Suspension

Definition

A Pharmaceutical suspension is a coarse dispersion in which internal phase is dispersed uniformly throughout the external phase.

The internal phase consisting of insoluble solid particles which is maintained uniformly throughout the suspending vehicle with aid of single or combination of suspending agents.

The external phase (suspending medium) is generally aqueous in some instance, may be an organic or oily liquid for non oral use.

2-Degree of flocculation (β)

Degree of flocculation: is the ratio of the sedimentation volume of the flocculated suspension F, to the sedimentation volume of the deflocculated suspension, F¥ß = F / F¥

(Vu/Vo )flocculatedß-------------------- =

(Vu/Vo )deflocculated

When the total volume of both the flocculated and the deflocculated suspensions are same;

ß = )Vu(floc / )Vu(defloc-The minimum value of ß is 1; this is the case when the sedimentation volume of

the flocculated suspension is equal to the sedimentation volume of deflocculatedsuspension.

-ß is more fundamental parameter than F since it relates the volume of flocculated sediment to that in a deflocculated system

Electrokinetic PropertiesZeta Potential

The zeta potential is defined as the difference in potential between the surface of the tightly bound layer )shear plane( and electro-neutral region of the solution.

The ions that gave the particle its charge, are called potential-determining ions.

Immediately adjacent to the surface of the particle is a layer of tightly bound solvent molecules, together with some ions oppositely charged to the potential determining ions.

These two layers of ions at the interface constitute a double layer of electric charge )shear plane(.

Zeta potential governs the degree of repulsion between the adjacent, similarly charged, dispersed particles.

If the zeta potential is reduced below a certain value, the attractive forces exceed the repulsive forces, and the particles come together. This phenomenon is known as flocculation.

Particles carry charge may acquire it from adjuvants as well as during process likecrystallization, grinding processing, ionization of functional group of the particle, adsorption of ions from solution e.g. ionic surfactants.

VI. Deflocculation and flocculationFlocculated Suspensions

In flocculated suspension, formed flocs )loose aggregates( will cause increasein sedimentation rate due to increase in size of sedimenting particles.

Hence, flocculated suspensions sediment more rapidly. Here, the sedimentation depends not only on the size of the flocs but also on the porosity of flocs .

In flocculated suspension the loose structure of the rapidly sedimenting flocs tends to preserve in the sediment, which contains an appreciable amount of entrapped liquid.

The volume of final sediment is thus relatively large and is easily redispersed by agitation.

Even the smallest particles are involved inflocs, so the supernatant appears clear.

Deflocculated suspensions

In deflocculated suspension, individual particles aresettling.

rate of sedimentation is slow. which prevents entrapping of liquid medium whichmakes it difficult to re-disperse by agitation.

This phenomenon called ‘cacking’ or ‘claying’. In deflocculated suspension,larger particles settle fast and smaller remain in supernatant liquidso supernatant appears cloudy