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8/14/2019 Swine Influenza 2009
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Influenza 2009Influenza 2009
2009.7.102009.7.10
Keelung General HospitalKeelung General HospitalChang Cheng-LongChang Cheng-Long
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1918 Pandemic influenza1918 Pandemic influenza
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NewsNews
April 29 2009 WHO Elevates Swine
April 29 2009 WHO Elevates SwineInfluenza Pandemic Alert Level To Phase 5Influenza Pandemic Alert Level To Phase 5
18:00 GMT, 29 April 2009, nine countries18:00 GMT, 29 A
pril 2009, nine countrieshave officially reported 148 cases of swinehave official
ly reported 148 cases of swineinfluenza A/H1N1 infection. The Unitedinfluenza A/H1N1 infection. The UnitedStates Government has reported 91States Government has r
eported 91laboratory confirmed human cases, with onelaborator
y confirmed human cases, with onedeath. Mexico has reported 26 confirmeddeath. Mexico has r
eported 26 confirmedhuman cases of infection including sevenhuman cases of infection includin
g sevendeaths.deaths.
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Mexico City under the grip of the swine fluoutbreak in April, 2009
@cnnbrk is CNNs breaking news account onTwitter
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20092009 33 44 H1N1H1N1 H1N1H1N1
H1N1H1N1..
http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/http://www.cdc.gov/h1n1flu/8/14/2019 Swine Influenza 2009
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8/14/2019 Swine Influenza 2009
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A1A1
A2A2 A3A3
A4A4
Antigenic Shift
http://www3.niaid.nih.gov/topics/Flu/Research/basic/AntigenicShiftIllustration.htm8/14/2019 Swine Influenza 2009
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RELENZA'sRELENZA'sMechanism of ActionMechanism of Action
Tamiflu
Relenza
http://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.htmlhttp://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.htmlhttp://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.htmlhttp://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.htmlhttp://www.relenza.com/hcp/relenza-action-mechanism.htmlhttp://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.htmlhttp://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.htmlhttp://changturtle.blogspot.com/2009/05/relenzas-mechanism-of-action.html8/14/2019 Swine Influenza 2009
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Cytokine StormCytokine Storm http://changturtle.blogspot.com/2009/05/cytokine-
storm.html
http://changturtle.blogspot.com/2009/05/cytokine-storm.htmlhttp://changturtle.blogspot.com/2009/05/cytokine-storm.html8/14/2019 Swine Influenza 2009
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Epidemic and Pandemic Alert and RespEpidemic and Pandemic Alert and Resp
(EPR)(EPR) :::: 66
20092009 66 1111 ---- 55 66 ::::
::::
55 :: 66 ::
http://changturtle.blogspot.com/2009/05/epidemic-and-pandemic-alert-and.htmlhttp://changturtle.blogspot.com/2009/05/epidemic-and-pandemic-alert-and.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/csr/disease/swineflu/assess/disease_swineflu_assess_20090511/zh/index.htmlhttp://www.who.int/entity/csr/disease/swineflu/assess/disease_swineflu_assess_20090511/zh/index.htmlhttp://www.who.int/entity/csr/disease/swineflu/3rd_meeting_ihr/zh/index.htmlhttp://www.who.int/entity/csr/disease/swineflu/3rd_meeting_ihr/zh/index.htmlhttp://www.who.int/entity/csr/disease/swineflu/3rd_meeting_ihr/zh/index.htmlhttp://www.who.int/entity/csr/disease/swineflu/assess/disease_swineflu_assess_20090511/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://www.who.int/entity/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/zh/index.htmlhttp://changturtle.blogspot.com/2009/05/epidemic-and-pandemic-alert-and.html8/14/2019 Swine Influenza 2009
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Tracking the progress of H1N1 swine fTracking the progress of H1N1 swine f
http://changturtle.blogspot.com/2009/05/tracking-progress-of-h1n1-swine-flu.htmlhttp://changturtle.blogspot.com/2009/05/tracking-progress-of-h1n1-swine-flu.htmlhttp://changturtle.blogspot.com/2009/05/tracking-progress-of-h1n1-swine-flu.html8/14/2019 Swine Influenza 2009
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H1N1 - pandemic influenzaH1N1 - pandemic influenza
phasesphases
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,, ` ,, ..
` ` ` ,, ,, ::
http://www.flickr.com/photos/turtle5001tw/3498686136/http://www.flickr.com/photos/turtle5001tw/3498686136/8/14/2019 Swine Influenza 2009
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* Fever* Fever* Cough* Cough* Sore throat* Sore throat
* Body aches* Body aches* Headache* Headache* Chills and fatigue* Chills and fatigue* Diarrhea and vomiting (possible)* Diarrhea and vomiting (possible)
Phase 5 is characterized by human-to-Phase 5 is characterized by human-to-human spread...human spread...
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ProphylaxisProphylaxis
H1N1 influenza in pregnancyH1N1 influenza in pregnancy
Prophylaxis with antiviral agents shouldProphylaxis with antiviral agents should
also be considered in the followingalso be considered in the followingindividuals (pre-exposure orindividuals (pre-exposure or
postexposure):postexposure):
o Close household contacts of a confirmedo Close household contacts of a confirmed
or suspected case who are at high risk foror suspected case who are at high risk forcomplications (eg, chronic medicalcomplications (eg, chronic medical
conditions, persons >65 y or 65 y or 65 y,conditions, persons >65 y or 65 y or 65 y,
pregnant women)pregnant women)
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Reverse GeneticsReverse Genetics
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ReassortmentReassortment
http://www.flickr.com/photos/turtle5001tw/3511198667/in/photostream/8/14/2019 Swine Influenza 2009
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Antigenic DriftAntigenic Drift
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FDA Approves New Influenza Vaccine Production FacilityFDA Approves New Influenza Vaccine Production Facility
ScienceDaily (May 7, 2009) The U.S.ScienceDaily (May 7, 2009) The U.S.Food and Drug Administration (FDA) hasFood and Drug Administration (FDA) hasannounced that it has approved a newannounced that it has approved a new
manufacturing facility used to producemanufacturing facility used to produceinfluenza virus vaccines. The facility isinfluenza virus vaccines. The facility isapproved for seasonal influenza vaccineapproved for seasonal influenza vaccineproduction and could be used for theproduction and could be used for the
production of vaccine against the newproduction of vaccine against the new2009 H1N1 influenza strain.2009 H1N1 influenza strain.
http://www.sciencedaily.com/releases/2009/05/090507175916.htm8/14/2019 Swine Influenza 2009
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Pandemic Virus geneticPandemic Virus genetic ReassortmentReassortment
http://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://www.flickr.com/photos/turtle5001tw/3516639187/in/photostream/http://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.htmlhttp://changturtle.blogspot.com/2009/05/pandemic-virus.html8/14/2019 Swine Influenza 2009
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18891889 19181918 19571957 19681968
http://www.flickr.com/photos/turtle5001tw/3517466050/in/photostream/8/14/2019 Swine Influenza 2009
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H5N1 outbreak in Afghanistan , Feb 2006H5N1 outbreak in Afghanistan , Feb 2006
http://www.blogger.com/H5N1%20Afghanistan%20since%20Feb%2027%202006http://www.flickr.com/photos/turtle5001tw/3518663211/http://changturtle.blogspot.com/2009/05/h5n1-outbreak-in-afghanistan-feb-2006.htmlhttp://changturtle.blogspot.com/2009/05/h5n1-outbreak-in-afghanistan-feb-2006.html8/14/2019 Swine Influenza 2009
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Qinghai , China on May 30, 2005 , H5N1Qinghai , China on May 30, 2005 , H5N1
http://changturtle.blogspot.com/2009/05/qinghai-china-on-may-30-2005.html8/14/2019 Swine Influenza 2009
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http://www.flickr.com/photos/23562155@N00/690186048/14/2019 Swine Influenza 2009
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How Bird Flu Has Spread Jul Oct 26 2005 HHow Bird Flu Has Spread Jul Oct 26 2005 H
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How Bird Flu Has Spread , Jul-Oct 26 2005 HHow Bird Flu Has Spread , Jul-Oct 26 2005 H
Up to date Map of H5N1 Outbreaks (JanuaryUp to date Map of H5N1 Outbreaks (January
http://changturtle.blogspot.com/2009/05/how-bird-flu-has-spread-jul-oct-26-2005.htmlhttp://changturtle.blogspot.com/2009/05/how-bird-flu-has-spread-jul-oct-26-2005.htmlhttp://www.flickr.com/photos/quiplash/56893419/in/pool-influenzahttp://changturtle.blogspot.com/2009/05/how-bird-flu-has-spread-jul-oct-26-2005.html8/14/2019 Swine Influenza 2009
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Up-to-date Map of H5N1 Outbreaks (JanuaryUp-to-date Map of H5N1 Outbreaks (January
2006)2006)
Russia says bird flu may spread to Europe Aug 15Russia says bird flu may spread to Europe Aug 15
http://www.flickr.com/photos/quiplash/86125728/in/pool-influenza8/14/2019 Swine Influenza 2009
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Russia says bird flu may spread to Europe , Aug 15,Russia says bird flu may spread to Europe , Aug 15,
20052005
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Crossroads of bird flu , AlaskaCrossroads of bird flu , Alaska
http://changturtle.blogspot.com/2009/05/crossroads-of-bird-flu.htmlhttp://changturtle.blogspot.com/2009/05/crossroads-of-bird-flu.htmlhttp://www.latimes.com/news/printedition/la-102106-sci-kipnuk-g,1,1144213.graphichttp://changturtle.blogspot.com/2009/05/crossroads-of-bird-flu.html8/14/2019 Swine Influenza 2009
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Probing the Mysterious Migration of SwansProbing the Mysterious Migration of Swans
Suspected in Spread of Avian FluSuspected in Spread of Avian Flu
http://www.nytimes.com/2006/09/12/science/12bird.html?_r=1&ref=sciencehttp://www.flickr.com/photos/hlthenvt/361078906/in/set-72157594189834822/8/14/2019 Swine Influenza 2009
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http://www.latimes.com/news/printedition/front/la-sci-kipnuk22oct22,1,47557,full.story?coll=la-headlines-frontpage8/14/2019 Swine Influenza 2009
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TackingTacking birdflubirdflu 20082008
http://news.bbc.co.uk/2/hi/in_depth/world/2005/bird_flu/default.stmhttp://changturtle.blogspot.com/2009/05/tacking-birdflu-2008.htmlhttp://changturtle.blogspot.com/2009/05/tacking-birdflu-2008.htmlhttp://changturtle.blogspot.com/2009/05/tacking-birdflu-2008.html