium Thiosulfate. Proc. W. Pharmacal. Soc. 24:135 (1981). 4. W.L Hayton, B.G. Archer. Kinetics of Accumulation of Trifluralin by Fish. Proc. W. Pharmacal. Soc.

24:147-149 (1981). 5. R.C. Speth, A Rashid and W.L. Hayton. Effects of Ligand Metabolism on Receptor Binding Assays.

Proc. W. Pharmacol. Soc. 29:489-492 {1986). 6. K. Stoeckel, W.L Hayton, J Kneer, R.A. Walstad and H.E. Rugstad. Pharmacokinetics of intravenous

cefetamet and oral cefetamet pivoxil in children. Proceedings of the International Congress for Infectious Diseases, Montreal, Canada, July 15-19, 1990.

August 6, 1991

FUNDS/PERSONNEL -- 2

• The Hildreth Foundation Athletic Scholarship Fund, $25,000, established with gifts from the Hildreth

Foundation and family

• The Josaphat Kubayanda Fund, $16,214, established with gifts from family, friends and colleagues to

support the annual Josphat Kubayanda Memorial Lecture in the Center for African Studies and the

Department of Spanish and Portuguese

Endowment Report

University Treasurer James L. Nichols updated trustees on the university's endowment, which stands

at $1.264 billion as of April 30. He reported that income distributed from the endowment to colleges and

departments during the past fiscal year (1998-99) reached an all-time high of$45.5 million. In an annual

report on the status of the university's tax exempt bonds, Nichols reported that the university's debt at the end

of March stood at $350 million.

The board also approved the appointment and reappointment of external investment managers to assist

in the management of the university's endowment fund.

Academic Appointments

• William L. Hayton of COLUMBUS (43214) has been named Charles H. Kimberly Professor in Pharmacy,

effective July 1, 2000 through June 30, 2003. Hayton received his B.S. degree in pharmacy from the

University of Washington and his doctorate in pharmaceutics from the State University ofNew York at

Buffalo. He joined the Ohio State faculty in 1990 as professor and chair of the Division of Pharmaceutics

after a 16-year tenure at the Washington State University College of Pharmacy.

• Evelyn B. Freeman ofWORTHINGTON has been named director of the College ofEducation's School of

Teaching and Learning, effective April 1, 2000 through June 30, 2004. A professor of teaching and

learning, Freeman also serves as associate dean in the college. Her areas of scholarship include the uses

and implementation of literature-based curricula, informational children's literature, and kindergarten

policies and practices.

• David E. Hahm of DUBLIN has been named chair of the Department of Greek and Latin in the College of

Humanities, effective May 1, 2000 through September 30, 2003. A specialist in ancient philosophy and

science and Greek literature, Hahm holds a doctorate from the University of Wisconsin and is the author of

The Origins of Stoic Cosmology.

• Krishnaswamy Srinivasan of DUBLIN has been named chair of the Department of Mechanical

Engineering, effective July 1, 2000 through June 30, 2004. A professor of dynamic systems, measurements

and controls, he holds a doctorate in mechanical engineering from Purdue University. His major research

interests include modeling and control of dynamic systems in a variety of applications.

-more-