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0 sec20 sec 1 min2 min Supplemental Fig. 3A
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Supplemental Fig. 1
100 mm
B50 mm
A
IL-1
b se
cret
ion
(pg/
wel
l)
Y2763
2Z-
YVAD
Asbes
tos
Contro
l
Y2763
2Z-
YVAD
CNT
Contro
l
Y2763
2Z-
YVAD
LPS
Contro
l0
10
20
30
40
50
60
CNT LPSAsbestos
*
*
*
#
#
#
#
#
Supplemental Fig. 2
0 sec 20 sec
1 min 2 min
Supplemental Fig. 3A
Supplemental Fig. 3B
0
100
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600
700
LPS priming
Contro
l
Contro
l
no treatmentY27632
LPS
0 sec
20 se
c
1 min
2 min
IL-1
b se
cret
ion
(pg/
wel
l)
MSU
Forward Reverse
ROCK1 S1 UCAGUCAGAAUUCACAGCUUGCUAA
UUAGCAAGCUGUGAAUUCUGACUGA
S2 GACAGAUGCGGGAGCUACAAGAUCA
UGAUCUUGUAGCUCCCGCAUCUGUC
S3 GCAUUUGGAGAAGUUCAAUUGGUAA
UUACCAAUUGAACUUCUCCAAAUGC
ROCK2 S4 GAAGCAGCUAUUAACAGAAAGAACA
UGUUCUUUCUGUUAAUAGCUGCUUC
S5 CCGUUGCCAUAUUAAGUGUCAUAAA
UUUAUGACACUUAAUAUGGCAACGG
S6 GGAGGAGAUUAUAGCACCUUGCAAA
UUUGCAAGGUGCUAUAAUCUCCUCC
Supplemental Fig. 4A
ROCK1 siRNA ROCK2 siRNA
Control siRNA
ROCK1
ROCK2
Control S1 S4S3 S5 S6
S1
S2
Supplemental Fig. 4B
