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Programme
Sunday 07 October 2012 16:00 - 17:45 Arrival and Registration
ATC Registration Desk
17:45 - 19:00 BUFFET DINNER ATC Foyer
19:00 - 19:15 Welcome ATC Auditorium
19:15 - 21:30 KEYNOTE SESSION ATC Auditorium
19:15 - 20:00 Mechanisms of 3'->5' RNA degradation 1Elena Conti Max Planck Institute of Biochemistry, Germany Talk kindly sponsored by Open Biology
20:00 - 20:45 Involvement of Low Complexity Polypeptide Sequences in the Formation of RNA Granules
2
Steven McKnight
UT Southwestern Medical Center, United States of America
20:45 - 21:30 Post-transcriptional gene regulation by small RNAs and RNA binding proteins
3
Nikolaus Rajewsky
Max Delbruck Center for Molecular Medicine, Germany
21:30 - 23:00 Drinks and Poster "Sneak Preview"
ATC Foyer, Helices A & B
Page 5
EMBO|EMBL Symposium The Complex Life of mRNA
Monday 08 October 2012 09:00 - 13:10 SESSION 2 - RNA Surveillance and Decay
Chair: Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany ATC Auditorium
09:00 - 09:25 Viral Noncoding RNPs 4Joan Steitz Yale University, United States of America
09:25 - 09:50 Eukaryotic mRNA Turnover 5Roy Parker HHMI/University of Colorado Boulder, United States of America
09:50 - 10:15 Production and destruction of RNA in human nuclei 6Torben Jensen Aarhus University, Denmark
10:15 - 10:45 COFFEE BREAK ATC Foyer
10:45 - 11:10 Tales from the Cellular Underworld: The Importance of mRNA Decay
7
Lynne Maquat University of Rochester Medical Center, United States of America
11:10 - 11:25 DHX34 activates NMD by promoting the transition from the SURF to the DECID complex
8
Nele Hug MRC HGU, IGMM, United Kingdom
11:25 - 11:50 Reining in the mRNA decay enzymes: Proteolytic control ofdecapping
9
Jens Lykke-AndersenUniversity of California San Diego, United States of America
Page 6
Programme
11:50 - 12:05 Uridylation prevents the formation of aberrant mRNAs by protecting deadenylated mRNA 3' ends
10
Dominique Gagliardi CNRS-University of Strasbourg, France
12:05 - 12:30 Non-coding RNAs and mRNAs: Brothers separated at birth?
11
David TollerveyUniversity of Edinburgh, United Kingdom
12:30 - 12:45 d4E-T: a eIF4E-binding protein that promotes deadenylation-dependent decay of target mRNAs to control cell proliferation
12
Cátia Igreja MPI for Developmental Biology Tuebingen, Germany
12:45 - 13:10 Virus-Host Interplay Leads to Widespread mRNA Destruction
13
Britt GlaunsingerUniversity of California Berkeley, United States of America
13:10 - 16:00 LUNCH and POSTER SESSION 1 ATC Foyer and Helices A & B
16:00 - 19:20 SESSION 3 - Mechanics and Regulation of Translation Chair: Karsten Weis, University of California, Berkeley, USA
ATC Auditorium
16:00 - 16:25 mRNA surveillance is driven by translation 14Rachel Green Johns Hopkins University School of Medicine, United States of America
16:25 - 16:40 CLIP-seq of the DEAD-box RNA helicase eIF4AIII reveals transcriptome-wide mapping of the exon junction complex in human
15
Herve Le Hir IBENS, France
Page 7
EMBO|EMBL Symposium The Complex Life of mRNA
16:40 - 17:05 RNA meets metabolism: from mRNA interactomes to REM networks
16
Matthias Hentze European Molecular Biology Laboratory (EMBL), Germany
17:05 - 17:35 COFFEE BREAKATC Foyer
17:35 - 18:00 Molecular mechanisms of ribosomal scanning and AUG selection: where to begin?
17
Alan Hinnebusch National Institutes of Health, United States of America
18:00 - 18:15 The cryo-EM structure of the UPF-EJC complex shows how UPF1 is poised to unwind the 3' end of a PTC-containing mRNP
18
Oscar Llorca Spanish National Research Council-CSIC, Spain
18:15 - 18:40 Translational Control of Higher Brain Function 19Joel Richter University of Massachusetts Medical School, United States of America
18:40 - 18:55 Physiological Role of NMD in Neuronal Development In Vivo
20
Eleen Shum UC San Diego, United States of America
18:55 - 19:20 Crystal structures of the eukaryotic ribosome and insights into the regulation and initiation of protein synthesis
21
Nenad Ban
ETH Zurich, Switzerland
19:20 - 21:00 DINNER EMBL Canteen
21:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing
Page 8
Programme
Tuesday 09 October 2012 09:00 - 12:40 SESSION 4 - Epigenetics and Transcription
Chair: Lynne Elizabeth Maquat, University of Rochester, USA
ATC Auditorium
09:00 - 09:25 Structure-guided dynamic transcriptome analysis elucidates the mRNA life cycle
22
Patrick Cramer Gene Center - LMU, Germany
09:25 - 09:40 Road-block termination defines a new class of cryptic transcripts
23
Domenico Libri CNRS - CGM, France
09:40 - 10:05 Chromatin and transcription regulate alternative splicing 24
Alberto Kornblihtt
FCEN, University of Buenos Aires and IFIBYNE-CONICET, Argentina
10:05 - 10:20 “Catching up” with polymerase: the mechanisms of Sen1-dependent termination
25
Odil Porrua Fuerte Centre de Genetique Moleculaire-CNRS, France
10:20 - 10:35 The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
26
Markus Landthaler Max-Delbrück-Center for Molecular Medicine, Germany
10:35 - 11:05 COFFEE BREAK ATC Foyer
11:05 - 11:30 Ending the message in eukaryotes: Gene loops, R-loops and noncoding RNA
27
Nicholas Proudfoot University of Oxford, United Kingdom
Page 9
EMBO|EMBL Symposium The Complex Life of mRNA
11:30 - 11:45 Global regulatory functions of Sen1-dependent Pol II termination factors
28
David Brow University of Wisconsin-Madison, United States of America
11:45 - 12:10 Splicing on chromatin 29Karla NeugebauerMPI-CBG, Germany
12:10 - 12:25 Single cell analysis reveals aspects of antisense RNA regulation and mode of action in PHO84 transcription repression
30
Daniel Zenklusen Université de Montréal, Canada
12:25 - 12:40 Genome-wide measurement of RNA structure in vivo 31Silvia Rouskin UCSF, United States of America
12:40 - 15:30 LUNCH and POSTER SESSION 2 ATC Foyer and Helices A & B
15:30 - 17:40 SESSION 5 - Pre-mRNA ProcessingChair: Alberto Kornblihtt, University of Buenos Aires, Argentina ATC Auditorium
15:30 - 15:55 Processing of mRNA precursors and links to human disease
32
James Manley Columbia University, United States of America
15:55 - 16:20 TELESCRIPTING: A New Dimension to mRNA Regulation 33
Gideon Dreyfuss
HHMI/University of Pennsylvania School of Medicine, United States of America
Page 10
Programme
16:20 - 16:35 ELAV mediates neuronal-specific 3’ UTR extension by suppressing proximal polyadenylation
34
Valerie Hilgers UC Berkeley, United States of America
16:35 - 17:00 How competition between RNA-binding proteins for overlapping binding sites controls splicing decisions
35
Jernej Ule
MRC Laboratory of Molecular Biology, United Kingdom
17:00 - 17:15 CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly
36
Anna-Lena SteckelbergInstitute for Genetics, University of Cologne, Germany
17:15 - 17:40 Pre-mRNA processing and mRNA metabolism 37Melissa Moore HHMI/University of Massachusetts Medical School, United States of America
17:40 - 18:00 Pre-dinner drinks ATC Foyer
18:00 - 20:00 DINNER EMBL Canteen
20:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing
Page 11
EMBO|EMBL Symposium The Complex Life of mRNA
Wednesday 10 October 2012 09:00 - 12:35 SESSION 6 - miRNA Function
Chair: Matthias W. Hentze, EMBL Heidelberg, Germany
ATC Auditorium
09:00 - 09:25 Structural insights into miRISC recruitment of the CCR4-NOT complex
38
Nahum Sonenberg McGill University, Canada
09:25 - 09:50 Function and Regulation of MicroRNAs 39Helge GrosshansFMI, Switzerland
09:50 - 10:05 The piRNA pathway and its role in the regulation of maternal mRNAs in the Drosophila early embryo
40
Bridlin BarckmannIGH Institute of Human Genetics, France
10:05 - 10:30 Regulation of miRNA-mediated Repression and miRNA Metabolism in Mammalian Cells
41
Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland
10:30 - 11:00 COFFEE BREAK ATC Foyer
11:00 - 11:25 Biogenesis and function of PIWI-interacting RNA in Drosophila
42
Mikiko Siomi Graduate School of Science, University of Tokyo, Japan
11:25 - 11:40 miRNA-mediated regulation of the cyrano lincRNA is a non-canonical pathway essential for early vertebrate development
43
Alena Shkumatava Whitehead Institute/MIT, United States of America
Page 12
Programme
11:40 - 12:05 Evolutionary plasticity of the protein interaction network that regulates mRNA stability
44
Elisa Izaurralde Max Planck Institute for Developmental Biology, Germany
12:05 - 12:20 Structure of yeast Argonaute with guide RNA 45David WeinbergWhitehead Institute / MIT, United States of America
12:20 - 12:35 The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
46
Astrid Haase Cold Spring Harbor Laboratory, United States of America
12:35 - 15:30 LUNCH and POSTER SESSION 3 ATC Foyer and Helices A & B
15:30 - 18:30 SESSION 7 - mRNA Export and Localization Chair: Melissa J. Moore, UMass Medical School/HHMI, USA
ATC Auditorium
15:30 - 15:55 Regulation of mRNA export and decay 47Karsten Weis UC Berkeley, United States of America
15:55 - 16:10 Blastomere-specific transcriptome profiling after the first embryonic division
48
Erin Osborne Nishimura University of North Carolina, United States of America
16:10 - 16:25 Structural studies of a minimal eIF4E-Cup complex 49Fulvia Bono Max Planck for Developmental Biology, Germany
16:25 - 16:55 COFFEE BREAK ATC Foyer
Page 13
EMBO|EMBL Symposium The Complex Life of mRNA
16:55 - 17:10 The Unfolded Protein Response in Fission Yeast Modulates Stability of Select mRNAs to Maintain Protein Homeostasis
50
Philipp Kimmig UCSF, United States of America
17:10 - 17:25 Insights into biogenesis and localization of mRNPs from in vitro reconstitution experiments
51
Dierk Niessing Helmholtz Zentrum München, Germany
17:25 - 17:50 Adaptation of the organism to its environment: fine-tuning RNA localization dynamics
52
Anne Ephrussi EMBL Heidelberg, Germany
17:50 - 18:15 Following Single mRNAs from Birth to Death: A Systems Approach
53
Robert Singer Albert Einstein College of Medicine, United States of America
18:15 - 18:30 Closing remarks ATC Auditorium
18:30 - 00:00 BANQUET DINNER and PARTY EMBL Canteen and ATC Foyer
Page 14
Posters A-Z
Adeli, Khosrow Translational Control of Apolipoprotein B mRNA via miRNAs and Localization in RNA Granules
54
Ahmad, Mohd Hafiz Analysis of mirna Transcriptome in Normal Peripheral Blood Mononuclear Cells, Chronic Myeloid Leukemia and K562 Cells
55
Allain, Frédéric Recognition of let-7 miRNA by the zinc knuckles of Lin28 56
Allmang, Christine The cap of selenoprotein mRNAs is hypermethylated : similarities with snRNA processing
57
Antic, Sanja Ribosome association of the mRNA degradation machinery and the miRNA effector complex in Drosophila cells
58
Aregger, Michael Cell-cycle-dependent phosphorylation of the RNA cap methyltransferaseis required for cell proliferation
59
Arnold, Andreas Investigating the function of Y-box binding proteins in C. elegans 60
Arribas, Laura The biological role of slicing for Arabidopsis Argonaute1 61
Asta, Francesco RUMP, a Drosophila hnRNP M homolog, elicits decay of mRNA targets 62
Attig, Jan The TIA/TIAL proteins regulate alternative polyA-site choice and thereby mRNA isoform expression
63
Babic, Ana Transcriptome profiling at the synapse 64
Page 15
EMBO|EMBL Symposium The Complex Life of mRNA
Barbosa, Cristina An upstream open reading frame regulates the translational efficiency of the human erythropoietin transcript
65
Bawankar, PraveenNOT10 and C2orf29 form a metazoan-specific module of the CCR4–NOT complex that docks onto the N-terminal domain of NOT1
66
Beckmann, Benedikt M. RNA-binding proteins in posttranscriptional control: defining a eukaryoticcore mRNA interactome
67
Béthune, Julien L. Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells
68
Bezzi, Marco PRMT5 links alternative splicing and apoptosis in mammalian brain development
69
Bhattacharyya, Suvendra N. Leishmania donovani downregulates miR-122 in Liver to Modulate Serum Cholesterol in Parasite Infected Mouse: Mechanism and Beyond
70
Bieniossek, Christoph Crafting TFIID: TAF8/TAF10 complex accretion breaks symmetry in human TFIID coactivator core structure
71
Blazquez, Lorea Inhibition of gene expression by combining RNA interference and U1 inhibition
72
Bo Eng, Cheong Molecular Cloning of Chalcone Synthase Gene from the Leaves of Strobilanthes crispus
73
Bohmer, Marc Indian Hedgehog Signalling is regulated by the miR-15/16/195/424/497 family
74
Page 16
Posters A-Z
Bohne, Jens U1snRNP-mediated poly(A) site suppression is the molecular basis of a complex immunodeficiency
75
Bojarska, ElzbietaSubstrate specificity of yeast scavenger decapping enzyme (Dcs1) for dinucleotide cap analogs
76
Bratu, Diana P. Loss of RNAi protein Armitage in the germline vs. soma delineates its requirement during Drosophila melanogaster oocyte development
77
Brümmer, Anneke Modeling the binding specificity of RNA-binding proteins: the case of GLD-1
78
Büttner, Lisa Imaging the nuclear trafficking and export of single ribosomes in vivo 79
Cano, Florencia RNA-binding E3 ubiquitin ligases regulate mRNA decay 80
Carmo Fonseca, Maria Non productive spliceosome assembly is sufficient to export unspliced RNA to the cytoplasm
81
Carré, Clément An automiG biosensor identifies chemical compounds that inhibit miRNAbiogenesis or Argonaute-2 mediated silencing
82
Carré, Clément Human GTPases associate with RNA polymerase II to mediate its nuclear import
83
Chen, Hung-Ta Site-specific mapping of Brf1 within the RNA polymerase III pre-initiation complex
84
Page 17
EMBO|EMBL Symposium The Complex Life of mRNA
Chen, Ying Crystal Structure and Heterodimerization of the NOT Box Domains of human NOT2 and NOT3
85
Chereda, Bradley Characterisation of the BCR-ABL 3’untranslated region 86
Ciminale, Vincenzo Expression kinetics and intracellular compartmentalization of HTLV-1 alternatively spliced mRNAs
87
Clayton, Christine E. An ARE-binding protein as post-transcriptional regulator of the trypanosome heat-shock response
88
Cleary, Michael Identification of mRNA decay networks in the Drosophila nervous system 89
Cook, Atlanta G. NF45 interacts with NF90, SPNR and Zfr via a conserved nucleotidyltransferase fold
90
Cosson, Bertrand Combining analyses of 3-D structure and phylogeny reveals a new partner of eIF4E
91
Costello, Joe A role for Puf3 in translational control following oxidative stress 92
Dallacqua, RodrigoDifferentially expressed genes in honey bee queen ovaries during metamorphosis
93
Dargemont, Catherine mRNA journey from transcription to the nuclear pore complex: Focus on histone marks and ubiquitin modifications
94
de Lucas, SusanaDeep-sequencing of RNAs associated to hStaufen 1 complexes identifies conserved sequences involved in RNA-protein interaction
95
Page 18
Posters A-Z
de Moor, Cornelia H. The role of poly(A) tail metabolism in immediate early gene expression 96
De Vito, FrancescaCanonical and non-canonical regulation of c-jun transcript by miR-200 family members
97
Deneke, Carlus Linking the biochemistry of mRNA degradation to mRNA decay experiments: Insights from mathematical modeling
98
Despic, Vladimir Study of pre-mRNA splicing during early zebrafish embryogenesis 99
Dhamija, Sonam Translational activation contributes to induction of the negative regulator of inflammation, MCPIP1, by IL-1 and IL-17
100
Diamant, Gil DSIF Restricts NF- κB Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes
101
Dikfidan, Aytac Structural and functional characterization of the polynucleotide kinase Clp1
102
Dimitrova, Lyudmila In vitro assembly of TRanscription-EXport complex 2 (TREX-2) from Chaetomium thermophilum
103
Dominissini, Dan Topology of the human and mouse m6A RNA methylomes 104
Donato Tanaka, Erica Multiple roles of miR-306 in honeybee Apis mellifera physiology and reproduction
105
Duarte Pereira, Sara Characterization of NAPRT1 alternative transcripts 106
Page 19
EMBO|EMBL Symposium The Complex Life of mRNA
Dueck, Anne microRNAs associated with the different human Argonaute proteins 107
Duszczyk, Malgorzata Dead End, a protein counteracting miRNA-mediated repression of tumour suppressor genes, contains non-canonical RNA binding domains
108
Dutertre, Martin Genome-wide analysis reveals specific patterns of alternative last exon regulation by genotoxic anticancer agents
109
Dziembowski, Andrzej The central channel controls both exonuclease and endonuclease activities of the exosome complex both in vivo and in vitro
110
Elek, Zsuzsanna Polymorphisms in regulatory regions of the WFS1 gene are putative risk factors of diabetes mellitus
111
Erben, Esteban Post-transcriptional control in trypanosomatids: identification of the mRNA fate modulators through a high-throughput tethering assay
112
Fareh, Mohamed The microvesicles enclosing the cluster miR-302-367 compromise tumorigenic proprieties of Glioma Initiating Cells
113
Fei, Jingyi Organization of long non-coding RNAs in nuclear bodies revealed by super resolution imaging
114
Feldbrugge, Michael Microtubule-dependent co-transport of mRNPs and endosomes in the model microorganism Ustilago maydis
115
Fontrodona, Laura Caenorhabditis elegans to address the autosomal dominant Retinitis Pigmentosa paradox for splicing related genes
116
Page 20
Posters A-Z
Fromm, Simon A. The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex
117
Gahura, Ondrej First splicing step in Saccharomyces cerevisiae requires Prp45 118
Galeano, Federica ADAR2 editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis
119
Garmendia, Cecilia Asymmetric localization of p-bodies during the yeast cell cycle 120
Gavaldá, Sandra A new link between mRNA surveillance and genome instability mediated by Trf4
121
Glória, Vânia At the crossroads between transcription and splicing regulation of CD6 exon 5 alternative splicing
122
Goebels, Carolin Analysis of the role of introns on gene expression in Cryptococcus neoformans
123
Göhring, Janett In Vivo Imaging of Endogenous RNA Variants in Plant Cells 124
Gonatopoulos Pournatzis, Thomas RAM: A Novel and Essential Component of the mRNA Cap Methylation Machinery
125
Gonzàlez-Porta, Mar Genome-wide characterization of transcript isoform predominance 126
Gorgoni, Barbara Mechanism of DAZL-mediated translational regulation during germ cell development
127
Page 21
EMBO|EMBL Symposium The Complex Life of mRNA
Graille, Marc RNA quality control pathways dedicated to the release of ribosomes stalled in translation
128
Graindorge, Antoine Held-Out-Wings (HOW) acts as a SXL co-repressor in msl2 mRNA regulation
129
Gray, Nicola K. Extensive and complex post-translational modification of poly(A)-binding protein (PABP) 1 may regulate its multi-functionality
130
Gregersen, Lea Haarup Transcriptome-wide analysis of the RNA binding pattern of the RNA helicase MOV10
131
Gribling-Burrer, Anne-Sophie Assembly of selenoprotein mRNPs: potential role of the Survival of MotorNeurons (SMN) and methylosome complexes involved in sn(o)RNP biogenesis
132
Grosswendt, Stefanie Transcriptome-wide identification of miRNA binding sites in C. elegans 133
Gruber, Andreas R. Cleavage Factor Im as a key regulator of 3’ UTR length 134
Grund, Kerstin Stress-dependent 3’end processing regulates the expression of two key proteases for coagulation, F2 and Urokinase
135
Grzybowska, Ewa New insight into HAX-1 functions: nucleocytoplasmic shuttling, involvement in mRNA processing, nuclear export and P-body localization
136
Guidugli Lazzarini, Karina Rosa Gene expression profiles associated with behavioral maturation of Apis mellifera workers
137
Page 22
Posters A-Z
Guimarães, Beatriz Gomes Activity of Trypanosoma brucei exosome component Rrp6 and its partner EAP3 towards different RNA substrates
138
Hafner, Markus Nucleocytoplasmic transport of mRNAs by Exportin 5 139
Hallegger, Martina miRNA profile of Dopamine neurons derived from induced pluripotent stem cells
140
Hammarskjold, Marie-Louise A conserved mechanism for expression of proteins from mRNAs with retained introns
141
Handler, Dominik Idenification of novel piRNA factors by an tissue specific transcriptome wide RNAi screen in Drosophila melanogaster
142
Hashimoto, Yoshifumi Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis
143
Hausser, Jean Integration of low- and high-throughput data sets reveals the kinetics of miRNA-dependent gene regulation
144
Helwak, Aleksandra Mapping the human miRNA interactome by CLASH reveals frequent non-canonical binding
145
Heras, Sara R. The Microprocessor controls the activity of mammalian LINE-1 retrotransposon
146
Hermesh, Orit The link of mRNA localization to the ER 147
Hett, Anne Studying the fate of aberrantly spliced human pre-mRNAs 148
Page 23
EMBO|EMBL Symposium The Complex Life of mRNA
Hlevnjak, Mario Structural and functional enrichment analysis of the distribution of mRNApyrimidine content versus protein polar requirement sequence profiles
149
Hofmann, Ilse (Presenter: Regina Fischer-Keso)Plakophilin 3 regulates the mRNA stability of plakophilin 2 150
Holmes, Rebecca K. Crosslinking reveals unexpected roles for the yeast SR protein Npl3 in RNA metabolism
151
Hornyik, Csaba Exploring the miRNA transcriptome of a tuber bearing crop, potato 152
Horos, Rastislav Dynamic responses of the hepatocytic mRNA interactome to metabolic reprogramming
153
Jalinot, Pierre Role of INT6/EIF3E in histone mRNA translation 154
Jambor, Helena A systematic exploration of RNA localization in Drosophila ovaries: Finding novel partners of the maternal determinants
155
Jonas, Stefanie Structural insight into the role of SMG5–SMG7 heterodimerization for nonsense-mediated mRNA decay
156
Joo, Chirlmin Single-Molecule Approach to MicroRNA Protein Complexes 157
Jopling, Catherine L. Transcription, splicing and processing of exonic microRNAs 158
Juli, Giada Inhibition of translation elongation in response to ribosomal stress 159
Page 24
Posters A-Z
Kaminski, Tim Regulation of RNAP II during stable elongation under induced stress 160
Karousis, Evangelos D. A rapid and straightforward approach for the isolation, cloning and expression analysis of subtle alternative transcript isoforms
161
Kellner, Julian NMStructure – Function studies of the RNA helicase DDX1 162
Kershaw, Chris The La-motif containing protein Slf1 is involved in the translation regulation of mRNAs destined for mitochondria
163
Kesarwani, Anil K. Feedback and salt stress regulation of nonsense-mediated decay factorsin Arabidopsis
164
Kim, Hajin Dynamics of the Mitochondrial Transcription Pre-Initiation Complex 165
Kim, Tae Don Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK cell cytotoxicity
166
Klinge, Sebastian Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6
167
Köhn, Marcel The non-coding Y3-RNA promotes histone-mRNA 3'-processing 168
Kolowerzo, Agnieszka Functional analysis of poly(A) RNA present in Cajal bodies 169
Kong, Ka-Yiu Edwin Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal splicing efficiency
170
Page 25
EMBO|EMBL Symposium The Complex Life of mRNA
Kramer, Susanne Simpler P-bodies? Insights into RNA granules formation in trypanosomes.
171
Kubitscheck, UlrichNuclear Export of single native mRNA 172
Kuhlmann, Sonja Structural basis for the molecular recognition of polyadenosine RNA by the Zn fingers of Nab2
173
Kumakura, Naoyoshi Assessment of plant RNA exosome as a viral resistance factor 174
Lanctôt, Christian Transcriptional pulsing of RNA polymerase I-dependent transgene expression in living cells
175
Lange, Sita J. Global or local? Predicting secondary structure and accessibility in mRNAs
176
Larivière, Laurent Structure of the Mediator head module 177
Lazzaretti, Daniela Structural and functional characterization of eIF1A nuclear export pathway
178
Le Gallic, Lionel Altered metabolism in Psoriasis leads to HuR mediated stabilization of selective mRNAs
179
Limousin, Taran miRNAs can inhibit translation initiation independently of PABP/eIF4G interaction
180
Linero, Florencia Natalia Translational strategy of New World arenavirus: The viral nucleoprotein as a translation initiation factor
181
Page 26
Posters A-Z
Lloyd, James PB SMG1 is an ancient nonsense-mediated mRNA decay effector that has been lost from multiple lineages
182
Löber, Jana Regulation of Nonsense-Mediated mRNA Decay by Cellular Stress 183
Loedige, Inga The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function
184
Longman, Dasa DHX34 and NAG/NBAS act in concert with core NMD factors to regulatecommon endogenous RNA targets in humans, zebrafish and C. elegans
185
Lyons, Shawn M. The C-terminal tail of Lsm4 is required for efficient histone mRNA degradation
186
Mackereth, Cameron D. Nucleic-acid binding by splicing factor Sup-12 and isoform control in nematode muscle
187
Magler, Iris Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity
188
Majewska, Aneta Differences in expression of inflammatory genes (Tnfa and Mcp-1) and their histone H3 acetylation in the liver of young and old hyperphagic obese mice
189
Makino, Debora L.The Crystal Structure of a Yeast 11-Subunit Exosome Complex Bound toRNA
190
Manojlovic, Zarko Translation regulation of type I collagen mRNAs; a silent mechanism of fibrogenesis
191
Page 27
EMBO|EMBL Symposium The Complex Life of mRNA
Martinho, Rui G. Defining the requirements for efficient gene expression during early embryonic development
192
Maryan, Natalia Lack of evidence for transcriptional ripple effect in the neighbourhood of mitogen activated genes
193
Maslovskaja, JuliaAIRE-regulated gene expression mainly occurs on transcriptional level and is promoter-independent
194
Mathys, HansruediMultitude of protein sequence elements and protein-protein interactions involved in miRNA-mediated repression in metazoa
195
Mattioli, Chiara Antagonistic role of spliceosome and microprocessor complex on processing of Splice site Overlapping (SO) pri-miRNAs
196
Mauxion, Fabienne H. The conserved C2ORF29 protein is a bona fide subunit of the CCR4-NOT complex
197
Meignin, Carine Sensing viral RNAs by the innate immune system in drosophila 198
Meinel, Dominik Cotranscriptional recruitment of mRNA export adaptors to genes: a genome-wide view
199
Mercier, Blandine Translation-dependent mRNA decay: a key regulator of gene expression in T cells?
200
Michaud, MorganeCytosolic mRNA trafficking to plant mitochondria 201
Mikl, Martin The mRNA splicing regulator SPK-1 is required for cell polarity in one-cellC. elegans embryos
202
Page 28
Posters A-Z
Militti, Cristina Drosophila UNR regulates dosage compensation complex assembly by acting as an RNA chaperone on roX2 noncoding RNA
203
Mircsof, Dennis The Role of NOPS proteins in regulating inhibitory synapse function 204
Mocquet, Vincent HTLV-1 Tax protein inhibits NMD by interacting with INT6/EIF3E and UPF1
205
Moda, Livia Maria Differential nutrition, mRNA expression and brain mophogenesis: the honeybee model
206
Modic, Miha The role of TDP-43 in Controlling the Selection of Alternative Polyadenylation Sites
207
Morales, Julia Translational control during sea urchin early development 208
Moran, Yehu The roles and mode of action of microRNAs in the sea anemone Nematostella vectensis
209
Moreira, Alex Gene Punctuation: alternative polyadenylation and transcription termination between closely spaced tandem genes
210
Mrvova, Silvia Acute lymphoblastic leukaemia cell lines have downregulated expressionof eIF3b
211
Müller-McNicoll, Michaela Novel roles for SR proteins in histone mRNA expression 212
Munschauer, Mathias Protein occupancy profiling globally maps putative cis-regulatory mRNA regions
213
Page 29
EMBO|EMBL Symposium The Complex Life of mRNA
Muthukrishnan, Anantha Barathi Plasticity of in vivo RNA production under the control of tetA promoter inindividual Escherichia coli cells
214
Nicholson, PamelaUnravelling the mammalian nonsense-mediated mRNA decay pathway by a combined tethering / knockdown approach
215
Niedzwiecka, AnnaBiophysical properties of full length human 5’-dependent 3’-poly(A)-specific ribonuclease (PARN)
216
Nishihara, TadashimiRNA-mediated recruitment of decapping factors to mRNA targets 217
Obermann, Diana A novel role for CELF1 in vegetal RNA localization during Xenopus laevis oogenesis
218
Ogami, Koichi Anti-proliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding proteinCPEB
219
Onofre, Cláudia Translational control of the human hemojuvelin via upstream open reading frames
220
Pagani, Franco Molecular mechanism underlying splicing correction mediated by Exon-Specific U1 snRNAs (ExSpeU1)
221
Pascual, Malena Repression at Smaug 1 mRNA silencing foci involves the miRNA pathway
222
Passos, Geraldo A.The messenger RNAs that code peripheral tissue antigens in the thymusare under two levels of control involving Aire and then microRNAs
223
Page 30
Posters A-Z
Pauli, Andrea Coding potential of the transcriptome during zebrafish embryogenesis 224
Petz, Michaela PDGF mediated regulation of IRES driven Laminin B1 expression during cancer invasion
225
Pimentel, CatarinaTranscriptional and post-transcriptional mechanisms controlling iron storage in yeast
226
Pires, Camilla Valente Transcriptome analysis of Apis mellifera haploid embryos males 227
Plotnikova, Aleksandra The decapping activator HPat a novel factor interacting with the miRNA effector complex
228
Polyansky, Anton A. Evidence for the stereo-chemical origins of the genetic code and direct complementary interactions between proteins and cognate mRNAs obtained from the analysis of protein-RNA complexes
229
Provenzani, Alessandro The RNA binding protein HuR is involved in the insurgence of drug resistance mechanism to doxorubicin in breast cancer cells.
230
Quintas, Ana Deciphering the RNA-binding mechanism of African swine fever virus g5R protein
231
Ramundo, Silvia Conditional repression of plastid gene expression reveals the complex life of some mRNAs in the chloroplast
232
Rashpa, Ravish Elucidating the role of Cap binding proteins in BicD dependent localization processes
233
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EMBO|EMBL Symposium The Complex Life of mRNA
Rayson, Samantha Conserved peptide upstream open reading frames as targets of nonsense-mediated mRNA decay
234
Ribas, Lluís (Presenter: Eva Novoa) A new mechanism for genome-wide control of gene expression levels 235
Rodriguez-Navarro, Susana TREX-2 mRNA export complex and SAGA dependent deubiquitylation 236
Rösel, Tanja U1C-dependent alternative splicing regulation: RNA-Seq analysis revealsU1C/U1-70K cross-regulation
237
Rota, Rossella Notch3-dependent myomiRs regulation in Rhabdomyosarcoma 238
Roudko, Vladimir Recruitment of Ccr4-Caf1 to the Not complex is required for efficient mRNA deadenylation in vivo
239
Roux, Milena The role of Arabidopsis PAT1 in plant innate immunity 240
Roy, Rahul Spatial organization of RNA polymerase II and spliceosome revealed by super-resolution imaging of mammalian cell nucleus
241
Rybak, AgnieszkaIn vivo Dicer targets 242
Sakakibara, Iori The Six1-Linc-MYH axis regulates muscle fiber phenotype 243
Sato, Ryosuke Analyses of underlying relationship between the subcellular localization and stimulatory activity on cap-dependent translation of RNA-binding protein HuD
244
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Posters A-Z
Savelyeva, Anna Transfection of human cells by artificial RNA-nucleophosmin 1 complexes
245
Sawh, Ahilya N. A Truncated Dicer Tilts the Balance of RNAi Pathways 246
Schaal, Heiner U1 in tug of war: The choice between two closely spaced, identical splice sites is controlled by outside-positioned splicing regulatory elements
247
Schamberger, Anita Experimental validation of human mirtrons: functional microRNAs can beproduced simultaneously from both arms in a flanking exon-independentmanner
248
Scheiffele, Peter Dynamic regulation of synaptic adhesion complexes by alternative splicing
249
Scherrer, Klaus The Gene and Genon Concept allows Functional and Information-theoretic Analysis of Gene Expression
250
Schmid, Tobias Inflammatory conditions induce IRES-dependent translation of cyp24A1 251
Schüler, Markus Analyzing transcriptome-wide protein occupancy profiling 252
Schüler, Markus doRiNA: A database of RNA interactions in post-transcriptional regulation
253
Schwartz, Schraga Exploring the 5th base of mRNA: Transcriptome wide mapping of the mamalian N6-methyladenosine landscape
254
Schwarz, Juliane A System Analysis of Translation in Stem Cells 255
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EMBO|EMBL Symposium The Complex Life of mRNA
Seibt, Julie Sleep-dependent mRNA translation consolidates cortical plasticity in vivo
256
Sellier, Chantal Fox proteins chase MBNL1 from CCUG aggregates: an explanation to the lesser severity of DM2 ?
257
Serpeloni, MarianamRNA transcription/export pathway in parasites: are they using the same way?
258
Sesma, Ane RBP35 is a novel auxiliary protein of the polyadenylation machinery of filamentous fungi
259
Shahbabian, Karen Coordinated assembly of localization and translational control factors on mRNA during transcription
260
Shalem, Ophir H. Measurements of the impact of 3' end sequences on gene expression reveal wide range and sequence dependent effects
261
Shao, Ada An NMD-microRNA Regulatory Circuit in the Brain 262
Sharbati, Soroush Intestinal Salmonella Typhimurium infection leads to miR-29a induced Caveolin 2 regulation
263
Sharma, Varun Kumar The microRNA regulatory network in T-cells transformed by human T-cellleukemia virus type 1
264
Shcherbata, Halyna Drosophila microRNA-9a canalizes the process of muscle attachment assembly via downregulation of Dystroglycan
265
Shcherbata, Halyna The miR-310s complex regulates cell differentiation and proliferation in Drosophila
266
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Posters A-Z
Shcherbata, Halyna R. Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain
267
Siebrasse, Jan-Peter Single Molecule Kinetics of the RNA Helicase Dbp5 268
Singh, Kusum K. Two functional MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay
269
Singhania, Richa Post-transcriptional and translational control of siRNA-generated mRNA cleavage fragments
270
Slobodin, Boris The COPI coat complex and two cis-acting motifs govern the intracellular localization of OXA1 mRNA and its contribution to mitochondrial function
271
Smolinski, Dariusz J. Correlation between mRNA metabolism and formation of Cajal bodies and cytoplasmic snRNP-rich bodies
272
Sperling, Joseph Genome-wide activation of latent donor splice sites in stress and disease 273
Sperling, Ruth A network of interactions within the supraspliceosome 274
Spiró, Zoltán Characterization of lin-5 mRNA localization in C. elegans embryos 275
Stepanov, Grigoriy Artificial Box C/D RNAs Affect pre-mRNA Maturation in Human Cells 276
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EMBO|EMBL Symposium The Complex Life of mRNA
Stevens, Stewart G. Translation efficiency in human cells – the poor correlation between mRNA and protein levels for many genes indicates widespread translational control
277
Stöhr, Nadine IGF2BP1 - A post-transcriptional ‘driver’ of tumor cell migration 278
Sträßer, Katja The phosphoproteome of ribosomes and two specific roles in translation 279
Subasic, Deni A switch in microRNA target regulation in C. elegans: from translational inhibition to mRNA degradation in miR-58 family mutants
280
Sugiyama, Tomoyasu Selective Elimination of Meiotic mRNAs in Vegetative Fission Yeast 281
Sun, Mai Comparative Dynamic Transcriptome Analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation
282
Susor, Andrej EJC component Magoh, is essential for processing of specific transcripts in the mammalian oocyte
283
Swida-Barteczka, Aleksandra Plant miRNAs originated from the 3’UTR of protein coding genes 284
Syntichaki, Popi The role of mRNA metabolism factors in the lifespan and stress responseof Caenorhabditis elegans
285
Takeuchi-Tomita, Nono Role of the N-terminal extension on the activity of mammalian mitochondrial ribosome recycling factor: implication for the role of GTP-hydrolysis in ribosome recycling
286
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Posters A-Z
Tamura, Teruko Interaction of THOC5, a member of mRNA export complex with its targetmRNA: CA/UG trinucleotide repeats directly bind to putative helical structure domain of THOC5
287
Tantale, Katjana HIV-1 transcription in live cells with single polymerase sensitivity 288
Tantale, Katjana 3’end cleavage buffers transcriptional noise 289
Tatomer, Deirdre C. Mutation of flash affects both histone locus body structure and histone pre-mRNA processing: separation of function mutations define regions required for discrete roles
290
Tebaldi, Toma Triomics: comparison between transcriptome, translatome and proteome variations
291
Teoh, Peik Lin The WAR complex controls the efficiency of FOS splicing 292
Theil, Kathrin 5' UTR-mediated translational repression by the RNA binding protein GLD-1
293
Tiedje, Christopher The p38/MK2-driven exchange of TTP by HuR regulates LPS-induced translation initiation of AU-rich element containing mRNAs
294
Tomasetto, Catherine L. Perispeckles are major assembly sites for the exon junction core complex
295
Tran, Doan Duy Hai THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for M-CSF induced macrophage differentiation, thereby playing a key role in the mRNA export of M-CSF inducible genes
296
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EMBO|EMBL Symposium The Complex Life of mRNA
Twyffels, Laure Competitive interplay between the cytoplasmic role of dTIS11 in ARE-mediated decay and its Transportin-dependent nuclear import
297
Ubby, Ifeoma Regulation of TMEM16A Alternative Splicing 298
Urban, Marc Small RNA pathways in female gamete specification in Arabidopsis thaliana
299
Valasek, Leos Yeast Translation Begins and Ends with Translation Initiation Factor 3 (eIF3)
300
Vanacova, Stepanka A Phosphoserine-Proline Switch in RNAP II CTD Controls Binding of an RNA Processing Factor
301
Vindry, Caroline dTIS11-dependent polysomal deadenylation is the key step in AU-Rich Element-mediated mRNA decay in Drosophila cells
302
Vlatakis, Ioannis C.Enhancer of RNA interference -1-like-1: one more player in the RNA processing game of the chloroplast
303
Wagner, Jasmin Intracellular microRNA licalization and trafficking 304
Wang, Shao-Win Pdc1 functions in the assembly of P-bodies in Schizosaccharomyces pombe
305
Wang, Zhen Mapping the transcriptome-wide exon junction complex binding sites using 2-step iCLIP of eIF4A3
306
Weill, Laure Musashi: a new layer in the combinatorial CPE code 307
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Posters A-Z
Wellner, Juliane Germ cell specific RNA stabilization in Xenopus embryos 308
Winkler, Sebastiaan The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4 Not complex
309
Wippich, Frank DYRK3 couples mTORC1 signaling to mRNA granule turnover 310
Wong, Justin J-L An atlas of differential mRNA regulation by miRNAs in stem and committed myeloid cells
311
Wurth, Laurence A role of the conserved RNA-binding protein UNR in cancer progression 312
Zagrovic, Bojan Sequence Signatures of Direct Complementarity between mRNAs and Cognate Proteins on Multiple Levels
313
Zielonka, ElisabethResponses of mRNA interactome and RNA-regulons to genotoxic stress 314
Zirkel, Anne M. IGF2BP1 promotes mesenchymal cell properties by enhancing the LEF1-dependent expression of fibronectin
315
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