0022-202X/79/7306-0589$02.00/0 THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, 73:589-591, 1979 Copyright © 1979 by The Williams & Wilkins Co.

A

A cid arachidonic transformations with, in nor­

mal and psoriatic skin, 180 fatty

in skin surface lipids, effects of aging on, 112

picogram levels, detection of Neisseria gonorrhoea, 521

Acid phosphatase, psoriatic scales, 554 Acne, research needs in, 434 Aging, 1

cell biology of, 8 cellular

immunity in, 24 in Werner's syndrome, unique pheno­

type, 92 chronic sun exposure and, effects on mel­

anocytes in human skin, 141 cutaneous

perspectives and problems in, 39 structural changes in, 47

effects on fatty acids in skin surface lipids, 112 melanocytes, chronic sun exposure and,

141 rate of linear nail growth, 126 steroid hormone metabolism in skin

and isolated sebaceous glands, 118 environmental influences and photocar­

cinogenesis in, 131 human skin, changes in mechanical prop-

erties related to, 84 immunologic, thymus as clock for, 29 mitochondrial lipoperoxidation and, 123 of collagen, 80 of melanocytes, 70 photocarcinogenesis and environmental

influences in, 131 research

current and future, 2 needs in,485

sebaceous gland activity changes in, 108 structural a lterations in

exposed skin, 59 unexposed human skin, 59

unexposed human dermis, model for, 54 wound healing and, .88

Alkali extraction, combined with ethidium bromide, technique for measurement of tissue DNA, 359

Alopecia areata, direct immunofluorescence of, 317 male pattern, direct immunofluorescence

of,317 Amyloidosis, cutaneous

primary localized, histogenesis of, 150 sequential change of epidermal keratino­

cytes to amyloid via fIlamentous de­generation, 150

Antibodies drug specific, role of enzymatic coupling

of drugs to proteins in induction of, 256

pemphigus, appearance of "pemphigus acantholysis factor" in human skin cultured with, 575

wheat protein, in dermatitis herpeti­formis , 570

Aprotinin, ineffectiveness of, on psoralen-

SUBJECT INDEX

UVA-(PUVA)-induced erythema, 527

B

Bil·th defects, research needs in, 460 Blister fluid, suction, lipids and proteins in,

determination of, 303 Bullous pemphigoid

demonstration of complement regulating protein, ,BIH, in skin biopsies from patients with, 551

serum eosinophil chemotactic factor levels in, 163

4-[3-Butoxy-4-methoxybenzyIJ-2-imidazoli­dinone, treatment of psoriatic lesions, double-blind trials, 261

C

Cholinesterase isoenzymes, skin and plasma, comparison, 239

Clonal priming, direct in vitro assessment of autologous HLA-associated factors required for immune response to din­itrochlorobenzene, 246

Collagen aging of, 80 type IV, in protoporphyria, 335

Complement, serum, activation, purification of mamman from Candida albicans for, 269

Connective tissue disease, research needs in, 485

Corneocytes, psoriatic, surface area mea­surements, effects of intralesional ste­roid therapy, 558

Cyclic GMP, epidermis effect of ischemia on, 220 histamine stimulated formation, 313

D

Dermatitis herpetiformis failure to detect gliadin or gliadin binding

sites in, 174 wheat protein antibiodies in, 570

Dermatogerontology, exfoliative cytologic procedures as nonintrusive method of,67

Dermatological diseases, prevalence, mor­bidity and cost of, 395

Dermatopharmacology, research needs in, 473

Dermatophyte, experimental lesions, pro­duction of, 198

Dermis dithiothreitol separation of, 207 unexposed human, aging model for, 54

7, 12-Dimethylbenz(a)antracene, and UVB effect on epidermal melanocytes, 538

Dinitrochlorobenzene, in vitro assessment of autologous HLA-associated factors required for immune response to, 246

Dithiothreitol, separation of newborn ro­dent dermis and epidermis with, 207

DNA cytophotometry, lymph node imprints

from patients with mycosis fungoides, 275

epidermal keratinocytes, repau' of ultra­violet light damage to, 217

fibroblasts, repair of ultraviolet light dam­age to, 217

589

Vol. 73, No.6 Printed in U. S. A.

interaction with 8-methoxypsoralen, LIt

vitro, 191 phage lambda, interstrand crosslinks in,

after exposure to 8-methoxypsoralen and trimethylpsoralen in light, 236

repair processes, protection of premature solar damage by, evidence in xerod­erma pigmentosum, 102

tissue, measurement, combined alkali ex­traction-ethidium bromide technique for, 359

Drug reactions, serum eosinophil chemotac­tic factor levels in, 163

Dyskeratosis congenita, psoralen-DNA cross-linking photoadducts in, delay in excision and promotion of sister chromatid exchange, 97

E

Eczema, atopic inlpaired H2 histamine granulocyte re­

sponse in, 184 research needs in, 414 serum eosinophil chemotactic factor

levels in, 163 EDCI, in psoriasis, 264 Elu triation, lymphocyte function after, com­

pared with ficoll-hypaque flotation, 231

Envu"onmental agents, skin reaction to, re­search need in, 501

Enzymatic coupling, drugs to proteins, role of, in induction of drug specific anti­bodies, 256

Eosinophil, serum, chemotactic factor levels in bullous pemphigoid, drug reactions and atopic eczema, 163

Epidermis comparative ultrastructure and cyto­

chemistry of response to tape strip­ping, ethanol and vitamin A acid in hairless mice, 203

cycl ic GMP system effect of ischemia on, 220 histamine stimulated formation, 313

dithiothreitol separation of, 207 a-fucosidase, multiple forms of, 288 ,B-galactosidase, heterogeneity, newborn

rat, 285 living, epidermal cell cultures as models

for, 135 Erythema, psora len-UVA-(PUVA)-in-

duced, aprotinin ineffectiveness on, 527

Erythrocyte conjugates of hapten, in vitro and in vivo detection of, 166

Ethanol, ultrastructure and cytochemistry of epidermal response to, hairless mice, 203

Ethidium bromide, combined with alkali ex­traction, technique for measurement of tissue DNA, 359

Eumelanogenesis, in retinal and follicular melanocY,tes, compared with pheo­melanogenesis, 278

European Society for Dermatological Re­seru'ch, 9th annual meeting

minutes, 583 presidential address, 582

Exfoliation, agents for, effect on rhino mouse skin, 354

590 SUBJECT INDEX

F

Fibrin, deposition and clearance, in chronic granulomatous inflammation, corre­lation with T-cell function, and pro­teinase inhibitor activity in tissue, 561

Fibroblasts cultured skin

age-related diseases in, 19 aging and, 15

photo inactivation of, by frationated treat­ment with 8-methoxypsoralen and long wave ultraviolet light, 176

ultraviolet light damage to DNA of, re­pair,217

Ficoll-hypaque flotation, lymphocyte func­tion after, compared with elutriation, 231

Follicular casts, inflammatory mediators in, method for assay of, 266

a-Fucosidase epidermal, multiple forms of, 288 psoriatic scales, 554

G

IJ-Galactosidase, heterogeneity, newborn rat epidermis, 285

Genetic disorders, research needs in, 460 Gerontology; cutaneous, perspectives and

problems in, 39 Gliadin, failure of detection, in dermatitis

herpetiform is, 174 Glycoprotein

cancer-related, accumulation, urinary, in psoriasis, 264

non collagenous, in protoporphyria, 335 Goeckerman regimen, components of, 170 Granulocyte, impaired H2 histamine re­

sponse in active atopic eczema, 184 Granulomatous inflammation, chronic, fi­

brin deposition and clearance in, cor­relation with T-cell function and pro­teinase inhibitor activity in tissue, 561

H

Hapten, erythrocyte conjugates, detection of in vitro and in vivo, 166

Histamine . impaired granulocyte response, in active

atopic eczema, 184 stimulation of cyclic GMP in epidermis,

313 Histometric analysis, human skin in organ

culture, 138 3-Hydroxy fatty acids, picogram levels, de­

tection of Neisseria gonorrhoea, 521

I

Immunity, cellular, in aging, 24 Immunologic aging, thymus as clock for, 29 Immunologic disease, research needs in, 414 Infections, dermatologic, research needs in,

452 Instrumentation, dermatologic, research

needsin,473 Ischemia, effect on cyclic GMP system of

epidermis, 220 Isoenzymes, cholinesterase, skin and

plasma, comparison, 239

K

Karyotype, cutaneous T cell lymphoma, clonal origin, 548

Keratinization, agents for, effect on rhino mouse skin, 354

Keratinocytes epidermal, ultraviolet light damage to

DNA of, repair, 217 sequential change to amyloid via fllamen­

tous degeneration, in cutaneous amy­loidosis, 150

Kinin-forming enzyme, human skin, purifi­cation and characterization of, 297

L

Langerhans cells, epidermal, kinetics of, 566 Letter to edi tor

chronic Trichophyton I'ubrum infection and blood groups, 392

reactive hyperemia in scleroderma, 259 regional variation of immunoglobulin de­

posits in NZB/W FI mice, tail-end suggestion, 392

tyrosine hydroxylation, 392 Lichen planus, changes in carbohydrate

expression of, in oral epithelial cell membranes, 364

Light, ultraviolet and 7, 12-dimethylbenz(alantracene, ef­

fect on epidermal melanocytes, 538 damage to DNA of cultured human epi­

dermal keratinocytes and fibroblasts, repair of, 217

effect on sunburn cell production, 243 local and systemic effects on epidermal

. melanocyte population, 306 modulation of prostaglandin E2 binding to

human skin membranes, 373 photoinactivation of skin fibroblasts, 176 psoralen and, induction of erythema, in­

effectiveness of aprotinin on, 527 Lipids

in suction blister fluid, determination of, 303

localization and composition of, in neo­natal mouse stratum granulosum and stratum corneum, 339

skin surface, fatty acids of, effect of aging on, 112

Lipoperoxidation, mitochondrial, in human skin, age-related, 123

Lupus erythematosus, systemic, concurrent linear scleroderma and, report of two cases, 368

Lymph node imprints, DNA-cytophotome­try of, from patients with mycosis fungo ides, 275

Lymphocyte function, after isolation by ficoll-hypaque

flotation or elutriation, 231 6-thioguanine resistance of, after photo­

chemotherapy, 211 Lymphoma, T cell , cutaneous, karyotype

studies 0'[, evidence for clonal origin, 548

M

Malassezia furfur, and immunological stud­ies on Pityrosporum genus, 321

Mannan, for activation of serum comple­ment, purification of, from Candida albicans, 269

a-Mannosidase, psoriatic scales, 554 Melanocytes

aging of, 70 epidermal, effects of

psoralen and UVA (PUV A) on, 533 UVB and 7,12-dimethylbenz(a)antra­

cene on, 538 extracellular sheath of, in nevus fuscocer­

uleus acromiodeltoideus and Mongo­lian spot, ultrastructure, 224

human skin, effects of aging and chronic sun exposure on, 141

local and systemic effects of UV-irradia­tion, 306

Vol. 73, No.6

retinal and follicular, eumelanogenesis and pheomelanogenesis, 278

Melanoma, malignant, research needs in, 491

Melanosome, differentiation, role of vesi­culo-globular bodies in, 278

Merkel cell, specialized junction with neu­rite, electron microscopy, 325

Methoxasalen, chronic photosensitization with, dermatological and ocular ex­amination after, 250

8-Methoxypsoralen interaction with DNA, in vitro, 191 interstrand crosslinks in DNA of phage

lambda after exposure to, 236 photo inactivation of skin fibroblasts and,

176 Mitochondria, lipoperoxidation, in human

skin, age-related, 123 Monocyte function, in psoriasis, 147 Mongolian spot, extracellular sheath of der­

mal melanocytes in, 224 Musk ambrette, assay of contact photosen­

sitivity to, guinea pig, 144 Mycosis fungoides, DNA-cytophotometry of

lymph node imprints in, 275

N

Nail growth, linear, rate of, effects of aging on, 126

Neoplasms, research needs in benign, 443 malignant, 443

Neurite, specialized junction with Merkel cell, electron microscopy, 325

Nevus fuscoceruleus acromiodeltoideus, ex­tracellular sheath of dermal melano­cytes in, 224

P

Papilloma virus 3, in warts of renal allograft patient, characterization of, 349

Pemphigoid, bullous demonstration of complement regulating

protein in skin biopsies from patients with,551

serum eosinophil chemotactic factor in, 163

Pemphigus acantholysis factor, appearance of, in human skin cultured with pem­phigus antibody, 575

Phagocytic chemotaxis, 515 Pheomelanogenesis, in retinal and follicular

melanocytes, compared with eume-lanogenesis, 278

Photocarcinogenesis, aging and environ­mental influences, 131

Photochemotherapy suppression of proliferative stimulus pro­

duced by stripping on hairless mice, 188

6-thioguanine resistant peripheral blood lymphocytes after, 211

Photosensitization chronic, with methoxsalen, dermatologi­

cal and ocular examination after, 250 contact, to musk ambrette, assay of, 144

Pityrosporum, immunological studies, and Malassezia furfur, 321

Preputial gland cells, isolation, separation and characterization, in sebaceous gland differentiation, 291

Propranolol, differential induction of abnor­mal proliferation of uninvolved pso­riatic epidermis, 545

Prostaglandin E 2, specific binding to mem­branes from human skin, receptor modulation by UVB-irradiation and chemical agents, 373

December 1979

Prote in complement regulat ing, demonstration of,

in skin biopsies from pat ients with bullous pemphigoid, 551

in suction blister fluid, determination of, 303

wheat, ant ibodies of, in dermatitis herpet­iformis, 570

Prote inase inhibi tor activi ty, T-cell function and, correlation with fibrin deposi­tion and clearance in chronic granu­lomatous inflammation, 561

P rotoporphyria, type IV collagen and non­collagenous glycoprotein in thick­ened vascular basal membrane in, 335

Pruritus, pain and, research need in, 495 Psoralen

DNA, cross- linking photoadducts in dy­skera tosis congenita, delay in excision and promotion of sister chromatid exchange, 97

effects of, with UV A on epidermal mela­nocytes, 533

6-thioguanine resistant peripheral blood lymphocytes and, 211

wi th UVA, induction of erythema, ineffec­tiveness of aprotinin on, 527

Psorias is abnormal prolifera tion of uninvolved epi­

dermis, differential induction by sa­line, propranolol , and tape stripping, in vivo, 545

accumulation of urinary cancer-related glycoprotein in, 264

arach idonic acid transformations in, 180 corneocytes of, surface area measure­

ments, effec ts of intralesional steroid therapy on, 558

Goeckerman regimen components, 170 monocyte function in, 147 multiple forms and glycoprote in nature of

ac id phosphatase, a-fucosidase and a-mannosidase of scales of, 554

reseaJ'ch needs in, 402 Ro 20- 1724 treatment, double-blind clini­

cal t rials, 261

R

Reviews of Books and Audiovisual Aids Botanical Dermatology, 584

Cancer Dermatology, 584 Clinical Shin Microbiology, 202 Gross and Microscopic Pathology of the

Shin, 584 Les Affections Dennatologiques en

O.RL. and Reparations Plastiques des Pertes de Substances Cutanee de la Face, 202

Metabolic Basis of Inherited Disease, 584 Physiology and Pathology of the Shin,

Vol. 5: Sweat Glands, Sllin Permea­tion, Lymphatics, Nails, 585

Sexually Transmitted Diseases, 202 UV-A: Biological Effects of Ultraviolet

Radiation with Emphasis on Hu­man Response to Longwave ULtra­violet, 202

Ro 20-1724, treatment of psoriatic lesions, double-blind clinical trials, 261

s Saline, differential induction of abnormal

prolifera tion of uninvolved psoriatic epidermis, 545

Scleroderma, linear, concurrent systemic lu­pus erythematosus and, report of two cases, 368

Sebaceous gland age-related changes in, 108 differentiation, preputia l gland cells, 291

Sensitization, contact simple chemical, 246 Society for Investigative Dermato logy, Inc.,

May 7-9, 1979, annual meeting, min-utes of, 373

Steroid hormone metabolism, in skin and isolated

sebaceous glands, effects of age on, 118

therapy, effect on surface area measure­ments of psoriatic corneocytes, 558

Stratum corneum, lipids in, localization and . composition of, 339

Stratum granulosum lipids in, localization and composition of, 339

Sun exposure, chronic, aging and, effects on melanocytes in human skin, 141

Sunburn cell production, longwave ultravi­olet radiation effect on, 243

Sweating disorders, research need in, 495

SUBJECT INDEX 591

T

T cell function, proteinase inhibitor activity in

tissue and, correlation with fibrin deposition and clearance in chronic granulomatous inflammation, 561

lymphoma, cutaneous, karyotype studies of, evidence for clonal origin, 548

T ape stripping differential induction of abnormal prolif­

eration of uninvolved psoriatic epi­dermis, 545

ultrastructure and cytochemistry of epi­dermial response to, 203

6-Thioguanine, peripheral blood lympho­cyte resistance to, after psoralen, long wave ul traviolet light therapy, 211

Thymus, as clock for immunologic aging, 29 Trimethylpsoralen, interstrand crosslinks in

DNA of phage lambda after exposure to, 236

Tyrosine metabolism, hepatic enzymes of, in tyrosinemia II, 530

Tyrosinemia II, hepatic enzymes of tyrosine metabolism in, 530

v

Vitamin A, ultrastructure and cytochemis­try of epidermal response to, hairless mice, 203

Vitiligo, research needs in, 491

w

Warts, renal a llograft patient, papiJlomavi­rus 3 in, characterization of, 349

Werner's syndrome, cellular aging in, unique phenotype, 92

Wound healing, aging and, 88

x

Xeroderma pigmentosum, evidence for DNA repair processes protecting from premature solar damage, 102