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SUP-ICUtrial
IntensivsymposiumHindsgavl,2018
SUP-ICU
AnInterna)onalplacebo-controlledRCT
SUP-ICU
• Popula>on• Acutelyadmi-edICUpa2entswithhighriskof
stress-relatedGIbleeding
• Interven>on• IVPPI(Pantoprazole)
• Comparator• IVPlacebo(Saline)
• Outcome• 90-daymortality
Status
SUP-ICU
Inclusioncompletedon:22October,201790-dayfollow-upcompletedon:20January,2018
Status
SUP-ICU
22months/94weeks/657days
SUP-ICU
Plans
• Database”cleaning”andmerging(February2018)
• Sta>s>csandmanuscriptwri>ng(March2018)
• Submissiontojournal(April2018)
SUP-ICU
PreliminaryResults
SUP-ICU
CONSORT
SUP-ICU
BaselineCharacteris>cs
SUP-ICU
Characteris2c SUP-ICU(n=3291)Age–years 67(55-75)Malegender–no.(%) 2106(64)HoursfromICUadmissiontorandomiza>on 15(5-27)Daysfromhospitaladmissiontorandomiza>on 1(1-3)Emergencysurgeryduringindexhospitaliza>on 1048(32)Elec>vesurgeryduringindexhospitaliza>on 304(9)
BaselineCharacteris>cs
SUP-ICU
Characteris2c SUP-ICU(n=3291)Comorbidi)es–no.(%)
Chroniclungdisease 657(20)Prev.myocardialinfarc>on 298(9)Chronicheartfailure(NYHAIII-IV) 199(5)Useofcor>costeroids 62(2)Hematologicalmalignancy 119(4)Metasta>ccancer 111(3)AIDS 7(0.2)
BaselineCharacteris>cs
SUP-ICU
Characteris2c SUP-ICU(n=3291)RiskfactorsforGIbleeding–no.(%)
Chronicliverdisease 94(3)ChronicRRT 45(1)Coagulopahty 646(20)Useofan>-coagulants 999(30)UseofNSAIDorASA 533(16)Useofintravenousthrombolysis 47(1)Invasivemechanicalven>la>on 2588(79)Vasopressorsorinotropes 2195(67)AcuteRRT -SAPSII -SOFAScore -
PreliminaryOutcomes
SUP-ICU
• 90-daymortality(n=1675) 31%
• OvertGIbleeding 7%• Clin.SignGIbleeding 3%• Nosocomialinfec>on 18%• Pneumonia(newonset) 16%• ClostridiumDifficile 2%• AMI 4%
Acknowledgements
SUP-ICU
Awarmthankyouto…
SUP-ICU
FundedbySupportedby
Grosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs Fond
Thankyou!
www.sup-icu.com
SUP-ICU