Supplement

Supplement Outline

ContentsSupplement1Supplementary Table 1. Studies of circulating metabolic traits and prostate cancer2Supplementary Table 2. Metabolite names, original units, and abbreviations6Supplementary Table 3. Characteristics of genetic variants associated with metabolites selected as instruments from Kettunen (2016)112Supplementary Table 4. Among ProtecT cases and controls, odds of prostate cancer for 227 metabolic traits133Supplementary Table 5. Among ProtecT cases and controls, odds of high-risk prostate cancer for 227 metabolic traits140Supplementary Table 6. Test of difference in odds ratios (for 227 metabolic traits) between total prostate cancer and high-risk prostate cancer147Supplementary Table 7. Test of difference in odds ratios between high-risk prostate cancer and low-risk prostate cancer152Supplementary Table 8. Test of difference in odds ratios between high-risk and low-risk prostate cancer for the set of top metabolites in the total analysis57Supplementary Table 9. Among ProtecT cases and controls, odds of low-risk prostate cancer for 227 metabolic traits158Supplementary Table 10. Test of difference in odds ratios between total prostate cancer and low-risk prostate cancer167Supplementary Table 11. Pearson correlations between prostate-specific antigen (PSA) and metabolites in ProtecT174Supplementary Table 12. Comparison of observational and causal estimates for the set of top metabolites in ProtecT which had genetic instruments79Supplementary Table 13. Causal estimates of prostate cancer for 107 metabolic traits180References for Supplementary Tables83Supplementary Acknowledgements84

Supplementary Table 1. Studies of circulating metabolic traits and prostate cancer

Authors

Sample

Analytical Method

Population

Key Findings

Osl et al. (2008)1

Serum

Flow-injection analysis-tandem mass spectrometry (FIA-MS/MS) or liquid chromatography tandem mass spectrometry (LC/MS/MS)

206 prostate cancer patients and 114 controls; Austria

Feature selection algorithm for which lysophosphatidyl-cholines with saturated fatty acid chains and serotonine ranked highest as candidate biomarkers distinguishing cases and controls

Lokhov et al. (2010)2

Plasma

Electrospray hybrid quadrupole time-of-flight mass spectrometry (MicrOTOF-Q)

40 prostate cancer patients and 30 controls; Russia

Acylcarnitine (area under the receiver-operator characteristics curve (AUC) 0.97) and arachidonoyl amine (AUC 0.86) better at distinguishing cases from controls than prostate-specific antigen (PSA) (AUC 0.59)

Fan et al. (2011)3

Serum

Nuclear magnetic resonance (NMR) spectroscopy

42 prostate cancer patients and 14 benign prostate hyperplasia controls; Ireland

Developed biomarker panels distinguishing BPH from prostate cancer (metabolite panel: Apolipoprotein A-IV, Serum amyloid P-component, and Gluthathione peroxidase 3); Gleason score 5 versus Gleason score 7 (metabolite panel: Kininogen-1, Protein AMBP, Coagulation factor XIII B chain, Complement factor H, and Gluthathione); organ confined versus non-organ confined prostate cancer (metabolite panel: Protein AMBP, Haptoglobin (R chain), and Pigment Epithelium-Derived Factor Kininogen-1)

Miyagi et al. (2011)4

Plasma

High-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)

134 prostate cancer patients and 666 controls; Japan

Across a variety of cancers (including prostate), compared to controls, 11 amino acids (asparagine, glutamine, citrulline, valine, methionine, leucine, tyrosine, phenylalanine, histidine, tryptophan, and arginine) showed decreases, while four amino acids (serine, proline, glycine, and ornithine) exhibited increases. Changes in glutamine, histidine, tryptophan, proline, and ornithine were detected for all cancer types included

Saylor et al. (2012)5

Plasma

Gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC/MS)

36 prostate cancer patients treated with androgen deprivation therapy (ADT); USA

56 metabolites in fasting blood samples of men with prostate cancer changed from baseline in response to androgen deprivation therapy (ADT) measured after three months

Zhou et al. (2012)6

Plasma

Electrospray ionization tandem mass spectrometry (ESI-MS/MS)

105 prostate cancer patients and 36 controls; USA

15 lipids used together had a sensitivity of 93.6%, specificity of 90.1% and accuracy of 97.3% for predicting prostate cancer

Huang et al. (2014)7

Serum

LC/MS

18 untreated prostate cancer, patients, 36 prostate cancer, patients receiving endocrine therapy, 18 healthy men; China

Mean serum levels of seven metabolites (deoxycholic acid, glycochenodeoxycholate, L-tryptophan, docosapentaenoic acid, arachidonic acid, deoxycytidine triphosphate, and pyridinoline) differed significantly between untreated prostate cancer patients and healthy controls

Mondul et al. (2014)8

Serum

LC/MS and GC-MS

74 prostate cancer cases and 74 controls within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers; Finland

Inverse association between 1-stearoylglycerol and incident prostate cancer (OR 0.34, 95% CI 0.20–0.58, p 6.3 x 10-5)

Mondul et al. (2015)9

Serum

LC/MS and GC-MS

200 prostate cancer cases and 200 controls within the ATBC Study; Finland

Inverse association between aggressive disease and certain lipids and fatty acids (top metabolites: inositol-1-phosphate (OR 0.56, 95% CI 0.39–0.81, p 0.002), oleoyl-linoleoyl-glycerophosphoinositol (OR 0.64, 95% CI 0.47–0.87, p 0.0042), 1-stearoylglycerophosphoglycerol (OR 0.69, 95% CI 0.50-0.95, p 0.0245), stearate (OR 0.65, 95% CI 0.47-0.90, p 0.0102), and docosadienoate (OR 0.66, 95% CI 0.48-0.92, p 0.0141). In addition, both alpha-ketoglutarate (OR 0.69, 95% CI 0.51-0.94, p 0.0201), and citrate (OR 0.69, 95% 0.50-0.95, p 0.0220) were associated with aggressive disease, as were elevated thyroxine (OR 1.65, 95% CI 1.08-2.54, p 0.0216) and trimethylamine oxide (OR 1.36, 95% CI 1.02-1.81, p 0.0389)

Zang et al. (2014)10

Serum

LC/MS

64 prostate cancer cases and 50 controls; USA

Determined that a panel of 40 metabolic spectral features had a 92.1% sensitivity, 94.3% specificity, and 93.0% accuracy for predicting presence of prostate cancer

Huang et al. (2016)11

Serum

Ultrahigh-performance liquid chromatography/mass spectroscopy (UHPLC-MS) and (GC-MS)

380 screen-detected cases and 300 matched controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

27 metabolites associated with prostate cancer (some also marking aggressive disease). Though none were significant after Bonferroni correction, pyroglutamine, gamma-glutamylphenylalanine, phenylpyruvate, N-acetylcitrulline, and stearoylcarnitine were the most strongly associated with prostate cancer

LC= liquid chromatograpgy, GC= gas chromatography, MS=mass spectroscopy, BPH=Benign prostatic hyperplasia

Supplementary Table 2. Metabolite names, original units, and abbreviations

Metabolite Name and Original Unit (before transformation)

Abbreviation

Acetoacetate (mmol/l)

ACACE

Acetate (mmol/l)

ACE

Alanine (mmol/l)

ALA

Albumin signal area

ALB

Apolipoprotein A-I (g/l)

APOA1

Apolipoprotein B (g/l)

APOB

Ratio of apolipoprotein B to apolipoprotein A-I

APOB.APOA1

3-hydroxybutyrate (mmol/l)

BOHBUT

Citrate (mmol/l)

CIT

Creatinine (mmol/l)

CREA

22:6, docosahexaenoic acid (mmol/l)

DHA

Ratio of 22:6 docosahexaenoic acid to total fatty acids (%)

DHA.FA

Esterified cholesterol (mmol/l)

ESTC

Omega-3 fatty acids (mmol/l)

FAW3

Ratio of omega-3 fatty acids to total fatty acids (%)

FAW3.FA

Omega-6 fatty acids (mmol/l)

FAW6

Ratio of omega-6 fatty acids to total fatty acids (%)

FAW6.FA

Free cholesterol (mmol/l)

FREEC

Glucose (mmol/l)

GLC

Glutamine (mmol/l)

GLN

Glycine (mmol/l)

GLY

Glycoprotein acetyls, mainly a1-acid glycoprotein (mmol/l)

GP

Total cholesterol in HDL (mmol/l)

HDL.C

Mean diameter for HDL particles nm

HDL.D

Triglycerides in HDL (mmol/l)

HDL.TG

Total cholesterol in HDL2 (mmol/l)

HDL2.C

Total cholesterol in HDL3 (mmol/l)

HDL3.C

Histidine (mmol/l)

HIS

Total cholesterol in IDL (mmol/l)

IDL.C

Total cholesterol to total lipids ratio in IDL (%)

IDL.C.PER

Cholesterol esters in IDL (mmol/l)

IDL.CE

Cholesterol esters to total lipids ratio in IDL (%)

IDL.CE.PER

Free cholesterol in IDL (mmol/l)

IDL.FC

Free cholesterol to total lipids ratio in IDL (%)

IDL.FC.PER

Total lipids in IDL (mmol/l)

IDL.L

Concentration of IDL particles(mol/l)

IDL.P

Phospholipids in IDL (mmol/l)

IDL.PL

Phospholipids to total lipids ratio in IDL (%)

IDL.PL.PER

Triglycerides in IDL (mmol/l)

IDL.TG

Triglycerides to total lipids ratio in IDL (%)

IDL.TG.PER

Isoleucine (mmol/l)

ILE

Total cholesterol in large HDL (mmol/l)

L.HDL.C

Total cholesterol to total lipids ratio in large HDL (%)

L.HDL.C.PER

Cholesterol esters in large HDL (mmol/l)

L.HDL.CE

Cholesterol esters to total lipids ratio in large HDL (%)

L.HDL.CE.PER

Free cholesterol in large HDL (mmol/l)

L.HDL.FC

Free cholesterol to total lipids ratio in large HDL (%)

L.HDL.FC.PER

Total lipids in large HDL (mmol/l)

L.HDL.L

Concentration of large HDL particles(mol/l)

L.HDL.P

Phospholipids in large HDL (mmol/l)

L.HDL.PL

Phospholipids to total lipids ratio in large HDL (%)

L.HDL.PL.PER

Triglycerides in large HDL (mmol/l)

L.HDL.TG

Triglycerides to total lipids ratio in large HDL (%)

L.HDL.TG.PER

Total cholesterol in large LDL (mmol/l)

L.LDL.C

Total cholesterol to total lipids ratio in large LDL (%)

L.LDL.C.PER

Cholesterol esters in large LDL (mmol/l)

L.LDL.CE

Cholesterol esters to total lipids ratio in large LDL (%)

L.LDL.CE.PER

Free cholesterol in large LDL (mmol/l)

L.LDL.FC

Free cholesterol to total lipids ratio in large LDL (%)

L.LDL.FC.PER

Total lipids in large LDL (mmol/l)

L.LDL.L

Concentration of large LDL particles(mol/l)

L.LDL.P

Phospholipids in large LDL (mmol/l)

L.LDL.PL

Phospholipids to total lipids ratio in large LDL (%)

L.LDL.PL.PER

Triglycerides in large LDL (mmol/l)

L.LDL.TG

Triglycerides to total lipids ratio in large LDL (%)

L.LDL.TG.PER

Total cholesterol in large VLDL (mmol/l)

L.VLDL.C

Total cholesterol to total lipids ratio in large VLDL (%)

L.VLDL.C.PER

Cholesterol esters in large VLDL (mmol/l)

L.VLDL.CE

Cholesterol esters to total lipids ratio in large VLDL (%)

L.VLDL.CE.PER

Free cholesterol in large VLDL (mmol/l)

L.VLDL.FC

Free cholesterol to total lipids ratio in large VLDL (%)

L.VLDL.FC.PER

Total lipids in large VLDL (mmol/l)

L.VLDL.L

Concentration of large VLDL particles(mol/l)

L.VLDL.P

Phospholipids in large VLDL (mmol/l)

L.VLDL.PL

Phospholipids to total lipids ratio in large VLDL (%)

L.VLDL.PL.PER

Triglycerides in large VLDL (mmol/l)

L.VLDL.TG

Triglycerides to total lipids ratio in large VLDL (%)

L.VLDL.TG.PER

18:2, linoleic acid (mmol/l)

LA

Ratio of 18:2 linoleic acid to total fatty acids (%)

LA.FA

Lactate (mmol/l)

LAC

Total cholesterol in LDL (mmol/l)

LDL.C

Mean diameter for LDL particles nm

LDL.D

Triglycerides in LDL (mmol/l)

LDL.TG

Leucine (mmol/l)

LEU

Total cholesterol in medium HDL (mmol/l)

M.HDL.C

Total cholesterol to total lipids ratio in medium HDL (%)

M.HDL.C.PER

Cholesterol esters in medium HDL (mmol/l)

M.HDL.CE

Cholesterol esters to total lipids ratio in medium HDL (%)

M.HDL.CE.PER

Free cholesterol in medium HDL (mmol/l)

M.HDL.FC

Free cholesterol to total lipids ratio in medium HDL (%)

M.HDL.FC.PER

Total lipids in medium HDL (mmol/l)

M.HDL.L

Concentration of medium HDL particles(mol/l)

M.HDL.P

Phospholipids in medium HDL (mmol/l)

M.HDL.PL

Phospholipids to total lipids ratio in medium HDL (%)

M.HDL.PL.PER

Triglycerides in medium HDL (mmol/l)

M.HDL.TG

Triglycerides to total lipids ratio in medium HDL (%)

M.HDL.TG.PER

Total cholesterol in medium LDL (mmol/l)

M.LDL.C

Total cholesterol to total lipids ratio in medium LDL (%)

M.LDL.C.PER

Cholesterol esters in medium LDL (mmol/l)

M.LDL.CE

Cholesterol esters to total lipids ratio in medium LDL (%)

M.LDL.CE.PER

Free cholesterol in medium LDL (mmol/l)

M.LDL.FC

Free cholesterol to total lipids ratio in medium LDL (%)

M.LDL.FC.PER

Total lipids in medium LDL (mmol/l)

M.LDL.L

Concentration of medium LDL particles(mol/l)

M.LDL.P

Phospholipids in medium LDL (mmol/l)

M.LDL.PL

Phospholipids to total lipids ratio in medium LDL (%)

M.LDL.PL.PER

Triglycerides in medium LDL (mmol/l)

M.LDL.TG

Triglycerides to total lipids ratio in medium LDL (%)

M.LDL.TG.PER

Total cholesterol in medium VLDL (mmol/l)

M.VLDL.C

Total cholesterol to total lipids ratio in medium VLDL (%)

M.VLDL.C.PER

Cholesterol esters in medium VLDL (mmol/l)

M.VLDL.CE

Cholesterol esters to total lipids ratio in medium VLDL (%)

M.VLDL.CE.PER

Free cholesterol in medium VLDL (mmol/l)

M.VLDL.FC

Free cholesterol to total lipids ratio in medium VLDL (%)

M.VLDL.FC.PER

Total lipids in medium VLDL (mmol/l)

M.VLDL.L

Concentration of medium VLDL particles(mol/l)

M.VLDL.P

Phospholipids in medium VLDL (mmol/l)

M.VLDL.PL

Phospholipids to total lipids ratio in medium VLDL (%)

M.VLDL.PL.PER

Triglycerides in medium VLDL (mmol/l)

M.VLDL.TG

Triglycerides to total lipids ratio in medium VLDL (%)

M.VLDL.TG.PER

Monounsaturated fatty acids; 16:1, 18:1 (mmol/l)

MUFA

Ratio of monounsaturated fatty acids to total fatty acid s (%)

MUFA.FA

Phosphatidylcholine and other cholines (mmol/l)

PC

Phenylalanine (mmol/l)

PHE

Polyunsaturated fatty acids (mmol/l)

PUFA

Ratio of polyunsaturated fatty acids to total fatty acid s (%)

PUFA.FA

Pyruvate (mmol/l)

PYR

Remnant cholesterol (non-HDL, non-LDL -cholesterol) mmol

REMNANT.C

Total cholesterol in small HDL (mmol/l)

S.HDL.C

Total cholesterol to total lipids ratio in small HDL (%)

S.HDL.C.PER

Cholesterol esters in small HDL (mmol/l)

S.HDL.CE

Cholesterol esters to total lipids ratio in small HDL (%)

S.HDL.CE.PER

Free cholesterol in small HDL (mmol/l)

S.HDL.FC

Free cholesterol to total lipids ratio in small HDL (%)

S.HDL.FC.PER

Total lipids in small HDL (mmol/l)

S.HDL.L

Concentration of small HDL particles(mol/l)

S.HDL.P

Phospholipids in small HDL (mmol/l)

S.HDL.PL

Phospholipids to total lipds ratio in small HDL (%)

S.HDL.PL.PER

Triglycerides in small HDL (mmol/l)

S.HDL.TG

Triglycerides to total lipids ratio in small HDL (%)

S.HDL.TG.PER

Total cholesterol in small LDL (mmol/l)

S.LDL.C

Total cholesterol to total lipids ratio in small LDL (%)

S.LDL.C.PER

Cholesterol esters in small LDL (mmol/l)

S.LDL.CE

Cholesterol esters to total lipids ratio in small LDL (%)

S.LDL.CE.PER

Free cholesterol in small LDL (mmol/l)

S.LDL.FC

Free cholesterol to total lipids ratio in small LDL (%)

S.LDL.FC.PER

Total lipids in small LDL (mmol/l)

S.LDL.L

Concentration of small LDL particles(mol/l)

S.LDL.P

Phospholipids in small LDL (mmol/l)

S.LDL.PL

Phospholipids to total lipids ratio in small LDL (%)

S.LDL.PL.PER

Triglycerides in small LDL (mmol/l)

S.LDL.TG

Triglycerides to total lipids ratio in small LDL (%)

S.LDL.TG.PER

Total cholesterol in small VLDL (mmol/l)

S.VLDL.C

Total cholesterol to total lipids ratio in small VLDL (%)

S.VLDL.C.PER

Cholesterol esters in small VLDL (mmol/l)

S.VLDL.CE

Cholesterol esters to total lipids ratio in small VLDL (%)

S.VLDL.CE.PER

Free cholesterol in small VLDL (mmol/l)

S.VLDL.FC

Free cholesterol to total lipids ratio in small VLDL (%)

S.VLDL.FC.PER

Total lipids in small VLDL (mmol/l)

S.VLDL.L

Concentration of small VLDL particles(mol/l)

S.VLDL.P

Phospholipids in small VLDL (mmol/l)

S.VLDL.PL

Phospholipids to total lipids ratio in small VLDL (%)

S.VLDL.PL.PER

Triglycerides in small VLDL (mmol/l)

S.VLDL.TG

Triglycerides to total lipids ratio in small VLDL (%)

S.VLDL.TG.PER

Serum total cholesterol (mmol/l)

SERUM.C

Serum total triglycerides (mmol/l)

SERUM.TG

Saturated fatty acids (mmol/l)

SFA

Ratio of saturated fatty acids to total fatty acids (%)

SFA.FA

Sphingomyelins (mmol/l)

SM

Ratio of triglycerides to phosphoglycerides

TG.PG

Total cholines (mmol/l)

TOTCHO

Total fatty acids (mmol/l)

TOTFA

Total phosphoglycerides (mmol/l)

TOTPG

Tyrosine (mmol/l)

TYR

Estimated degree of unsaturation

UNSAT

Valine (mmol/l)

VAL

Total cholesterol in VLDL (mmol/l)

VLDL.C

Mean diameter for VLDL particles nm

VLDL.D

Triglycerides in VLDL (mmol/l)

VLDL.TG

Total cholesterol in very large HDL (mmol/l)

XL.HDL.C

Total cholesterol to total lipids ratio in very large HD L (%)

XL.HDL.C.PER

Cholesterol esters in very large HDL (mmol/l)

XL.HDL.CE

Cholesterol esters to total lipids ratio in very large HDL (%)

XL.HDL.CE.PER

Free cholesterol in very large HDL (mmol/l)

XL.HDL.FC

Free cholesterol to total lipids ratio in very large HDL (%)

XL.HDL.FC.PER

Total lipids in very large HDL (mmol/l)

XL.HDL.L

Concentration of very large HDL particles(mol/l)

XL.HDL.P

Phospholipids in very large HDL (mmol/l)

XL.HDL.PL

Phospholipids to total lipids ratio in very large HDL (%)

XL.HDL.PL.PER

Triglycerides in very large HDL (mmol/l)

XL.HDL.TG

Triglycerides to total lipids ratio in very large HDL (%)

XL.HDL.TG.PER

Total cholesterol in very large VLDL (mmol/l)

XL.VLDL.C

Total cholesterol to total lipids ratio in very large VL DL (%)

XL.VLDL.C.PER

Cholesterol esters in very large VLDL (mmol/l)

XL.VLDL.CE

Cholesterol esters to total lipids ratio in very large VLDL (%)

XL.VLDL.CE.PER

Free cholesterol in very large VLDL (mmol/l)

XL.VLDL.FC

Free cholesterol to total lipids ratio in very large VLD L (%)

XL.VLDL.FC.PER

Total lipids in very large VLDL (mmol/l)

XL.VLDL.L

Concentration of very large VLDL particles(mol/l)

XL.VLDL.P

Phospholipids in very large VLDL (mmol/l)

XL.VLDL.PL

Phospholipids to total lipids ratio in very large VLDL (%)

XL.VLDL.PL.PER

Triglycerides in very large VLDL (mmol/l)

XL.VLDL.TG

Triglycerides to total lipids ratio in very large VLDL (%)

XL.VLDL.TG.PER

Total cholesterol in very small VLDL (mmol/l)

XS.VLDL.C

Total cholesterol to total lipids ratio in very small VLDL (%)

XS.VLDL.C.PER

Cholesterol esters in very small VLDL (mmol/l)

XS.VLDL.CE

Cholesterol esters to total lipids ratio in very small VLDL (%)

XS.VLDL.CE.PER

Free cholesterol in very small VLDL (mmol/l)

XS.VLDL.FC

Free cholesterol to total lipids ratio in very small VLDL (%)

XS.VLDL.FC.PER

Total lipids in very small VLDL (mmol/l)

XS.VLDL.L

Concentration of very small VLDL particles(mol/l)

XS.VLDL.P

Phospholipids in very small VLDL (mmol/l)

XS.VLDL.PL

Phospholipids to total lipids ratio in very small VLDL (%)

XS.VLDL.PL.PER

Triglycerides in very small VLDL (mmol/l)

XS.VLDL.TG

Triglycerides to total lipids ratio in very small VLDL (%)

XS.VLDL.TG.PER

Total cholesterol in chylomicrons and extremely large VLDL (mmol/l)

XXL.VLDL.C

Total cholesterol to total lipids ratio in chylomicrons and extremely large VLDL

XXL.VLDL.C.PER

Cholesterol esters in chylomicrons and extremely large VLDL (mmol/l)

XXL.VLDL.CE

Cholesterol esters to total lipids ratio in chylomicrons and extremely large VLDL

XXL.VLDL.CE.PER

Free cholesterol in chylomicrons and extremely large VLDL (mmol/l)

XXL.VLDL.FC

Free cholesterol to total lipids ratio in chylomicrons and extremely large VLDL

XXL.VLDL.FC.PER

Total lipids in chylomicrons and extremely large VLDL (mmol/l)

XXL.VLDL.L

Concentration of chylomicrons and extremely large VLDL particles(mol/l)

XXL.VLDL.P

Phospholipids in chylomicrons and extremely large VLDL (mmol/l)

XXL.VLDL.PL

Phospholipids to total lipids ratio in chylomicrons and extremely large VLDL

XXL.VLDL.PL.PER

Triglycerides in chylomicrons and extremely large VLDL (mmol/l)

XXL.VLDL.TG

Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL

XXL.VLDL.TG.PER

Supplementary Table 3. Characteristics of genetic variants associated with metabolites selected as instruments from Kettunen (2016)1

Met

SNP

Chr

EA

OA

EAF

Beta

SE

P value

AcAce

rs2169387

19

G

A

0.870

0.086

0.015

3.61E-08

Ace

rs6933521

17

C

T

0.120

-0.092

0.016

8.10E-09

Ala

rs1260326

10

C

T

0.639

-0.105

0.010

7.40E-26

Ala

rs149191093

6

T

C

0.043

-0.162

0.025

4.05E-11

Ala

rs2160387

10

C

T

0.403

-0.071

0.010

1.49E-13

Alb

rs185567543

15

T

A

0.018

-0.486

0.042

6.61E-30

ApoA1

rs144064722

15

G

A

0.025

0.204

0.035

8.30E-09

ApoA1

rs1461729

19

G

A

0.862

0.086

0.015

1.77E-08

ApoA1

rs174594

3

A

C

0.589

0.072

0.011

1.32E-11

ApoA1

rs247617

6

A

C

0.286

0.197

0.012

7.90E-63

ApoA1

rs261291

5

C

T

0.375

0.144

0.011

2.58E-39

ApoA1

rs6507939

8

C

A

0.839

0.108

0.014

5.03E-14

ApoA1

rs75835816

19

C

G

0.020

-0.221

0.039

1.67E-08

ApoB

rs10056811

16

A

G

0.341

0.086

0.011

1.35E-15

ApoB

rs115849089

19

A

G

0.107

-0.100

0.017

1.04E-08

ApoB

rs11591147

1

T

G

0.031

-0.438

0.035

2.50E-34

ApoB

rs142130958

9

A

G

0.106

-0.200

0.017

7.78E-32

ApoB

rs144064722

15

G

A

0.025

0.199

0.035

2.29E-08

ApoB

rs1883711

11

C

G

0.057

0.144

0.025

1.95E-08

ApoB

rs2980875

19

G

A

0.484

-0.070

0.010

6.68E-12

ApoB

rs635634

20

T

C

0.198

0.074

0.013

7.71E-09

ApoB

rs6756629

10

A

G

0.078

-0.113

0.019

1.90E-09

ApoB

rs7412

9

T

C

0.056

-0.428

0.026

4.39E-59

bOHBut

rs35909200

6

G

T

0.168

0.091

0.012

3.37E-13

Cit

rs172642

7

C

A

0.481

0.080

0.009

4.80E-18

Cit

rs2040771

13

T

C

0.476

-0.091

0.009

1.28E-22

Cit

rs2921604

16

C

T

0.444

0.097

0.009

3.65E-25

Crea

rs10265221

18

C

T

0.239

0.073

0.011

7.53E-11

Crea

rs2079742

7

C

T

0.178

0.096

0.013

8.61E-14

Crea

rs3119311

17

C

T

0.120

0.091

0.016

5.29E-09

Crea

rs6127099

11

T

A

0.278

-0.060

0.011

3.28E-08

Crea

rs61524473

5

C

T

0.259

0.085

0.011

1.21E-15

DHA

rs11604424

3

T

C

0.757

-0.083

0.014

7.84E-09

DHA

rs143988316

9

T

C

0.069

-0.150

0.024

1.10E-09

DHA

rs2281591

17

G

A

0.134

-0.108

0.018

3.66E-09

DHA

rs261334

5

C

G

0.769

-0.110

0.015

1.44E-13

Est.C

rs1077835

5

G

A

0.250

0.101

0.014

4.06E-12

Est.C

rs112032422

9

C

T

0.105

-0.215

0.020

1.40E-25

Est.C

rs11591147

1

T

G

0.029

-0.461

0.040

1.63E-30

Est.C

rs144064722

15

G

A

0.026

0.276

0.039

4.11E-12

Est.C

rs3741298

3

T

C

0.770

-0.082

0.015

2.29E-08

Est.C

rs4075673

10

C

T

0.600

-0.084

0.013

2.75E-11

Est.C

rs7412

9

T

C

0.057

-0.441

0.028

1.14E-54

Est.C

rs79225634

16

T

C

0.352

0.095

0.013

2.78E-13

FAw3

rs1077835

5

G

A

0.250

0.089

0.014

1.08E-09

FAw3

rs11604424

3

T

C

0.756

-0.090

0.014

3.32E-10

FAw3

rs1260326

10

C

T

0.637

-0.097

0.013

3.37E-14

FAw3

rs143988316

9

T

C

0.069

-0.171

0.024

2.95E-12

FAw6

rs10402112

9

A

T

0.100

-0.166

0.021

3.80E-15

FAw6

rs11591147

1

T

G

0.029

-0.309

0.040

1.12E-14

FAw6

rs1260326

10

C

T

0.637

-0.078

0.013

9.73E-10

FAw6

rs144064722

15

G

A

0.026

0.237

0.040

2.29E-09

FAw6

rs1800588

5

T

C

0.249

0.143

0.014

9.47E-23

FAw6

rs3741298

3

T

C

0.770

-0.143

0.015

7.32E-23

FAw6

rs7412

9

T

C

0.057

-0.272

0.028

8.06E-22

FAw6

rs79225634

16

T

C

0.352

0.085

0.013

7.52E-11

FAw6

rs821840

6

G

A

0.252

0.086

0.015

4.77E-09

Free.C

rs1077835

5

G

A

0.250

0.166

0.014

2.52E-30

Free.C

rs115445558

10

C

G

0.084

-0.127

0.022

1.33E-08

Free.C

rs11591147

1

T

G

0.029

-0.495

0.040

3.45E-35

Free.C

rs11604424

3

T

C

0.757

-0.078

0.014

4.92E-08

Free.C

rs13392272

10

T

C

0.399

0.100

0.013

2.98E-15

Free.C

rs142130958

9

A

G

0.106

-0.231

0.020

1.10E-29

Free.C

rs144064722

15

G

A

0.026

0.281

0.039

1.37E-12

Free.C

rs7412

9

T

C

0.057

-0.305

0.028

6.14E-27

Free.C

rs75679663

7

A

C

0.026

-0.263

0.043

1.85E-09

Free.C

rs79225634

16

T

C

0.352

0.088

0.013

1.10E-11

Glc

rs10466351

3

T

C

0.384

0.072

0.010

3.28E-13

Glc

rs7729232

16

A

T

0.004

0.407

0.072

1.79E-08

Glc

rs878521

18

A

G

0.220

0.092

0.012

7.98E-14

Gln

rs1260326

10

C

T

0.639

0.062

0.010

9.87E-10

Gln

rs6729711

10

A

G

0.181

-0.070

0.012

2.23E-08

Gln

rs7078003

2

T

C

0.196

0.074

0.012

2.96E-10

Gly

rs10083777

6

T

C

0.173

-0.106

0.015

2.97E-13

Gly

rs1047891

10

A

C

0.334

0.487

0.011

1.00E-200

Gly

rs13298772

20

C

T

0.053

0.273

0.023

3.74E-33

Gly

rs147007805

10

A

T

0.075

-0.140

0.024

8.05E-09

Gly

rs1992855

14

C

T

0.410

0.062

0.011

5.60E-09

Gly

rs2169387

19

G

A

0.867

-0.130

0.016

1.31E-16

Gp

rs115849089

19

A

G

0.101

-0.105

0.017

1.29E-09

Gp

rs1260326

10

C

T

0.637

-0.087

0.011

5.24E-16

Gp

rs13234157

18

A

C

0.123

-0.110

0.016

6.36E-12

Gp

rs182695896

15

C

A

0.019

0.295

0.041

9.57E-13

Gp

rs28929474

4

T

C

0.018

-0.286

0.039

2.74E-13

Gp

rs77303550

6

T

C

0.186

0.153

0.013

4.04E-30

HDL.C

rs111894427

3

T

C

0.052

0.134

0.022

1.83E-09

HDL.C

rs1461729

19

G

A

0.870

0.094

0.014

1.32E-10

HDL.C

rs174594

3

A

C

0.589

0.069

0.010

3.35E-11

HDL.C

rs247617

6

A

C

0.298

0.227

0.011

5.76E-97

HDL.C

rs261291

5

C

T

0.373

0.129

0.010

6.80E-36

HDL.C

rs291

19

C

T

0.231

0.096

0.012

2.90E-16

HDL.C

rs6507939

8

C

A

0.843

0.093

0.013

9.48E-12

HDL.D

rs1532085

5

G

A

0.595

-0.230

0.010

3.26E-106

HDL.D

rs16940011

5

G

C

0.105

-0.112

0.017

2.05E-11

HDL.D

rs174578

3

A

T

0.402

-0.098

0.010

2.50E-20

HDL.D

rs247617

6

A

C

0.289

0.177

0.011

1.83E-53

HDL.D

rs4860970

15

T

C

0.414

0.069

0.012

2.93E-08

HDL.D

rs6065904

11

A

G

0.233

-0.178

0.012

1.73E-47

HDL.D

rs6507939

8

C

A

0.839

0.113

0.014

8.32E-16

HDL.D

rs7412

9

T

C

0.056

0.150

0.026

1.25E-08

HDL.D

rs75551077

19

C

G

0.086

0.138

0.018

1.20E-13

His

rs1801020

16

G

A

0.728

0.078

0.012

5.83E-11

His

rs1998848

4

A

G

0.054

0.147

0.024

4.91E-10

His

rs3733402

15

A

G

0.568

0.081

0.010

9.14E-15

IDL.C

rs11591147

1

T

G

0.031

-0.500

0.035

1.55E-45

IDL.C

rs142130958

9

A

G

0.102

-0.238

0.017

4.20E-42

IDL.C

rs182695896

15

C

A

0.019

0.260

0.041

3.89E-10

IDL.C

rs1883711

11

C

G

0.057

0.149

0.025

3.02E-09

IDL.C

rs261334

5

C

G

0.769

-0.119

0.012

2.00E-21

IDL.C

rs2980860

19

G

A

0.481

-0.065

0.010

5.20E-10

IDL.C

rs62523994

19

A

G

0.391

0.060

0.011

2.34E-08

IDL.C

rs635634

20

T

C

0.201

0.083

0.013

2.06E-10

IDL.C

rs6756629

10

A

G

0.082

-0.129

0.019

1.73E-11

IDL.C

rs7412

9

T

C

0.056

-0.533

0.026

5.08E-92

IDL.C

rs7786322

18

T

A

0.249

0.070

0.012

8.99E-09

IDL.C

rs79225634

16

T

C

0.353

0.090

0.011

2.45E-16

IDL.C

rs952275

10

G

T

0.427

0.109

0.010

3.58E-25

IDL.FC

rs11591147

1

T

G

0.031

-0.505

0.035

1.28E-46

IDL.FC

rs17248720

9

T

C

0.105

-0.232

0.017

1.62E-43

IDL.FC

rs185567543

15

T

A

0.018

0.276

0.042

7.59E-11

IDL.FC

rs1883711

11

C

G

0.057

0.149

0.025

2.74E-09

IDL.FC

rs261334

5

C

G

0.775

-0.139

0.012

1.55E-30

IDL.FC

rs2954021

19

G

A

0.546

-0.060

0.010

1.36E-09

IDL.FC

rs635634

20

T

C

0.198

0.077

0.012

6.91E-10

IDL.FC

rs6756629

10

A

G

0.078

-0.120

0.018

8.52E-11

IDL.FC

rs7412

9

T

C

0.056

-0.523

0.025

1.09E-93

IDL.FC

rs7786322

18

T

A

0.246

0.071

0.011

1.24E-09

IDL.FC

rs79225634

16

T

C

0.337

0.080

0.010

5.61E-14

IDL.FC

rs952275

10

G

T

0.433

0.109

0.010

1.47E-27

IDL.L

rs11591147

1

T

G

0.031

-0.481

0.035

3.33E-42

IDL.L

rs142130958

9

A

G

0.102

-0.235

0.017

4.30E-41

IDL.L

rs182695896

15

C

A

0.019

0.294

0.041

1.51E-12

IDL.L

rs1883711

11

C

G

0.057

0.156

0.025

4.85E-10

IDL.L

rs261334

5

C

G

0.769

-0.132

0.012

3.74E-26

IDL.L

rs2980860

19

G

A

0.481

-0.073

0.010

3.81E-12

IDL.L

rs3741298

3

T

C

0.771

-0.078

0.012

2.99E-10

IDL.L

rs62523994

19

A

G

0.391

0.059

0.011

3.42E-08

IDL.L

rs635634

20

T

C

0.201

0.085

0.013

5.41E-11

IDL.L

rs7412

9

T

C

0.056

-0.505

0.026

1.92E-82

IDL.L

rs76866386

10

C

T

0.082

-0.122

0.019

1.41E-10

IDL.L

rs7786322

18

T

A

0.249

0.072

0.012

2.72E-09

IDL.L

rs79225634

16

T

C

0.353

0.087

0.011

2.97E-15

IDL.L

rs952275

10

G

T

0.427

0.109

0.010

3.14E-25

IDL.P

rs11591147

1

T

G

0.031

-0.464

0.035

1.82E-39

IDL.P

rs142130958

9

A

G

0.102

-0.230

0.017

1.76E-39

IDL.P

rs182695896

15

C

A

0.019

0.305

0.041

2.13E-13

IDL.P

rs1883711

11

C

G

0.057

0.159

0.025

2.57E-10

IDL.P

rs261334

5

C

G

0.769

-0.140

0.012

5.98E-29

IDL.P

rs2980860

19

G

A

0.481

-0.075

0.010

5.92E-13

IDL.P

rs3741298

3

T

C

0.771

-0.085

0.012

5.87E-12

IDL.P

rs635634

20

T

C

0.201

0.085

0.013

7.01E-11

IDL.P

rs7412

9

T

C

0.056

-0.482

0.026

5.03E-75

IDL.P

rs76866386

10

C

T

0.082

-0.117

0.019

8.69E-10

IDL.P

rs7786322

18

T

A

0.249

0.072

0.012

3.36E-09

IDL.P

rs79225634

16

T

C

0.353

0.083

0.011

3.11E-14

IDL.P

rs952275

10

G

T

0.427

0.108

0.010

1.21E-24

IDL.PL

rs11591147

1

T

G

0.031

-0.488

0.035

1.59E-43

IDL.PL

rs17248720

9

T

C

0.105

-0.227

0.017

9.24E-42

IDL.PL

rs182695896

15

C

A

0.019

0.292

0.041

1.81E-12

IDL.PL

rs2207132

11

A

G

0.060

0.154

0.025

5.72E-10

IDL.PL

rs261334

5

C

G

0.775

-0.127

0.012

1.17E-25

IDL.PL

rs3741298

3

T

C

0.778

-0.079

0.012

3.53E-11

IDL.PL

rs635634

20

T

C

0.198

0.077

0.012

7.30E-10

IDL.PL

rs6756629

10

A

G

0.078

-0.112

0.018

1.44E-09

IDL.PL

rs7412

9

T

C

0.056

-0.505

0.025

2.19E-87

IDL.PL

rs7786322

18

T

A

0.246

0.073

0.011

3.87E-10

IDL.PL

rs79225634

16

T

C

0.337

0.079

0.010

1.21E-13

IDL.PL

rs952275

10

G

T

0.433

0.106

0.010

3.98E-26

IDL.TG

rs113531395

7

T

C

0.026

-0.246

0.036

2.44E-11

IDL.TG

rs115849089

19

A

G

0.101

-0.098

0.017

2.05E-08

IDL.TG

rs157594

9

G

T

0.588

0.126

0.012

4.34E-26

IDL.TG

rs182695896

15

C

A

0.019

0.348

0.041

4.45E-17

IDL.TG

rs1883711

11

C

G

0.057

0.155

0.025

6.67E-10

IDL.TG

rs247617

6

A

C

0.289

-0.084

0.011

4.51E-13

IDL.TG

rs261334

5

C

G

0.769

-0.197

0.012

1.09E-56

IDL.TG

rs4075673

10

C

T

0.602

-0.102

0.010

5.92E-22

IDL.TG

rs660240

1

C

T

0.785

0.079

0.012

5.70E-10

IDL.TG

rs79225634

16

T

C

0.353

0.062

0.011

1.60E-08

IDL.TG

rs9302635

6

C

T

0.175

-0.078

0.013

1.27E-08

Ile

rs1260326

10

C

T

0.639

-0.086

0.010

9.75E-18

L.HDL.C

rs174583

3

T

C

0.392

-0.078

0.010

2.92E-14

L.HDL.C

rs247617

6

A

C

0.298

0.210

0.011

1.93E-82

L.HDL.C

rs261291

5

C

T

0.373

0.179

0.010

2.39E-68

L.HDL.C

rs291

19

C

T

0.231

0.101

0.012

1.45E-17

L.HDL.C

rs429358

9

C

T

0.170

-0.092

0.013

1.46E-11

L.HDL.C

rs6065904

11

A

G

0.229

-0.135

0.012

1.72E-30

L.HDL.C

rs6507939

8

C

A

0.843

0.095

0.013

3.34E-12

L.HDL.C

rs6544366

10

T

G

0.268

0.064

0.011

8.14E-09

L.HDL.CE

rs174529

3

C

T

0.409

-0.082

0.011

1.53E-14

L.HDL.CE

rs247617

6

A

C

0.289

0.209

0.011

2.90E-73

L.HDL.CE

rs261291

5

C

T

0.377

0.181

0.011

8.02E-64

L.HDL.CE

rs429358

9

C

T

0.168

-0.090

0.014

1.29E-10

L.HDL.CE

rs6065904

11

A

G

0.233

-0.133

0.012

4.17E-27

L.HDL.CE

rs6507939

8

C

A

0.839

0.097

0.014

5.76E-12

L.HDL.CE

rs6544366

10

T

G

0.275

0.067

0.011

9.62E-09

L.HDL.CE

rs75551077

19

C

G

0.086

0.150

0.018

7.52E-16

L.HDL.FC

rs174578

3

A

T

0.394

-0.082

0.010

8.02E-16

L.HDL.FC

rs247617

6

A

C

0.298

0.197

0.011

9.47E-73

L.HDL.FC

rs261291

5

C

T

0.373

0.181

0.010

1.47E-69

L.HDL.FC

rs291

19

C

T

0.231

0.104

0.012

1.04E-18

L.HDL.FC

rs429358

9

C

T

0.170

-0.074

0.013

4.53E-08

L.HDL.FC

rs6065904

11

A

G

0.229

-0.135

0.012

2.86E-30

L.HDL.FC

rs6507939

8

C

A

0.843

0.089

0.013

6.08E-11

L.HDL.FC

rs6544366

10

T

G

0.268

0.062

0.011

2.30E-08

L.HDL.FC

rs6957745

18

C

T

0.176

0.076

0.013

1.23E-08

L.HDL.L

rs1532085

5

G

A

0.595

-0.191

0.010

8.04E-73

L.HDL.L

rs174578

3

A

T

0.402

-0.088

0.010

1.36E-16

L.HDL.L

rs247617

6

A

C

0.289

0.206

0.011

8.57E-72

L.HDL.L

rs291

19

C

T

0.228

0.098

0.012

4.18E-15

L.HDL.L

rs429358

9

C

T

0.168

-0.083

0.014

3.48E-09

L.HDL.L

rs6065904

11

A

G

0.233

-0.125

0.012

5.51E-24

L.HDL.L

rs6507939

8

C

A

0.839

0.102

0.014

4.37E-13

L.HDL.P

rs1532085

5

G

A

0.595

-0.194

0.010

1.57E-75

L.HDL.P

rs174578

3

A

T

0.402

-0.089

0.010

4.89E-17

L.HDL.P

rs247617

6

A

C

0.289

0.204

0.011

7.60E-70

L.HDL.P

rs291

19

C

T

0.228

0.097

0.012

6.05E-15

L.HDL.P

rs429358

9

C

T

0.168

-0.082

0.014

5.57E-09

L.HDL.P

rs6065904

11

A

G

0.233

-0.121

0.012

1.64E-22

L.HDL.P

rs6507939

8

C

A

0.839

0.104

0.014

2.11E-13

L.HDL.PL

rs1532085

5

G

A

0.595

-0.184

0.010

1.02E-67

L.HDL.PL

rs174578

3

A

T

0.402

-0.086

0.010

4.95E-16

L.HDL.PL

rs247617

6

A

C

0.289

0.202

0.011

1.67E-68

L.HDL.PL

rs291

19

C

T

0.228

0.098

0.012

3.18E-15

L.HDL.PL

rs429358

9

C

T

0.168

-0.079

0.014

1.52E-08

L.HDL.PL

rs6065904

11

A

G

0.233

-0.103

0.012

8.83E-17

L.HDL.PL

rs6507939

8

C

A

0.839

0.102

0.014

6.16E-13

L.LDL.C

rs11591147

1

T

G

0.031

-0.524

0.035

5.69E-50

L.LDL.C

rs142130958

9

A

G

0.105

-0.233

0.016

1.07E-44

L.LDL.C

rs182695896

15

C

A

0.019

0.298

0.041

6.05E-13

L.LDL.C

rs193084249

1

G

A

0.032

0.180

0.031

1.48E-08

L.LDL.C

rs2207132

11

A

G

0.060

0.142

0.025

1.13E-08

L.LDL.C

rs261334

5

C

G

0.775

-0.070

0.012

6.63E-09

L.LDL.C

rs34042070

6

G

C

0.202

0.069

0.012

2.68E-08

L.LDL.C

rs3741298

3

T

C

0.778

-0.069

0.012

8.86E-09

L.LDL.C

rs495828

20

T

G

0.221

0.072

0.012

1.61E-09

L.LDL.C

rs6756629

10

A

G

0.078

-0.141

0.018

2.03E-14

L.LDL.C

rs73066442

18

G

A

0.246

0.073

0.011

2.90E-10

L.LDL.C

rs7412

9

T

C

0.056

-0.573

0.025

2.63E-112

L.LDL.C

rs79225634

16

T

C

0.337

0.086

0.010

4.42E-16

L.LDL.C

rs934197

10

A

G

0.287

0.114

0.011

1.74E-24

L.LDL.CE

rs11591147

1

T

G

0.031

-0.518

0.035

8.60E-49

L.LDL.CE

rs142130958

9

A

G

0.102

-0.237

0.017

1.19E-41

L.LDL.CE

rs182695896

15

C

A

0.019

0.292

0.041

1.91E-12

L.LDL.CE

rs193084249

1

G

A

0.032

0.183

0.031

8.68E-09

L.LDL.CE

rs2207132

11

A

G

0.060

0.143

0.025

9.50E-09

L.LDL.CE

rs2980860

19

G

A

0.481

-0.065

0.010

4.88E-10

L.LDL.CE

rs34042070

6

G

C

0.199

0.074

0.013

1.54E-08

L.LDL.CE

rs3741298

3

T

C

0.771

-0.074

0.012

2.78E-09

L.LDL.CE

rs635634

20

T

C

0.201

0.074

0.013

1.24E-08

L.LDL.CE

rs6756629

10

A

G

0.082

-0.134

0.019

2.78E-12

L.LDL.CE

rs73066442

18

G

A

0.249

0.069

0.012

1.24E-08

L.LDL.CE

rs7412

9

T

C

0.056

-0.571

0.026

1.54E-105

L.LDL.CE

rs79225634

16

T

C

0.353

0.094

0.011

1.33E-17

L.LDL.CE

rs934197

10

A

G

0.285

0.115

0.011

6.60E-23

L.LDL.FC

rs11591147

1

T

G

0.031

-0.526

0.035

2.02E-50

L.LDL.FC

rs142130958

9

A

G

0.105

-0.239

0.016

6.49E-47

L.LDL.FC

rs185567543

15

T

A

0.018

0.313

0.042

1.81E-13

L.LDL.FC

rs2207132

11

A

G

0.060

0.136

0.025

4.65E-08

L.LDL.FC

rs261334

5

C

G

0.775

-0.080

0.012

3.33E-11

L.LDL.FC

rs495828

20

T

G

0.221

0.074

0.012

4.67E-10

L.LDL.FC

rs6756629

10

A

G

0.078

-0.142

0.018

1.86E-14

L.LDL.FC

rs73066442

18

G

A

0.246

0.074

0.011

2.29E-10

L.LDL.FC

rs7412

9

T

C

0.056

-0.593

0.025

2.03E-120

L.LDL.FC

rs79225634

16

T

C

0.337

0.083

0.010

4.05E-15

L.LDL.FC

rs934197

10

A

G

0.287

0.116

0.011

2.97E-25

L.LDL.L

rs11591147

1

T

G

0.031

-0.516

0.035

2.07E-48

L.LDL.L

rs142130958

9

A

G

0.102

-0.240

0.017

1.11E-42

L.LDL.L

rs182695896

15

C

A

0.019

0.316

0.041

2.72E-14

L.LDL.L

rs193084249

1

G

A

0.032

0.178

0.031

2.25E-08

L.LDL.L

rs2207132

11

A

G

0.060

0.146

0.025

4.78E-09

L.LDL.L

rs261334

5

C

G

0.769

-0.072

0.012

9.64E-09

L.LDL.L

rs2980860

19

G

A

0.481

-0.070

0.010

2.82E-11

L.LDL.L

rs34042070

6

G

C

0.199

0.072

0.013

3.47E-08

L.LDL.L

rs3741298

3

T

C

0.771

-0.076

0.012

9.84E-10

L.LDL.L

rs635634

20

T

C

0.201

0.077

0.013

3.91E-09

L.LDL.L

rs6756629

10

A

G

0.082

-0.131

0.019

6.79E-12

L.LDL.L

rs73066442

18

G

A

0.249

0.072

0.012

2.49E-09

L.LDL.L

rs7412

9

T

C

0.056

-0.573

0.026

4.82E-106

L.LDL.L

rs79225634

16

T

C

0.353

0.092

0.011

5.75E-17

L.LDL.L

rs934197

10

A

G

0.285

0.116

0.011

2.77E-23

L.LDL.P

rs11591147

1

T

G

0.031

-0.509

0.035

4.46E-47

L.LDL.P

rs142130958

9

A

G

0.102

-0.238

0.017

5.37E-42

L.LDL.P

rs182695896

15

C

A

0.019

0.329

0.041

2.21E-15

L.LDL.P

rs193084249

1

G

A

0.032

0.176

0.031

3.32E-08

L.LDL.P

rs2207132

11

A

G

0.060

0.147

0.025

3.65E-09

L.LDL.P

rs261334

5

C

G

0.769

-0.084

0.012

2.63E-11

L.LDL.P

rs2980860

19

G

A

0.481

-0.072

0.010

4.75E-12

L.LDL.P

rs3741298

3

T

C

0.771

-0.081

0.012

6.76E-11

L.LDL.P

rs635634

20

T

C

0.201

0.078

0.013

2.71E-09

L.LDL.P

rs6756629

10

A

G

0.082

-0.129

0.019

1.38E-11

L.LDL.P

rs73066442

18

G

A

0.249

0.073

0.012

2.10E-09

L.LDL.P

rs7412

9

T

C

0.056

-0.559

0.026

4.52E-101

L.LDL.P

rs79225634

16

T

C

0.353

0.090

0.011

1.88E-16

L.LDL.P

rs934197

10

A

G

0.285

0.116

0.011

3.03E-23

L.LDL.PL

rs11591147

1

T

G

0.031

-0.505

0.035

1.47E-46

L.LDL.PL

rs142130958

9

A

G

0.105

-0.232

0.016

3.10E-44

L.LDL.PL

rs182695896

15

C

A

0.019

0.302

0.041

3.35E-13

L.LDL.PL

rs193084249

1

G

A

0.032

0.173

0.031

4.89E-08

L.LDL.PL

rs2207132

11

A

G

0.060

0.144

0.025

6.75E-09

L.LDL.PL

rs261334

5

C

G

0.775

-0.081

0.012

1.87E-11

L.LDL.PL

rs3741298

3

T

C

0.778

-0.078

0.012

7.54E-11

L.LDL.PL

rs635634

20

T

C

0.198

0.079

0.012

3.70E-10

L.LDL.PL

rs6756629

10

A

G

0.078

-0.134

0.018

4.57E-13

L.LDL.PL

rs73066442

18

G

A

0.246

0.075

0.011

9.67E-11

L.LDL.PL

rs7412

9

T

C

0.056

-0.552

0.025

3.97E-104

L.LDL.PL

rs79225634

16

T

C

0.337

0.083

0.010

3.89E-15

L.LDL.PL

rs934197

10

A

G

0.287

0.113

0.011

3.21E-24

L.VLDL.C

rs10889331

1

T

G

0.693

0.086

0.012

3.81E-13

L.VLDL.C

rs1260326

10

C

T

0.639

-0.089

0.010

8.49E-18

L.VLDL.C

rs34482346

18

C

G

0.121

-0.128

0.015

1.44E-16

L.VLDL.C

rs438811

9

T

C

0.234

0.094

0.012

1.82E-14

L.VLDL.C

rs72999033

9

T

C

0.059

-0.150

0.021

2.31E-12

L.VLDL.C

rs76975037

19

A

C

0.087

-0.148

0.018

6.37E-17

L.VLDL.C

rs821840

6

G

A

0.264

-0.092

0.012

6.10E-15

L.VLDL.C

rs9472125

17

T

C

0.166

-0.093

0.016

1.41E-08

L.VLDL.CE

rs1260326

10

C

T

0.637

-0.083

0.011

2.08E-14

L.VLDL.CE

rs1569209

19

G

T

0.063

-0.194

0.021

4.94E-19

L.VLDL.CE

rs2980860

19

G

A

0.481

-0.060

0.010

1.13E-08

L.VLDL.CE

rs34482346

18

C

G

0.120

-0.126

0.016

7.49E-15

L.VLDL.CE

rs483082

9

T

G

0.229

0.096

0.013

2.88E-14

L.VLDL.CE

rs72999033

9

T

C

0.061

-0.148

0.022

1.12E-11

L.VLDL.CE

rs7527004

1

A

G

0.697

0.079

0.011

3.96E-12

L.VLDL.CE

rs77697917

7

T

C

0.023

0.214

0.037

1.44E-08

L.VLDL.CE

rs821840

6

G

A

0.256

-0.106

0.012

1.82E-17

L.VLDL.FC

rs10455872

17

G

A

0.041

-0.158

0.028

2.38E-08

L.VLDL.FC

rs1168041

1

C

T

0.722

0.090

0.011

1.91E-15

L.VLDL.FC

rs1260326

10

C

T

0.639

-0.095

0.010

7.17E-20

L.VLDL.FC

rs3812316

18

G

C

0.125

-0.125

0.015

4.73E-16

L.VLDL.FC

rs41293995

2

A

C

0.031

-0.178

0.032

2.69E-08

L.VLDL.FC

rs438811

9

T

C

0.234

0.093

0.012

4.92E-14

L.VLDL.FC

rs72999033

9

T

C

0.059

-0.157

0.021

2.17E-13

L.VLDL.FC

rs76975037

19

A

C

0.087

-0.140

0.018

2.87E-15

L.VLDL.FC

rs821840

6

G

A

0.264

-0.071

0.012

2.47E-09

L.VLDL.L

rs10455872

17

G

A

0.041

-0.163

0.028

8.00E-09

L.VLDL.L

rs11207978

1

C

T

0.189

-0.082

0.013

5.16E-10

L.VLDL.L

rs115849089

19

A

G

0.101

-0.138

0.017

2.79E-15

L.VLDL.L

rs1260326

10

C

T

0.637

-0.088

0.011

4.90E-16

L.VLDL.L

rs34437827

18

G

A

0.175

-0.103

0.014

1.01E-13

L.VLDL.L

rs483082

9

T

G

0.229

0.088

0.013

3.91E-12

L.VLDL.L

rs9472125

17

T

C

0.166

-0.093

0.016

1.63E-08

L.VLDL.P

rs115849089

19

A

G

0.101

-0.139

0.017

2.15E-15

L.VLDL.P

rs1260326

10

C

T

0.637

-0.098

0.011

1.90E-19

L.VLDL.P

rs13234157

18

A

C

0.123

-0.120

0.016

1.43E-13

L.VLDL.P

rs2980882

19

G

A

0.484

-0.060

0.010

1.14E-08

L.VLDL.P

rs35529421

1

A

T

0.297

-0.088

0.011

2.01E-14

L.VLDL.P

rs55730499

17

T

C

0.041

-0.161

0.028

1.94E-08

L.VLDL.PL

rs1260326

10

C

T

0.639

-0.097

0.010

9.13E-21

L.VLDL.PL

rs34437827

18

G

A

0.183

-0.096

0.013

7.09E-13

L.VLDL.PL

rs4350231

1

A

G

0.301

-0.077

0.011

9.56E-13

L.VLDL.PL

rs438811

9

T

C

0.234

0.095

0.012

1.05E-14

L.VLDL.PL

rs76975037

19

A

C

0.087

-0.156

0.018

1.06E-18

L.VLDL.PL

rs821840

6

G

A

0.264

-0.068

0.012

6.73E-09

L.VLDL.PL

rs9472125

17

T

C

0.166

-0.096

0.017

1.16E-08

L.VLDL.TG

rs10455872

17

G

A

0.041

-0.165

0.028

5.39E-09

L.VLDL.TG

rs1260326

10

C

T

0.639

-0.094

0.010

9.83E-20

L.VLDL.TG

rs17411024

19

A

G

0.087

-0.154

0.018

9.64E-18

L.VLDL.TG

rs34346326

18

C

T

0.173

-0.110

0.013

9.42E-17

L.VLDL.TG

rs4350231

1

A

G

0.301

-0.071

0.011

5.45E-11

L.VLDL.TG

rs438811

9

T

C

0.234

0.090

0.012

2.92E-13

L.VLDL.TG

rs72999033

9

T

C

0.059

-0.133

0.021

4.64E-10

L.VLDL.TG

rs9472125

17

T

C

0.166

-0.091

0.016

3.08E-08

LA

rs10402112

9

A

T

0.100

-0.171

0.021

7.90E-16

LA

rs1260326

10

C

T

0.637

-0.082

0.013

1.28E-10

LA

rs144064722

15

G

A

0.026

0.230

0.040

7.45E-09

LA

rs144723570

12

T

C

0.011

-0.332

0.060

3.42E-08

LA

rs17414716

1

G

A

0.028

-0.300

0.038

3.26E-15

LA

rs1800588

5

T

C

0.249

0.129

0.014

7.41E-19

LA

rs7412

9

T

C

0.057

-0.295

0.028

3.40E-25

LA

rs79225634

16

T

C

0.352

0.096

0.013

1.66E-13

LA

rs821840

6

G

A

0.252

0.084

0.015

1.43E-08

LA

rs99780

3

T

C

0.401

0.148

0.012

3.35E-32

Lac

rs1260326

10

C

T

0.639

-0.058

0.010

7.23E-09

Lac

rs762523

13

G

A

0.660

0.053

0.010

3.96E-08

LDL.C

rs10056811

16

A

G

0.341

0.088

0.010

4.74E-17

LDL.C

rs112635299

4

T

G

0.018

0.232

0.040

8.66E-09

LDL.C

rs11591147

1

T

G

0.031

-0.515

0.035

2.85E-48

LDL.C

rs142130958

9

A

G

0.105

-0.231

0.016

6.16E-44

LDL.C

rs182695896

15

C

A

0.019

0.311

0.041

6.37E-14

LDL.C

rs193084249

1

G

A

0.032

0.180

0.031

1.42E-08

LDL.C

rs2207132

11

A

G

0.060

0.140

0.025

2.08E-08

LDL.C

rs62523994

19

A

G

0.389

0.057

0.010

2.57E-08

LDL.C

rs635634

20

T

C

0.198

0.070

0.012

2.99E-08

LDL.C

rs6756629

10

A

G

0.078

-0.143

0.018

1.22E-14

LDL.C

rs73066442

18

G

A

0.246

0.071

0.011

9.71E-10

LDL.C

rs73107473

18

A

G

0.181

0.077

0.013

1.63E-08

LDL.C

rs7412

9

T

C

0.056

-0.592

0.025

1.75E-119

LDL.C

rs934197

10

A

G

0.287

0.120

0.011

5.14E-27

LDL.D

rs10468017

5

T

C

0.314

0.180

0.011

6.33E-58

LDL.D

rs1260326

10

C

T

0.637

0.065

0.011

1.39E-09

LDL.D

rs28456

3

G

A

0.368

-0.061

0.011

1.82E-08

LDL.D

rs75627662

9

T

C

0.207

-0.085

0.013

6.40E-11

Leu

rs12325419

6

A

G

0.120

-0.082

0.015

4.55E-08

Leu

rs1260326

10

C

T

0.639

-0.080

0.010

1.07E-15

Leu

rs17789027

15

G

A

0.384

0.109

0.010

6.16E-30

M.HDL.C

rs2126259

19

C

T

0.869

0.094

0.014

1.36E-10

M.HDL.C

rs247617

6

A

C

0.298

0.165

0.011

7.55E-52

M.HDL.C

rs429358

9

C

T

0.170

-0.083

0.013

7.33E-10

M.HDL.C

rs4939883

8

C

T

0.831

0.073

0.013

2.32E-08

M.HDL.C

rs590820

1

G

A

0.437

-0.058

0.010

1.71E-08

M.HDL.C

rs75835816

19

C

G

0.019

-0.238

0.038

6.27E-10

M.HDL.CE

rs2126259

19

C

T

0.862

0.089

0.015

3.11E-09

M.HDL.CE

rs247617

6

A

C

0.289

0.161

0.011

3.15E-44

M.HDL.CE

rs429358

9

C

T

0.168

-0.081

0.014

7.73E-09

M.HDL.CE

rs6073966

11

T

C

0.144

0.087

0.015

3.93E-09

M.HDL.CE

rs75835816

19

C

G

0.019

-0.233

0.038

1.33E-09

M.HDL.FC

rs247617

6

A

C

0.298

0.159

0.011

7.52E-48

M.HDL.FC

rs4939884

8

C

T

0.830

0.083

0.013

2.31E-10

M.HDL.FC

rs590820

1

G

A

0.437

-0.062

0.010

1.59E-09

M.HDL.FC

rs75835816

19

C

G

0.019

-0.228

0.038

3.13E-09

M.HDL.FC

rs9987289

19

G

A

0.882

0.107

0.015

2.08E-12

M.HDL.L

rs247617

6

A

C

0.289

0.136

0.011

5.70E-32

M.HDL.L

rs6073966

11

T

C

0.144

0.100

0.015

1.40E-11

M.HDL.L

rs6507939

8

C

A

0.839

0.087

0.014

6.40E-10

M.HDL.L

rs75835816

19

C

G

0.019

-0.218

0.038

1.42E-08

M.HDL.L

rs9987289

19

G

A

0.875

0.095

0.015

1.38E-09

M.HDL.P

rs247617

6

A

C

0.289

0.120

0.011

1.49E-25

M.HDL.P

rs6073966

11

T

C

0.144

0.104

0.015

1.80E-12

M.HDL.P

rs6507939

8

C

A

0.839

0.092

0.014

6.59E-11

M.HDL.P

rs9987289

19

G

A

0.875

0.091

0.016

5.57E-09

M.HDL.PL

rs12239737

1

A

T

0.270

-0.064

0.011

1.57E-08

M.HDL.PL

rs247617

6

A

C

0.298

0.134

0.011

1.04E-34

M.HDL.PL

rs4939884

8

C

T

0.830

0.093

0.013

1.10E-12

M.HDL.PL

rs6073958

11

C

T

0.196

0.078

0.012

4.27E-10

M.HDL.PL

rs75835816

19

C

G

0.019

-0.212

0.038

3.80E-08

M.HDL.PL

rs9987289

19

G

A

0.882

0.099

0.015

1.05E-10

M.LDL.C

rs112635299

4

T

G

0.018

0.237

0.040

4.03E-09

M.LDL.C

rs11591147

1

T

G

0.031

-0.510

0.035

2.83E-47

M.LDL.C

rs12916

16

C

T

0.424

0.084

0.010

1.86E-16

M.LDL.C

rs142130958

9

A

G

0.105

-0.221

0.016

2.19E-40

M.LDL.C

rs182695896

15

C

A

0.019

0.325

0.042

1.95E-14

M.LDL.C

rs193084249

1

G

A

0.032

0.182

0.031

1.04E-08

M.LDL.C

rs2207132

11

A

G

0.060

0.137

0.025

3.69E-08

M.LDL.C

rs2980875

19

G

A

0.485

-0.058

0.010

5.86E-09

M.LDL.C

rs3741298

3

T

C

0.778

-0.072

0.012

1.49E-09

M.LDL.C

rs73066442

18

G

A

0.246

0.071

0.011

8.03E-10

M.LDL.C

rs7412

9

T

C

0.056

-0.565

0.025

9.52E-109

M.LDL.C

rs76866386

10

C

T

0.078

-0.142

0.018

1.42E-14

M.LDL.C

rs934197

10

A

G

0.287

0.113

0.011

3.50E-24

M.LDL.CE

rs112635299

4

T

G

0.018

0.246

0.042

6.19E-09

M.LDL.CE

rs11591147

1

T

G

0.031

-0.506

0.035

1.39E-46

M.LDL.CE

rs142130958

9

A

G

0.102

-0.231

0.017

1.06E-39

M.LDL.CE

rs182695896

15

C

A

0.019

0.316

0.041

2.78E-14

M.LDL.CE

rs193084249

1

G

A

0.032

0.181

0.031

1.32E-08

M.LDL.CE

rs2207132

11

A

G

0.060

0.142

0.025

1.35E-08

M.LDL.CE

rs2980860

19

G

A

0.481

-0.068

0.010

8.66E-11

M.LDL.CE

rs34042070

6

G

C

0.199

0.072

0.013

3.47E-08

M.LDL.CE

rs3741298

3

T

C

0.771

-0.083

0.012

2.15E-11

M.LDL.CE

rs6756629

10

A

G

0.082

-0.135

0.019

1.94E-12

M.LDL.CE

rs73066442

18

G

A

0.249

0.067

0.012

2.95E-08

M.LDL.CE

rs7412

9

T

C

0.056

-0.546

0.026

2.04E-96

M.LDL.CE

rs79225634

16

T

C

0.353

0.092

0.011

5.03E-17

M.LDL.CE

rs934197

10

A

G

0.285

0.113

0.011

4.00E-22

M.LDL.L

rs112635299

4

T

G

0.018

0.245

0.042

7.26E-09

M.LDL.L

rs11591147

1

T

G

0.031

-0.501

0.035

1.24E-45

M.LDL.L

rs142130958

9

A

G

0.102

-0.230

0.017

2.82E-39

M.LDL.L

rs182695896

15

C

A

0.019

0.325

0.041

5.32E-15

M.LDL.L

rs193084249

1

G

A

0.032

0.181

0.031

1.32E-08

M.LDL.L

rs2207132

11

A

G

0.060

0.138

0.025

3.29E-08

M.LDL.L

rs2980860

19

G

A

0.481

-0.072

0.010

6.95E-12

M.LDL.L

rs3741298

3

T

C

0.771

-0.088

0.012

1.71E-12

M.LDL.L

rs6756629

10

A

G

0.082

-0.132

0.019

5.54E-12

M.LDL.L

rs73066442

18

G

A

0.249

0.070

0.012

9.31E-09

M.LDL.L

rs7412

9

T

C

0.056

-0.541

0.026

1.31E-94

M.LDL.L

rs79225634

16

T

C

0.353

0.091

0.011

1.43E-16

M.LDL.L

rs934197

10

A

G

0.285

0.110

0.011

4.16E-21

M.LDL.P

rs112635299

4

T

G

0.018

0.239

0.042

1.67E-08

M.LDL.P

rs11591147

1

T

G

0.031

-0.494

0.035

1.91E-44

M.LDL.P

rs142130958

9

A

G

0.102

-0.227

0.017

2.38E-38

M.LDL.P

rs182695896

15

C

A

0.019

0.335

0.041

7.35E-16

M.LDL.P

rs193084249

1

G

A

0.032

0.179

0.031

1.67E-08

M.LDL.P

rs2207132

11

A

G

0.060

0.139

0.025

2.77E-08

M.LDL.P

rs2980860

19

G

A

0.481

-0.074

0.010

1.38E-12

M.LDL.P

rs3741298

3

T

C

0.771

-0.092

0.012

1.38E-13

M.LDL.P

rs6756629

10

A

G

0.082

-0.129

0.019

1.32E-11

M.LDL.P

rs73066442

18

G

A

0.249

0.070

0.012

7.20E-09

M.LDL.P

rs7412

9

T

C

0.056

-0.526

0.026

1.65E-89

M.LDL.P

rs79225634

16

T

C

0.353

0.090

0.011

2.98E-16

M.LDL.PL

rs11591147

1

T

G

0.031

-0.475

0.035

3.64E-41

M.LDL.PL

rs12916

16

C

T

0.424

0.082

0.010

8.44E-16

M.LDL.PL

rs142130958

9

A

G

0.105

-0.210

0.016

1.77E-36

M.LDL.PL

rs144064722

15

G

A

0.025

0.235

0.034

1.12E-11

M.LDL.PL

rs193084249

1

G

A

0.032

0.180

0.031

1.37E-08

M.LDL.PL

rs6756629

10

A

G

0.078

-0.132

0.018

1.16E-12

M.LDL.PL

rs73066442

18

G

A

0.246

0.071

0.011

9.54E-10

M.LDL.PL

rs7412

9

T

C

0.056

-0.519

0.025

9.76E-92

M.VLDL.C

rs115849089

19

A

G

0.107

-0.164

0.017

2.67E-22

M.VLDL.C

rs1168041

1

C

T

0.722

0.094

0.011

1.43E-16

M.VLDL.C

rs183130

6

T

C

0.295

-0.105

0.012

2.39E-18

M.VLDL.C

rs2954021

19

G

A

0.546

-0.069

0.010

2.76E-12

M.VLDL.C

rs3826688

9

C

T

0.677

0.092

0.011

2.20E-16

M.VLDL.C

rs3846661

16

G

A

0.425

0.066

0.010

8.95E-11

M.VLDL.C

rs72836561

7

T

C

0.025

0.208

0.036

9.94E-09

M.VLDL.C

rs72999033

9

T

C

0.059

-0.176

0.021

1.04E-16

M.VLDL.CE

rs115849089

19

A

G

0.101

-0.163

0.017

7.89E-21

M.VLDL.CE

rs1168041

1

C

T

0.727

0.087

0.012

2.52E-13

M.VLDL.CE

rs247617

6

A

C

0.289

-0.097

0.011

4.77E-17

M.VLDL.CE

rs2980860

19

G

A

0.481

-0.072

0.010

3.61E-12

M.VLDL.CE

rs34482346

18

C

G

0.120

-0.100

0.016

5.10E-10

M.VLDL.CE

rs429358

9

C

T

0.168

0.119

0.014

2.50E-17

M.VLDL.CE

rs4296389

10

T

C

0.320

-0.107

0.011

7.73E-22

M.VLDL.CE

rs72836561

7

T

C

0.025

0.210

0.036

7.06E-09

M.VLDL.CE

rs72999033

9

T

C

0.061

-0.180

0.021

1.17E-16

M.VLDL.CE

rs79225634

16

T

C

0.353

0.075

0.011

9.01E-12

M.VLDL.FC

rs115849089

19

A

G

0.107

-0.165

0.017

2.74E-22

M.VLDL.FC

rs1168002

1

G

A

0.697

0.088

0.011

4.20E-16

M.VLDL.FC

rs1260326

10

C

T

0.639

-0.099

0.010

1.38E-21

M.VLDL.FC

rs12916

16

C

T

0.424

0.059

0.010

7.44E-09

M.VLDL.FC

rs13234157

18

A

C

0.125

-0.128

0.015

1.39E-16

M.VLDL.FC

rs2980875

19

G

A

0.485

-0.066

0.010

3.08E-11

M.VLDL.FC

rs3826688

9

C

T

0.677

0.090

0.011

1.68E-15

M.VLDL.FC

rs72999033

9

T

C

0.059

-0.166

0.021

6.80E-15

M.VLDL.FC

rs821840

6

G

A

0.264

-0.085

0.012

5.82E-13

M.VLDL.L

rs115849089

19

A

G

0.101

-0.170

0.017

1.27E-22

M.VLDL.L

rs1260326

10

C

T

0.637

-0.096

0.011

2.98E-19

M.VLDL.L

rs2980860

19

G

A

0.481

-0.062

0.010

2.75E-09

M.VLDL.L

rs34346326

18

C

T

0.170

-0.108

0.014

4.64E-15

M.VLDL.L

rs3826688

9

C

T

0.678

0.085

0.011

1.02E-13

M.VLDL.L

rs4350231

1

A

G

0.296

-0.073

0.011

1.13E-10

M.VLDL.L

rs72836561

7

T

C

0.025

0.206

0.036

1.40E-08

M.VLDL.L

rs72999033

9

T

C

0.061

-0.160

0.021

1.17E-13

M.VLDL.L

rs821840

6

G

A

0.256

-0.079

0.012

1.77E-10

M.VLDL.P

rs115849089

19

A

G

0.101

-0.165

0.017

2.04E-21

M.VLDL.P

rs1168041

1

C

T

0.727

0.080

0.012

1.55E-11

M.VLDL.P

rs1260326

10

C

T

0.637

-0.096

0.011

4.67E-19

M.VLDL.P

rs34346326

18

C

T

0.170

-0.113

0.014

4.02E-16

M.VLDL.P

rs6065904

11

A

G

0.233

0.069

0.012

2.24E-08

M.VLDL.P

rs6982636

19

A

G

0.485

-0.062

0.010

2.18E-09

M.VLDL.P

rs72836561

7

T

C

0.025

0.206

0.036

1.43E-08

M.VLDL.P

rs821840

6

G

A

0.256

-0.076

0.012

1.04E-09

M.VLDL.PL

rs115849089

19

A

G

0.107

-0.168

0.017

5.42E-23

M.VLDL.PL

rs1260326

10

C

T

0.639

-0.098

0.010

4.48E-21

M.VLDL.PL

rs12916

16

C

T

0.424

0.057

0.010

2.69E-08

M.VLDL.PL

rs13234157

18

A

C

0.125

-0.123

0.015

1.72E-15

M.VLDL.PL

rs2980875

19

G

A

0.485

-0.067

0.010

2.44E-11

M.VLDL.PL

rs3826688

9

C

T

0.677

0.092

0.011

3.30E-16

M.VLDL.PL

rs4350231

1

A

G

0.301

-0.084

0.011

8.71E-15

M.VLDL.PL

rs6065904

11

A

G

0.229

0.067

0.012

1.66E-08

M.VLDL.PL

rs72836561

7

T

C

0.025

0.202

0.036

2.87E-08

M.VLDL.PL

rs72999033

9

T

C

0.059

-0.163

0.021

2.45E-14

M.VLDL.PL

rs821840

6

G

A

0.264

-0.092

0.012

9.86E-15

M.VLDL.PL

rs9472125

17

T

C

0.166

-0.092

0.016

2.28E-08

M.VLDL.TG

rs1168001

1

A

G

0.697

0.072

0.011

2.57E-11

M.VLDL.TG

rs1260326

10

C

T

0.639

-0.095

0.010

6.80E-20

M.VLDL.TG

rs6065904

11

A

G

0.229

0.077

0.012

9.11E-11

M.VLDL.TG

rs72999033

9

T

C

0.059

-0.138

0.021

8.96E-11

M.VLDL.TG

rs77697917

7

T

C

0.023

0.209

0.037

2.77E-08

M.VLDL.TG

rs79236614

19

G

C

0.089

-0.166

0.017

1.61E-21

M.VLDL.TG

rs821840

6

G

A

0.264

-0.070

0.012

3.31E-09

M.VLDL.TG

rs9472125

17

T

C

0.166

-0.091

0.016

2.60E-08

MUFA

rs115849089

19

A

G

0.107

-0.121

0.020

1.79E-09

MUFA

rs1260326

10

C

T

0.637

-0.118

0.013

3.53E-20

MUFA

rs1800588

5

T

C

0.249

0.130

0.014

4.76E-19

MUFA

rs41272659

10

A

G

0.024

-0.245

0.042

1.06E-08

MUFA

rs8107974

9

T

A

0.065

-0.150

0.025

2.42E-09

PC

rs1077835

5

G

A

0.251

0.184

0.014

5.91E-37

PC

rs11591147

1

T

G

0.029

-0.260

0.040

8.62E-11

PC

rs143020224

9

G

C

0.121

-0.120

0.019

7.94E-10

PC

rs3741298

3

T

C

0.770

-0.097

0.014

2.33E-11

PC

rs821840

6

G

A

0.251

0.139

0.015

2.76E-21

Phe

rs182695896

15

C

A

0.018

0.245

0.040

1.09E-09

Phe

rs2731672

16

C

T

0.740

0.095

0.012

3.85E-16

Phe

rs4253238

15

T

C

0.555

0.067

0.010

2.53E-11

Pyr

rs1260326

10

C

T

0.639

-0.081

0.010

5.47E-16

Pyr

rs74249229

6

T

C

0.050

-0.153

0.023

2.13E-11

S.HDL.L

rs10468017

5

T

C

0.314

-0.101

0.011

2.58E-19

S.HDL.L

rs1260326

10

C

T

0.637

-0.079

0.011

1.91E-13

S.HDL.L

rs185567543

15

T

A

0.018

0.288

0.042

7.85E-12

S.HDL.L

rs6073958

11

C

T

0.196

0.200

0.013

3.36E-54

S.HDL.L

rs7412

9

T

C

0.056

-0.192

0.026

2.68E-13

S.HDL.P

rs10468017

5

T

C

0.314

-0.105

0.011

8.12E-21

S.HDL.P

rs1260326

10

C

T

0.637

-0.087

0.011

5.41E-16

S.HDL.P

rs6073958

11

C

T

0.196

0.202

0.013

2.62E-55

S.HDL.TG

rs182695896

15

C

A

0.019

0.255

0.041

7.43E-10

S.HDL.TG

rs3764261

6

A

C

0.299

-0.148

0.011

3.62E-42

S.HDL.TG

rs429358

9

C

T

0.170

0.100

0.013

1.49E-13

S.HDL.TG

rs4296389

10

T

C

0.313

-0.077

0.011

5.08E-13

S.HDL.TG

rs6065904

11

A

G

0.229

0.090

0.012

2.76E-14

S.HDL.TG

rs6957745

18

C

T

0.176

-0.090

0.013

2.40E-11

S.HDL.TG

rs79236614

19

G

C

0.089

-0.165

0.017

4.37E-21

S.HDL.TG

rs9472125

17

T

C

0.167

-0.092

0.016

1.93E-08

S.LDL.C

rs112635299

4

T

G

0.018

0.249

0.040

6.59E-10

S.LDL.C

rs11591147

1

T

G

0.031

-0.483

0.035

6.40E-43

S.LDL.C

rs142130958

9

A

G

0.105

-0.207

0.016

7.81E-36

S.LDL.C

rs182695896

15

C

A

0.019

0.319

0.041

1.18E-14

S.LDL.C

rs193084249

1

G

A

0.032

0.177

0.031

2.25E-08

S.LDL.C

rs34042070

6

G

C

0.202

0.076

0.012

8.55E-10

S.LDL.C

rs4614977

10

G

C

0.077

-0.130

0.018

3.18E-12

S.LDL.C

rs4703667

16

C

G

0.395

0.090

0.010

2.55E-18

S.LDL.C

rs7412

9

T

C

0.056

-0.492

0.025

5.52E-83

S.LDL.C

rs934197

10

A

G

0.287

0.103

0.011

2.18E-20

S.LDL.L

rs112635299

4

T

G

0.018

0.239

0.042

1.56E-08

S.LDL.L

rs11591147

1

T

G

0.031

-0.461

0.035

6.07E-39

S.LDL.L

rs12916

16

C

T

0.443

0.087

0.010

1.26E-16

S.LDL.L

rs142130958

9

A

G

0.102

-0.215

0.017

8.27E-35

S.LDL.L

rs182695896

15

C

A

0.019

0.322

0.041

8.45E-15

S.LDL.L

rs193084249

1

G

A

0.032

0.174

0.031

3.97E-08

S.LDL.L

rs2980860

19

G

A

0.481

-0.077

0.010

1.90E-13

S.LDL.L

rs73066442

18

G

A

0.249

0.069

0.012

1.40E-08

S.LDL.L

rs7412

9

T

C

0.056

-0.466

0.026

2.19E-70

S.LDL.L

rs76866386

10

C

T

0.082

-0.129

0.019

1.20E-11

S.LDL.P

rs11591147

1

T

G

0.031

-0.444

0.035

3.37E-36

S.LDL.P

rs142130958

9

A

G

0.102

-0.208

0.017

1.67E-32

S.LDL.P

rs182695896

15

C

A

0.019

0.335

0.041

7.00E-16

S.LDL.P

rs2980860

19

G

A

0.481

-0.080

0.010

1.97E-14

S.LDL.P

rs4703667

16

C

G

0.410

0.087

0.011

7.64E-16

S.LDL.P

rs7412

9

T

C

0.056

-0.429

0.026

1.44E-59

S.LDL.P

rs76866386

10

C

T

0.082

-0.125

0.019

6.26E-11

S.VLDL.C

rs115849089

19

A

G

0.107

-0.125

0.017

1.55E-13

S.VLDL.C

rs11591147

1

T

G

0.031

-0.338

0.035

1.04E-21

S.VLDL.C

rs142130958

9

A

G

0.105

-0.173

0.016

2.38E-25

S.VLDL.C

rs182695896

15

C

A

0.019

0.268

0.041

8.63E-11

S.VLDL.C

rs2980875

19

G

A

0.485

-0.067

0.010

1.81E-11

S.VLDL.C

rs3764261

6

A

C

0.299

-0.103

0.011

3.97E-21

S.VLDL.C

rs429358

9

C

T

0.170

0.138

0.013

2.23E-24

S.VLDL.C

rs646776

1

T

C

0.780

0.070

0.012

5.62E-09

S.VLDL.C

rs6544366

10

T

G

0.268

-0.106

0.011

2.05E-21

S.VLDL.C

rs79225634

16

T

C

0.337

0.078

0.010

1.69E-13

S.VLDL.FC

rs115849089

19

A

G

0.107

-0.151

0.017

3.42E-19

S.VLDL.FC

rs13225450

18

T

C

0.126

-0.099

0.015

5.19E-11

S.VLDL.FC

rs142130958

9

A

G

0.105

-0.156

0.016

6.07E-21

S.VLDL.FC

rs182695896

15

C

A

0.019

0.233

0.041

1.72E-08

S.VLDL.FC

rs2980875

19

G

A

0.485

-0.073

0.010

2.60E-13

S.VLDL.FC

rs3764261

6

A

C

0.299

-0.106

0.011

2.64E-22

S.VLDL.FC

rs429358

9

C

T

0.170

0.139

0.013

1.20E-24

S.VLDL.FC

rs59014134

16

T

C

0.251

0.076

0.013

2.16E-09

S.VLDL.L

rs115849089

19

A

G

0.101

-0.165

0.017

2.45E-21

S.VLDL.L

rs13234157

18

A

C

0.123

-0.105

0.016

7.47E-11

S.VLDL.L

rs142130958

9

A

G

0.102

-0.140

0.017

1.52E-15

S.VLDL.L

rs247617

6

A

C

0.289

-0.116

0.011

2.31E-23

S.VLDL.L

rs2878419

16

T

C

0.420

0.070

0.010

3.28E-11

S.VLDL.L

rs2980860

19

G

A

0.481

-0.076

0.010

3.48E-13

S.VLDL.L

rs429358

9

C

T

0.168

0.126

0.014

2.11E-19

S.VLDL.L

rs72836561

7

T

C

0.025

0.204

0.036

2.14E-08

S.VLDL.P

rs115849089

19

A

G

0.101

-0.172

0.017

4.98E-23

S.VLDL.P

rs1168041

1

C

T

0.727

0.083

0.012

2.28E-12

S.VLDL.P

rs247617

6