Student’s Name_______________________

Heptachlor Assignment -- Spring 2018

All parts of the assignments must be performed in order to earn an A on this assignment.

A. Write a brief essay on the additional information you were able to derive from Crystal Ball that the averages or

conservative values alone did not provide. Submit this essay as part 1 of your assignment.

B. The heptachlor exercise described in module 5 was run for exposure to heptachlor of a child who drank cow's milk

contaminated from age 6 to age 10. The data used in this run are different from those described in module 5. The

following graphs were obtained.

Heptachlor ingested by cattle is given in mg/day

Heptachlor ingested by humans (mg/day)

Average lifetime exposure in mg/kg/day

Please answer the following questions, based on the graphs shown above.

a. How much heptachlor did the cattle ingest (mg heptachlor/day)?

b. How much heptachlor accumulated in the milk (mg heptachlor/liter of milk)?

c. How much heptachlor did each child ingest (mg heptachlor/day)?

d. What is the average lifetime human dose (mg heptachlor/kg body weight.day) due to the children drinking this milk?

e. What is the probable incremental lifetime cancer risk for these children?

f. What is the probability that the risk lies between 1E-6 and 1E-4?

g. What is the probability that the risk is greater than 1E-4?

h. What conclusions can you draw from the sensitivity chart?

i. What are the parameters that have the greatest influence on the results, and for which you would want to get more accurate data if you could, and control if possible.

j. What other tidbits have you found?

C. Repeat the entire case study in Module 5 for exposure to heptachlor of a child who drank cow's milk contaminated as described in the attachment given in the module from age 6 to 10. Run the program. Include your spreadsheet and answers to all the same questions as in step B, based on the results of your run.