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! "
Neuron, Volume 61
Supplemental Data
Computational Influence of Adult
Neurogenesis on Memory Encoding
James B. Aimone, Janet Wiles, and Fred H. Gage
Supplemental Material (Part I)
Supplemental Figures
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Supplemental Material (Part II)
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1. Expanded Description of Model
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E$,(.$2(!13!,14(.!/$,&.+0$12 PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ";!
Table I*!O(2('+.!R14(.!A+'+,(0('/ PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP "@!
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!!!!)0+0$/0$7/PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP "?!
QQP!K:(':$(=!13!,14(.!/0'&70&'( PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP "C!
<(&'12!$2$0$+.$S+0$12!+24!-+'+,(0('/* PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP "C!
Table II*!<(&'12!<&,8('/PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP "D!
Table III*!<(&'12!A+'+,(0('/ PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP "F!
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Table IV*!T122(70$12!A+'+,(0('/!UQ24(-(24(20!13!R14(.!J+2%(VPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP 5I!
QQQP!T1,-&0$2%!G70$:$0B!W!6$%$0$S(4!#$'$2%!J+0(!R14(.PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP 5;!
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O(2('+.!,+0&'+0$12!13!$,,+0&'(!2(&'12/PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP 5?!
R+0&'+0$12!13!/B2+-0$7!7122(70$:$0BPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP 5C!
R+0&'+0$12!13!-9B/$1.1%B!-+'+,(0('/ PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP 5H!
XP!<(0=1'>!Y(+'2$2%PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;"!
XQP!T(..!6(+09PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;5!
XQQP!ZM-('$,(20+.!6(/$%2PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;;!
Z201'9$2+.!T1'0(M!Q2-&0/ PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;;!
O'1=09!-9+/(!13!(M-('$,(20 PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;@!
A+00('2!/(-+'+0$12!0+/>PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;@!
E(,-1'+.!/(-+'+0$12PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;?!
J(/-12/(!01!3+,$.$+'!+24!21:(.!(2:$'12,(20/ PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;?!
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R14&.+0$12!13!2(&'1%(2(/$/*!)0'(// PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;?!
J(3('(27(/ PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP ;D!
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I. General Model Structure and Timeline
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!
Timeline of model simulation
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Table I: General Model Parameters
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EvtWeek!$/!09(!2&,8('!13!/$,&.+0(4!(:(20/!$2!(+79!=((>!
tstep!$/!09(!.(2%09!13!(+79!4$/7'(0(!0$,(N$20(':+.!31'!=9$79!+70$:$0B!$/!7+.7&.+0(4!!
tevent (training)!$/!09(!.(2%09!13!0$,(!09+0!(+79!(:(20!$/!/$,&.+0(4!4&'$2%!0'+$2$2%!
tevent (testing)!$/!09(!2&,8('!13!0$,(!09+0!(+79!(:(20!$/!/$,&.+0(4!4&'$2%!0(/0$2%!
Range $/!09(!/(-010(,-1'+.!(M0(20!13!09(!,14(.!&/(4!$2!09(/(!(M-('$,(20/!
!
Simulation details
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%(2('+0(4!3'1,!+!&2$31',!4$/0'$8&0$12^!&/$2%!09(!rand()3&270$12!$2!RGEYG]^!1'!3'1,!+!O+&//$+2!4$/0'$8&0$12^!&/$2%!09(!randn()3&270$12!$2!RGEYG]^!=9$79!'(0&'2/!+!'+241,!:+.&(!3'1,!+!21',+.!4$/0'$8&0$12!=$09!,(+2!I!+24!/0+24+'4!4(:$+0$12!13!"P!!E1!+00+$2!+!'+241,!:+.&(^!^!3'1,!+!4$33('(20!
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Statistics
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/$,&.+0(4!$24(-(24(20.BP!!L9$.(!09(!$2$0$+.$S+0$12!-+'+,(0('/!=('(!09(!/+,(!31'!(+79!2(0=1'>^!09(!
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! "C
II. Overview of model structure
!
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.+B('!'(-'(/(20$2%!+!7(..N%'1&-!=$09$2!09(!6ONi$.&/!7$'7&$0!1'!12(!13!$0/!$2-&0/U/((!Figure 1AVP!!Z+79!
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=1'>P!
Neuron initialization and parameters:
!
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4B2+,$7!:+'$+8.(/!&/(4!01!7+.7&.+0(!+70$:$0B!=$09$2!(:(20/P!!#1'!212N2(&'1%(2$7!7(..!.+B('/^!,+2B!13!09(!
-9B/$1.1%B!-+'+,(0('/!=('(!&2$31',!+7'1//!.$>(!2(&'12/^!8&0!8(7+&/(!2(&'1%(2(/$/!$20'14&7(/!
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!
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2(&'12/!9+:(!21!4(24'$0$7!+'81'$S+0$12*!"f&RQ<P!!E9(!,+0&'+0$12!-'17(//!&/(4!01!%'1=!09(!4(24'$0(/!$/!
! "D
4(/7'$8(4!8(.1=P!!)&8/(c&(20!2(&'12/!+44(4!01!09(!.+B('!=('(!-'1:$4(4!=$09!'+241,!%M!+24!%B!.17+0$12/^!
091&%9!09(B!=('(!8$+/(4!01!09(!$22('!OT!.+B('!U%Sk,(+2U%SVV!+24!+./1!9+:(!,$2$,&,!4(24'$0(/P!!!
!
E9(!2(&'1%(2$7!.+B('!+./1!0'+7>/!/(:('+.!109('!-9B/$7+.!-+'+,(0('/!1:('!0$,(*!
!
67'!$/!09(!+%(!13!09(!2(&'12!U=((>/V!
8&'&!$/!09(!,(,8'+2(!'(/$/0+27(!UONK9,/e!(/0$,+0(4!3'1,!2&,8('!13!/B2+-/(/V!
*.+!$/!09(!+--'1M$,+0(!:1.&,(!13!09(!2(&'12!U(/0$,+0(4!3'1,!/$S(!13!2(&'12V!
!
E9(/(!-+'+,(0('/!=('(!210!4$'(70.B!&/(4!$2!7+.7&.+0$2%!+70$:$0B^!8&0!=('(!$,-1'0+20!31'!7+.7&.+0$2%!
,+0&'+0$12N4(-(24(20!-9B/$1.1%B!-+'+,(0('/!U/((!8(.1=VP!
Table II: Neuron Numbers
9'++):"4'!) 9'++)-,&;'!)
<-+"4'!=)
6/(,"+)9'++)
-,&;'!)
<"11!.30&"('=)
-',!.7'#'202)
!"(')</'++2>$"4=)
?'"(@)!"(')
<A$'"(@=)
<B.!)0#"/(0C')
#',!.#2).#+4=))
.ZT! 5II! "II^III! NN! NN!
,ZT! 5II! "II^III! NN! NN!
]T! "5I! "I^III! NN! NN!
RT! 55I! ;I^III! NN! NN!
iQ! 55I! ;I^III! NN! NN!
OT! FII!U/0+'0V!
l"CII!U0(/0V!
"^III^III! "Ig4+B!
Ul"?hg,1209V!
PII"?!
Ul"P?hg4+BV!
A9B/$1.1%B!-+'+,(0('/!
!
E9(!31..1=$2%!-9B/$1.1%B!-+'+,(0('/!+'(!&/('N4(3$2(4!:+.&(/!31'!$24$:$4&+.!2(&'12/!$2!09(!,14(.P!!E9(/(!
-+'+,(0('/!=('(!/0+0$7!=$09$2!+2!(:(20^!8&0!,+B!8(!4B2+,$7!1:('!.12%('!-('$14/!13!0$,(!4&(!01!
,+0&'+0$12P!!E9($'!&/(!=$..!8(!4(/7'$8(4!$2!/&8/(c&(20!/(70$12/*!
*D@!'2@.+$)$/!09(!:1.0+%(!U'(.+0$:(!01!'(/0V!+81:(!=9$79!09(!2(&'12!3$'(/!
$E>$*!$/!09(!79+2%(!$2!3$'$2%!'+0(!31'!(+79!,X!+81:(!09'(/91.4!
E&"3!$/!09(!,+M$,&,!3$'$2%!'+0(!31'!09(!2(&'12!
E&0#!$/!09(!,$2$,&,!3$'$2%!'+0(!31'!09(!2(&'12!U2(&'12/!09+0!8&'/0V!
FGH6I6!$/!+!,+0&'+0$12!4(-(24(20!-+'+,(0('!09+0!'(-'(/(20!09(!2(&'12a/!'(.+0$:(!/(2/$0$:$0B!01!
OG]G^!'(.+0$:(!01!%.&0+,+0(!!
FGH+,("&"(')!$/!09(!-+'+,(0('!09+0!'(-'(/(20!09(!2(&'12a/!'(.+0$:(!/(2/$0$:$0B!01!%.&0+,+0(!+24!$/!/(0!01!
8(!(c&+.!01!"P!
#!$/!09(!,(,8'+2(!0$,(!712/0+20!13!09(!2(&'12!
67'B0!')$/!09(!+%(!+0!=9$79!09(!$,,+0&'(!3$'$2%!'+0(!$/!(/0$,+0(4!
!
#1'!+..!212N2(&'1%(2$7!7(..!.+B('/^!09(/(!2(&'12/!=('(!$2$0$+.$S(4!01!:+.&(/!$2!E+8.(!QQ^!+24!09(B!'(,+$2!
712/0+20!09'1&%91&0!09(!/0&4BP!!#1'!09(!2(&'1%(2$7!7(..!.+B('!UOT!12.BV^!,1/0!13!09(/(!-+'+,(0('/!=('(!
$2$0$+.$S(4!+0!$,,+0&'(!:+.&(/!+24!/.1=.B!+--'1+79!09($'!,+0&'(!.(:(./!U/((!/(70$12!QXV!
! "F
Table III: Neuron Parameters
!
9'++):"4'!) *D@!'2@.+$)<&*=)
$E>$*)
<J5>&*=)
E&"3)<J5=)
E&0#)<J5=)
FGH6I6) #)
<&2=)
67'B0!')<K''A2=)
.ZT! 5?! PIIF! 5I! I! N"! 5I! NN!
,ZT! 5?! PIIF! 5I! I! N"! 5I! NN!
]T! "5! PI@;! 5;I! I! N"! "I! NN!
RT! 5I! PI@F! ?I! I! N"! ;I! NN!
iQ! "?! PIFF! CH! I! N"! ;I! NN!
OT!W!$,,+0&'(! 5I! ! ;I! I! 5! l"CI! @!
OT!W!,+0&'(! ;?! PIF;! D5! 5I! N"! @I! NN!
!
!
G70$:$0B!:+'$+8.(/!
!
E9(!31..1=$2%!:+'$+8.(/!31'!$24$:$4&+.!2(&'12/!=('(!4B2+,$7!=$09$2!+2!(:(20!+24!=('(!&/(4!01!4(0(',$2(!
09(!+70$:$0B!13!09(!2(&'12/*!
!
*!$/!09(!:1.0+%(!U'(.+0$:(!01!'(/0V!13!2(&'12!0!
B!$/!09(!3$'$2%!13!2(&'12!$2!09(!-'(:$1&/!0$,(!/0(-!
%E0!'!$/!09(!-10(20$+.!31'!09+0!2(&'12!01!3$'(!$2!09+0!0$,(!/0(-!
$!$/!+!0'+7>$2%!:+'$+8.(!09+0!4$/0'$8&0(/!/-$>$2%!+771'4$2%!01!09(!3$'$2%!'+0(P!!!
Connection initialization and parameters:
)
T122(70$12/!$2!09(!,14(.!=('(!4(/7'$8(4!8B!+!/(0!13!/0+0$7!-+'+,(0('/!+24!+!/(0!13!(M-('$(27(N4(-(24(20!
:+'$+8.(/P!
!
O(2('+.!-+'+,(0('/!
!
#$'/0^!(+79!/B2+-/(!0B-(!9+/!%(2('+.!-+'+,(0('/!4(/7'$8$2%!09(!/0'&70&'(!13!09(!7122(70$12!=$09$2!09(!
2(0=1'>P!!T122(70$12/!=('(!,+4(!&/$2%!+!21',+.!4$/0'$8&0$12!+'1&24!+!0+'%(0!S12(P!!!
!
%24#!UE+'%(0V!!W!E9(!+:('+%(!41'/+.N:(20'+.!.17+0$12!13!09(!/B2+-/(!'(.+0$:(!01!/1&'7(!2(&'12a/!/1,+P!
&24#!UJ+2%(V!W!E9(!/-+0$+.!:+'$+27(!13!09(!41'/+.N:(20'+.!/B2+-/(!.17+0$12!!
'24#L+./"+)U6(2/$0BV!W!E9(!4(2/$0B!13!/B2+-/(/!+0!09(!7(20('!13!/B2+-/(!4$/0'$8&0$12!
'24#L0$'"+)UQ4(+.!6(2/$0BV!W!E9(!'(.+0$:(!4(2/$0B!13!/B2+-/(/!$2!09(!=91.(!2(0=1'>!
K&"3!W!E9(!,+M$,&,!/B2+-0$7!/0'(2%09!31'!09(!7122(70$12!
K&"3L0&&"(,!')W!E9(!,+M$,&,!/B2+-0$7!/0'(2%09!31'!09(!7122(70$12!1201!+2!$,,+0&'(!2(&'12!
A24#"12')W!E9(!'+0(!+0!=9$79!/B2+-/(/!,+0&'(!U$24(-(24(20!3'1,!2(&'12!,+0&'+0$12!'+0(/V!
A/.&1)$/!09(!'+0(!09+0!/B2+-0$7!71,-(0$0$12!=$22('/!+'(!4(0(',$2(4!
"5L24#!W!E9(!/$S(!13!+2!$,,+0&'(!2(&'12a/!4(24'$0(!'(c&$'(4!31'!09+0!/B2+-/(!01!8(!31',(4!
"3L&"3!$/!09(!/-+0$+.!=$409!U41'/+.N:(20'+.!+M$/V!13!09(!4(24'$0$7!+'81'$S+0$12!13!+!3&..B!,+0&'(!2(&'12!
"4L&"3)$/!09(!/-+0$+.!=$409!U0'+2/:('/(!+M$/V!13!09(!4(24'$0$7!+'81'$S+0$12!13!+!3&..B!,+0&'(!2(&'12!
"7'!'B!!$/!09(!'(3('(27(!+%(!U=((>/V!+--'1M$,+0$2%!=9(2!212N/-$2B!/B2+-/(/!+'(!3$'/0!-'(/(20!
A/.##!$/!09(!+--'1M$,+0(!2&,8('!13!=((>/!'(c&$'(4!31'!7122(70$12!01!3&..B!4(:(.1-!U=((>/V!
!
G0!'&20$,(^!09(!-+'+,(0('/!%24#)+24!&24#!+'(!+4m&/0(4!31'!09(!Range!1:('!=9$79!09(!,14(.!$/!/$,&.+0(4P!!G/!
09(!,14(.!$/!12.B!/$,&.+0$2%!+!09$7>!/.$7(!13!09(!4(20+0(!%B'&/^!'+09('!09+2!09(!=91.(!/0'&70&'(^!09(!
-+'+,(0('/!,&/0!8(!'(/7+.(4!+771'4$2%.BP!!E9(!/7+.$2%!$/!+/!31..1=/*!
! "H
!
8"#7'24#
24#
I'' % ! UQQP"V!
8"#7'24#
24#
I&& % ! UQQP5V!
!
!
J+2%(!$/!+!2&,8('!8(0=((2!I!+24!"^!+24!/(0!01!(c&+.!IP@!$2!09(/(!/$,&.+0$12/P!!!E9$/!/(':(/!01!!
Q2!09(!7+/(!13!09(!.12%N'+2%(!RT!01!OT!-'1m(70$12!^!09(!/7+.$2%!13!%24#)+24!&24#)$/!+./1!712/0'+$2(4!8B!09(!
+44$0$12+.!(c&+.$0$(/!UNIP?I$%24#$IP?IV!+24!U&24#)$IP;IV!01!(2/&'(!09+0!09(!/1&'7(!2(&'12!!
!
! 5I
Table IV: Connection Parameters (Independent of Model Range)
!
!
)B2+-/(!O(2('+0$12!
!
)B2+-/(/!=('(!7'(+0(4!+771'4$2%!01!09(!31..1=$2%!(c&+0$12/P!!<10(*!8(7+&/(!09(!2(0=1'>!$/!$2$0$+.$S(4!=$09!
12.B!$,,+0&'(!%'+2&.(!7(../^!/B2+-/(/!01!+24!3'1,!09(!OT!.+B('!=('(!7'(+0(4!4&'$2%!09(!,+0&'+0$12!
-'17(//!+24!210!4&'$2%!$2$0$+.$S+0$12!U/((!/(70$12!QXVP!!E9(!31..1=$2%!(c&+0$12/!4(/7'$8(!91=!/B2+-/(/!
=('(!791/(2!+0!8109!0$,(/P!
!
#1'!(+79!2(&'12!$2!09(!/1&'7(!.+B('^!09(!2&,8('!13!/B2+-/(/!09+0!09(!2(&'12!7122(70/!01^!-24#"12'2^!$/!
4(0(',$2(4!8B*!
!
0$'"+24#("!7'(24#"12'2 -- ^)#% ! UQQP;V!
=9('(*!
! <0+'%(0!$/!09(!2&,8('!13!2(&'12/!$2!09(!0+'%(0!7(..!.+B('!
! '/B2^$4(+.)$/!09(!$4(+.!4(2/$0B!13!09+0!-'1m(70$12!
!
K27(!09(!2&,8('!13!/B2+-/(/!'(c&$'(4!31'!09(!/1&'7(!2(&'12!=+/!4(0(',$2(4^!+!/(0!13!212N'(-(+0$2%!0+'%(0!
U1'!/1&'7(V!2(&'12/!=('(!/(.(70(4!8B!09(!31..1=$2%!(c&+0$12!=9$79!=+/!'(-(+0(4!&20$.!</B2+-/(/!=('(!31&24!
31'!(+79!2(&'12!
!
! "24#24#("!7'(-("! &'( ^#% ! UQQP@V!
!
=9('(*!
(<%24#L&24#=!'(-'(/(20/!+!'+241,!2&,8('!3'1,!+!O+&//$+2!4$/0'$8&0$12!13!/0+24+'4!4(:$+0$12!&24#!
+'1&24!09(!0+'%(0!S12()%24#P!!!
)
Q,-1'0+20.B^!12.B!12(!/B2+-/(!=+/!-(',$00(4!8(0=((2!0=1!2(&'12/^!$3!+!/B2+-/(!+.'(+4B!(M$/0(4!=$09!09(!
/(.(70(4!2(&'12!(c&+0$12!QQP@!=+/!'(-(+0(4P!
)
!"##$%&'"#(!)*+#(,-./$&(
")*+#(0-#/$(
#*+#12"%-2(3$#*'&+(
#*+#1'4$-2 56-7(869:56-7;(
'66-&<.$=*+#->*$(8?@$A$#&:
=%"6> $B1*+#(-/$.$C(85$$=*:(
=%"##(85$$=*:
Granule Cell Afferents lEC to GC 0 0.14 75% 0.105 1.7 1.7 0.05 0.1 3 3 2.5
mEC to GC 0 0.14 75% 0.105 2.2 2.2 0.05 0.1 2.5 3 2.25
MC to GC +/-0.3 0.15 50% 0.15 2.8 2.8 0.05 0.1 2 3 4
BC to GC 0 0.2 50% 0.1 2.2 -1.0 -- -- 0 1 4
HI to GC 0 0.1 100% 0.1 3.0 -3.0 -- -- 3 2 2.5
Basket Cell Afferents lEC to BC 0 0.14 75% 0.105 2.4 -- -- -- -- -- --
mEC to BC 0 0.14 75% 0.105 3.2 -- -- -- -- -- --
MC to BC +/-0.3 0.15 50% 0.15 1.7 -- -- -- -- -- --
GC to BC 0 0.05 100% 0.05 32.7 2.2 -- -- 1.5 2 2
Hilar Neuron Afferents GC to MC 0 0.05 100% 0.05 5.6 2.2 -- -- 1.5 2 2
GC to HI 0 0.05 100% 0.05 5.6 2.2 -- -- 1.5 2 2
! 5"
Z+79!7(..!.+B('!=+/!0'(+0(4!+/!+
! 55
-+'+,(0('!=+/!/7+.(4!+771'4$2%.BP!!Q2!+44$0$12^!7122(70$12!/0'(2%09/!=('(!,14$3$(4!01!+771&20!31'!09(!
4$33('(20!2&,8('!13!'(/&.0$2%!/B2+-/(/!U8'1+4('!2(0=1'>!f!/-+'/('!-'1m(70$12/VP!
!
S'+'/(0.#).B)-',!.#)"#$)9.##'/(0.#)%@420.+.74)%"!"&'('!2T)
!
E9(!-9B/$1.1%B!+24!7(..!71&20/!13!09(!,14(.(4!2(&'12/!$2!09(!2(0=1'>!+'(!%$:(2!$2!/&--!E+8.(!QQ^!QQQ^!+24!
7122(70$12!-+'+,(0('/!+'(!%$:(2!$2!/&--!E+8.(!QXP!!E9(/(!-9B/$1.1%B!-'1-('0$(/!=('(!(/0$,+0(4!3'1,!8109!
-9B/$1.1%B!/0&4$(/U)1.0(/S!(0!+.P^!"HH?e!Y&8>(!(0!+.P^!"HHFe!o$221!(0!+.P^!5II;V!+24!,14(.$2%!/0&4$(/!
UA+0012!+24!R7<+&%9012^!"HH?e!)+209+>&,+'!(0!+.P^!5II?VP!!T122(70$:$0B!=+/!4(0(',$2(4!8B!'(:$(=!
.$0('+0&'(!13!09(!4(20+0(!%B'&/!7$'7&$0!+24!$20('2(&'12/!UA+0012!+24!R7<+&%9012^!"HH?e!#'(&24!+24!
]&S/+>$^!"HHCe!G24('/12!(0!+.P^!5IIDVP!!#$2+..B^!/B2+-0$7!=($%90/!=('(!(/0$,+0(4!01!+77&'+0(.B!'(-'(/(20!
09(!'(.+0$:(!$,-+70!13!4$33('(20!7122(70$12/!+24!,+$20+$2!09(!2(0=1'>!+0!18/(':(4!+70$:$0B!.(:(./!Uo&2%!+24!
R7<+&%9012^!"HH;e!Y(&0%(8!(0!+.P^!5IIDVP!
!
E9(!,+0&'+0$12!-'17(//!13!2(=!2(&'12/!=+/!+./1!0+>(2!3'1,!09(!.$0('+0&'(P!!O(2('+..B^!09(!2(=!2(&'12/!
,1'-91.1%B!+24!-9B/$1.1%B!=+/!,+4(!01!7.1/(.B!'(-.$7+0(!Up9+1!(0!+.P^!5IICV!+24!UZ/-1/$01!(0!+.P^!5II?V^!
'(/-(70$:(.BP!!!
!
E9('(!+'(!7('0+$2!7+:(+0/!01!(M0'+70$2%!-9B/$1.1%B!4+0+!3'1,!09(!.$0('+0&'(P!!R1/0!-9B/$1.1%B!/0&4$(/!13!
4(20+0(!%B'&/!$20('2(&'12/!+'(!3'1,!/0&4$(/!&/$2%!/.$7(!'(71'4$2%/!3'1,!($09('!-1/02+0+.!1'!:('B!B1&2%!
+4&.0!'+0/!U0B-$7+..B!.(//!09+2!;?!4+B/!1.4!$2!09(!/0&4$(/!7$0(4!+81:(VP!!Q2!7120'+/0^!/0&4$(/!$2:(/0$%+0$2%!
+4&.0N81'2!2(&'12/!&/(!1.4('!+2$,+./!8B!2(7(//$0BP!!#&'09(',1'(^!09('(!$/!712/$4('+8.(!:+'$+0$12!+7'1//!
4$33('(20!/0&4$(/^!+24!'(/&.0/!+'(!210!2(7(//+'$.B!71,-+'+8.(!+7'1//!4$33('(20!,(09141.1%$(/P!!!
<(:('09(.(//^!=(!8(.$(:(!09+0!/1!.12%!+/!09(!'(.+0$:(!:+.&(/!13!09(/(!-+'+,(0('/!+'(!712/$/0(20!=$09!
8$1.1%$7+.!/B/0(,^!09(!/-(7$3$7!:+.&(/!13!,+2B!13!09(/(!-'1-('0$(/!+'(!.(//!712/(c&(20$+.P!!!
!
!
! 5;
III. Computing Activity – Digitized Firing Rate Model
!
UC'!C0'KT)
)
L(!&/(4!+!,14(.!09+0!=(!'(3('!01!+/!+!4$%$0$S(4!3$'$2%!'+0(!,14(.!U6#JVP!!Q2!09(!6#J!,14(.^!09(!2(0=1'>!
=+/!&-4+0(4!+0!+!0$,(!/7+.(!712/$4('+8.B!.12%('!09+2!+!21',+.!/-$>$2%!,14(.^!8&0!+0!/91'0('!$20(':+./!09+2!
+!3$'$2%!'+0(!,14(.!=1&.4!0B-$7+..B!9+:(P!!L(!791/(!01!,14(.!+0!09$/!'(/1.&0$12!8(7+&/(!09(!-9B/$1.1%B!13!
2(=!2(&'12/!+24!,+2B!4(20+0(!%B'&/!$20('2(&'12/!+'(!210!=(..!&24('/0114!+0!09(!9$%9!'(/1.&0$12!
2(7(//+'B!31'!+!7124&70+27(!8+/(4!,14(.P!!i1=(:('^!-+'+,(0('/!09+0!=1&.4!+33(70!3$'$2%!'+0(^!/&79!+/!0$,(!
712/0+20/^!,+M$,&,!3$'$2%!'+0(/^!+24!+70$:+0$12!09'(/91.4/^!+'(!8(00('!&24('/0114^!+..1=$2%!&/!01!,14(.!+0!
+!/.$%90.B!.12%('!0$,(!/7+.(P!!!
!
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,(,8'+2(!4(-1.+'$S+0$12!+24!(/0$,+0(/!+!3$'$2%!'+0(!31'!09+0!2(&'12P!!E9(2^!09$/!3$'$2%!'+0(!$/!&/(4!01!
7+.7&.+0(!09(!2&,8('!13!/-$>(/!09+0!2(&'12!=1&.4!9+:(!1:('!09+0!5?,/!0$,(P!!#1'!,1/0!2(&'12/!$2!09$/!
/B/0(,^!,+M$,&,!3$'$2%!'+0(/!+'(!/&33$7$(20.B!.1=!+/!01!210!'(/&.0!$2!,1'(!09+2!12(!/-$>(!-('!0$,(!/0(-P!!!
!
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!
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09(!31..1=$2%!(c&+0$12!31'!(+79!2(&'12!0*!
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References
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R1'-91N3&270$12+.!79+'+70('$S+0$12!13!2(&'12+.!7(../!+0!4$33('(20!/0+%(/!13!,+0&'+0$12!$2!%'+2&.(!
7(..!.+B('!13!+4&.0!'+0!4(20+0(!%B'&/P!]'+$2!J(/!"I"D*5"N;"P!
G24('/12!A^!R1''$/!J^!G,+'+.!6O^!].$//!E^!oP!Kr^!(4/!U5IIDV!E9(!i$--17+,-&/!]11>P!<(=!v1'>*!
KM31'4!`2$:('/$0B!A'(//P!
Z/-1/$01!R)^!A$+00$!XT^!Y+-.+%2(!6G^!R1'%(2/0('2!<G^!#(''+'$!TT^!A$01//$!#o^!)79$24('!G#!U5II?V!
<(&'12+.!6$33('(20$+0$12!$2!09(!G4&.0!i$--17+,-&/!J(7+-$0&.+0(/!Z,8'B12$7!6(:(.1-,(20P!
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#'(&24!E#^!]&S/+>$!O!U"HHCV!Q20('2(&'12/!13!09(!9$--17+,-&/P!i$--17+,-&/!C*;@DN@DIP!
O(!)^!v+2%!Ti^!i/&!r)^!R$2%!OY^!)12%!i!U5IIDV!G!7'$0$7+.!-('$14!31'!(29+27(4!/B2+-0$7!-.+/0$7$0B!$2!
2(=.B!%(2('+0(4!2(&'12/!13!09(!+4&.0!8'+$2P!<(&'12!?@*??HN?CCP!
O(!)^!O19!ZY^!)+$.1'!rG^!r$0+8+0+>(!v^!R$2%!OY^!)12%!i!U5IICV!OG]G!'(%&.+0(/!/B2+-0$7!$20(%'+0$12!
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