SYMPHONY Newslettersymphony-project.eu/sites/... · a-hip & Microfluidics/Point-of care diagnostics/Single cell/ molecule analysis – Select iosciences, 15-16 March 2016, Madrid,

SYMPHONY Newsletter Integrated SYsteM based on PHOtonic microresonators and

Microfluidic Components for rapid detectioN of toxins in milk

and dairY products

December 2016 Newsletter, Issue 3

www.symphony-project.eu

IN THIS ISSUE

Dissemination SYMPHONY was presented at

several international

conferences, dedicated

workshops and clustering

events.

See more from pag. 2

Technical news The present concentration

protocol gives at least 15 times

enrichment of Aflatoxin with a

99.75% clearance of proteins .

Find more results of the project

at pag. 5

Focus on partner Starting from previous issue, all

the partners will be presented

in details. In this number ACREO

and QCL. EPIGEM and CONCAST

will follow in the last issue. Read

more from pag. 6.

This project has received funding from the European Union’s Seventh Framework Programme FP7-ICT-2013-10 under

grant agreement No 610580. Project duration: 1st November 2013 - 31st October 2016.

2 SYMPHONY Newsletter N. 3, December 2016

Grant agreement 610580 www.symphony-project.eu

A s partner in many EU-ICT FP7 projects on bio-chemical

sensing and prototype development for applications in Water,

Health, Food and Security, Acreo had seven posters and a

dedicated booth (see picture) at the big World Congress on

Biosensors 2016 in Gothenburg (May 25-27, http://

www.biosensors-congress.elsevier.com/) with more than 1000

participants. All the contributions exemplified the potential of

various bio-chemical sensing with their specific bio-

functionalization for different applications as in SYMPHONY,

SAFEWATER (www.safewater-project.eu), SENSATION (http://

www.vinnova.se/sv/Resultat/Projekt/Effekta/2011-01544/

SENSATION-III), Integrated printed biosensor platforms

(www.acreo.se/projects/integrated-printed-biosensor-platforms).

The functional prototypes images presented at the booth showed

how these technical solutions can solve many societal challenges

in the near future.

Symphony dissemination and exploitation

Conferences

Biosensors2016

Poster by Acreo “Functionalization of

surfaces for specific analyte capturing

and sensing” -

LOACE2016

LioniX Invited talk “An integrated opto-

fluidic platform for applications in drug

development, Point-of-Care and

Companion Diagnostics”

SPIE Photonics Europe 2016

T. Chalyan (UniTn) presented

SYMPHONY project with a talk

“Biosensors based on Si3N4

Asymmetric Mach-Zehnder

Interferometers

SPIE Photonics West 2016

G. Pucker (FBK) presented “WGM

resonator based integrated optical

circuits for lab-on-a-chip sensors at

~0.85 µm”

MicroNanoConference 2015

Two oral presentations by Acreo

presenting results from bio-

functionalization and chemical sensing.

Optics 2016

UniTN (Tatevik Chalyan) presented

Symphony project at 4th International

Symposium on Optics and its

Applications dedicated to 100th

Anniversary of the Optical Society.

INDIA

L. Pavesi (UniTN) presented last results

on silicon microresonators at IWPSD

2015 and Discussion Meeting on on

Emerging Themes in Nanophotonics.

www.symphony-project.eu

L ioniX had a dedicated booth and an invited talk at Lab-on-

a-Chip & Microfluidics/Point-of care diagnostics/Single cell/

molecule analysis – Select Biosciences, 15-16 March 2016,

Madrid, Spain. Lab-on-a-Chip & Microfluidics was a multitrack

event, running alongside Point Of Care Diagnostics and Single

Molecule & Single Cell Analysis. Providing cost-effective

access to project solutions and new business opportunities is

key to Lab-on-a-Chip’s history as a successful event.



MycoKey kick off meeting

ISOCS-MiNaB-ICT-MNBS 2016

SYMPHONY clustering events

Project SYMPHONY was presented at ISOCS-MiNaB- ICT-MNBS 2016, 25-29 June, Otranto (Lecce),

Italy, a joint event on: “Sensing for Smart Anything Everywhere: Materials, Technologies,

Applications”. During Project innovation session: MNBS enabling smart agriculture, food,

environment & PoC FBK

(Leandro Lorenzelli) presented

the current status and the

achievements during the last

year of the project. UniTN

presented the technical details

with a paper “SYMPHONY

sensors based on Si3N4

Asymmetric Mach-Zehnder

Interferometers” during the

session of Smart Sensors. More

discussions were during poster

session, where the last results

were presented. Tatevik Chalyan (UniTN) and Leandro Lorenzelli (FBK) at MNBS 2016

Andrea Adami presented the SYMPHONY project concept at the kick off meeting of the European

Project MycoKey on 26 April 106 in Martina Franca, Italy. MycoKey is the new project funded by

European Commission under Horizon 2020 programme, Societal challenge 2 "Food security,

sustainable agriculture and forestry, marine, maritime and inland water research and the

bioeconomy challenge" - topic “ Biological contamination of crops and the food chain”.

It aims to deliver in 2019 the first integrated ICT based solutions to address mycotoxin

contamination along the food and feed chain, by using an holistic and sustainable approach.



Latest publications



Technical news

The use Mussel adhesive protein (Mfp-1) as adhesive on

concentration unit, gave a well functionalized surface, with

preserved antibody functionality, applicable in many bio

sensing techniques.

The present concentration protocol gives at least 15 times

enrichment of Aflatoxin with a 99.75% clearance of proteins

The integration of gratings and coupling to VCSEL and

detectors was achieved. the sensor module, it is now

available as sensor and PCB. The sensor board has been

designed to generate VCSEL excitation and read the

photodiode response.

Sensor is capable to detect the concentration

demonstrated by the concentrator testing in 5 minutes

with a flow rate to 10µl/min

Tangential flow filtration was demonstrated to overcome

the technical limitations in throughput of continuous flow

devices and commercial cassettes by Millipore (Pellicon XL

device, PVDF filter, 0.22µm pore size) by providing a clean

sample stream at about 2ml/min

CONCAST provided a batch of naturally contaminated milk

as reference materials for the sample preparation research.

The batch was freeze-dried for preservation.

SYMPHONY news

Alina Samusenko completed

her PhD at UniTN/FBK with a

thesis titled: “Silicon-based

photonic integrated circuit for

label-free biosensing” on

design, fabrication and

characterization of a photonic

integrated sensor circuit, which

meets the required

specifications, and develop a

low-cost on-chip integrated

photodetector for conversion of

optical response from a

biosensor into electric signal.

In the framework of microfluidics activities at FBK, Andrea Capuano started a PhD in FBK/UniTn on the realization of a silicon-dry film based miniaturized system for electrophoretic protein separation for the sample preparation. His activity focuses on the design of microfluidic channels, the evaluation of electrophoretic performance, testing the devices and setting up computer simulation of microfluidic structures. (picture of the electrophoretic chip on the front page)

Sketch of the integrated

photonic sensor circuit

Pre-concentration of

Aflatoxin (AFM1) from

contaminated milk

obtained via

immobilized antibodies

(anti-aflatoxin M1 Ab)

on Mfp-1.



Focus on partners - ACREO

Acreo Swedish ICT is a Swedish research institute

providing cutting edge resources and knowledge

within electronics, optics and communication

technologies. We have the facilities and lab

resources to offer advanced R&D as well as small

scale production and prototyping

RESEARCH TOPICS

Acreo’s role is to enable sustainable growth in industry and society and we do that

mainly by taking research concepts to prototypes. We have the competence to handle

all your needs from analyse, modelling and design, processing and manufacturing to

the final product characterization. We provide contract R&D, research based

consulting, prototyping, licensing and products and lab infrastructure such as testbeds

and demonstrators, collaboration platforms and networks and SME-support. We are

always open for new innovation projects and new ideas.

ROLE IN SYMPHONY

The Sensor System department roles in the Symphony project are on development of

bio-selective surfaces, pre-concentration of toxin (repeatable catching and release of

toxin), and system integration.

CONTACTS

Cristina Rusu

e-mail: [email protected]

https://www.acreo.se/

ACREO SWEDISH ICT AB, Sensor Systems Dept.

Schematic of the pre-concentration step



MISSION

QUADRACHEM LABORATORIES LIMITED is UK

distributor and quality partner of advanced

analytical solutions and innovative technology.

PRODUCTS AND TECHNOLOGIES

QCL supplies a wide range of analytical solutions to UK industry and academia. We have

extensive business with the dairy market supplying industry standard systems such as

Cryoscopes, the Fluorophos® Assay and LactoScope Dairy Analysers. We also supply and

support a range of spectroscopic analyser systems covering laboratory to in-line

installations in many different markets.

Over the last few years QCL has succesfully launched a number of new innovative product

lines in the UK focusing on delivering quality systems that solve our customers’ analytical

challanges.

ROLE IN SYMPHONY

QCL is providing commercial support to the SYMPHONY project. Being a supplier of

analytical systems to the dairy industry QCL understands the constraints that the modern

dairy business is under and the key requirements for any new analytical solution. During

the SYMPHONY project we have focused on ensuring target specifications of the

SYMPHONY system are consistent with industry requirments for raw milk testing so that a

final system can be realistically deployed in the market place.

CONTACTS

Dr Mark L. Whatton

www.qclscientific.com

Focus on partners-QCL

http://www.qclscientific.com

Project Coordinator:

Dr. Leandro Lorenzelli

Tel. +39 0461 314 455

e-mail [email protected]

Technical Manager:

Dr. Andrea Adami

Tel. +39 0461 314 497

e-mail [email protected]

Fondazione Bruno Kessler

Center for Materials and Microsystems

Via Sommarive, 18

38123 Povo, Italy

Project Website:

http://www.symphony-project.eu/

To subscribe/unsuscribe write an e-mail to: [email protected]

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Documents

SYMPHONY Newslettersymphony-project.eu/sites/... · a-hip & Microfluidics/Point-of care diagnostics/Single cell/ molecule analysis – Select iosciences, 15-16 March 2016, Madrid,